ENSG00000104325

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000220764 ENSG00000104325 HEK293_OSMI2_6hA HEK293_TMG_6hB DECR1 protein_coding protein_coding 23.30315 11.25433 26.88294 2.349394 0.6254804 1.255466 2.8048327 1.497298 3.128426 0.3285785 0.1224726 1.0580768 0.12376250 0.1326667 0.11670000 -0.01596667 0.8420556403 0.0004166229 FALSE  
ENST00000517314 ENSG00000104325 HEK293_OSMI2_6hA HEK293_TMG_6hB DECR1 protein_coding nonsense_mediated_decay 23.30315 11.25433 26.88294 2.349394 0.6254804 1.255466 1.9166434 1.511311 1.632761 0.6812775 0.8712196 0.1108073 0.08005417 0.1153000 0.05973333 -0.05556667 0.8548076305 0.0004166229 FALSE  
ENST00000517761 ENSG00000104325 HEK293_OSMI2_6hA HEK293_TMG_6hB DECR1 protein_coding protein_coding 23.30315 11.25433 26.88294 2.349394 0.6254804 1.255466 0.5784331 0.000000 1.619479 0.0000000 0.6266534 7.3482667 0.02655833 0.0000000 0.06123333 0.06123333 0.0004166229 0.0004166229 FALSE  
ENST00000519007 ENSG00000104325 HEK293_OSMI2_6hA HEK293_TMG_6hB DECR1 protein_coding processed_transcript 23.30315 11.25433 26.88294 2.349394 0.6254804 1.255466 6.8914134 2.894194 8.373636 0.3269197 0.4826496 1.5294385 0.28567083 0.2762333 0.31220000 0.03596667 0.8872758544 0.0004166229 FALSE  
ENST00000523447 ENSG00000104325 HEK293_OSMI2_6hA HEK293_TMG_6hB DECR1 protein_coding processed_transcript 23.30315 11.25433 26.88294 2.349394 0.6254804 1.255466 9.7932442 4.679746 11.323252 1.1020641 0.7868324 1.2729801 0.41775000 0.4099667 0.42040000 0.01043333 0.9879613521 0.0004166229 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000104325 E001 1.0481105 0.0153787590 0.113458399   8 90001405 90001445 41 + 0.167 0.444 1.924
ENSG00000104325 E002 1.6444447 0.0121989077 0.324232792 0.56351508 8 90001446 90001457 12 + 0.337 0.508 0.923
ENSG00000104325 E003 2.4241118 0.0105210540 0.144156088 0.35360333 8 90001458 90001462 5 + 0.422 0.658 1.116
ENSG00000104325 E004 5.0461723 0.0053357515 0.119664494 0.31530594 8 90001463 90001475 13 + 0.677 0.884 0.829
ENSG00000104325 E005 5.0461723 0.0053357515 0.119664494 0.31530594 8 90001476 90001476 1 + 0.677 0.884 0.829
ENSG00000104325 E006 5.9653378 0.0050894569 0.283593225 0.52404927 8 90001477 90001477 1 + 0.772 0.909 0.530
ENSG00000104325 E007 5.9653378 0.0050894569 0.283593225 0.52404927 8 90001478 90001479 2 + 0.772 0.909 0.530
ENSG00000104325 E008 15.3933857 0.0021552587 0.279769144 0.51985071 8 90001480 90001487 8 + 1.229 1.128 -0.358
ENSG00000104325 E009 37.9672814 0.0011710147 0.150611771 0.36317009 8 90001488 90001516 29 + 1.601 1.512 -0.303
ENSG00000104325 E010 48.9514394 0.0007542495 0.736345850 0.85817970 8 90001517 90001561 45 + 1.684 1.666 -0.063
ENSG00000104325 E011 0.5283420 0.3388325878 0.959804840   8 90005292 90005369 78 + 0.170 0.161 -0.095
ENSG00000104325 E012 4.2558386 0.0063292840 0.003552985 0.02666631 8 90005448 90005731 284 + 0.524 0.931 1.686
ENSG00000104325 E013 1.1067030 0.0140523937 0.030865070   8 90005732 90005845 114 + 0.422 0.000 -13.745
ENSG00000104325 E014 1.1224633 0.0264741563 0.748133713   8 90006036 90006277 242 + 0.337 0.276 -0.402
ENSG00000104325 E015 2.3299188 0.0394271566 0.015694335 0.08071650 8 90015541 90015666 126 + 0.631 0.159 -2.886
ENSG00000104325 E016 1.0460853 0.1156813921 0.445312345   8 90016734 90017123 390 + 0.232 0.371 0.937
ENSG00000104325 E017 37.6329933 0.0010564690 0.653625809 0.80585922 8 90017124 90017131 8 + 1.575 1.547 -0.096
ENSG00000104325 E018 64.6345464 0.0123733813 0.620979633 0.78452799 8 90017132 90017202 71 + 1.810 1.765 -0.153
ENSG00000104325 E019 95.4725853 0.0008363552 0.065002289 0.21391190 8 90017203 90017301 99 + 1.987 1.913 -0.248
ENSG00000104325 E020 64.7240458 0.0007941018 0.305621054 0.54624516 8 90017302 90017326 25 + 1.811 1.763 -0.164
ENSG00000104325 E021 0.0000000       8 90018564 90018815 252 +      
ENSG00000104325 E022 0.3150090 0.0312625203 0.632939666   8 90018816 90018908 93 + 0.091 0.160 0.926
ENSG00000104325 E023 86.0534751 0.0006254120 0.173711487 0.39548223 8 90018909 90018966 58 + 1.937 1.881 -0.188
ENSG00000104325 E024 101.4773119 0.0004251253 0.643669278 0.79932322 8 90019086 90019172 87 + 1.997 1.980 -0.057
ENSG00000104325 E025 115.9525931 0.0004771740 0.254637407 0.49313820 8 90020909 90021056 148 + 2.037 2.074 0.126
ENSG00000104325 E026 0.0000000       8 90029284 90029464 181 +      
ENSG00000104325 E027 0.1308682 0.0326491905 0.257118128   8 90030455 90030525 71 + 0.000 0.159 12.628
ENSG00000104325 E028 112.4981658 0.0020812976 0.966294562 0.98504622 8 90036841 90036940 100 + 2.036 2.034 -0.006
ENSG00000104325 E029 0.1779838 0.0336818633 1.000000000   8 90036941 90037021 81 + 0.092 0.000 -10.978
ENSG00000104325 E030 0.2027342 0.0347831667 0.255160302   8 90042479 90042727 249 + 0.000 0.160 12.631
ENSG00000104325 E031 65.3521493 0.0031362625 0.837334766 0.91796408 8 90042728 90042732 5 + 1.798 1.808 0.034
ENSG00000104325 E032 104.3355107 0.0017606724 0.444033438 0.66140189 8 90042733 90042800 68 + 1.992 2.022 0.100
ENSG00000104325 E033 131.7924514 0.0004315941 0.494596267 0.69719460 8 90044849 90044995 147 + 2.098 2.119 0.070
ENSG00000104325 E034 0.1426347 0.0323978125 1.000000000   8 90045032 90045086 55 + 0.091 0.000 -10.974
ENSG00000104325 E035 86.0782568 0.0007125476 0.591024387 0.76441159 8 90051677 90051739 63 + 1.917 1.938 0.070
ENSG00000104325 E036 71.8662104 0.0007733951 0.130528759 0.33264482 8 90051838 90053633 1796 + 1.824 1.888 0.217