ENSG00000103222

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000399410 ENSG00000103222 HEK293_OSMI2_6hA HEK293_TMG_6hB ABCC1 protein_coding protein_coding 19.61303 26.45028 15.1056 0.7255702 0.2210891 -0.8077898 10.3300640 12.601561 10.1616393 1.5414433 1.0601009 -0.3101947 0.54962500 0.47676667 0.67093333 0.19416667 3.449027e-01 5.979612e-16 FALSE TRUE
ENST00000572882 ENSG00000103222 HEK293_OSMI2_6hA HEK293_TMG_6hB ABCC1 protein_coding protein_coding 19.61303 26.45028 15.1056 0.7255702 0.2210891 -0.8077898 0.9718313 1.870781 0.9004904 0.1123400 0.5463516 -1.0466158 0.05106250 0.07070000 0.06060000 -0.01010000 8.251243e-01 5.979612e-16 FALSE TRUE
ENST00000574761 ENSG00000103222 HEK293_OSMI2_6hA HEK293_TMG_6hB ABCC1 protein_coding retained_intron 19.61303 26.45028 15.1056 0.7255702 0.2210891 -0.8077898 1.6688931 2.367980 1.5014247 0.1154904 0.2178235 -0.6538276 0.08227083 0.08953333 0.09966667 0.01013333 9.428674e-01 5.979612e-16 FALSE TRUE
ENST00000676806 ENSG00000103222 HEK293_OSMI2_6hA HEK293_TMG_6hB ABCC1 protein_coding processed_transcript 19.61303 26.45028 15.1056 0.7255702 0.2210891 -0.8077898 3.8793765 5.385538 0.0000000 0.9877801 0.0000000 -9.0756230 0.17229583 0.20253333 0.00000000 -0.20253333 5.979612e-16 5.979612e-16 FALSE TRUE
MSTRG.12147.8 ENSG00000103222 HEK293_OSMI2_6hA HEK293_TMG_6hB ABCC1 protein_coding   19.61303 26.45028 15.1056 0.7255702 0.2210891 -0.8077898 0.9771302 1.358295 1.0371608 0.7478652 0.3591426 -0.3858962 0.05067500 0.05200000 0.06940000 0.01740000 8.991731e-01 5.979612e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000103222 E001 0.0000000       16 15949138 15949260 123 +      
ENSG00000103222 E002 0.1308682 0.0311338175 8.897821e-01   16 15949577 15949615 39 + 0.000 0.092 8.549
ENSG00000103222 E003 1.2547365 0.0228874030 8.515431e-01   16 15949616 15949656 41 + 0.365 0.339 -0.161
ENSG00000103222 E004 1.7303534 0.0520051049 6.659970e-01 8.136924e-01 16 15949657 15949677 21 + 0.366 0.460 0.508
ENSG00000103222 E005 26.5246473 0.0051645212 3.305785e-01 5.695271e-01 16 15949678 15949799 122 + 1.464 1.403 -0.212
ENSG00000103222 E006 97.4125490 0.0042733298 5.819414e-03 3.884710e-02 16 16007816 16007992 177 + 2.051 1.931 -0.400
ENSG00000103222 E007 109.3394316 0.0005201864 3.518833e-04 4.257472e-03 16 16009776 16009901 126 + 2.096 1.981 -0.386
ENSG00000103222 E008 122.0899640 0.0007283564 4.723435e-03 3.312930e-02 16 16014491 16014628 138 + 2.126 2.040 -0.288
ENSG00000103222 E009 119.9411223 0.0003970068 1.151188e-02 6.443577e-02 16 16016496 16016621 126 + 2.108 2.034 -0.250
ENSG00000103222 E010 93.1791280 0.0004377662 4.902662e-02 1.772708e-01 16 16033109 16033170 62 + 1.995 1.931 -0.216
ENSG00000103222 E011 101.9354348 0.0026573758 3.989219e-01 6.273405e-01 16 16036472 16036603 132 + 2.005 1.978 -0.091
ENSG00000103222 E012 166.5685119 0.0005187872 1.034623e-02 5.961682e-02 16 16044450 16044680 231 + 2.242 2.176 -0.220
ENSG00000103222 E013 146.1870951 0.0003017008 1.638735e-02 8.322715e-02 16 16045836 16046013 178 + 2.187 2.125 -0.209
ENSG00000103222 E014 143.1381306 0.0002918193 6.634993e-03 4.288064e-02 16 16048142 16048303 162 + 2.183 2.110 -0.244
ENSG00000103222 E015 126.5448339 0.0003467664 2.136818e-04 2.826836e-03 16 16052724 16052816 93 + 2.151 2.041 -0.369
ENSG00000103222 E016 173.2132669 0.0003428551 1.333520e-01 3.370275e-01 16 16056092 16056295 204 + 2.239 2.207 -0.109
ENSG00000103222 E017 0.9458845 0.0172671820 9.580219e-01   16 16056296 16057159 864 + 0.274 0.289 0.107
ENSG00000103222 E018 0.4820342 0.0213303316 2.318996e-02   16 16057431 16057571 141 + 0.365 0.000 -14.293
ENSG00000103222 E019 132.8357916 0.0017653289 5.950391e-02 2.016882e-01 16 16068156 16068302 147 + 2.144 2.086 -0.194
ENSG00000103222 E020 126.0355688 0.0011536624 1.189019e-01 3.140643e-01 16 16071642 16071729 88 + 2.109 2.063 -0.152
ENSG00000103222 E021 0.5365243 0.0222877200 1.000000e+00   16 16076174 16076325 152 + 0.158 0.169 0.113
ENSG00000103222 E022 119.1416113 0.0018660476 6.119249e-01 7.781436e-01 16 16076326 16076401 76 + 2.063 2.054 -0.030
ENSG00000103222 E023 133.1426449 0.0014583578 3.740500e-01 6.074140e-01 16 16079352 16079478 127 + 2.078 2.122 0.147
ENSG00000103222 E024 118.7295333 0.0021059759 5.730216e-01 7.523290e-01 16 16083366 16083542 177 + 2.037 2.070 0.112
ENSG00000103222 E025 141.3951099 0.0045338671 3.858444e-01 6.171555e-01 16 16086824 16086991 168 + 2.101 2.151 0.167
ENSG00000103222 E026 161.2372708 0.0002986855 3.749705e-02 1.483002e-01 16 16090405 16090588 184 + 2.223 2.173 -0.167
ENSG00000103222 E027 0.0000000       16 16097992 16098281 290 +      
ENSG00000103222 E028 0.7282998 0.7151200108 7.030331e-01   16 16098873 16098902 30 + 0.275 0.179 -0.789
ENSG00000103222 E029 131.2935425 0.0007418443 7.763898e-02 2.400919e-01 16 16102627 16102717 91 + 2.134 2.086 -0.162
ENSG00000103222 E030 12.0098239 0.0038518047 1.821964e-01 4.068708e-01 16 16105400 16105460 61 + 1.165 1.040 -0.448
ENSG00000103222 E031 10.7589765 0.0031119445 3.331425e-01 5.717662e-01 16 16106526 16106737 212 + 1.109 1.020 -0.325
ENSG00000103222 E032 159.7850278 0.0002723853 1.495801e-01 3.616475e-01 16 16106738 16106873 136 + 2.205 2.173 -0.106
ENSG00000103222 E033 213.4916199 0.0002321637 1.033539e-01 2.878441e-01 16 16111375 16111582 208 + 2.331 2.301 -0.103
ENSG00000103222 E034 249.0947278 0.0002001847 5.342860e-02 1.877191e-01 16 16114766 16115076 311 + 2.339 2.396 0.189
ENSG00000103222 E035 0.0000000       16 16120577 16120692 116 +      
ENSG00000103222 E036 196.8017462 0.0003133062 1.258680e-02 6.878608e-02 16 16121975 16122174 200 + 2.222 2.301 0.263
ENSG00000103222 E037 137.0494962 0.0060977678 7.916822e-02 2.431730e-01 16 16124789 16124915 127 + 2.054 2.147 0.313
ENSG00000103222 E038 140.4195361 0.0014721219 4.154374e-02 1.587588e-01 16 16125810 16125911 102 + 2.070 2.153 0.279
ENSG00000103222 E039 167.4025633 0.0003046338 1.632651e-03 1.454831e-02 16 16131789 16131935 147 + 2.133 2.237 0.348
ENSG00000103222 E040 205.9560483 0.0004009785 1.070267e-01 2.940178e-01 16 16134350 16134508 159 + 2.256 2.310 0.180
ENSG00000103222 E041 220.7986246 0.0002433074 8.222545e-01 9.092698e-01 16 16136478 16136644 167 + 2.315 2.331 0.054
ENSG00000103222 E042 208.1601680 0.0002317919 7.585032e-01 8.716669e-01 16 16138364 16138558 195 + 2.286 2.305 0.061
ENSG00000103222 E043 1050.9167396 0.0011956059 6.173944e-08 2.408633e-06 16 16141173 16143257 2085 + 2.928 3.033 0.349