ENSG00000103978

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000389834 ENSG00000103978 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM87A protein_coding protein_coding 15.46022 2.984305 27.67477 0.09522662 0.77846 3.208799 12.1550572 2.334636 21.765857 0.2315937 0.1001050 3.215294 0.80033333 0.7790667 0.7878667 0.0088 1.00000000 0.03123854 FALSE  
MSTRG.10638.3 ENSG00000103978 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM87A protein_coding   15.46022 2.984305 27.67477 0.09522662 0.77846 3.208799 0.4979689 0.000000 1.476765 0.0000000 0.5980837 7.216033 0.01894583 0.0000000 0.0524000 0.0524 0.03123854 0.03123854 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000103978 E001 0.0000000       15 42210447 42210451 5 -      
ENSG00000103978 E002 141.5557830 0.0003617262 0.3571539705 0.593396570 15 42210452 42211138 687 - 1.970 2.023 0.176
ENSG00000103978 E003 74.9467652 0.3993457234 0.2313047565 0.466635000 15 42211139 42211339 201 - 1.669 1.886 0.736
ENSG00000103978 E004 234.7829389 0.0002393589 0.1601916485 0.377108448 15 42211340 42211749 410 - 2.188 2.247 0.196
ENSG00000103978 E005 79.4523245 0.0014208335 0.8372747598 0.917935707 15 42217803 42217833 31 - 1.725 1.753 0.094
ENSG00000103978 E006 1.3094372 0.0130602053 1.0000000000   15 42217834 42218006 173 - 0.264 0.272 0.056
ENSG00000103978 E007 101.8983749 0.0006298897 0.6360345091 0.794305117 15 42218323 42218375 53 - 1.837 1.827 -0.035
ENSG00000103978 E008 72.2323174 0.0005882146 0.4167711591 0.641204534 15 42218376 42218378 3 - 1.693 1.657 -0.124
ENSG00000103978 E009 107.5919762 0.0016599728 0.6252505345 0.787471885 15 42219581 42219642 62 - 1.855 1.894 0.132
ENSG00000103978 E010 82.5454299 0.0067613622 0.4666882998 0.677839989 15 42220062 42220135 74 - 1.739 1.798 0.197
ENSG00000103978 E011 2.3883531 0.0127664351 0.4084793577 0.634865337 15 42226603 42226804 202 - 0.386 0.558 0.866
ENSG00000103978 E012 1.2872596 0.0160546837 0.3340829331   15 42226805 42226805 1 - 0.235 0.438 1.281
ENSG00000103978 E013 66.2561606 0.9979383927 0.3262549455 0.565432437 15 42226806 42226909 104 - 1.605 1.877 0.918
ENSG00000103978 E014 1.2900360 0.0215095216 0.3397817711   15 42227615 42227710 96 - 0.235 0.438 1.279
ENSG00000103978 E015 60.6044477 0.0305028546 0.1239645247 0.322004764 15 42227711 42227769 59 - 1.591 1.745 0.521
ENSG00000103978 E016 83.5849598 0.0092066572 0.8779211021 0.940205428 15 42228712 42228820 109 - 1.748 1.753 0.017
ENSG00000103978 E017 75.4176797 0.0223997450 0.1519021618 0.365094482 15 42231192 42231260 69 - 1.716 1.596 -0.410
ENSG00000103978 E018 1.9652508 0.0110473820 0.0637996344 0.211238722 15 42231844 42231915 72 - 0.292 0.651 1.862
ENSG00000103978 E019 1.7421428 0.0182561606 0.5906900019 0.764175126 15 42232879 42233212 334 - 0.317 0.438 0.693
ENSG00000103978 E020 84.1615557 0.0214910965 0.3918972561 0.621934097 15 42233213 42233306 94 - 1.757 1.697 -0.202
ENSG00000103978 E021 55.6639578 0.0050464265 0.6890820240 0.828485901 15 42236320 42236354 35 - 1.577 1.564 -0.044
ENSG00000103978 E022 59.3160536 0.0130668281 0.5077330694 0.706216137 15 42236355 42236419 65 - 1.605 1.566 -0.132
ENSG00000103978 E023 87.8572715 0.0124013287 0.9636668670 0.983726848 15 42237432 42237544 113 - 1.765 1.788 0.079
ENSG00000103978 E024 71.5717336 0.0073572460 0.7835029861 0.886690841 15 42237545 42237615 71 - 1.675 1.713 0.130
ENSG00000103978 E025 0.0000000       15 42239668 42239669 2 -      
ENSG00000103978 E026 71.1873727 0.0010581541 0.2840758307 0.524564352 15 42239670 42239731 62 - 1.686 1.631 -0.185
ENSG00000103978 E027 80.3894546 0.0007044540 0.1358144787 0.341063545 15 42244050 42244131 82 - 1.742 1.665 -0.260
ENSG00000103978 E028 56.6736780 0.0095299751 0.3112126954 0.551597329 15 42244132 42244167 36 - 1.592 1.522 -0.241
ENSG00000103978 E029 2.5697832 0.0120107667 0.0544243328 0.190081680 15 42257935 42258790 856 - 0.365 0.728 1.720
ENSG00000103978 E030 2.5064593 0.0085418747 0.0003254704 0.003988768 15 42258791 42258990 200 - 0.292 0.901 2.861
ENSG00000103978 E031 72.1584001 0.0083587606 0.2474507984 0.485249675 15 42260958 42261002 45 - 1.694 1.623 -0.243
ENSG00000103978 E032 64.6362999 0.0224195658 0.1134936436 0.304977510 15 42261196 42261249 54 - 1.653 1.512 -0.480
ENSG00000103978 E033 0.0000000       15 42262123 42262243 121 -      
ENSG00000103978 E034 96.9567589 0.0142331866 0.0229405696 0.105750172 15 42264090 42264203 114 - 1.829 1.664 -0.559
ENSG00000103978 E035 74.8788426 0.0005518132 0.0824723826 0.249669951 15 42267947 42268032 86 - 1.718 1.622 -0.325
ENSG00000103978 E036 0.0000000       15 42271555 42271601 47 -      
ENSG00000103978 E037 52.5912784 0.0200736895 0.1676078382 0.387383766 15 42272063 42272123 61 - 1.571 1.431 -0.480
ENSG00000103978 E038 0.4466850 0.0244411696 1.0000000000   15 42272676 42272888 213 - 0.133 0.001 -7.142
ENSG00000103978 E039 0.9279113 0.0155035569 0.1869077115   15 42272889 42272962 74 - 0.170 0.437 1.861
ENSG00000103978 E040 2.2679663 0.0127193754 0.9087904407 0.956460557 15 42272963 42273254 292 - 0.407 0.437 0.164
ENSG00000103978 E041 51.5337679 0.9633382448 0.5352803492 0.725777569 15 42273255 42273584 330 - 1.533 1.611 0.266