ENSG00000104067

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000346128 ENSG00000104067 HEK293_OSMI2_6hA HEK293_TMG_6hB TJP1 protein_coding protein_coding 11.65845 9.638157 16.4645 3.083105 0.7206772 0.7719096 0.3098859 0.5706416 0.04661973 0.2231528 0.02784277 -3.35827122 0.03925417 0.06613333 0.00300000 -0.06313333 7.157658e-04 3.124484e-06 FALSE TRUE
ENST00000400007 ENSG00000104067 HEK293_OSMI2_6hA HEK293_TMG_6hB TJP1 protein_coding protein_coding 11.65845 9.638157 16.4645 3.083105 0.7206772 0.7719096 2.6696774 3.2952709 3.16144961 1.1791431 0.34530316 -0.05962608 0.24925833 0.32903333 0.19310000 -0.13593333 1.306708e-01 3.124484e-06 FALSE FALSE
ENST00000400011 ENSG00000104067 HEK293_OSMI2_6hA HEK293_TMG_6hB TJP1 protein_coding protein_coding 11.65845 9.638157 16.4645 3.083105 0.7206772 0.7719096 5.2728419 4.8160687 7.33160861 1.4646805 2.25485786 0.60524775 0.47851667 0.51100000 0.43466667 -0.07633333 8.954844e-01 3.124484e-06 FALSE TRUE
ENST00000545208 ENSG00000104067 HEK293_OSMI2_6hA HEK293_TMG_6hB TJP1 protein_coding protein_coding 11.65845 9.638157 16.4645 3.083105 0.7206772 0.7719096 0.4450554 0.0000000 1.97472695 0.0000000 0.63964201 7.63279673 0.02736667 0.00000000 0.12393333 0.12393333 3.124484e-06 3.124484e-06 FALSE TRUE
ENST00000614355 ENSG00000104067 HEK293_OSMI2_6hA HEK293_TMG_6hB TJP1 protein_coding protein_coding 11.65845 9.638157 16.4645 3.083105 0.7206772 0.7719096 0.6498237 0.5743317 1.02864493 0.3313225 0.35276353 0.82984298 0.05021250 0.04566667 0.06086667 0.01520000 9.103443e-01 3.124484e-06 FALSE TRUE
ENST00000677774 ENSG00000104067 HEK293_OSMI2_6hA HEK293_TMG_6hB TJP1 protein_coding protein_coding 11.65845 9.638157 16.4645 3.083105 0.7206772 0.7719096 1.3785811 0.0000000 1.32835248 0.0000000 1.02384871 7.06431432 0.08517500 0.00000000 0.08670000 0.08670000 4.648566e-01 3.124484e-06 FALSE TRUE
MSTRG.10351.8 ENSG00000104067 HEK293_OSMI2_6hA HEK293_TMG_6hB TJP1 protein_coding   11.65845 9.638157 16.4645 3.083105 0.7206772 0.7719096 0.8134488 0.1978136 1.51177588 0.1151076 0.16764241 2.87239398 0.05565417 0.02936667 0.09293333 0.06356667 4.350943e-01 3.124484e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000104067 E001 2.9527282 0.0750911779 2.651378e-04 3.377072e-03 15 29699367 29700151 785 - 0.169 0.886 3.814
ENSG00000104067 E002 16.6195560 0.1981032013 1.886718e-02 9.198936e-02 15 29700152 29700234 83 - 0.946 1.501 1.969
ENSG00000104067 E003 147.7301358 1.2794107247 3.072012e-01 5.478124e-01 15 29700235 29700772 538 - 1.949 2.378 1.436
ENSG00000104067 E004 181.7478530 1.3937824963 3.830352e-01 6.147672e-01 15 29700773 29701244 472 - 2.084 2.434 1.170
ENSG00000104067 E005 78.1647946 0.8425172456 2.924940e-01 5.331638e-01 15 29701245 29701388 144 - 1.710 2.080 1.247
ENSG00000104067 E006 89.5424326 1.1227072220 3.368147e-01 5.752331e-01 15 29701389 29701594 206 - 1.772 2.136 1.224
ENSG00000104067 E007 69.7525203 0.8162597044 3.094515e-01 5.499445e-01 15 29701595 29701689 95 - 1.691 2.007 1.067
ENSG00000104067 E008 22.1238627 0.1210199023 1.343813e-01 3.387087e-01 15 29704162 29704200 39 - 1.223 1.511 1.000
ENSG00000104067 E009 31.3782394 0.1335055941 2.843969e-01 5.249119e-01 15 29704201 29704221 21 - 1.391 1.635 0.834
ENSG00000104067 E010 55.3105676 0.0598591040 1.417675e-01 3.501262e-01 15 29704222 29704305 84 - 1.631 1.873 0.818
ENSG00000104067 E011 116.2903124 0.0013649916 2.596556e-05 4.762962e-04 15 29705528 29705745 218 - 1.956 2.186 0.771
ENSG00000104067 E012 212.7121891 0.0040057771 2.417416e-01 4.784965e-01 15 29708559 29709036 478 - 2.264 2.387 0.407
ENSG00000104067 E013 85.2358920 0.0053412019 9.756524e-01 9.896390e-01 15 29710831 29711000 170 - 1.892 1.979 0.294
ENSG00000104067 E014 104.6582016 0.0042900953 2.025702e-01 4.328017e-01 15 29716611 29716838 228 - 2.000 2.026 0.088
ENSG00000104067 E015 72.5275112 0.0015506093 6.630352e-01 8.117908e-01 15 29718021 29718118 98 - 1.827 1.889 0.209
ENSG00000104067 E016 217.0637493 0.0062087966 3.675824e-01 6.020712e-01 15 29718266 29718892 627 - 2.308 2.343 0.117
ENSG00000104067 E017 121.8892163 0.0059583498 1.065182e-01 2.931987e-01 15 29718893 29719138 246 - 2.074 2.075 0.002
ENSG00000104067 E018 6.6375754 0.0060457918 1.603083e-01 3.772731e-01 15 29719777 29720016 240 - 0.910 0.796 -0.441
ENSG00000104067 E019 0.5177432 0.0391921135 3.410084e-01   15 29720017 29720128 112 - 0.093 0.274 1.886
ENSG00000104067 E020 139.4431115 0.0086713573 3.087991e-01 5.493345e-01 15 29720358 29720708 351 - 2.120 2.151 0.102
ENSG00000104067 E021 56.9244862 0.0138391444 7.454146e-02 2.338917e-01 15 29726379 29726479 101 - 1.760 1.713 -0.159
ENSG00000104067 E022 86.2983655 0.0158234104 3.909854e-02 1.524330e-01 15 29726781 29726991 211 - 1.947 1.877 -0.235
ENSG00000104067 E023 51.2513745 0.0099155928 9.169083e-03 5.457264e-02 15 29727937 29728019 83 - 1.739 1.633 -0.358
ENSG00000104067 E024 0.5474829 0.5017997363 7.274773e-02   15 29732134 29732432 299 - 0.000 0.375 13.661
ENSG00000104067 E025 51.4835413 0.0009665880 5.859596e-02 1.996396e-01 15 29732433 29732528 96 - 1.713 1.695 -0.063
ENSG00000104067 E026 74.8294699 0.0006467681 1.044327e-02 6.004763e-02 15 29732631 29732815 185 - 1.874 1.843 -0.103
ENSG00000104067 E027 0.0000000       15 29732816 29732933 118 -      
ENSG00000104067 E028 85.3194728 0.0005511080 2.050916e-04 2.730423e-03 15 29733094 29733313 220 - 1.947 1.877 -0.237
ENSG00000104067 E029 52.8044636 0.0196758912 1.224239e-01 3.196308e-01 15 29734274 29734382 109 - 1.734 1.682 -0.178
ENSG00000104067 E030 73.3165889 0.0154578963 3.270982e-02 1.352497e-01 15 29737264 29737414 151 - 1.881 1.808 -0.245
ENSG00000104067 E031 0.1614157 0.0374395620 7.930650e-01   15 29741022 29741330 309 - 0.093 0.000 -10.293
ENSG00000104067 E032 59.0713226 0.0156158030 9.330875e-02 2.698932e-01 15 29741331 29741436 106 - 1.776 1.738 -0.130
ENSG00000104067 E033 59.9780260 0.0057293082 9.262297e-03 5.495545e-02 15 29742642 29742781 140 - 1.795 1.722 -0.244
ENSG00000104067 E034 0.1723744 0.3145355445 3.258850e-01   15 29742782 29743029 248 - 0.000 0.159 12.026
ENSG00000104067 E035 0.3040503 0.0244411696 3.764441e-01   15 29758903 29760308 1406 - 0.169 0.000 -11.292
ENSG00000104067 E036 55.9473841 0.0059364557 8.865109e-03 5.321666e-02 15 29761139 29761286 148 - 1.770 1.682 -0.298
ENSG00000104067 E037 62.2171855 0.0223828845 7.728707e-03 4.804921e-02 15 29761601 29761769 169 - 1.840 1.665 -0.593
ENSG00000104067 E038 47.4443133 0.0039256599 4.249047e-06 1.000119e-04 15 29762335 29762438 104 - 1.735 1.522 -0.723
ENSG00000104067 E039 94.7230567 0.0117402724 6.369681e-07 1.918280e-05 15 29766266 29766542 277 - 2.042 1.788 -0.854
ENSG00000104067 E040 64.2829762 0.0148659351 3.280528e-06 8.015959e-05 15 29772064 29772166 103 - 1.880 1.607 -0.927
ENSG00000104067 E041 53.6551566 0.0204846655 1.026116e-04 1.528312e-03 15 29773233 29773357 125 - 1.798 1.550 -0.842
ENSG00000104067 E042 0.0000000       15 29800496 29800645 150 -      
ENSG00000104067 E043 26.2952803 0.0156184018 1.471487e-02 7.701080e-02 15 29800646 29800702 57 - 1.465 1.329 -0.468
ENSG00000104067 E044 0.5657866 0.0198856112 6.812001e-01   15 29820527 29820674 148 - 0.169 0.272 0.875
ENSG00000104067 E045 0.0000000       15 29821416 29821548 133 -      
ENSG00000104067 E046 26.4498614 0.0476307146 8.952978e-01 9.493794e-01 15 29822002 29822503 502 - 1.396 1.463 0.230
ENSG00000104067 E047 4.6690951 0.0057665656 8.647539e-01 9.329879e-01 15 29956232 29956364 133 - 0.723 0.764 0.168
ENSG00000104067 E048 2.7892579 0.0629712587 3.429406e-01 5.806269e-01 15 29968667 29968921 255 - 0.463 0.694 1.051