ENSG00000103316

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000543948 ENSG00000103316 HEK293_OSMI2_6hA HEK293_TMG_6hB CRYM protein_coding protein_coding 0.827808 0.8224712 0.6421298 0.01456621 0.1180381 -0.3522412 0.323837926 0.65438075 0.00000000 0.09589454 0.00000000 -6.053938 0.414637500 0.79293333 0.00000000 -0.79293333 0.002300398 0.002300398 FALSE TRUE
ENST00000570401 ENSG00000103316 HEK293_OSMI2_6hA HEK293_TMG_6hB CRYM protein_coding protein_coding 0.827808 0.8224712 0.6421298 0.01456621 0.1180381 -0.3522412 0.005657411 0.04525929 0.00000000 0.04525929 0.00000000 -2.466217 0.006854167 0.05483333 0.00000000 -0.05483333 0.880928916 0.002300398   FALSE
ENST00000571358 ENSG00000103316 HEK293_OSMI2_6hA HEK293_TMG_6hB CRYM protein_coding protein_coding 0.827808 0.8224712 0.6421298 0.01456621 0.1180381 -0.3522412 0.048479570 0.07677322 0.00000000 0.07677322 0.00000000 -3.117250 0.054458333 0.09646667 0.00000000 -0.09646667 0.894236423 0.002300398   FALSE
ENST00000572914 ENSG00000103316 HEK293_OSMI2_6hA HEK293_TMG_6hB CRYM protein_coding protein_coding 0.827808 0.8224712 0.6421298 0.01456621 0.1180381 -0.3522412 0.365519498 0.00000000 0.36969198 0.00000000 0.15280134 5.246758 0.429104167 0.00000000 0.64170000 0.64170000 0.085406762 0.002300398 FALSE TRUE
ENST00000574787 ENSG00000103316 HEK293_OSMI2_6hA HEK293_TMG_6hB CRYM protein_coding processed_transcript 0.827808 0.8224712 0.6421298 0.01456621 0.1180381 -0.3522412 0.014796560 0.00000000 0.04853933 0.00000000 0.04853933 2.549406 0.015845833 0.00000000 0.06386667 0.06386667 0.767061531 0.002300398   FALSE
ENST00000576703 ENSG00000103316 HEK293_OSMI2_6hA HEK293_TMG_6hB CRYM protein_coding protein_coding 0.827808 0.8224712 0.6421298 0.01456621 0.1180381 -0.3522412 0.032074154 0.03269471 0.22389852 0.03269471 0.22389852 2.453754 0.041754167 0.03960000 0.29443333 0.25483333 0.973746958 0.002300398 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000103316 E001 0.0000000       16 21238874 21238945 72 -      
ENSG00000103316 E002 0.0000000       16 21243872 21243991 120 -      
ENSG00000103316 E003 0.0000000       16 21243992 21244068 77 -      
ENSG00000103316 E004 0.0000000       16 21258518 21258520 3 -      
ENSG00000103316 E005 3.7888949 0.010087198 0.51666054 0.71280702 16 21258521 21258788 268 - 0.609 0.702 0.396
ENSG00000103316 E006 4.0747844 0.101932016 0.92345358 0.96404866 16 21258789 21258845 57 - 0.725 0.679 -0.191
ENSG00000103316 E007 0.0000000       16 21261083 21261253 171 -      
ENSG00000103316 E008 3.6289072 0.097504466 0.85080349 0.92548918 16 21261254 21261283 30 - 0.689 0.635 -0.232
ENSG00000103316 E009 2.7354352 0.109524167 0.81523345 0.90535706 16 21261284 21261291 8 - 0.606 0.551 -0.250
ENSG00000103316 E010 4.0882456 0.008070577 0.21420626 0.44660844 16 21261292 21261338 47 - 0.559 0.742 0.783
ENSG00000103316 E011 0.1426347 0.032649190 0.26571783   16 21261339 21262036 698 - 0.158 0.000 -12.373
ENSG00000103316 E012 4.9371199 0.007746734 0.36995469 0.60391997 16 21262037 21262158 122 - 0.654 0.779 0.515
ENSG00000103316 E013 0.0000000       16 21262159 21262336 178 -      
ENSG00000103316 E014 7.1616044 0.004292577 0.26210356 0.50125603 16 21267554 21267737 184 - 0.970 0.842 -0.486
ENSG00000103316 E015 0.1308682 0.033551989 0.92158632   16 21268547 21268684 138 - 0.000 0.092 10.569
ENSG00000103316 E016 4.9614810 0.041363195 0.12180852 0.31873551 16 21269790 21269891 102 - 0.880 0.661 -0.878
ENSG00000103316 E017 3.0316650 0.037788126 0.01927721 0.09343056 16 21275532 21275594 63 - 0.797 0.424 -1.668
ENSG00000103316 E018 3.5235897 0.010687182 0.58310070 0.75904548 16 21277431 21277557 127 - 0.694 0.611 -0.354
ENSG00000103316 E019 1.6132769 0.018026293 0.73442851 0.85693671 16 21277558 21277584 27 - 0.365 0.425 0.336
ENSG00000103316 E020 3.7914652 0.027277079 0.74540330 0.86393689 16 21278082 21278169 88 - 0.609 0.663 0.234
ENSG00000103316 E021 2.2863312 0.013779453 0.72918353 0.85373799 16 21278170 21278174 5 - 0.440 0.498 0.294
ENSG00000103316 E022 2.5895737 0.010626154 0.47304968 0.68219388 16 21278175 21278245 71 - 0.440 0.559 0.581
ENSG00000103316 E023 2.7392229 0.009621434 0.37697331 0.60983404 16 21278246 21278275 30 - 0.440 0.586 0.705
ENSG00000103316 E024 1.8822678 0.015700727 0.21491690 0.44746380 16 21278276 21278290 15 - 0.273 0.497 1.290
ENSG00000103316 E025 1.7208521 0.013696863 0.06647298 0.21712800 16 21278291 21278336 46 - 0.158 0.497 2.290
ENSG00000103316 E026 0.2735028 0.027442404 0.65676479   16 21278721 21278853 133 - 0.158 0.092 -0.885
ENSG00000103316 E027 0.2735028 0.027442404 0.65676479   16 21278854 21278960 107 - 0.158 0.092 -0.885
ENSG00000103316 E028 0.0000000       16 21283508 21283712 205 -      
ENSG00000103316 E029 0.3447487 0.464173013 0.56507771   16 21283810 21284104 295 - 0.000 0.171 11.600
ENSG00000103316 E030 0.3032425 0.027753912 0.43166175   16 21302978 21303062 85 - 0.000 0.169 11.571
ENSG00000103316 E031 0.1308682 0.033551989 0.92158632   16 21303063 21303083 21 - 0.000 0.092 10.569