ENSG00000103653

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000220003 ENSG00000103653 HEK293_OSMI2_6hA HEK293_TMG_6hB CSK protein_coding protein_coding 112.9178 171.4635 74.56108 26.6363 2.863337 -1.201298 15.149513 24.904925 5.836911 5.431553 0.2925595 -2.0912636 0.1318833 0.14226667 0.0785000 -0.06376667 0.009002960 0.00900296 FALSE TRUE
ENST00000439220 ENSG00000103653 HEK293_OSMI2_6hA HEK293_TMG_6hB CSK protein_coding protein_coding 112.9178 171.4635 74.56108 26.6363 2.863337 -1.201298 60.768457 97.673591 29.980284 21.257882 1.6138021 -1.7036211 0.4965833 0.55633333 0.4021333 -0.15420000 0.235484411 0.00900296 FALSE TRUE
ENST00000567135 ENSG00000103653 HEK293_OSMI2_6hA HEK293_TMG_6hB CSK protein_coding retained_intron 112.9178 171.4635 74.56108 26.6363 2.863337 -1.201298 12.840122 16.955393 15.334657 1.339751 0.7546106 -0.1448584 0.1353583 0.10576667 0.2055667 0.09980000 0.116056795 0.00900296 FALSE FALSE
ENST00000569462 ENSG00000103653 HEK293_OSMI2_6hA HEK293_TMG_6hB CSK protein_coding protein_coding 112.9178 171.4635 74.56108 26.6363 2.863337 -1.201298 7.029309 5.429941 11.866544 1.401331 1.5942999 1.1264522 0.0812500 0.03613333 0.1580000 0.12186667 0.009671271 0.00900296 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000103653 E001 11.105976 2.837637e-03 7.923655e-04 8.218022e-03 15 74782080 74782088 9 + 0.597 1.089 1.932
ENSG00000103653 E002 46.025410 8.685755e-04 5.631567e-05 9.232257e-04 15 74782089 74782148 60 + 1.359 1.652 1.004
ENSG00000103653 E003 84.881047 5.492238e-04 1.324886e-08 6.045034e-07 15 74782149 74782492 344 + 1.608 1.919 1.050
ENSG00000103653 E004 13.188683 2.587496e-03 2.206175e-01 4.542093e-01 15 74782493 74782503 11 + 0.967 1.118 0.553
ENSG00000103653 E005 10.289950 3.760595e-03 1.698745e-01 3.903065e-01 15 74782504 74782504 1 + 0.839 1.028 0.710
ENSG00000103653 E006 87.270696 1.919388e-02 4.074361e-01 6.340330e-01 15 74782505 74782591 87 + 1.816 1.888 0.240
ENSG00000103653 E007 85.771713 8.180938e-03 9.093793e-02 2.654044e-01 15 74782592 74782604 13 + 1.777 1.889 0.377
ENSG00000103653 E008 178.452076 1.802049e-03 9.015199e-02 2.640682e-01 15 74782605 74782667 63 + 2.124 2.200 0.252
ENSG00000103653 E009 246.614842 2.418848e-04 5.548477e-01 7.396660e-01 15 74782668 74782720 53 + 2.302 2.330 0.091
ENSG00000103653 E010 3.581409 7.278630e-03 9.362423e-01 9.703285e-01 15 74784435 74784442 8 + 0.597 0.620 0.100
ENSG00000103653 E011 12.831138 2.730650e-03 7.630654e-01 8.744706e-01 15 74784443 74784523 81 + 1.043 1.088 0.164
ENSG00000103653 E012 1.168208 5.036175e-02 6.181197e-02   15 74788544 74788577 34 + 0.527 0.185 -2.161
ENSG00000103653 E013 2.923124 9.146485e-03 6.081157e-01 7.756417e-01 15 74789804 74789937 134 + 0.597 0.517 -0.369
ENSG00000103653 E014 2.623638 8.919166e-03 8.206864e-01 9.084484e-01 15 74790817 74790946 130 + 0.527 0.494 -0.159
ENSG00000103653 E015 3.056508 1.799393e-01 2.873315e-01 5.281085e-01 15 74793046 74793248 203 + 0.342 0.598 1.308
ENSG00000103653 E016 9.105589 7.354165e-02 1.393716e-01 3.465526e-01 15 74797914 74798211 298 + 0.712 0.983 1.054
ENSG00000103653 E017 7.758873 5.821648e-03 3.204805e-01 5.601235e-01 15 74798212 74798232 21 + 0.758 0.906 0.577
ENSG00000103653 E018 508.617817 3.233066e-04 1.016531e-02 5.883518e-02 15 74798233 74798312 80 + 2.667 2.626 -0.135
ENSG00000103653 E019 14.881982 2.042361e-01 4.336113e-01 6.539771e-01 15 74798313 74798435 123 + 1.218 1.098 -0.429
ENSG00000103653 E020 23.362592 2.111384e-01 4.743902e-01 6.831178e-01 15 74798436 74798614 179 + 1.381 1.291 -0.315
ENSG00000103653 E021 455.343541 1.265430e-03 1.426283e-02 7.539554e-02 15 74798615 74798636 22 + 2.628 2.572 -0.189
ENSG00000103653 E022 421.745966 1.699061e-03 1.765998e-02 8.785879e-02 15 74798637 74798651 15 + 2.598 2.537 -0.203
ENSG00000103653 E023 721.033895 4.479215e-04 5.499830e-05 9.038104e-04 15 74798652 74798728 77 + 2.833 2.769 -0.213
ENSG00000103653 E024 9.472458 8.383666e-02 8.059050e-01 8.996628e-01 15 74798729 74798825 97 + 0.967 0.932 -0.132
ENSG00000103653 E025 962.765716 1.727185e-04 4.966822e-06 1.144634e-04 15 74798826 74798938 113 + 2.952 2.897 -0.182
ENSG00000103653 E026 7.147545 2.105163e-01 3.304808e-01 5.694264e-01 15 74798939 74799051 113 + 0.997 0.786 -0.807
ENSG00000103653 E027 11.662094 1.161728e-01 2.327049e-01 4.682851e-01 15 74799178 74799271 94 + 1.182 0.976 -0.746
ENSG00000103653 E028 1231.671627 1.309351e-04 8.576058e-03 5.193790e-02 15 74799272 74799491 220 + 3.034 3.012 -0.074
ENSG00000103653 E029 651.770514 1.409942e-04 9.831129e-01 9.933462e-01 15 74800412 74800474 63 + 2.734 2.745 0.035
ENSG00000103653 E030 379.875021 6.599284e-04 1.369775e-01 3.429242e-01 15 74800475 74800488 14 + 2.527 2.503 -0.082
ENSG00000103653 E031 411.789433 5.607150e-04 3.967607e-02 1.538975e-01 15 74800489 74800505 17 + 2.572 2.536 -0.118
ENSG00000103653 E032 20.315935 8.431147e-02 3.667428e-02 1.460187e-01 15 74800506 74800680 175 + 1.484 1.158 -1.138
ENSG00000103653 E033 686.076857 5.949594e-04 2.059144e-01 4.369512e-01 15 74800681 74800746 66 + 2.774 2.761 -0.044
ENSG00000103653 E034 13.843847 3.614162e-03 8.660610e-04 8.818628e-03 15 74800747 74800822 76 + 1.324 1.014 -1.108
ENSG00000103653 E035 611.766294 1.429176e-04 2.503089e-02 1.123040e-01 15 74800823 74800851 29 + 2.735 2.708 -0.090
ENSG00000103653 E036 843.965384 9.891449e-05 7.949411e-01 8.932837e-01 15 74800852 74800922 71 + 2.849 2.856 0.024
ENSG00000103653 E037 5.014706 8.997811e-02 4.102394e-02 1.573744e-01 15 74800923 74801011 89 + 0.339 0.785 2.109
ENSG00000103653 E038 909.492278 9.664512e-05 6.120565e-01 7.782277e-01 15 74801012 74801102 91 + 2.884 2.888 0.012
ENSG00000103653 E039 807.211627 1.028790e-04 5.941301e-01 7.664299e-01 15 74801522 74801595 74 + 2.832 2.835 0.009
ENSG00000103653 E040 15.313098 1.170375e-02 5.451359e-02 1.902657e-01 15 74801630 74801694 65 + 1.286 1.089 -0.701
ENSG00000103653 E041 1160.275709 8.841784e-05 2.288433e-01 4.638464e-01 15 74801695 74801890 196 + 2.972 2.998 0.087
ENSG00000103653 E042 11.811874 1.369335e-02 5.575660e-01 7.415368e-01 15 74801891 74801996 106 + 0.967 1.045 0.288
ENSG00000103653 E043 563.905762 1.613012e-03 6.734252e-04 7.212151e-03 15 74801997 74802083 87 + 2.596 2.696 0.332
ENSG00000103653 E044 1935.939690 1.436783e-03 1.463482e-10 1.002958e-08 15 74802331 74803197 867 + 3.104 3.237 0.442