ENSG00000103043

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261776 ENSG00000103043 HEK293_OSMI2_6hA HEK293_TMG_6hB VAC14 protein_coding protein_coding 42.48703 63.26808 24.12217 10.08289 0.8898439 -1.390748 26.538247 39.685271 15.518724 7.4404748 0.8876776 -1.354028 0.62353750 0.62023333 0.6453667 0.02513333 9.444616e-01 2.700239e-13 FALSE  
ENST00000566416 ENSG00000103043 HEK293_OSMI2_6hA HEK293_TMG_6hB VAC14 protein_coding protein_coding 42.48703 63.26808 24.12217 10.08289 0.8898439 -1.390748 1.793625 3.375692 0.000000 0.5184920 0.0000000 -8.403307 0.03286667 0.05466667 0.0000000 -0.05466667 3.297039e-13 2.700239e-13 FALSE  
ENST00000571759 ENSG00000103043 HEK293_OSMI2_6hA HEK293_TMG_6hB VAC14 protein_coding processed_transcript 42.48703 63.26808 24.12217 10.08289 0.8898439 -1.390748 6.078379 9.601252 3.109203 1.2728652 0.1508561 -1.623547 0.14054583 0.15433333 0.1288333 -0.02550000 7.118786e-01 2.700239e-13 FALSE  
MSTRG.12939.9 ENSG00000103043 HEK293_OSMI2_6hA HEK293_TMG_6hB VAC14 protein_coding   42.48703 63.26808 24.12217 10.08289 0.8898439 -1.390748 4.904281 8.025672 3.455098 0.7758341 0.6627820 -1.213523 0.13265417 0.12986667 0.1428667 0.01300000 9.682381e-01 2.700239e-13 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000103043 E001 0.2735028 0.0274424043 0.393593453   16 70687439 70687440 2 - 0.196 0.073 -1.640
ENSG00000103043 E002 0.5767453 0.0194486508 0.982906845   16 70687441 70687441 1 - 0.196 0.190 -0.056
ENSG00000103043 E003 555.7360517 0.0014346432 0.019811621 0.095250059 16 70687442 70688039 598 - 2.621 2.695 0.247
ENSG00000103043 E004 140.5692741 0.0003562844 0.275913985 0.515990053 16 70688040 70688042 3 - 2.045 2.099 0.181
ENSG00000103043 E005 210.6552141 0.0003390546 0.013020240 0.070535161 16 70688043 70688090 48 - 2.191 2.281 0.300
ENSG00000103043 E006 530.6980371 0.0097885816 0.225136279 0.459541244 16 70688091 70691049 2959 - 2.601 2.673 0.240
ENSG00000103043 E007 19.4377794 0.0018724874 0.596264160 0.767836224 16 70691786 70691787 2 - 1.271 1.237 -0.117
ENSG00000103043 E008 30.9486781 0.0144411188 0.931824657 0.968032609 16 70691788 70691861 74 - 1.424 1.448 0.083
ENSG00000103043 E009 44.7795998 0.0008676842 0.591413505 0.764666065 16 70691862 70692049 188 - 1.560 1.607 0.161
ENSG00000103043 E010 321.7141938 0.0016926896 0.517894305 0.713534262 16 70692821 70692971 151 - 2.415 2.450 0.118
ENSG00000103043 E011 297.2977441 0.0037798876 0.480580477 0.687491172 16 70695544 70695623 80 - 2.414 2.405 -0.031
ENSG00000103043 E012 0.8092192 0.0177272317 0.212481230   16 70695624 70695856 233 - 0.000 0.282 11.742
ENSG00000103043 E013 0.8985812 0.0172671820 0.152180819   16 70696890 70697138 249 - 0.000 0.321 12.001
ENSG00000103043 E014 267.8256049 0.0011981040 0.284718840 0.525254824 16 70697139 70697173 35 - 2.375 2.360 -0.049
ENSG00000103043 E015 302.2113021 0.0039761586 0.397685218 0.626523713 16 70697174 70697257 84 - 2.425 2.412 -0.042
ENSG00000103043 E016 395.7890947 0.0047299099 0.657126542 0.808081164 16 70698637 70698811 175 - 2.530 2.531 0.003
ENSG00000103043 E017 18.3393852 0.0248211664 0.013784328 0.073479059 16 70699259 70700245 987 - 0.951 1.274 1.164
ENSG00000103043 E018 0.4458772 0.0217681645 0.693024492   16 70731275 70731307 33 - 0.196 0.135 -0.639
ENSG00000103043 E019 0.6071052 0.0193874923 0.979257209   16 70731308 70731359 52 - 0.196 0.190 -0.055
ENSG00000103043 E020 2.3787771 0.0097071002 0.739658541 0.860190461 16 70731360 70731494 135 - 0.433 0.504 0.359
ENSG00000103043 E021 313.7328466 0.0049818893 0.259668379 0.498621582 16 70731495 70731627 133 - 2.452 2.422 -0.098
ENSG00000103043 E022 337.5813347 0.0002981196 0.912134687 0.958204661 16 70744423 70744579 157 - 2.455 2.466 0.036
ENSG00000103043 E023 0.3336024 0.0244411696 0.796657532   16 70744580 70744638 59 - 0.000 0.135 10.421
ENSG00000103043 E024 0.5177432 0.0252697503 0.698936754   16 70745026 70745082 57 - 0.196 0.136 -0.634
ENSG00000103043 E025 260.8307275 0.0716691583 0.414841811 0.639695640 16 70762540 70762605 66 - 2.296 2.365 0.229
ENSG00000103043 E026 236.2691865 0.4939488770 0.392170287 0.622141567 16 70762881 70762924 44 - 2.216 2.331 0.385
ENSG00000103043 E027 295.6991130 1.3037256528 0.551456685 0.737317255 16 70762925 70763025 101 - 2.323 2.426 0.344
ENSG00000103043 E028 183.2523029 1.1333979857 0.544633698 0.732364648 16 70772109 70772169 61 - 2.127 2.216 0.299
ENSG00000103043 E029 111.3227098 0.7128403243 0.496514635 0.698577102 16 70772170 70772172 3 - 1.924 1.999 0.252
ENSG00000103043 E030 119.5798825 0.2572678133 0.501043964 0.701520209 16 70780790 70780797 8 - 1.974 2.024 0.168
ENSG00000103043 E031 336.6400807 0.0094375587 0.567239686 0.748208479 16 70780798 70780939 142 - 2.436 2.468 0.107
ENSG00000103043 E032 283.2653199 0.0003552934 0.088481481 0.260966507 16 70781869 70782003 135 - 2.408 2.379 -0.096
ENSG00000103043 E033 254.7875504 0.0048796451 0.099075558 0.280137001 16 70783033 70783139 107 - 2.378 2.326 -0.175
ENSG00000103043 E034 246.9246410 0.0147067578 0.136933618 0.342844811 16 70783445 70783554 110 - 2.384 2.305 -0.263
ENSG00000103043 E035 254.6388972 0.0056651473 0.005909885 0.039301189 16 70784113 70784220 108 - 2.415 2.312 -0.345
ENSG00000103043 E036 0.1723744 0.0474794732 1.000000000   16 70784770 70784775 6 - 0.000 0.073 9.422
ENSG00000103043 E037 215.0718612 0.0003817931 0.000197741 0.002649596 16 70784776 70784838 63 - 2.335 2.245 -0.299
ENSG00000103043 E038 271.3201514 0.0002422511 0.027670334 0.120299324 16 70785702 70785869 168 - 2.401 2.361 -0.133
ENSG00000103043 E039 0.3032425 0.0274424043 0.795423537   16 70785870 70786214 345 - 0.000 0.135 10.419
ENSG00000103043 E040 235.4850292 0.0005942286 0.124499930 0.322926268 16 70786215 70786365 151 - 2.332 2.304 -0.096
ENSG00000103043 E041 0.0000000       16 70786366 70786427 62 -      
ENSG00000103043 E042 250.2549447 0.0106187115 0.927801381 0.965962541 16 70800797 70801161 365 - 2.325 2.334 0.031