ENSG00000102974

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264010 ENSG00000102974 HEK293_OSMI2_6hA HEK293_TMG_6hB CTCF protein_coding protein_coding 36.39473 34.56484 36.72266 10.45837 1.280428 0.0873407 17.139380 12.503640 11.207815 5.472621 3.690931 -0.1577098 0.4416708 0.3073667 0.3132000 0.005833333 1.000000e+00 8.970629e-14 FALSE TRUE
ENST00000642420 ENSG00000102974 HEK293_OSMI2_6hA HEK293_TMG_6hB CTCF protein_coding retained_intron 36.39473 34.56484 36.72266 10.45837 1.280428 0.0873407 5.419386 7.019577 0.000000 2.919394 0.000000 -9.4572940 0.1501125 0.1773000 0.0000000 -0.177300000 8.970629e-14 8.970629e-14 FALSE TRUE
ENST00000644753 ENSG00000102974 HEK293_OSMI2_6hA HEK293_TMG_6hB CTCF protein_coding protein_coding 36.39473 34.56484 36.72266 10.45837 1.280428 0.0873407 8.554307 10.312655 20.316501 1.002367 3.871240 0.9775479 0.2613750 0.3757333 0.5470333 0.171300000 7.068872e-01 8.970629e-14 FALSE TRUE
ENST00000646771 ENSG00000102974 HEK293_OSMI2_6hA HEK293_TMG_6hB CTCF protein_coding protein_coding 36.39473 34.56484 36.72266 10.45837 1.280428 0.0873407 3.436079 3.534018 4.142973 1.527561 1.087135 0.2287587 0.0944000 0.0956000 0.1109667 0.015366667 9.506576e-01 8.970629e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000102974 E001 1.3106546 0.0133818485 9.903287e-01   16 67562467 67562488 22 + 0.360 0.360 -0.002
ENSG00000102974 E002 2.2563515 0.0093811084 2.997128e-01 5.401305e-01 16 67562489 67562525 37 + 0.417 0.591 0.844
ENSG00000102974 E003 6.0482695 0.0091201247 2.993170e-01 5.397327e-01 16 67562526 67562572 47 + 0.767 0.908 0.547
ENSG00000102974 E004 6.7376519 0.1480270999 6.050857e-01 7.735855e-01 16 67562573 67562588 16 + 0.798 0.955 0.602
ENSG00000102974 E005 38.5422650 0.0515915388 6.041407e-01 7.729791e-01 16 67562589 67562724 136 + 1.540 1.643 0.352
ENSG00000102974 E006 0.8565226 0.7593079082 9.005084e-01   16 67567891 67568531 641 + 0.220 0.301 0.597
ENSG00000102974 E007 0.1723744 0.1606257940 4.713472e-01   16 67570741 67570772 32 + 0.000 0.122 11.118
ENSG00000102974 E008 0.1723744 0.1606257940 4.713472e-01   16 67570773 67570773 1 + 0.000 0.122 11.118
ENSG00000102974 E009 0.1723744 0.1606257940 4.713472e-01   16 67570774 67570777 4 + 0.000 0.122 11.118
ENSG00000102974 E010 0.5778428 0.1183986492 9.359456e-02   16 67570778 67570840 63 + 0.000 0.298 12.811
ENSG00000102974 E011 0.9172423 0.0442896826 6.560664e-01   16 67570841 67571147 307 + 0.217 0.296 0.592
ENSG00000102974 E012 98.4996716 0.0009013204 1.181003e-01 3.127421e-01 16 67571148 67571264 117 + 2.023 1.966 -0.189
ENSG00000102974 E013 0.0000000       16 67572483 67572599 117 +      
ENSG00000102974 E014 0.4349185 0.0217681645 5.776602e-01   16 67610590 67610823 234 + 0.216 0.121 -1.003
ENSG00000102974 E015 61.4021690 0.0006824088 2.012093e-02 9.629681e-02 16 67610824 67610826 3 + 1.842 1.737 -0.355
ENSG00000102974 E016 441.3312889 0.0003755828 2.992309e-06 7.417354e-05 16 67610827 67611321 495 + 2.687 2.602 -0.282
ENSG00000102974 E017 420.3289987 0.0001875499 9.986551e-06 2.094019e-04 16 67611322 67611613 292 + 2.661 2.585 -0.254
ENSG00000102974 E018 335.7573979 0.0004322119 2.220490e-04 2.915941e-03 16 67611951 67612121 171 + 2.565 2.487 -0.258
ENSG00000102974 E019 2.4055185 0.1676184822 9.782404e-01 9.908815e-01 16 67612122 67612465 344 + 0.553 0.514 -0.179
ENSG00000102974 E020 3.6830522 0.4810744506 4.784708e-01 6.860570e-01 16 67614328 67614962 635 + 0.791 0.512 -1.206
ENSG00000102974 E021 1.1142650 0.5420928220 5.367835e-01   16 67614963 67615308 346 + 0.413 0.220 -1.271
ENSG00000102974 E022 11.4603380 0.1759782481 7.744579e-01 8.813942e-01 16 67615309 67616744 1436 + 1.137 1.046 -0.331
ENSG00000102974 E023 332.5809578 0.0005527553 5.200301e-05 8.606674e-04 16 67616745 67616878 134 + 2.565 2.476 -0.294
ENSG00000102974 E024 298.0812410 0.0006624967 4.314947e-02 1.629372e-01 16 67620697 67620817 121 + 2.497 2.451 -0.155
ENSG00000102974 E025 0.9452873 0.0163578605 8.584352e-03   16 67620818 67620886 69 + 0.468 0.000 -15.310
ENSG00000102974 E026 1.6508054 0.4225263316 5.680676e-01 7.488410e-01 16 67620887 67621441 555 + 0.521 0.293 -1.268
ENSG00000102974 E027 274.7696865 0.0002168227 2.574239e-01 4.961638e-01 16 67621442 67621591 150 + 2.453 2.430 -0.077
ENSG00000102974 E028 0.3751086 0.0338157688 1.958121e-01   16 67623320 67623409 90 + 0.000 0.217 12.670
ENSG00000102974 E029 0.7735102 0.0188499424 6.626750e-01   16 67626509 67626554 46 + 0.216 0.293 0.579
ENSG00000102974 E030 309.6128154 0.0001793816 1.900798e-02 9.249790e-02 16 67626555 67626715 161 + 2.516 2.470 -0.154
ENSG00000102974 E031 2.2197849 0.0093016059 5.961571e-01 7.677889e-01 16 67626716 67627910 1195 + 0.554 0.467 -0.416
ENSG00000102974 E032 359.6865691 0.0003338463 2.356482e-01 4.715824e-01 16 67628370 67628552 183 + 2.544 2.569 0.081
ENSG00000102974 E033 293.0024940 0.0002092341 4.878855e-02 1.767707e-01 16 67629398 67629533 136 + 2.446 2.489 0.144
ENSG00000102974 E034 0.7260870 0.0604489611 1.000000e+00   16 67635515 67635632 118 + 0.216 0.218 0.011
ENSG00000102974 E035 286.3475678 0.0002085174 2.640478e-03 2.121665e-02 16 67636690 67636851 162 + 2.425 2.491 0.218
ENSG00000102974 E036 112.4666651 0.0003840259 2.307245e-02 1.061909e-01 16 67637688 67637693 6 + 2.016 2.094 0.262
ENSG00000102974 E037 1308.0832846 0.0001571818 9.938374e-23 3.934183e-20 16 67637694 67639177 1484 + 3.065 3.161 0.320