ENSG00000103091

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262144 ENSG00000103091 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR59 protein_coding protein_coding 33.75716 38.37881 32.66847 1.035043 0.9941996 -0.2323454 4.835910 5.948377 3.865883 0.1780946 0.2329585 -0.62039447 0.14146250 0.1554667 0.11813333 -0.03733333 0.388887269 0.001931848 FALSE  
ENST00000536050 ENSG00000103091 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR59 protein_coding protein_coding 33.75716 38.37881 32.66847 1.035043 0.9941996 -0.2323454 2.028269 1.523420 3.009119 0.1593278 0.1534544 0.97737434 0.06137083 0.0397000 0.09220000 0.05250000 0.001931848 0.001931848 FALSE  
ENST00000569549 ENSG00000103091 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR59 protein_coding retained_intron 33.75716 38.37881 32.66847 1.035043 0.9941996 -0.2323454 2.408231 2.122541 2.978387 0.2720717 0.7835110 0.48679314 0.07221250 0.0550000 0.09006667 0.03506667 0.657192790 0.001931848 FALSE  
ENST00000570070 ENSG00000103091 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR59 protein_coding retained_intron 33.75716 38.37881 32.66847 1.035043 0.9941996 -0.2323454 3.975259 4.154632 4.125631 1.1008584 0.2920148 -0.01008173 0.11777917 0.1073000 0.12640000 0.01910000 0.860833005 0.001931848 FALSE  
MSTRG.13035.1 ENSG00000103091 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR59 protein_coding   33.75716 38.37881 32.66847 1.035043 0.9941996 -0.2323454 8.472724 10.102325 9.092878 1.3470586 0.5843503 -0.15172007 0.25288750 0.2622667 0.27833333 0.01606667 0.947834779 0.001931848 FALSE  
MSTRG.13035.3 ENSG00000103091 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR59 protein_coding   33.75716 38.37881 32.66847 1.035043 0.9941996 -0.2323454 6.484612 10.010933 3.221186 0.7613614 1.6454795 -1.63288113 0.18863333 0.2621667 0.10160000 -0.16056667 0.720651028 0.001931848 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000103091 E001 0.0000000       16 74844980 74845015 36 -      
ENSG00000103091 E002 326.8014436 0.0018880527 9.194417e-02 2.673029e-01 16 74871362 74874078 2717 - 2.467 2.519 0.173
ENSG00000103091 E003 227.6705440 0.0010314980 1.783977e-06 4.713134e-05 16 74874079 74874259 181 - 2.249 2.390 0.472
ENSG00000103091 E004 231.5638748 0.0007164544 1.138025e-03 1.095283e-02 16 74874260 74874394 135 - 2.290 2.381 0.304
ENSG00000103091 E005 133.1103959 0.0018569795 1.169664e-03 1.119706e-02 16 74874395 74874425 31 - 2.025 2.152 0.426
ENSG00000103091 E006 125.4174756 0.0018554622 1.121857e-03 1.083346e-02 16 74874426 74874444 19 - 1.995 2.125 0.437
ENSG00000103091 E007 255.2684529 0.0005334965 1.110810e-03 1.075185e-02 16 74885653 74885795 143 - 2.334 2.419 0.283
ENSG00000103091 E008 1.6969095 0.0121518555 8.555811e-01 9.279718e-01 16 74885796 74886235 440 - 0.427 0.397 -0.165
ENSG00000103091 E009 241.6725904 0.0011027246 3.420485e-02 1.394094e-01 16 74886270 74886396 127 - 2.324 2.387 0.212
ENSG00000103091 E010 0.9357337 0.0201008796 2.211236e-02   16 74886397 74886469 73 - 0.491 0.096 -3.077
ENSG00000103091 E011 186.3303941 0.0009588993 1.830343e-01 4.078677e-01 16 74887683 74887755 73 - 2.225 2.269 0.147
ENSG00000103091 E012 139.1437033 0.0003971055 3.847056e-01 6.162568e-01 16 74888169 74888210 42 - 2.111 2.141 0.101
ENSG00000103091 E013 119.4475565 0.0003556418 5.929908e-01 7.656318e-01 16 74888211 74888243 33 - 2.051 2.071 0.069
ENSG00000103091 E014 139.9152254 0.0004312609 1.057356e-01 2.918988e-01 16 74888244 74888319 76 - 2.095 2.149 0.181
ENSG00000103091 E015 1.8011607 0.4662426962 7.009753e-01 8.362317e-01 16 74889660 74889702 43 - 0.355 0.459 0.573
ENSG00000103091 E016 78.7277939 0.0024746113 2.946609e-02 1.257716e-01 16 74889703 74889722 20 - 1.813 1.919 0.359
ENSG00000103091 E017 145.0183716 0.0003797470 5.352204e-04 5.995168e-03 16 74889723 74889815 93 - 2.070 2.183 0.377
ENSG00000103091 E018 162.8516681 0.0031877753 8.338097e-02 2.515501e-01 16 74892484 74892565 82 - 2.148 2.220 0.238
ENSG00000103091 E019 118.3815446 0.0004239011 8.841286e-01 9.434502e-01 16 74893679 74893706 28 - 2.060 2.057 -0.010
ENSG00000103091 E020 182.2652214 0.0003634378 2.434581e-01 4.804796e-01 16 74893707 74893812 106 - 2.223 2.258 0.117
ENSG00000103091 E021 0.5115862 0.0212330043 9.056114e-01   16 74893813 74893940 128 - 0.152 0.175 0.246
ENSG00000103091 E022 0.7567544 0.0921050913 4.509883e-01   16 74899698 74899754 57 - 0.152 0.297 1.231
ENSG00000103091 E023 197.6137178 0.0033407359 8.975106e-01 9.505714e-01 16 74903947 74904100 154 - 2.276 2.286 0.031
ENSG00000103091 E024 2.4807134 0.0105270887 9.734910e-01 9.886652e-01 16 74904101 74904346 246 - 0.546 0.542 -0.018
ENSG00000103091 E025 3.1744017 0.0239966017 3.976488e-01 6.265010e-01 16 74908733 74908907 175 - 0.679 0.543 -0.599
ENSG00000103091 E026 131.3825202 0.0024722150 6.593426e-01 8.095785e-01 16 74908908 74908977 70 - 2.090 2.111 0.072
ENSG00000103091 E027 105.3886381 0.0033490301 6.180448e-01 7.824645e-01 16 74909501 74909524 24 - 1.990 2.017 0.091
ENSG00000103091 E028 180.2208878 0.0007443448 2.783400e-01 5.184530e-01 16 74909525 74909657 133 - 2.216 2.251 0.119
ENSG00000103091 E029 27.3939875 0.0282095998 1.049365e-01 2.905458e-01 16 74909658 74909735 78 - 1.523 1.374 -0.514
ENSG00000103091 E030 21.4475281 0.0252587236 5.474356e-02 1.907606e-01 16 74909747 74909821 75 - 1.444 1.256 -0.652
ENSG00000103091 E031 128.2545720 0.0003726530 3.388042e-03 2.568949e-02 16 74909822 74909917 96 - 2.026 2.127 0.338
ENSG00000103091 E032 24.0653235 0.0024659598 3.829636e-05 6.641074e-04 16 74912005 74912117 113 - 1.543 1.247 -1.026
ENSG00000103091 E033 30.0088324 0.0012544225 5.702959e-05 9.333979e-04 16 74912118 74912197 80 - 1.619 1.364 -0.877
ENSG00000103091 E034 211.9064872 0.0004422900 4.930868e-01 6.960374e-01 16 74912198 74912362 165 - 2.295 2.316 0.069
ENSG00000103091 E035 1.5469005 0.0142322837 7.894905e-02 2.427244e-01 16 74915460 74915679 220 - 0.546 0.242 -1.752
ENSG00000103091 E036 0.4986023 0.0276698147 3.016978e-02   16 74915680 74915717 38 - 0.354 0.000 -12.711
ENSG00000103091 E037 0.0000000       16 74915718 74915869 152 -      
ENSG00000103091 E038 218.6119472 0.0003383940 1.314244e-01 3.340349e-01 16 74915870 74915994 125 - 2.344 2.308 -0.121
ENSG00000103091 E039 7.9626568 0.0039254492 1.000991e-01 2.819935e-01 16 74915995 74916126 132 - 1.044 0.858 -0.694
ENSG00000103091 E040 238.6243816 0.0003267956 4.086763e-05 7.010367e-04 16 74916127 74916259 133 - 2.420 2.323 -0.323
ENSG00000103091 E041 205.0932307 0.0005313686 2.717456e-05 4.951040e-04 16 74917929 74918008 80 - 2.364 2.255 -0.366
ENSG00000103091 E042 259.0376194 0.0002665771 1.365114e-05 2.745148e-04 16 74921947 74922103 157 - 2.457 2.359 -0.325
ENSG00000103091 E043 119.6550549 0.0007130910 4.194659e-02 1.598101e-01 16 74923926 74923949 24 - 2.102 2.034 -0.230
ENSG00000103091 E044 148.5744842 0.0007872815 9.289889e-03 5.504664e-02 16 74923950 74924003 54 - 2.206 2.125 -0.270
ENSG00000103091 E045 0.8817055 0.2022494271 4.707846e-01   16 74930768 74930792 25 - 0.151 0.305 1.294
ENSG00000103091 E046 186.1581565 0.0004925055 3.431026e-03 2.594012e-02 16 74938150 74938250 101 - 2.305 2.226 -0.263
ENSG00000103091 E047 99.1250444 0.0004738538 2.015740e-01 4.316107e-01 16 74938251 74938266 16 - 2.012 1.967 -0.150
ENSG00000103091 E048 82.5819999 0.0006350826 1.938931e-01 4.220122e-01 16 74942738 74942739 2 - 1.935 1.884 -0.170
ENSG00000103091 E049 176.5668352 0.0002754825 5.199342e-02 1.843857e-01 16 74942740 74942826 87 - 2.261 2.209 -0.173
ENSG00000103091 E050 142.5545904 0.0005990599 2.634642e-02 1.163316e-01 16 74948519 74948556 38 - 2.180 2.112 -0.227
ENSG00000103091 E051 186.7175300 0.0002614238 3.185704e-01 5.584256e-01 16 74949718 74949798 81 - 2.270 2.245 -0.082
ENSG00000103091 E052 0.3503582 0.0283164718 7.002253e-01   16 74949852 74949947 96 - 0.152 0.096 -0.753
ENSG00000103091 E053 191.2773535 0.0005443519 3.135292e-01 5.537417e-01 16 74951458 74951543 86 - 2.279 2.253 -0.086
ENSG00000103091 E054 97.2879853 0.0022610468 5.073695e-02 1.814417e-01 16 74956475 74956483 9 - 2.020 1.939 -0.271
ENSG00000103091 E055 180.3107540 0.0005460292 3.314991e-02 1.364557e-01 16 74956484 74956610 127 - 2.273 2.214 -0.196
ENSG00000103091 E056 0.8571428 0.0168223647 3.082848e-01   16 74959350 74959592 243 - 0.353 0.175 -1.335
ENSG00000103091 E057 1.7135976 0.0122044364 1.798697e-01 4.038127e-01 16 74960620 74960783 164 - 0.264 0.509 1.413
ENSG00000103091 E058 2.1567821 0.1044139165 3.363438e-01 5.747778e-01 16 74962820 74963247 428 - 0.598 0.397 -0.987
ENSG00000103091 E059 98.0093554 0.0004463418 2.953518e-01 5.358236e-01 16 74965773 74965822 50 - 1.997 1.961 -0.124
ENSG00000103091 E060 0.4341107 0.0225899383 2.009102e-01   16 74979012 74979116 105 - 0.000 0.241 11.166
ENSG00000103091 E061 3.9045184 0.0064105457 4.328281e-03 3.098173e-02 16 74983716 74983808 93 - 0.886 0.476 -1.750
ENSG00000103091 E062 0.8807956 0.0172078663 5.271067e-01   16 74984603 74984963 361 - 0.353 0.242 -0.754
ENSG00000103091 E063 77.9261789 0.0010812199 1.542838e-01 3.683787e-01 16 74984964 74985123 160 - 1.911 1.851 -0.200
ENSG00000103091 E064 0.0000000       16 74996972 74997173 202 -      
ENSG00000103091 E065 0.0000000       16 75000023 75000173 151 -