ENSG00000104447

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000220888 ENSG00000104447 HEK293_OSMI2_6hA HEK293_TMG_6hB TRPS1 protein_coding protein_coding 1.566094 0.7755964 3.284268 0.1559019 0.3185119 2.068098 0.43798313 0.06528703 1.2074875 0.01186213 0.1536431 4.015362 0.17820833 0.0885 0.36673333 0.27823333 0.00645263 0.00645263 FALSE TRUE
ENST00000395713 ENSG00000104447 HEK293_OSMI2_6hA HEK293_TMG_6hB TRPS1 protein_coding protein_coding 1.566094 0.7755964 3.284268 0.1559019 0.3185119 2.068098 0.01770195 0.08382370 0.0000000 0.08382370 0.0000000 -3.229952 0.02611667 0.1807 0.00000000 -0.18070000 0.74596611 0.00645263 FALSE FALSE
ENST00000395715 ENSG00000104447 HEK293_OSMI2_6hA HEK293_TMG_6hB TRPS1 protein_coding protein_coding 1.566094 0.7755964 3.284268 0.1559019 0.3185119 2.068098 0.55688733 0.62648570 1.1699552 0.23281726 0.3433345 0.890532 0.36268333 0.7308 0.36056667 -0.37023333 0.35784519 0.00645263 FALSE TRUE
ENST00000518018 ENSG00000104447 HEK293_OSMI2_6hA HEK293_TMG_6hB TRPS1 protein_coding protein_coding 1.566094 0.7755964 3.284268 0.1559019 0.3185119 2.068098 0.07336788 0.00000000 0.2165815 0.00000000 0.2165815 4.501958 0.04882917 0.0000 0.05763333 0.05763333 1.00000000 0.00645263 FALSE FALSE
ENST00000640765 ENSG00000104447 HEK293_OSMI2_6hA HEK293_TMG_6hB TRPS1 protein_coding protein_coding 1.566094 0.7755964 3.284268 0.1559019 0.3185119 2.068098 0.40140797 0.00000000 0.6455130 0.00000000 0.3306236 6.034553 0.35173750 0.0000 0.20200000 0.20200000 0.53207534 0.00645263 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000104447 E001 131.1936544 0.0008021709 4.272955e-09 2.177809e-07 8 115408496 115412548 4053 - 2.003 2.178 0.586
ENSG00000104447 E002 59.3000264 0.0012031437 8.305516e-01 9.140955e-01 8 115412549 115413813 1265 - 1.705 1.714 0.032
ENSG00000104447 E003 12.1409500 0.0138903322 4.838529e-01 6.896736e-01 8 115413814 115413921 108 - 1.069 0.969 -0.367
ENSG00000104447 E004 32.3137485 0.0326143273 7.114791e-01 8.427708e-01 8 115413922 115414428 507 - 1.471 1.394 -0.266
ENSG00000104447 E005 45.9026247 0.0047910534 6.140607e-01 7.795764e-01 8 115414429 115415084 656 - 1.613 1.575 -0.131
ENSG00000104447 E006 14.6871708 0.0023776317 1.987197e-01 4.280572e-01 8 115418330 115418452 123 - 1.158 1.019 -0.504
ENSG00000104447 E007 0.0000000       8 115492188 115492221 34 -      
ENSG00000104447 E008 0.0000000       8 115515190 115515283 94 -      
ENSG00000104447 E009 39.1924537 0.0032884744 5.665916e-01 7.477079e-01 8 115587001 115587604 604 - 1.543 1.501 -0.144
ENSG00000104447 E010 16.0583342 0.0120567662 2.141363e-01 4.465295e-01 8 115603873 115604050 178 - 1.199 1.062 -0.492
ENSG00000104447 E011 30.2873797 0.0157744962 1.034398e-01 2.879558e-01 8 115604051 115604650 600 - 1.461 1.307 -0.533
ENSG00000104447 E012 21.0386346 0.0021473537 1.840140e-01 4.091696e-01 8 115604651 115605002 352 - 1.302 1.181 -0.428
ENSG00000104447 E013 35.0694971 0.0019680377 1.047800e-03 1.027597e-02 8 115619132 115619709 578 - 1.538 1.285 -0.872
ENSG00000104447 E014 7.6796660 0.0363258200 7.879477e-01 8.893621e-01 8 115619710 115619746 37 - 0.888 0.837 -0.194
ENSG00000104447 E015 7.1706685 0.0149360827 6.532965e-01 8.056180e-01 8 115619747 115619773 27 - 0.867 0.799 -0.263
ENSG00000104447 E016 8.9698896 0.0454666819 7.631023e-01 8.744953e-01 8 115619774 115619847 74 - 0.952 0.874 -0.297
ENSG00000104447 E017 8.1130011 0.0700664884 7.650941e-01 8.757054e-01 8 115619848 115619912 65 - 0.895 0.907 0.043
ENSG00000104447 E018 10.4918006 0.1003953665 6.456450e-01 8.005766e-01 8 115619913 115620060 148 - 0.989 1.019 0.109
ENSG00000104447 E019 0.0000000       8 115620061 115620070 10 -      
ENSG00000104447 E020 0.4952057 0.4131222363 5.723315e-01   8 115623601 115623610 10 - 0.132 0.203 0.753
ENSG00000104447 E021 1.4418981 0.1948158335 4.501475e-01 6.657962e-01 8 115623611 115623758 148 - 0.314 0.442 0.736
ENSG00000104447 E022 0.1308682 0.0326491905 1.254815e-01   8 115637234 115637330 97 - 0.000 0.201 12.106
ENSG00000104447 E023 0.0000000       8 115661570 115661678 109 -      
ENSG00000104447 E024 0.3206185 0.0249608161 1.000000e+00   8 115667874 115668294 421 - 0.131 0.000 -10.426
ENSG00000104447 E025 8.8808428 0.0053310152 5.707360e-01 7.508106e-01 8 115668545 115668975 431 - 0.951 0.875 -0.287
ENSG00000104447 E026 0.1614157 0.0404315512 1.000000e+00   8 115669345 115669483 139 - 0.071 0.000 -9.440
ENSG00000104447 E027 0.0000000       8 115700936 115701072 137 -      
ENSG00000104447 E028 0.0000000       8 115809633 115809673 41 -