ENSG00000104093

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000558124 ENSG00000104093 HEK293_OSMI2_6hA HEK293_TMG_6hB DMXL2 protein_coding processed_transcript 5.463978 3.303918 8.590588 0.3440843 0.8101122 1.375897 0.8458979 0.3399097 1.7100038 0.170804553 0.3554614 2.29735698 0.13704167 0.09713333 0.19556667 0.098433333 0.659432803 0.008956936 FALSE FALSE
ENST00000559059 ENSG00000104093 HEK293_OSMI2_6hA HEK293_TMG_6hB DMXL2 protein_coding processed_transcript 5.463978 3.303918 8.590588 0.3440843 0.8101122 1.375897 0.4945955 0.4400989 0.4252697 0.229233819 0.2300076 -0.04833256 0.08990833 0.13616667 0.04610000 -0.090066667 0.890648898 0.008956936   FALSE
ENST00000559769 ENSG00000104093 HEK293_OSMI2_6hA HEK293_TMG_6hB DMXL2 protein_coding retained_intron 5.463978 3.303918 8.590588 0.3440843 0.8101122 1.375897 1.0425269 1.3054733 0.4036091 0.084924345 0.2562311 -1.66924200 0.27910417 0.39903333 0.04230000 -0.356733333 0.034230040 0.008956936   FALSE
ENST00000560211 ENSG00000104093 HEK293_OSMI2_6hA HEK293_TMG_6hB DMXL2 protein_coding retained_intron 5.463978 3.303918 8.590588 0.3440843 0.8101122 1.375897 0.3197189 0.2225015 0.5196762 0.022994390 0.1788098 1.18787037 0.05550833 0.06766667 0.05953333 -0.008133333 0.935629959 0.008956936   FALSE
ENST00000560891 ENSG00000104093 HEK293_OSMI2_6hA HEK293_TMG_6hB DMXL2 protein_coding protein_coding 5.463978 3.303918 8.590588 0.3440843 0.8101122 1.375897 1.3448086 0.4560081 2.8985714 0.076445740 0.2216152 2.64188391 0.21028333 0.13673333 0.34900000 0.212266667 0.060706124 0.008956936 FALSE TRUE
ENST00000561079 ENSG00000104093 HEK293_OSMI2_6hA HEK293_TMG_6hB DMXL2 protein_coding retained_intron 5.463978 3.303918 8.590588 0.3440843 0.8101122 1.375897 0.3235919 0.1653995 0.7562018 0.086674021 0.1283794 2.12707984 0.05027917 0.04873333 0.08680000 0.038066667 0.689237020 0.008956936 FALSE TRUE
MSTRG.10811.3 ENSG00000104093 HEK293_OSMI2_6hA HEK293_TMG_6hB DMXL2 protein_coding   5.463978 3.303918 8.590588 0.3440843 0.8101122 1.375897 0.8407912 0.1641262 1.4138662 0.009975022 0.1887866 3.03160797 0.12695417 0.05126667 0.16446667 0.113200000 0.008956936 0.008956936 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000104093 E001 0.1426347 0.0319247365 1.000000e+00   15 51447711 51447787 77 - 0.066 0.000 -7.820
ENSG00000104093 E002 0.1426347 0.0319247365 1.000000e+00   15 51447788 51447790 3 - 0.066 0.000 -10.467
ENSG00000104093 E003 93.9047544 0.0005112583 8.331245e-24 3.723255e-21 15 51447791 51448811 1021 - 1.773 2.171 1.338
ENSG00000104093 E004 54.6670390 0.0014871871 4.449026e-03 3.165921e-02 15 51448812 51449193 382 - 1.618 1.796 0.604
ENSG00000104093 E005 25.6713801 0.0013847046 1.904952e-01 4.175762e-01 15 51450129 51450194 66 - 1.318 1.442 0.428
ENSG00000104093 E006 41.4279023 0.0010306494 6.366352e-04 6.895988e-03 15 51450195 51450346 152 - 1.489 1.714 0.769
ENSG00000104093 E007 0.8545700 0.5111338360 4.609680e-01   15 51450347 51450673 327 - 0.266 0.000 -11.737
ENSG00000104093 E008 20.1809533 0.0017841400 1.727795e-01 3.941836e-01 15 51451645 51451697 53 - 1.215 1.354 0.488
ENSG00000104093 E009 1.6025059 0.2105142475 1.178425e-01 3.122835e-01 15 51453248 51453549 302 - 0.262 0.618 1.927
ENSG00000104093 E010 20.7930137 0.0021121075 1.328504e-03 1.237375e-02 15 51453550 51453641 92 - 1.188 1.470 0.985
ENSG00000104093 E011 15.9010388 0.0454499570 1.799098e-01 4.038761e-01 15 51455151 51455228 78 - 1.102 1.306 0.721
ENSG00000104093 E012 18.5194493 0.5470562584 2.183558e-01 4.514633e-01 15 51456066 51456193 128 - 1.120 1.437 1.113
ENSG00000104093 E013 9.5003640 0.2948759333 1.259100e-01 3.253414e-01 15 51456309 51456312 4 - 0.853 1.183 1.218
ENSG00000104093 E014 10.3041844 0.3354191171 1.661211e-01 3.853303e-01 15 51456313 51456324 12 - 0.896 1.188 1.070
ENSG00000104093 E015 11.9006035 0.3820648596 1.697590e-01 3.901710e-01 15 51456325 51456369 45 - 0.945 1.259 1.132
ENSG00000104093 E016 11.9249443 0.4048367910 2.644701e-01 5.036965e-01 15 51457328 51457371 44 - 0.974 1.200 0.820
ENSG00000104093 E017 15.1339798 0.4986552128 3.214578e-01 5.609771e-01 15 51457372 51457446 75 - 1.077 1.271 0.689
ENSG00000104093 E018 8.8219650 0.4299830604 7.385368e-01 8.595690e-01 15 51457447 51457466 20 - 0.917 0.904 -0.049
ENSG00000104093 E019 15.7781355 0.3517778376 5.664495e-01 7.476365e-01 15 51458506 51458627 122 - 1.132 1.182 0.179
ENSG00000104093 E020 0.6190593 0.0200676285 8.593542e-01   15 51458628 51458708 81 - 0.173 0.214 0.373
ENSG00000104093 E021 15.6187702 0.5270266846 2.765890e-01 5.165585e-01 15 51458709 51458795 87 - 1.075 1.315 0.850
ENSG00000104093 E022 5.7174068 0.0053897814 7.500328e-03 4.702881e-02 15 51458796 51459190 395 - 0.647 1.022 1.470
ENSG00000104093 E023 14.5012403 0.0792055681 2.158908e-01 4.485096e-01 15 51459598 51459660 63 - 1.053 1.258 0.734
ENSG00000104093 E024 5.2525764 0.0207173064 2.802210e-01 5.203431e-01 15 51459661 51459782 122 - 0.679 0.866 0.749
ENSG00000104093 E025 4.8838149 0.0607400576 5.520454e-01 7.377417e-01 15 51463076 51463378 303 - 0.711 0.620 -0.386
ENSG00000104093 E026 17.9892655 0.0186592801 2.035244e-01 4.339647e-01 15 51463379 51463496 118 - 1.157 1.306 0.525
ENSG00000104093 E027 24.3998203 0.0019681053 6.456867e-01 8.006014e-01 15 51464675 51464876 202 - 1.308 1.366 0.204
ENSG00000104093 E028 16.6209372 0.0359309070 7.973827e-01 8.948195e-01 15 51465566 51465651 86 - 1.158 1.194 0.127
ENSG00000104093 E029 14.2394645 0.5253439441 5.559205e-01 7.404690e-01 15 51466184 51466311 128 - 1.091 1.136 0.161
ENSG00000104093 E030 22.3572646 0.0057697090 9.942737e-01 9.987079e-01 15 51471223 51471401 179 - 1.283 1.302 0.067
ENSG00000104093 E031 32.8018445 0.0111441757 8.390137e-01 9.188447e-01 15 51474344 51474592 249 - 1.432 1.472 0.136
ENSG00000104093 E032 28.1893982 0.0105324730 6.552068e-01 8.068188e-01 15 51476589 51476716 128 - 1.367 1.431 0.222
ENSG00000104093 E033 9.3438971 0.0238040622 2.248890e-01 4.592917e-01 15 51476717 51476719 3 - 0.888 1.072 0.682
ENSG00000104093 E034 22.2374285 0.0210831266 5.820617e-01 7.584126e-01 15 51478271 51478347 77 - 1.261 1.342 0.282
ENSG00000104093 E035 29.6487915 0.0081859176 5.774288e-01 7.553996e-01 15 51479948 51480139 192 - 1.403 1.378 -0.087
ENSG00000104093 E036 85.4131045 0.0035509577 3.340118e-02 1.371837e-01 15 51480542 51481623 1082 - 1.867 1.774 -0.316
ENSG00000104093 E037 25.9844879 0.0017030977 1.908534e-02 9.276366e-02 15 51486073 51486337 265 - 1.379 1.193 -0.651
ENSG00000104093 E038 18.9205929 0.0420460348 6.023980e-01 7.717921e-01 15 51487954 51488119 166 - 1.192 1.286 0.330
ENSG00000104093 E039 11.7017130 0.1879590819 8.621770e-01 9.315334e-01 15 51488548 51488645 98 - 1.017 1.041 0.091
ENSG00000104093 E040 18.6688880 0.0018924593 1.544398e-01 3.686528e-01 15 51491578 51491747 170 - 1.236 1.116 -0.426
ENSG00000104093 E041 16.7028363 0.0022619518 1.699673e-02 8.544808e-02 15 51495024 51495134 111 - 1.210 0.967 -0.882
ENSG00000104093 E042 95.4945399 0.0005229687 1.556401e-10 1.059369e-08 15 51498552 51500231 1680 - 1.945 1.652 -0.991
ENSG00000104093 E043 19.2709926 0.0021812747 1.108564e-04 1.628967e-03 15 51502806 51503033 228 - 1.286 0.866 -1.529
ENSG00000104093 E044 11.7913626 0.0027175915 6.935091e-03 4.433754e-02 15 51507134 51507253 120 - 1.078 0.736 -1.304
ENSG00000104093 E045 13.2274814 0.0175836639 1.566234e-03 1.408358e-02 15 51514442 51514559 118 - 1.131 0.682 -1.716
ENSG00000104093 E046 10.1842719 0.0389318934 3.074666e-02 1.295880e-01 15 51517078 51517167 90 - 1.018 0.680 -1.316
ENSG00000104093 E047 13.7633407 0.0178703233 6.446423e-03 4.191076e-02 15 51535663 51535784 122 - 1.141 0.782 -1.342
ENSG00000104093 E048 47.1620439 0.0015929451 1.416430e-07 5.076877e-06 15 51536166 51536862 697 - 1.655 1.288 -1.264
ENSG00000104093 E049 24.1009465 0.0036859143 1.494695e-02 7.789171e-02 15 51537488 51537759 272 - 1.348 1.137 -0.745
ENSG00000104093 E050 20.2821811 0.0276044787 1.741565e-01 3.960706e-01 15 51538213 51538452 240 - 1.267 1.118 -0.529
ENSG00000104093 E051 14.4743831 0.0490445894 1.277869e-02 6.954609e-02 15 51542333 51542507 175 - 1.165 0.781 -1.436
ENSG00000104093 E052 15.4776292 0.0300027212 3.460704e-05 6.094352e-04 15 51545583 51545766 184 - 1.211 0.548 -2.592
ENSG00000104093 E053 11.8292552 0.0028731042 1.143279e-04 1.670152e-03 15 51547230 51547331 102 - 1.101 0.549 -2.196
ENSG00000104093 E054 10.2946482 0.0053338650 8.432708e-04 8.638884e-03 15 51547332 51547408 77 - 1.041 0.549 -1.978
ENSG00000104093 E055 8.5117189 0.0056562423 5.362580e-02 1.881706e-01 15 51563381 51563447 67 - 0.948 0.682 -1.046
ENSG00000104093 E056 11.9558487 0.0056393965 1.741123e-02 8.696293e-02 15 51564125 51564260 136 - 1.079 0.784 -1.114
ENSG00000104093 E057 10.5639938 0.0540885595 7.961063e-02 2.440561e-01 15 51565088 51565166 79 - 1.026 0.735 -1.116
ENSG00000104093 E058 0.0000000       15 51567043 51568486 1444 -      
ENSG00000104093 E059 8.8643533 0.0770310825 7.204216e-02 2.288903e-01 15 51568487 51568558 72 - 0.962 0.621 -1.364
ENSG00000104093 E060 11.1492476 0.0051546590 8.200478e-02 2.487617e-01 15 51576056 51576181 126 - 1.035 0.827 -0.783
ENSG00000104093 E061 0.0000000       15 51603607 51603701 95 -      
ENSG00000104093 E062 10.7498033 0.0027739045 4.511638e-01 6.664753e-01 15 51622459 51622833 375 - 1.007 0.936 -0.267