ENSG00000103266

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000219548 ENSG00000103266 HEK293_OSMI2_6hA HEK293_TMG_6hB STUB1 protein_coding protein_coding 291.6387 430.6564 145.5975 90.35412 3.651632 -1.564486 199.97252 314.12291 70.33771 82.447422 1.760146 -2.15879965 0.6453875 0.7074333 0.4841667 -0.2232667 0.07004739 0.0459753 FALSE TRUE
ENST00000564370 ENSG00000103266 HEK293_OSMI2_6hA HEK293_TMG_6hB STUB1 protein_coding protein_coding 291.6387 430.6564 145.5975 90.35412 3.651632 -1.564486 40.95252 48.51036 45.26444 1.731255 4.557720 -0.09989365 0.1619792 0.1272667 0.3097667 0.1825000 0.04597530 0.0459753 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000103266 E001 131.576319 0.0477610221 3.169785e-01 5.569894e-01 16 680224 680409 186 + 2.052 1.995 -0.194
ENSG00000103266 E002 45.145568 0.0146532455 1.231842e-05 2.511648e-04 16 680410 680418 9 + 1.081 1.612 1.852
ENSG00000103266 E003 61.184592 0.0058338575 1.800388e-09 1.000964e-07 16 680419 680423 5 + 1.170 1.747 1.989
ENSG00000103266 E004 134.631332 0.1329669770 2.429433e-02 1.100050e-01 16 680424 680429 6 + 1.563 2.071 1.715
ENSG00000103266 E005 165.042846 0.1509537938 4.199167e-02 1.599189e-01 16 680430 680438 9 + 1.676 2.157 1.620
ENSG00000103266 E006 1429.162647 0.1018297758 8.840313e-01 9.433937e-01 16 680439 680684 246 + 2.951 3.053 0.341
ENSG00000103266 E007 77.239852 0.1893091640 3.323310e-02 1.366765e-01 16 680685 681036 352 + 2.076 1.673 -1.357
ENSG00000103266 E008 45.942173 0.1428639028 4.607873e-03 3.251435e-02 16 681037 681062 26 + 1.916 1.416 -1.700
ENSG00000103266 E009 80.799388 0.1273619301 1.650858e-02 8.367015e-02 16 681063 681151 89 + 2.082 1.700 -1.287
ENSG00000103266 E010 1189.246367 0.0799838835 6.853569e-01 8.260859e-01 16 681152 681208 57 + 2.941 2.961 0.064
ENSG00000103266 E011 935.185183 0.0714726356 5.881295e-01 7.624211e-01 16 681209 681223 15 + 2.852 2.853 0.003
ENSG00000103266 E012 1413.635324 0.0808447761 4.374398e-01 6.568183e-01 16 681224 681275 52 + 3.057 3.027 -0.098
ENSG00000103266 E013 1845.919514 0.0724745071 3.039470e-01 5.445160e-01 16 681276 681350 75 + 3.191 3.138 -0.175
ENSG00000103266 E014 8.951542 0.0043527506 1.453985e-01 3.555057e-01 16 681351 681390 40 + 1.028 0.865 -0.610
ENSG00000103266 E015 1628.281899 0.0461152974 2.102229e-01 4.421047e-01 16 681438 681480 43 + 3.138 3.084 -0.182
ENSG00000103266 E016 2189.746528 0.0000770432 4.404663e-04 5.131886e-03 16 681481 681603 123 + 3.237 3.228 -0.032
ENSG00000103266 E017 2076.838378 1.6169301200 5.608350e-01 7.438916e-01 16 681793 681880 88 + 3.138 3.211 0.244
ENSG00000103266 E018 88.042756 0.4562527533 8.603567e-01 9.305554e-01 16 681881 681903 23 + 1.970 1.797 -0.580
ENSG00000103266 E019 124.303530 0.6534945532 9.885888e-01 9.960612e-01 16 681904 682019 116 + 2.196 1.917 -0.934
ENSG00000103266 E020 1615.038298 1.5314955134 5.540890e-01 7.391703e-01 16 682020 682058 39 + 3.031 3.102 0.234
ENSG00000103266 E021 1190.711021 1.4289948779 5.501190e-01 7.363494e-01 16 682059 682076 18 + 2.904 2.968 0.213
ENSG00000103266 E022 2317.165808 1.6558044487 5.641593e-01 7.462552e-01 16 682165 682281 117 + 3.184 3.259 0.251
ENSG00000103266 E023 57.949858 0.2279762869 7.451291e-01 8.637429e-01 16 682282 682363 82 + 1.712 1.642 -0.235
ENSG00000103266 E024 1694.590902 1.5343272700 5.346574e-01 7.254261e-01 16 682364 682415 52 + 3.035 3.126 0.302
ENSG00000103266 E025 2529.207607 1.6778398495 5.578049e-01 7.416974e-01 16 682416 682688 273 + 3.214 3.298 0.281
ENSG00000103266 E026 291.540565 0.9077777364 5.097347e-01 7.077828e-01 16 682689 682801 113 + 2.310 2.356 0.155
ENSG00000103266 E027 22.204599 0.0337236426 5.249971e-02 1.854763e-01 16 682807 682870 64 + 1.440 1.205 -0.822