ENSG00000102921

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262384 ENSG00000102921 HEK293_OSMI2_6hA HEK293_TMG_6hB N4BP1 protein_coding protein_coding 10.70512 7.139344 15.51905 1.320978 1.102796 1.119087 4.833898 6.32318475 4.072492 1.17002649 0.1657296 -0.6334811 0.5657958 0.88720000 0.2642333 -0.6229667 5.811731e-18 5.811731e-18 FALSE TRUE
ENST00000564124 ENSG00000102921 HEK293_OSMI2_6hA HEK293_TMG_6hB N4BP1 protein_coding retained_intron 10.70512 7.139344 15.51905 1.320978 1.102796 1.119087 1.892104 0.01704045 4.613874 0.01704045 1.5823236 7.4178390 0.1260292 0.00380000 0.2857667 0.2819667 1.125206e-04 5.811731e-18 FALSE TRUE
ENST00000565423 ENSG00000102921 HEK293_OSMI2_6hA HEK293_TMG_6hB N4BP1 protein_coding processed_transcript 10.70512 7.139344 15.51905 1.320978 1.102796 1.119087 1.713600 0.25691135 3.169854 0.25691135 0.5502538 3.5745278 0.1244333 0.03076667 0.2018667 0.1711000 1.576319e-01 5.811731e-18 FALSE TRUE
MSTRG.12585.3 ENSG00000102921 HEK293_OSMI2_6hA HEK293_TMG_6hB N4BP1 protein_coding   10.70512 7.139344 15.51905 1.320978 1.102796 1.119087 1.432774 0.04457219 2.999811 0.04457219 1.1938936 5.7853634 0.0931875 0.00520000 0.2062333 0.2010333 1.171920e-02 5.811731e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000102921 E001 550.5933870 0.0021875948 2.902660e-50 9.939440e-47 16 48538726 48542879 4154 - 2.536 2.887 1.169
ENSG00000102921 E002 127.7017567 0.0008527557 9.895984e-01 9.965403e-01 16 48542880 48543163 284 - 2.086 2.145 0.199
ENSG00000102921 E003 65.6046292 0.0009082850 4.315270e-03 3.091869e-02 16 48543164 48543261 98 - 1.732 1.917 0.623
ENSG00000102921 E004 0.6536007 0.0889032092 3.590713e-01   16 48546097 48546146 50 - 0.118 0.301 1.679
ENSG00000102921 E005 35.6001318 0.0016142789 1.406677e-01 3.485614e-01 16 48546147 48546181 35 - 1.494 1.640 0.497
ENSG00000102921 E006 51.5903162 0.0008838813 4.325976e-01 6.531908e-01 16 48546182 48546254 73 - 1.676 1.773 0.329
ENSG00000102921 E007 3.7385384 0.0072417092 2.439796e-01 4.809984e-01 16 48546255 48546584 330 - 0.729 0.603 -0.537
ENSG00000102921 E008 74.0299541 0.0036764781 7.352804e-03 4.633131e-02 16 48548007 48548114 108 - 1.908 1.835 -0.247
ENSG00000102921 E009 70.7719529 0.0007079110 1.357526e-07 4.894674e-06 16 48551386 48551482 97 - 1.930 1.766 -0.552
ENSG00000102921 E010 78.4573352 0.0005232488 1.060559e-06 2.991816e-05 16 48553539 48553669 131 - 1.962 1.827 -0.456
ENSG00000102921 E011 367.4529144 0.0002958212 5.066635e-44 1.147241e-40 16 48560754 48561957 1204 - 2.650 2.467 -0.609
ENSG00000102921 E012 131.5914540 0.0003861958 1.478492e-20 4.684363e-18 16 48561958 48562444 487 - 2.224 1.997 -0.758
ENSG00000102921 E013 0.0000000       16 48603660 48603712 53 -      
ENSG00000102921 E014 0.2922838 0.0255553787 9.729858e-01   16 48609420 48609774 355 - 0.118 0.125 0.097
ENSG00000102921 E015 20.6706903 0.0021004035 3.725441e-01 6.060893e-01 16 48609775 48610180 406 - 1.346 1.336 -0.037
ENSG00000102921 E016 0.1426347 0.0325233839 4.710677e-01   16 48619849 48620148 300 - 0.118 0.001 -8.064