ENSG00000104044

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000353809 ENSG00000104044 HEK293_OSMI2_6hA HEK293_TMG_6hB OCA2 protein_coding protein_coding 2.452405 2.411476 2.512873 0.2159874 0.2127394 0.05918078 1.109040 1.219714 2.2387602 0.20399792 0.2068496 0.870807 0.4471208 0.4987667 0.8905333 0.3917667 1.329792e-03 2.05121e-06 FALSE TRUE
ENST00000354638 ENSG00000104044 HEK293_OSMI2_6hA HEK293_TMG_6hB OCA2 protein_coding protein_coding 2.452405 2.411476 2.512873 0.2159874 0.2127394 0.05918078 1.266301 1.143050 0.1845242 0.09370435 0.0565958 -2.567434 0.5240833 0.4790667 0.0722000 -0.4068667 2.051210e-06 2.05121e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000104044 E001 42.982955 0.013581269 0.671025355 0.81700748 15 27754875 27755472 598 - 1.651 1.620 -0.106
ENSG00000104044 E002 22.117386 0.005011810 0.350082586 0.58729649 15 27844959 27845052 94 - 1.316 1.381 0.228
ENSG00000104044 E003 22.062529 0.001799105 0.344564982 0.58212203 15 27851382 27851475 94 - 1.316 1.380 0.219
ENSG00000104044 E004 14.446365 0.004747205 0.173443171 0.39514153 15 27871154 27871258 105 - 1.109 1.230 0.432
ENSG00000104044 E005 8.712822 0.097311641 0.724671492 0.85090607 15 27871863 27871922 60 - 0.955 1.007 0.193
ENSG00000104044 E006 14.699326 0.021420302 0.902222823 0.95299166 15 27926127 27926254 128 - 1.188 1.197 0.033
ENSG00000104044 E007 16.143717 0.008014243 0.244350335 0.48146350 15 27951784 27951892 109 - 1.175 1.272 0.344
ENSG00000104044 E008 14.342352 0.007357194 0.635401863 0.79382228 15 27955158 27955215 58 - 1.154 1.192 0.134
ENSG00000104044 E009 22.064854 0.011036126 0.210233319 0.44211114 15 27957588 27957735 148 - 1.300 1.397 0.340
ENSG00000104044 E010 23.485031 0.002213098 0.729001721 0.85361340 15 27966690 27966822 133 - 1.372 1.390 0.062
ENSG00000104044 E011 25.989295 0.017339119 0.095383147 0.27366073 15 27983345 27983483 139 - 1.504 1.356 -0.510
ENSG00000104044 E012 19.898842 0.024264181 0.527189549 0.71998374 15 27985064 27985188 125 - 1.344 1.291 -0.184
ENSG00000104044 E013 11.397593 0.026472700 0.067647830 0.21978491 15 27986587 27986643 57 - 1.194 0.979 -0.777
ENSG00000104044 E014 14.097341 0.046286445 0.463302372 0.67534225 15 27989601 27989666 66 - 1.214 1.143 -0.252
ENSG00000104044 E015 4.605794 0.005844571 0.002837152 0.02242141 15 27990576 27990647 72 - 0.446 0.885 1.897
ENSG00000104044 E016 17.004006 0.018413804 0.881327552 0.94201049 15 28014776 28014929 154 - 1.259 1.242 -0.060
ENSG00000104044 E017 14.075702 0.012450998 0.901103497 0.95242994 15 28016104 28016186 83 - 1.185 1.167 -0.066
ENSG00000104044 E018 9.651540 0.003624592 0.673043177 0.81826273 15 28018397 28018411 15 - 0.998 1.037 0.141
ENSG00000104044 E019 16.698725 0.002330384 0.939794819 0.97210828 15 28018412 28018557 146 - 1.243 1.230 -0.044
ENSG00000104044 E020 12.214241 0.002762111 0.943481892 0.97407132 15 28022501 28022573 73 - 1.120 1.120 0.000
ENSG00000104044 E021 15.439153 0.003697314 0.308848649 0.54934282 15 28024845 28024902 58 - 1.252 1.158 -0.334
ENSG00000104044 E022 25.811392 0.001755762 0.362670153 0.59788760 15 28027871 28028059 189 - 1.457 1.390 -0.231
ENSG00000104044 E023 16.248367 0.009192857 0.869732994 0.93569841 15 28032065 28032163 99 - 1.226 1.237 0.039
ENSG00000104044 E024 15.978935 0.002525292 0.952527109 0.97828868 15 28081648 28081895 248 - 1.234 1.222 -0.042
ENSG00000104044 E025 0.642642 0.019387492 0.844346256   15 28099111 28099223 113 - 0.235 0.199 -0.308
ENSG00000104044 E026 7.798347 0.004096099 0.809641344 0.90194250 15 28099224 28099315 92 - 0.966 0.932 -0.128