ENSG00000104218

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262210 ENSG00000104218 HEK293_OSMI2_6hA HEK293_TMG_6hB CSPP1 protein_coding protein_coding 9.217612 3.933149 16.8757 0.1535792 0.5851377 2.098382 0.6167959 0.3110481 0.0000000 0.31104805 0.00000000 -5.004717 0.07506667 0.07736667 0.00000000 -0.0773666667 7.135081e-01 7.555205e-06 FALSE TRUE
ENST00000676317 ENSG00000104218 HEK293_OSMI2_6hA HEK293_TMG_6hB CSPP1 protein_coding protein_coding 9.217612 3.933149 16.8757 0.1535792 0.5851377 2.098382 1.2710846 1.1422051 2.4522348 0.27726282 0.27227144 1.095571 0.16416667 0.29700000 0.14450000 -0.1525000000 4.017573e-01 7.555205e-06 FALSE TRUE
ENST00000677938 ENSG00000104218 HEK293_OSMI2_6hA HEK293_TMG_6hB CSPP1 protein_coding retained_intron 9.217612 3.933149 16.8757 0.1535792 0.5851377 2.098382 0.5109570 0.2154773 0.9188513 0.05714715 0.07649869 2.042465 0.06360417 0.05453333 0.05430000 -0.0002333333 1.000000e+00 7.555205e-06   FALSE
ENST00000678204 ENSG00000104218 HEK293_OSMI2_6hA HEK293_TMG_6hB CSPP1 protein_coding nonsense_mediated_decay 9.217612 3.933149 16.8757 0.1535792 0.5851377 2.098382 0.1919705 0.0000000 1.1960331 0.00000000 0.10139713 6.914126 0.01210417 0.00000000 0.07146667 0.0714666667 7.555205e-06 7.555205e-06 FALSE FALSE
ENST00000678216 ENSG00000104218 HEK293_OSMI2_6hA HEK293_TMG_6hB CSPP1 protein_coding retained_intron 9.217612 3.933149 16.8757 0.1535792 0.5851377 2.098382 0.5422066 0.0000000 0.9956027 0.00000000 0.51542245 6.651917 0.03294583 0.00000000 0.05913333 0.0591333333 5.074499e-01 7.555205e-06 FALSE TRUE
ENST00000678318 ENSG00000104218 HEK293_OSMI2_6hA HEK293_TMG_6hB CSPP1 protein_coding protein_coding 9.217612 3.933149 16.8757 0.1535792 0.5851377 2.098382 0.4165326 0.0000000 0.9485534 0.00000000 0.50968544 6.582787 0.03077917 0.00000000 0.05423333 0.0542333333 5.307286e-01 7.555205e-06 FALSE TRUE
ENST00000678362 ENSG00000104218 HEK293_OSMI2_6hA HEK293_TMG_6hB CSPP1 protein_coding nonsense_mediated_decay 9.217612 3.933149 16.8757 0.1535792 0.5851377 2.098382 1.3328558 0.1319416 2.1537569 0.13194156 0.48269108 3.930169 0.11125000 0.03183333 0.12630000 0.0944666667 3.457631e-01 7.555205e-06 FALSE TRUE
ENST00000679060 ENSG00000104218 HEK293_OSMI2_6hA HEK293_TMG_6hB CSPP1 protein_coding retained_intron 9.217612 3.933149 16.8757 0.1535792 0.5851377 2.098382 1.1098312 0.6347718 2.0110235 0.09809827 0.36790475 1.648225 0.10696667 0.16120000 0.11843333 -0.0427666667 7.476587e-01 7.555205e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000104218 E001 0.3807181 0.0425557944 0.4289806554   8 67062417 67062425 9 + 0.073 0.196 1.637
ENSG00000104218 E002 1.5337289 0.0638972863 0.8478438227 0.923753331 8 67062426 67062520 95 + 0.359 0.331 -0.170
ENSG00000104218 E003 0.3337900 0.0297528250 0.4275932465   8 67064093 67064315 223 + 0.073 0.196 1.636
ENSG00000104218 E004 0.3150090 0.0281741702 0.4265135194   8 67064316 67064335 20 + 0.073 0.196 1.638
ENSG00000104218 E005 0.3150090 0.0281741702 0.4265135194   8 67064336 67064339 4 + 0.073 0.196 1.638
ENSG00000104218 E006 0.3150090 0.0281741702 0.4265135194   8 67064340 67064345 6 + 0.073 0.196 1.638
ENSG00000104218 E007 0.1426347 0.0320350267 1.0000000000   8 67064346 67064347 2 + 0.073 0.000 -11.323
ENSG00000104218 E008 0.4458772 0.0217681645 0.1363839775   8 67064348 67064361 14 + 0.073 0.330 2.635
ENSG00000104218 E009 0.5767453 0.0193874923 0.0408116177   8 67064362 67064367 6 + 0.073 0.432 3.218
ENSG00000104218 E010 0.5767453 0.0193874923 0.0408116177   8 67064368 67064369 2 + 0.073 0.432 3.218
ENSG00000104218 E011 0.8807956 0.0172671820 0.2054201654   8 67064370 67064374 5 + 0.190 0.432 1.634
ENSG00000104218 E012 0.8807956 0.0172671820 0.2054201654   8 67064375 67064377 3 + 0.190 0.432 1.634
ENSG00000104218 E013 2.2576048 0.0710482049 0.5362863420 0.726497730 8 67064378 67064387 10 + 0.449 0.581 0.633
ENSG00000104218 E014 2.4002395 0.0947722500 0.6332921054 0.792527488 8 67064388 67064390 3 + 0.475 0.581 0.498
ENSG00000104218 E015 2.7643894 0.0527948652 0.4734893137 0.682444357 8 67064391 67064391 1 + 0.502 0.643 0.641
ENSG00000104218 E016 3.3912711 0.1446573641 0.7530541635 0.868571875 8 67064392 67064398 7 + 0.589 0.642 0.230
ENSG00000104218 E017 4.6551853 0.2590332025 0.5535103677 0.738717061 8 67064399 67064403 5 + 0.678 0.781 0.420
ENSG00000104218 E018 8.9071450 0.3102641859 0.1473701192 0.358546793 8 67064404 67064422 19 + 0.837 1.161 1.198
ENSG00000104218 E019 9.2487574 0.3439256539 0.1724555638 0.393777128 8 67064423 67064425 3 + 0.861 1.160 1.107
ENSG00000104218 E020 9.2377987 0.3473559014 0.1979706390 0.427105344 8 67064426 67064427 2 + 0.871 1.142 1.000
ENSG00000104218 E021 17.9888931 0.6062821874 0.5343259805 0.725151439 8 67064428 67064454 27 + 1.205 1.262 0.202
ENSG00000104218 E022 20.9264647 0.6556978826 0.5364101309 0.726607463 8 67064455 67064496 42 + 1.266 1.324 0.202
ENSG00000104218 E023 9.5706522 0.4738578147 0.7223730358 0.849549012 8 67064497 67064524 28 + 0.968 0.974 0.022
ENSG00000104218 E024 6.1190939 0.3513846462 0.8826897177 0.942714395 8 67064525 67064526 2 + 0.811 0.780 -0.120
ENSG00000104218 E025 7.0609846 0.4274637567 0.9016554096 0.952700447 8 67064527 67064538 12 + 0.866 0.820 -0.177
ENSG00000104218 E026 0.0000000       8 67069680 67069802 123 +      
ENSG00000104218 E027 0.1614157 0.0334401646 1.0000000000   8 67072940 67074242 1303 + 0.073 0.000 -11.322
ENSG00000104218 E028 41.0257747 0.0193629442 0.5988911080 0.769487601 8 67074243 67074351 109 + 1.572 1.532 -0.137
ENSG00000104218 E029 1.1044901 0.1791860609 0.1369133108   8 67074806 67074923 118 + 0.357 0.000 -13.644
ENSG00000104218 E030 20.9697332 0.0055739458 0.6051900858 0.773647453 8 67076482 67076487 6 + 1.285 1.258 -0.097
ENSG00000104218 E031 36.6180702 0.0011262022 0.0448256021 0.167188312 8 67076488 67076581 94 + 1.540 1.425 -0.396
ENSG00000104218 E032 0.3503582 0.0317830251 0.4293710235   8 67078367 67078487 121 + 0.073 0.196 1.635
ENSG00000104218 E033 0.0000000       8 67079351 67079462 112 +      
ENSG00000104218 E034 0.1614157 0.0334401646 1.0000000000   8 67083848 67083914 67 + 0.073 0.000 -11.322
ENSG00000104218 E035 0.1614157 0.0334401646 1.0000000000   8 67083915 67084338 424 + 0.073 0.000 -11.322
ENSG00000104218 E036 41.4015882 0.0011300274 0.0045841377 0.032391280 8 67086007 67086110 104 + 1.600 1.434 -0.569
ENSG00000104218 E037 0.0000000       8 67086111 67086331 221 +      
ENSG00000104218 E038 0.3150090 0.0281741702 0.4265135194   8 67086823 67086846 24 + 0.073 0.196 1.638
ENSG00000104218 E039 12.1355645 0.0157096323 0.0345381518 0.140319917 8 67091803 67091883 81 + 1.111 0.859 -0.936
ENSG00000104218 E040 0.5339515 0.9558026465 0.8634084381   8 67092398 67093524 1127 + 0.199 0.000 -11.963
ENSG00000104218 E041 0.0000000       8 67093525 67093542 18 +      
ENSG00000104218 E042 20.5654115 0.0017634157 0.0434746405 0.163786274 8 67093543 67093547 5 + 1.310 1.148 -0.570
ENSG00000104218 E043 39.6935880 0.0011870353 0.0066419570 0.042909754 8 67093548 67093641 94 + 1.584 1.424 -0.547
ENSG00000104218 E044 110.3368152 0.0017897596 0.0001727436 0.002365412 8 67095293 67095732 440 + 2.015 1.874 -0.475
ENSG00000104218 E045 5.5224631 0.0159533298 0.0594663607 0.201608188 8 67095733 67097393 1661 + 0.813 0.515 -1.276
ENSG00000104218 E046 0.8933700 0.0771364838 0.1529450243   8 67099188 67099301 114 + 0.320 0.000 -13.610
ENSG00000104218 E047 5.3756470 0.0056407174 0.0039965631 0.029135365 8 67099302 67101239 1938 + 0.825 0.330 -2.319
ENSG00000104218 E048 6.7384929 0.0302513096 0.0172540817 0.086376202 8 67101240 67102448 1209 + 0.903 0.513 -1.628
ENSG00000104218 E049 1.5556008 0.0139849438 0.0325651709 0.134875863 8 67102449 67102888 440 + 0.452 0.000 -14.313
ENSG00000104218 E050 1.3332076 0.0196504514 0.3774237713   8 67102889 67103036 148 + 0.359 0.196 -1.174
ENSG00000104218 E051 41.3082694 0.0101673973 0.0168017544 0.084728719 8 67103037 67103135 99 + 1.600 1.425 -0.600
ENSG00000104218 E052 0.1779838 0.0395187374 1.0000000000   8 67105569 67105661 93 + 0.073 0.000 -11.311
ENSG00000104218 E053 34.5038150 0.0012765013 0.0070000518 0.044643600 8 67105905 67105975 71 + 1.526 1.354 -0.594
ENSG00000104218 E054 0.0000000       8 67110651 67111273 623 +      
ENSG00000104218 E055 41.5714845 0.0073090877 0.0047191243 0.033106781 8 67111972 67112065 94 + 1.609 1.414 -0.668
ENSG00000104218 E056 1.0997382 0.0562209742 0.8892712481   8 67112066 67112075 10 + 0.283 0.328 0.296
ENSG00000104218 E057 0.0000000       8 67113652 67113804 153 +      
ENSG00000104218 E058 20.8111457 0.0142548631 0.0681328238 0.220883121 8 67113805 67113817 13 + 1.315 1.147 -0.594
ENSG00000104218 E059 23.4502113 0.0065158805 0.0974814191 0.277363095 8 67113818 67113862 45 + 1.357 1.228 -0.452
ENSG00000104218 E060 0.0000000       8 67113863 67114328 466 +      
ENSG00000104218 E061 0.3807181 0.0425557944 0.4289806554   8 67114329 67114370 42 + 0.073 0.196 1.637
ENSG00000104218 E062 0.8204382 0.1573709830 0.1548560673   8 67114371 67115196 826 + 0.137 0.430 2.192
ENSG00000104218 E063 0.0000000       8 67115197 67115264 68 +      
ENSG00000104218 E064 0.3206185 0.0274424043 0.7313339316   8 67115265 67115913 649 + 0.135 0.000 -12.276
ENSG00000104218 E065 46.9596351 0.0189267083 0.2573279680 0.496065234 8 67115914 67116122 209 + 1.639 1.559 -0.273
ENSG00000104218 E066 35.4383086 0.0202827646 0.6522265341 0.804882255 8 67118248 67118305 58 + 1.509 1.488 -0.072
ENSG00000104218 E067 38.1831997 0.0588956293 0.4178346941 0.642008064 8 67118306 67118369 64 + 1.550 1.481 -0.234
ENSG00000104218 E068 0.0000000       8 67118370 67118385 16 +      
ENSG00000104218 E069 19.9619627 0.0103409513 0.4176288882 0.641842828 8 67118743 67118751 9 + 1.278 1.226 -0.184
ENSG00000104218 E070 30.9432400 0.0155308155 0.9166425416 0.960488322 8 67118752 67118821 70 + 1.438 1.485 0.164
ENSG00000104218 E071 0.8217936 0.0190402900 0.4743670443   8 67120879 67121130 252 + 0.190 0.330 1.055
ENSG00000104218 E072 0.1426347 0.0320350267 1.0000000000   8 67123088 67123159 72 + 0.073 0.000 -11.323
ENSG00000104218 E073 0.1779838 0.0395187374 1.0000000000   8 67131045 67131236 192 + 0.073 0.000 -11.311
ENSG00000104218 E074 19.7777474 0.0018418864 0.5699743785 0.750275205 8 67131951 67131960 10 + 1.247 1.319 0.254
ENSG00000104218 E075 44.7944142 0.0219835288 0.4228433909 0.645741642 8 67131961 67132080 120 + 1.612 1.580 -0.107
ENSG00000104218 E076 0.4161375 0.0849684469 0.7514562780   8 67134024 67134165 142 + 0.135 0.195 0.635
ENSG00000104218 E077 54.5898267 0.0466639245 0.3043262857 0.544888694 8 67137456 67137603 148 + 1.702 1.631 -0.244
ENSG00000104218 E078 1.1246762 0.0147315987 0.8553886375   8 67137604 67139040 1437 + 0.282 0.330 0.311
ENSG00000104218 E079 0.2852693 0.2621543845 0.8454630922   8 67139077 67139334 258 + 0.134 0.000 -11.850
ENSG00000104218 E080 52.9761576 0.0172675701 0.4992313654 0.700304537 8 67149783 67149935 153 + 1.678 1.646 -0.108
ENSG00000104218 E081 0.3337900 0.0297528250 0.4275932465   8 67152613 67152712 100 + 0.073 0.196 1.636
ENSG00000104218 E082 0.0000000       8 67152925 67154023 1099 +      
ENSG00000104218 E083 52.0823766 0.0162878636 0.8020360471 0.897529561 8 67154024 67154136 113 + 1.652 1.691 0.135
ENSG00000104218 E084 12.6282649 0.0031510359 0.4422002633 0.660216432 8 67154877 67157626 2750 + 1.091 1.028 -0.230
ENSG00000104218 E085 1.7291590 0.0654935481 0.0316580538 0.132215175 8 67157627 67157857 231 + 0.478 0.000 -14.364
ENSG00000104218 E086 2.3883691 0.0927157609 0.3224211648 0.561874633 8 67157858 67158237 380 + 0.529 0.329 -1.073
ENSG00000104218 E087 2.1162714 0.0284127540 0.8440435718 0.921609508 8 67158238 67158446 209 + 0.453 0.432 -0.106
ENSG00000104218 E088 51.6319945 0.0124231396 0.0241291967 0.109460061 8 67158447 67158596 150 + 1.606 1.795 0.641
ENSG00000104218 E089 17.6988502 0.0150788239 0.0029214455 0.022926462 8 67158991 67158995 5 + 1.115 1.432 1.114
ENSG00000104218 E090 39.2054649 0.0010216492 0.0043265623 0.030973771 8 67158996 67159137 142 + 1.489 1.683 0.661
ENSG00000104218 E091 42.0746597 0.0008877282 0.9300550520 0.967036438 8 67161811 67161915 105 + 1.569 1.598 0.100
ENSG00000104218 E092 0.3337900 0.0297528250 0.4275932465   8 67162638 67162762 125 + 0.073 0.196 1.636
ENSG00000104218 E093 38.5250434 0.0010598250 0.8383999047 0.918556804 8 67163732 67163798 67 + 1.529 1.566 0.127
ENSG00000104218 E094 0.4458772 0.0217681645 0.1363839775   8 67163799 67164237 439 + 0.073 0.330 2.635
ENSG00000104218 E095 49.0445902 0.0008557115 0.3822047577 0.614023145 8 67164391 67164508 118 + 1.625 1.698 0.247
ENSG00000104218 E096 6.5626563 0.1739204296 0.1048057724 0.290300141 8 67164509 67166342 1834 + 0.692 1.072 1.461
ENSG00000104218 E097 0.3088520 0.0265301436 0.4318074090   8 67172206 67172415 210 + 0.073 0.195 1.631
ENSG00000104218 E098 29.7119328 0.0218481408 0.0343324454 0.139758351 8 67172416 67172462 47 + 1.367 1.587 0.755
ENSG00000104218 E099 43.6062354 0.0563660478 0.2939646550 0.534616558 8 67172463 67172555 93 + 1.555 1.683 0.436
ENSG00000104218 E100 1.9368825 0.0774164175 0.1707416815 0.391486844 8 67172769 67172777 9 + 0.479 0.196 -1.823
ENSG00000104218 E101 3.3232453 0.0613407246 0.1097118676 0.298552676 8 67172778 67172864 87 + 0.649 0.331 -1.601
ENSG00000104218 E102 3.0262095 0.0109537884 0.3212054136 0.560718774 8 67172865 67172973 109 + 0.594 0.432 -0.780
ENSG00000104218 E103 0.1308682 0.0326491905 0.1564322370   8 67174823 67175295 473 + 0.000 0.195 13.052
ENSG00000104218 E104 47.8602406 0.8567775286 0.3178682244 0.557836574 8 67175296 67175436 141 + 1.546 1.808 0.888
ENSG00000104218 E105 33.4026205 0.0906025835 0.0572736421 0.196639527 8 67177680 67177726 47 + 1.394 1.667 0.936
ENSG00000104218 E106 39.4189140 0.0043810503 0.0508387482 0.181687088 8 67179863 67179926 64 + 1.510 1.661 0.514
ENSG00000104218 E107 0.3088520 0.0265301436 0.4318074090   8 67189386 67189839 454 + 0.073 0.195 1.631
ENSG00000104218 E108 0.4231520 0.0483905043 0.1462633965   8 67189840 67190014 175 + 0.073 0.328 2.625
ENSG00000104218 E109 1.5649439 0.0120436885 0.1022903401 0.285894775 8 67190015 67190649 635 + 0.282 0.584 1.634
ENSG00000104218 E110 55.5238281 0.0050685898 0.6045958919 0.773231276 8 67190650 67190759 110 + 1.681 1.738 0.194
ENSG00000104218 E111 3.6570148 0.0975910580 0.8539111545 0.927061583 8 67190760 67190944 185 + 0.600 0.645 0.198
ENSG00000104218 E112 17.0155119 0.0657709854 0.4251431761 0.647361284 8 67191194 67192097 904 + 1.217 1.097 -0.430
ENSG00000104218 E113 5.1785859 0.0315092104 0.1438801833 0.353221375 8 67192098 67192217 120 + 0.653 0.895 0.972
ENSG00000104218 E114 7.7639753 0.0287443481 0.4825087373 0.688730994 8 67192218 67192626 409 + 0.858 0.979 0.458
ENSG00000104218 E115 4.8731435 0.2263259936 0.8522405668 0.926318611 8 67192627 67192688 62 + 0.703 0.750 0.189
ENSG00000104218 E116 6.5790592 0.0927386494 0.6666678059 0.814107781 8 67192689 67192803 115 + 0.790 0.899 0.424
ENSG00000104218 E117 13.0420645 0.0347412148 0.2064005482 0.437450052 8 67192804 67193463 660 + 1.118 0.957 -0.590
ENSG00000104218 E118 62.3885374 0.0136400705 0.7741535029 0.881250455 8 67193464 67193602 139 + 1.730 1.775 0.150
ENSG00000104218 E119 2.5276366 0.2810158443 0.1615090725 0.378990966 8 67194627 67194718 92 + 0.356 0.762 1.913
ENSG00000104218 E120 127.1362016 0.0086711619 0.0607709396 0.204573091 8 67195382 67196778 1397 + 2.012 2.132 0.402