ENSG00000104064

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000220429 ENSG00000104064 HEK293_OSMI2_6hA HEK293_TMG_6hB GABPB1 protein_coding protein_coding 9.613473 2.973131 17.07958 0.7355155 0.665935 2.518218 4.8701408 1.47900489 8.9793385 0.40134790 0.3291832 2.5938665 0.51686250 0.48910000 0.525833333 0.03673333 0.88783912 0.00196027 FALSE TRUE
ENST00000396464 ENSG00000104064 HEK293_OSMI2_6hA HEK293_TMG_6hB GABPB1 protein_coding protein_coding 9.613473 2.973131 17.07958 0.7355155 0.665935 2.518218 1.8390812 0.98640992 2.4443972 0.22859778 0.2650842 1.3005574 0.24299167 0.35610000 0.144800000 -0.21130000 0.07605706 0.00196027 FALSE TRUE
ENST00000560825 ENSG00000104064 HEK293_OSMI2_6hA HEK293_TMG_6hB GABPB1 protein_coding protein_coding 9.613473 2.973131 17.07958 0.7355155 0.665935 2.518218 0.1171696 0.25840480 0.1460651 0.16412961 0.1460651 -0.7822629 0.02741250 0.07030000 0.008066667 -0.06223333 0.47932236 0.00196027 FALSE TRUE
MSTRG.10789.3 ENSG00000104064 HEK293_OSMI2_6hA HEK293_TMG_6hB GABPB1 protein_coding   9.613473 2.973131 17.07958 0.7355155 0.665935 2.518218 0.8458249 0.03936851 1.7074673 0.03936851 0.1977369 5.1205477 0.05592500 0.02616667 0.100733333 0.07456667 0.30463439 0.00196027 FALSE TRUE
MSTRG.10789.5 ENSG00000104064 HEK293_OSMI2_6hA HEK293_TMG_6hB GABPB1 protein_coding   9.613473 2.973131 17.07958 0.7355155 0.665935 2.518218 0.7887154 0.00000000 1.2666455 0.00000000 0.3455302 6.9962142 0.05312917 0.00000000 0.073266667 0.07326667 0.00196027 0.00196027 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000104064 E001 3.8308874 0.0067918798 8.796084e-01 0.941092094 15 50275389 50277262 1874 - 0.599 0.580 -0.083
ENSG00000104064 E002 113.8928613 0.0006283132 9.993267e-01 1.000000000 15 50277263 50278117 855 - 1.943 1.954 0.037
ENSG00000104064 E003 58.7797317 0.0015033326 9.784276e-01 0.990991317 15 50278118 50278401 284 - 1.659 1.668 0.032
ENSG00000104064 E004 22.5647246 0.0144450642 6.973638e-01 0.833832610 15 50278402 50278480 79 - 1.251 1.299 0.169
ENSG00000104064 E005 32.5516600 0.0077380072 1.130332e-01 0.304214729 15 50278481 50278541 61 - 1.435 1.300 -0.471
ENSG00000104064 E006 72.2881930 0.0012734907 6.855112e-05 0.001089838 15 50278542 50278784 243 - 1.784 1.557 -0.772
ENSG00000104064 E007 1.8102524 0.0108372597 4.225318e-01 0.645510752 15 50282279 50282391 113 - 0.395 0.231 -1.082
ENSG00000104064 E008 0.8981716 0.0172671820 1.000000e+00   15 50285880 50285881 2 - 0.241 0.230 -0.083
ENSG00000104064 E009 1.2131806 0.0208244855 6.137493e-01   15 50285882 50285893 12 - 0.276 0.380 0.656
ENSG00000104064 E010 11.2990356 0.0037617289 1.868938e-03 0.016189986 15 50285894 50286067 174 - 0.902 1.250 1.266
ENSG00000104064 E011 69.7003153 0.0058401273 3.772004e-01 0.610026033 15 50286068 50286183 116 - 1.723 1.790 0.228
ENSG00000104064 E012 96.0922781 0.0005911143 8.798137e-02 0.259979129 15 50289483 50289665 183 - 1.859 1.944 0.286
ENSG00000104064 E013 33.6448647 0.0010979649 7.095169e-01 0.841481356 15 50289666 50289668 3 - 1.424 1.463 0.134
ENSG00000104064 E014 85.6995717 0.0004778049 2.484231e-01 0.486233096 15 50300789 50300902 114 - 1.813 1.877 0.216
ENSG00000104064 E015 5.2800106 0.0048763646 4.792438e-02 0.174844496 15 50301113 50301220 108 - 0.748 0.381 -1.715
ENSG00000104064 E016 34.1761247 0.0028106043 4.661342e-02 0.171610104 15 50301221 50301256 36 - 1.457 1.299 -0.546
ENSG00000104064 E017 81.0425384 0.0006367406 4.456387e-01 0.662527413 15 50301257 50301368 112 - 1.805 1.777 -0.093
ENSG00000104064 E018 91.1574542 0.0005721096 2.370753e-02 0.108190258 15 50302929 50303123 195 - 1.867 1.767 -0.337
ENSG00000104064 E019 29.1758221 0.0017161553 9.267237e-01 0.965436643 15 50303966 50303972 7 - 1.366 1.383 0.057
ENSG00000104064 E020 29.0519684 0.0016660594 9.009892e-01 0.952346154 15 50303973 50303973 1 - 1.364 1.383 0.066
ENSG00000104064 E021 79.9246833 0.0005889040 7.698366e-01 0.878551796 15 50303974 50304133 160 - 1.796 1.792 -0.014
ENSG00000104064 E022 49.4427576 0.0108085016 1.620108e-01 0.379743391 15 50309691 50309798 108 - 1.571 1.686 0.391
ENSG00000104064 E023 1.3304311 0.1337200823 7.664923e-01   15 50314416 50314670 255 - 0.310 0.232 -0.559
ENSG00000104064 E024 0.1426347 0.0329878144 1.000000e+00   15 50327193 50327329 137 - 0.060 0.001 -6.855
ENSG00000104064 E025 2.5897320 0.0081609186 2.001445e-01 0.429877629 15 50346372 50346395 24 - 0.420 0.654 1.102
ENSG00000104064 E026 26.4492384 0.7406233940 2.782837e-01 0.518417806 15 50354985 50355408 424 - 1.258 1.555 1.029