ENSG00000103657

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000443617 ENSG00000103657 HEK293_OSMI2_6hA HEK293_TMG_6hB HERC1 protein_coding protein_coding 6.856648 11.28944 4.882048 3.249375 0.3133919 -1.20774 1.1762857 1.4582348 1.1484189 0.30053270 0.2976515 -0.3419256 0.21208750 0.13630000 0.23093333 0.09463333 5.533812e-01 2.389333e-08 FALSE TRUE
ENST00000558324 ENSG00000103657 HEK293_OSMI2_6hA HEK293_TMG_6hB HERC1 protein_coding nonsense_mediated_decay 6.856648 11.28944 4.882048 3.249375 0.3133919 -1.20774 0.5920854 1.5291550 0.1793821 0.19212340 0.1793821 -3.0227668 0.08202500 0.15696667 0.03256667 -0.12440000 2.895294e-01 2.389333e-08 TRUE FALSE
ENST00000559996 ENSG00000103657 HEK293_OSMI2_6hA HEK293_TMG_6hB HERC1 protein_coding retained_intron 6.856648 11.28944 4.882048 3.249375 0.3133919 -1.20774 1.2371341 2.9509816 0.0000000 1.16187527 0.0000000 -8.2099317 0.12656250 0.23973333 0.00000000 -0.23973333 2.389333e-08 2.389333e-08 FALSE FALSE
ENST00000561348 ENSG00000103657 HEK293_OSMI2_6hA HEK293_TMG_6hB HERC1 protein_coding retained_intron 6.856648 11.28944 4.882048 3.249375 0.3133919 -1.20774 0.5475558 0.5646401 0.2686308 0.38931700 0.2686308 -1.0443042 0.06087083 0.04633333 0.05940000 0.01306667 8.426815e-01 2.389333e-08   FALSE
ENST00000561436 ENSG00000103657 HEK293_OSMI2_6hA HEK293_TMG_6hB HERC1 protein_coding retained_intron 6.856648 11.28944 4.882048 3.249375 0.3133919 -1.20774 1.0395514 1.6832413 0.3455774 1.22233403 0.3455774 -2.2515522 0.11565000 0.13276667 0.06276667 -0.07000000 7.607447e-01 2.389333e-08 FALSE FALSE
MSTRG.10995.2 ENSG00000103657 HEK293_OSMI2_6hA HEK293_TMG_6hB HERC1 protein_coding   6.856648 11.28944 4.882048 3.249375 0.3133919 -1.20774 0.3914374 0.1021474 0.4782739 0.10214740 0.4782739 2.1222944 0.08102083 0.00970000 0.10360000 0.09390000 9.662387e-01 2.389333e-08 FALSE TRUE
MSTRG.10995.3 ENSG00000103657 HEK293_OSMI2_6hA HEK293_TMG_6hB HERC1 protein_coding   6.856648 11.28944 4.882048 3.249375 0.3133919 -1.20774 0.3251745 0.3501751 0.9213066 0.03331716 0.3408830 1.3705576 0.07356250 0.03546667 0.18793333 0.15246667 1.623905e-01 2.389333e-08 FALSE TRUE
MSTRG.10995.4 ENSG00000103657 HEK293_OSMI2_6hA HEK293_TMG_6hB HERC1 protein_coding   6.856648 11.28944 4.882048 3.249375 0.3133919 -1.20774 1.3002770 2.3071889 1.1523806 0.61720862 0.1415652 -0.9952931 0.20461250 0.20570000 0.23946667 0.03376667 8.893698e-01 2.389333e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000103657 E001 27.4223439 0.0944263994 5.118572e-04 5.784982e-03 15 63608618 63608802 185 - 1.015 1.603 2.064
ENSG00000103657 E002 25.9731253 0.0016628517 4.671943e-12 4.284036e-10 15 63608803 63608836 34 - 0.959 1.588 2.220
ENSG00000103657 E003 34.6839092 0.0071246970 3.750908e-11 2.899365e-09 15 63608837 63608876 40 - 1.111 1.704 2.055
ENSG00000103657 E004 50.4804431 0.2409729002 2.040497e-02 9.732709e-02 15 63608877 63609035 159 - 1.336 1.847 1.744
ENSG00000103657 E005 19.7641208 0.1602646704 2.106806e-01 4.426104e-01 15 63609036 63609037 2 - 1.167 1.387 0.773
ENSG00000103657 E006 78.7275182 0.5231139609 1.802544e-01 4.043770e-01 15 63609038 63609266 229 - 1.670 2.000 1.113
ENSG00000103657 E007 102.1057317 0.3959717294 1.238528e-01 3.218229e-01 15 63612251 63612556 306 - 1.757 2.119 1.216
ENSG00000103657 E008 30.5443701 0.0014011165 1.473605e-03 1.342986e-02 15 63615768 63615780 13 - 1.323 1.588 0.910
ENSG00000103657 E009 61.4684019 0.0008684069 2.143950e-05 4.054171e-04 15 63615781 63615920 140 - 1.622 1.880 0.873
ENSG00000103657 E010 78.9539001 0.0124910467 1.014095e-01 2.843830e-01 15 63616430 63616682 253 - 1.779 1.959 0.607
ENSG00000103657 E011 0.4644705 0.0217681645 1.930578e-01   15 63616683 63616732 50 - 0.000 0.257 11.918
ENSG00000103657 E012 31.3160211 0.0310310635 6.101690e-01 7.770269e-01 15 63622815 63622837 23 - 1.438 1.542 0.356
ENSG00000103657 E013 38.0142012 0.0236255296 2.194780e-01 4.528022e-01 15 63622838 63622891 54 - 1.473 1.644 0.581
ENSG00000103657 E014 69.4647415 0.0468408194 4.272971e-01 6.489502e-01 15 63623725 63623890 166 - 1.746 1.892 0.490
ENSG00000103657 E015 59.3879399 0.0175556334 3.102905e-01 5.507653e-01 15 63624158 63624280 123 - 1.683 1.822 0.468
ENSG00000103657 E016 40.2134959 0.0235427859 4.953004e-01 6.976632e-01 15 63624281 63624327 47 - 1.524 1.653 0.439
ENSG00000103657 E017 0.7804750 0.0169762922 6.265171e-02   15 63625942 63625984 43 - 0.405 0.104 -2.515
ENSG00000103657 E018 54.2861630 0.0140057886 4.807693e-01 6.876198e-01 15 63625985 63626154 170 - 1.657 1.780 0.415
ENSG00000103657 E019 48.6909844 0.0359212841 3.574217e-01 5.936149e-01 15 63628677 63628815 139 - 1.582 1.750 0.570
ENSG00000103657 E020 39.7138088 0.0287933224 5.802980e-01 7.573732e-01 15 63630466 63630519 54 - 1.527 1.646 0.406
ENSG00000103657 E021 30.7496903 0.0182953387 5.843656e-01 7.599113e-01 15 63630520 63630531 12 - 1.424 1.535 0.382
ENSG00000103657 E022 52.3566406 0.0114355181 3.504282e-01 5.876410e-01 15 63630532 63630635 104 - 1.642 1.764 0.414
ENSG00000103657 E023 0.1723744 0.0825237487 7.494091e-01   15 63630636 63630697 62 - 0.000 0.104 10.339
ENSG00000103657 E024 0.0000000       15 63632291 63632605 315 -      
ENSG00000103657 E025 41.6495133 0.0086887885 3.627903e-01 5.979872e-01 15 63632709 63632811 103 - 1.543 1.662 0.405
ENSG00000103657 E026 43.7411457 0.0066617866 5.736905e-01 7.527823e-01 15 63633848 63633962 115 - 1.584 1.673 0.306
ENSG00000103657 E027 23.6172048 0.0411437224 7.155195e-01 8.452280e-01 15 63633963 63633970 8 - 1.304 1.425 0.419
ENSG00000103657 E028 48.0286024 0.0032993124 8.144801e-02 2.477121e-01 15 63634733 63634888 156 - 1.584 1.740 0.529
ENSG00000103657 E029 0.2027342 0.0343003216 7.500266e-01   15 63634889 63634941 53 - 0.000 0.104 10.339
ENSG00000103657 E030 51.9998939 0.4350980002 2.454880e-01 4.829479e-01 15 63635961 63636142 182 - 1.545 1.804 0.879
ENSG00000103657 E031 0.9526617 0.0159802591 5.757012e-01   15 63636988 63637134 147 - 0.334 0.258 -0.515
ENSG00000103657 E032 48.4232067 0.0009312734 2.997503e-03 2.338501e-02 15 63637505 63637643 139 - 1.553 1.762 0.712
ENSG00000103657 E033 43.2960559 0.0009883108 1.573144e-03 1.413150e-02 15 63638411 63638536 126 - 1.487 1.718 0.787
ENSG00000103657 E034 24.9590529 0.0056109775 1.547659e-02 7.986999e-02 15 63638711 63638776 66 - 1.254 1.496 0.841
ENSG00000103657 E035 59.7486611 0.4907749675 2.757531e-01 5.158653e-01 15 63640152 63640445 294 - 1.614 1.860 0.831
ENSG00000103657 E036 38.5840898 0.2730973594 1.134945e-01 3.049775e-01 15 63641470 63641643 174 - 1.348 1.702 1.214
ENSG00000103657 E037 31.0895954 0.2213657413 1.346784e-01 3.391844e-01 15 63642957 63643058 102 - 1.299 1.597 1.024
ENSG00000103657 E038 38.1566571 0.3675463791 3.002240e-01 5.406445e-01 15 63643404 63643550 147 - 1.470 1.650 0.615
ENSG00000103657 E039 33.8351779 0.3242659616 2.720484e-01 5.119123e-01 15 63644992 63645097 106 - 1.410 1.604 0.666
ENSG00000103657 E040 49.7462043 0.5123595547 4.195373e-01 6.432855e-01 15 63645483 63645682 200 - 1.628 1.740 0.382
ENSG00000103657 E041 41.4824328 0.4400325144 4.193822e-01 6.431929e-01 15 63648069 63648199 131 - 1.550 1.664 0.388
ENSG00000103657 E042 48.6420320 0.4917999693 4.245926e-01 6.469795e-01 15 63649725 63649925 201 - 1.619 1.730 0.376
ENSG00000103657 E043 36.2903763 0.0133614943 3.357523e-01 5.742156e-01 15 63651253 63651380 128 - 1.499 1.612 0.386
ENSG00000103657 E044 32.9289170 0.0020870818 1.122222e-01 3.028191e-01 15 63652414 63652541 128 - 1.435 1.585 0.514
ENSG00000103657 E045 40.1163649 0.4537653962 5.021657e-01 7.022897e-01 15 63654119 63654324 206 - 1.568 1.632 0.218
ENSG00000103657 E046 43.3294364 0.0014127177 2.681576e-01 5.078095e-01 15 63655742 63655955 214 - 1.567 1.679 0.381
ENSG00000103657 E047 48.7114415 0.0009292186 5.467622e-01 7.339969e-01 15 63656088 63656358 271 - 1.638 1.720 0.278
ENSG00000103657 E048 34.8650804 0.0035223019 9.149990e-01 9.596612e-01 15 63658544 63658718 175 - 1.519 1.566 0.161
ENSG00000103657 E049 40.1042499 0.0061835077 2.688992e-01 5.086522e-01 15 63659736 63659936 201 - 1.533 1.651 0.403
ENSG00000103657 E050 19.8783992 0.0028577107 7.442042e-01 8.631303e-01 15 63660973 63661025 53 - 1.273 1.343 0.246
ENSG00000103657 E051 49.0714004 0.3253184800 4.901159e-01 6.940648e-01 15 63661753 63662021 269 - 1.647 1.721 0.250
ENSG00000103657 E052 10.6235818 0.1721186798 9.294674e-01 9.667537e-01 15 63662984 63663004 21 - 1.031 1.071 0.147
ENSG00000103657 E053 45.1616219 0.4558673877 4.112136e-01 6.369581e-01 15 63663005 63663204 200 - 1.563 1.711 0.503
ENSG00000103657 E054 24.5012526 0.0866744314 2.626383e-01 5.018540e-01 15 63664470 63664594 125 - 1.298 1.461 0.565
ENSG00000103657 E055 33.4944960 0.0091450788 4.489762e-01 6.649906e-01 15 63665919 63666150 232 - 1.463 1.564 0.347
ENSG00000103657 E056 20.9346115 0.0146038512 5.142759e-01 7.111810e-01 15 63666356 63666472 117 - 1.262 1.369 0.373
ENSG00000103657 E057 24.9976309 0.2265669112 3.322653e-01 5.710701e-01 15 63669538 63669698 161 - 1.301 1.470 0.585
ENSG00000103657 E058 27.3951595 0.0015052941 2.588454e-01 4.976780e-01 15 63672496 63672694 199 - 1.470 1.442 -0.097
ENSG00000103657 E059 48.2271338 0.0010188996 1.542411e-04 2.149489e-03 15 63674342 63674740 399 - 1.767 1.623 -0.490
ENSG00000103657 E060 44.1955765 0.0061201776 5.775597e-02 1.977877e-01 15 63674741 63675093 353 - 1.688 1.614 -0.254
ENSG00000103657 E061 3.3832252 0.0078366766 3.646339e-01 5.996014e-01 15 63675094 63675117 24 - 0.521 0.703 0.804
ENSG00000103657 E062 43.5225582 0.0882919675 9.940752e-01 9.986357e-01 15 63677845 63678365 521 - 1.657 1.633 -0.080
ENSG00000103657 E063 19.9660431 0.0089869927 8.093170e-02 2.466763e-01 15 63680077 63680160 84 - 1.376 1.272 -0.362
ENSG00000103657 E064 41.0703442 0.0302374878 2.286500e-01 4.636643e-01 15 63680537 63680776 240 - 1.655 1.591 -0.219
ENSG00000103657 E065 32.2732533 0.0414192316 7.372589e-02 2.322239e-01 15 63686359 63686532 174 - 1.597 1.451 -0.501
ENSG00000103657 E066 8.8087437 0.0349411910 3.320371e-02 1.365940e-01 15 63686533 63686535 3 - 1.114 0.883 -0.855
ENSG00000103657 E067 18.0470931 0.0034613050 2.823041e-04 3.550976e-03 15 63689589 63689699 111 - 1.410 1.160 -0.877
ENSG00000103657 E068 18.2074482 0.0018423687 1.999720e-03 1.706611e-02 15 63690541 63690647 107 - 1.390 1.192 -0.694
ENSG00000103657 E069 17.3684850 0.0024019252 7.081268e-04 7.511319e-03 15 63692411 63692566 156 - 1.383 1.153 -0.809
ENSG00000103657 E070 19.9701760 0.0062032020 1.089065e-04 1.604808e-03 15 63693964 63694157 194 - 1.459 1.191 -0.934
ENSG00000103657 E071 22.1791877 0.0028991904 5.900397e-03 3.925039e-02 15 63694312 63694549 238 - 1.447 1.292 -0.540
ENSG00000103657 E072 14.2924810 0.0339066315 5.543358e-01 7.393539e-01 15 63694774 63694894 121 - 1.174 1.176 0.005
ENSG00000103657 E073 25.5596700 0.0076562023 2.655832e-01 5.049834e-01 15 63696124 63696339 216 - 1.436 1.402 -0.116
ENSG00000103657 E074 32.0447245 0.0457066666 5.415507e-02 1.894524e-01 15 63698728 63698996 269 - 1.604 1.433 -0.586
ENSG00000103657 E075 16.6645734 0.0021568856 1.635760e-01 3.820620e-01 15 63706780 63706831 52 - 1.282 1.214 -0.240
ENSG00000103657 E076 20.4697667 0.0016815939 1.451110e-03 1.327257e-02 15 63712775 63712895 121 - 1.429 1.235 -0.676
ENSG00000103657 E077 28.2203868 0.0168193724 1.713138e-02 8.593168e-02 15 63713353 63713665 313 - 1.563 1.378 -0.639
ENSG00000103657 E078 19.9402944 0.2046411738 6.814421e-01 8.235743e-01 15 63716302 63716473 172 - 1.419 1.225 -0.679
ENSG00000103657 E079 0.0000000       15 63718429 63718573 145 -      
ENSG00000103657 E080 13.8592128 0.0247851598 3.330805e-03 2.537664e-02 15 63718574 63718694 121 - 1.322 1.009 -1.118
ENSG00000103657 E081 13.2726863 0.0172603453 5.395048e-03 3.667600e-02 15 63718783 63718897 115 - 1.274 1.029 -0.876
ENSG00000103657 E082 17.7830737 0.0077239398 4.509531e-04 5.231740e-03 15 63723182 63723355 174 - 1.404 1.143 -0.915
ENSG00000103657 E083 19.6730416 0.0127477598 3.469339e-03 2.615643e-02 15 63725292 63725513 222 - 1.429 1.200 -0.800
ENSG00000103657 E084 17.0842166 0.0829441880 1.081276e-02 6.157795e-02 15 63727647 63727838 192 - 1.426 1.065 -1.274
ENSG00000103657 E085 14.9709755 0.0195493042 5.416370e-09 2.696641e-07 15 63729236 63729368 133 - 1.449 0.857 -2.130
ENSG00000103657 E086 16.1512942 0.0025811974 2.378979e-09 1.289928e-07 15 63729497 63729649 153 - 1.441 0.971 -1.671
ENSG00000103657 E087 17.7795082 0.0034467641 6.768163e-05 1.078429e-03 15 63732924 63733145 222 - 1.410 1.127 -0.994
ENSG00000103657 E088 0.0000000       15 63734643 63734723 81 -      
ENSG00000103657 E089 10.5600803 0.0676000504 3.694343e-03 2.744224e-02 15 63734724 63734849 126 - 1.247 0.864 -1.404
ENSG00000103657 E090 12.9952906 0.0257571016 6.093912e-06 1.366909e-04 15 63746918 63747083 166 - 1.363 0.872 -1.775
ENSG00000103657 E091 14.1800876 0.0186200724 1.128985e-06 3.155490e-05 15 63747724 63747858 135 - 1.396 0.917 -1.720
ENSG00000103657 E092 15.9603195 0.0362339654 7.971193e-05 1.237605e-03 15 63749367 63749538 172 - 1.425 0.994 -1.528
ENSG00000103657 E093 13.5451046 0.0681399162 3.345061e-03 2.545090e-02 15 63749647 63749791 145 - 1.345 0.946 -1.432
ENSG00000103657 E094 0.1779838 0.0930994257 3.136127e-01   15 63752515 63752957 443 - 0.142 0.000 -11.409
ENSG00000103657 E095 15.5051989 0.0077657095 1.786537e-07 6.238845e-06 15 63752958 63753085 128 - 1.416 0.972 -1.584
ENSG00000103657 E096 18.5355290 0.0023207828 1.493228e-10 1.020871e-08 15 63754505 63754648 144 - 1.503 1.030 -1.669
ENSG00000103657 E097 16.1182749 0.0286672559 2.248775e-09 1.226377e-07 15 63755229 63755325 97 - 1.499 0.838 -2.375
ENSG00000103657 E098 23.2077937 0.0276644506 1.619245e-08 7.247891e-07 15 63756437 63756748 312 - 1.620 1.061 -1.953
ENSG00000103657 E099 12.7374020 0.1011014934 7.080667e-04 7.511151e-03 15 63758175 63758369 195 - 1.364 0.858 -1.831
ENSG00000103657 E100 8.9046634 0.1149012257 2.387470e-03 1.960577e-02 15 63764096 63764191 96 - 1.210 0.736 -1.774
ENSG00000103657 E101 22.4840812 0.0246917311 1.844801e-11 1.518612e-09 15 63774694 63775164 471 - 1.634 0.971 -2.331
ENSG00000103657 E102 4.2949980 0.0898442884 2.948830e-04 3.678142e-03 15 63775165 63775187 23 - 0.980 0.367 -2.688
ENSG00000103657 E103 16.6180723 0.0750742668 6.447527e-04 6.959502e-03 15 63775188 63775563 376 - 1.458 0.987 -1.670
ENSG00000103657 E104 7.8545074 0.0084469370 1.015389e-05 2.124386e-04 15 63775564 63775649 86 - 1.162 0.679 -1.839
ENSG00000103657 E105 1.0352465 0.0865644820 6.710777e-01   15 63779583 63780009 427 - 0.249 0.366 0.772
ENSG00000103657 E106 0.1779838 0.0930994257 3.136127e-01   15 63780462 63780552 91 - 0.142 0.000 -11.409
ENSG00000103657 E107 1.4394976 0.0128435202 3.037409e-01 5.443169e-01 15 63833822 63833826 5 - 0.467 0.318 -0.840
ENSG00000103657 E108 4.0536902 0.0062501244 1.890285e-03 1.633742e-02 15 63833827 63833948 122 - 0.900 0.499 -1.688