ENSG00000102893

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000299167 ENSG00000102893 HEK293_OSMI2_6hA HEK293_TMG_6hB PHKB protein_coding protein_coding 10.52406 4.025628 15.98142 0.4975498 0.3877204 1.986433 2.7371319 0.8036754 4.6115827 0.4308116 0.3099347 2.505862 0.2709500 0.17713333 0.2887000 0.111566667 7.904102e-01 1.206208e-10 FALSE TRUE
ENST00000566037 ENSG00000102893 HEK293_OSMI2_6hA HEK293_TMG_6hB PHKB protein_coding protein_coding 10.52406 4.025628 15.98142 0.4975498 0.3877204 1.986433 1.8165820 0.0000000 3.5654065 0.0000000 0.5567745 8.481963 0.1049958 0.00000000 0.2226000 0.222600000 1.206208e-10 1.206208e-10 FALSE FALSE
ENST00000566044 ENSG00000102893 HEK293_OSMI2_6hA HEK293_TMG_6hB PHKB protein_coding protein_coding 10.52406 4.025628 15.98142 0.4975498 0.3877204 1.986433 2.5118675 0.6854193 3.5699575 0.1732269 0.1933881 2.363988 0.2300458 0.18503333 0.2241667 0.039133333 8.593818e-01 1.206208e-10 FALSE TRUE
MSTRG.12579.1 ENSG00000102893 HEK293_OSMI2_6hA HEK293_TMG_6hB PHKB protein_coding   10.52406 4.025628 15.98142 0.4975498 0.3877204 1.986433 0.9075563 1.2593664 0.5973079 0.3024769 0.5973079 -1.063609 0.1110250 0.30733333 0.0368000 -0.270533333 1.112301e-01 1.206208e-10 FALSE TRUE
MSTRG.12579.4 ENSG00000102893 HEK293_OSMI2_6hA HEK293_TMG_6hB PHKB protein_coding   10.52406 4.025628 15.98142 0.4975498 0.3877204 1.986433 0.5762689 0.2077555 0.6769174 0.1587109 0.2860654 1.657428 0.0744875 0.04543333 0.0415000 -0.003933333 9.576839e-01 1.206208e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000102893 E001 0.4873834 0.4621563406 2.425065e-01   16 47461123 47461294 172 + 0.076 0.321 2.520
ENSG00000102893 E002 1.3441662 0.1089828374 9.491484e-01   16 47461295 47461325 31 + 0.337 0.318 -0.116
ENSG00000102893 E003 1.3026600 0.0142670205 9.209299e-01   16 47461326 47461328 3 + 0.335 0.317 -0.116
ENSG00000102893 E004 1.3026600 0.0142670205 9.209299e-01   16 47461329 47461330 2 + 0.335 0.317 -0.116
ENSG00000102893 E005 1.4452947 0.0127034943 7.680477e-01 8.774270e-01 16 47461331 47461335 5 + 0.372 0.317 -0.337
ENSG00000102893 E006 9.5804616 0.0036034188 3.554916e-01 5.921536e-01 16 47461336 47461349 14 + 1.013 0.902 -0.414
ENSG00000102893 E007 26.1521748 0.0420602626 9.877767e-01 9.957274e-01 16 47461350 47461426 77 + 1.391 1.385 -0.022
ENSG00000102893 E008 1.5832999 0.1567339366 3.594884e-01 5.954303e-01 16 47461427 47461504 78 + 0.330 0.503 0.938
ENSG00000102893 E009 4.6689186 0.0886035066 5.561282e-01 7.405754e-01 16 47462112 47462340 229 + 0.672 0.774 0.418
ENSG00000102893 E010 2.6832257 0.0086298524 7.888290e-01 8.897998e-01 16 47462341 47462452 112 + 0.521 0.567 0.210
ENSG00000102893 E011 3.9506540 0.0304069759 8.997603e-01 9.517699e-01 16 47462667 47463097 431 + 0.653 0.627 -0.113
ENSG00000102893 E012 9.2179180 0.0554953733 8.159193e-02 2.480387e-01 16 47463098 47463713 616 + 1.025 0.723 -1.161
ENSG00000102893 E013 4.0693797 0.1310439915 8.008132e-01 8.967513e-01 16 47463714 47463881 168 + 0.655 0.679 0.104
ENSG00000102893 E014 5.9759571 0.0053921855 4.915263e-01 6.950100e-01 16 47463882 47463898 17 + 0.780 0.872 0.358
ENSG00000102893 E015 32.2532943 0.2311591473 5.745551e-01 7.533797e-01 16 47463899 47463993 95 + 1.462 1.505 0.147
ENSG00000102893 E016 44.3465948 0.0631200095 5.490482e-01 7.356374e-01 16 47497399 47497488 90 + 1.590 1.655 0.222
ENSG00000102893 E017 54.2491132 0.0025164810 3.042413e-01 5.448054e-01 16 47499756 47499894 139 + 1.710 1.653 -0.194
ENSG00000102893 E018 48.7682852 0.0018087165 1.079748e-01 2.956787e-01 16 47502991 47503090 100 + 1.675 1.580 -0.322
ENSG00000102893 E019 49.0049780 0.0167383556 3.462814e-01 5.838385e-01 16 47511665 47511772 108 + 1.672 1.590 -0.279
ENSG00000102893 E020 45.1512416 0.0016410172 5.272490e-02 1.860539e-01 16 47515521 47515601 81 + 1.649 1.528 -0.411
ENSG00000102893 E021 49.6236557 0.0009615427 6.124568e-03 4.033399e-02 16 47547433 47547548 116 + 1.692 1.529 -0.557
ENSG00000102893 E022 0.5117739 0.0232441305 7.830599e-01   16 47547549 47548164 616 + 0.142 0.187 0.472
ENSG00000102893 E023 0.1614157 0.0334614778 1.000000e+00   16 47562398 47562495 98 + 0.077 0.000 -8.185
ENSG00000102893 E024 33.3983682 0.0011732734 1.779921e-02 8.835765e-02 16 47580295 47580358 64 + 1.523 1.352 -0.590
ENSG00000102893 E025 41.6490137 0.0018087126 8.960513e-03 5.363769e-02 16 47587668 47587763 96 + 1.618 1.445 -0.593
ENSG00000102893 E026 76.2380361 0.0006327966 7.073331e-04 7.505712e-03 16 47588905 47589102 198 + 1.875 1.712 -0.551
ENSG00000102893 E027 0.5283420 0.4288334178 7.489991e-01   16 47590305 47590838 534 + 0.145 0.188 0.450
ENSG00000102893 E028 53.0584897 0.0007992799 1.587247e-03 1.423184e-02 16 47593500 47593557 58 + 1.725 1.542 -0.622
ENSG00000102893 E029 43.8895824 0.0009546606 1.984484e-02 9.534361e-02 16 47594137 47594149 13 + 1.638 1.492 -0.496
ENSG00000102893 E030 60.6901937 0.0006142674 6.589049e-02 2.159427e-01 16 47594150 47594214 65 + 1.764 1.669 -0.324
ENSG00000102893 E031 46.1564540 0.0007971065 3.432430e-01 5.809189e-01 16 47596373 47596427 55 + 1.641 1.586 -0.187
ENSG00000102893 E032 60.6842948 0.0029776173 3.065174e-02 1.293035e-01 16 47596428 47596531 104 + 1.774 1.648 -0.425
ENSG00000102893 E033 0.0000000       16 47597804 47598036 233 +      
ENSG00000102893 E034 57.0805983 0.0007903192 9.924342e-01 9.979069e-01 16 47610826 47610920 95 + 1.717 1.716 -0.002
ENSG00000102893 E035 0.1426347 0.0323687500 1.000000e+00   16 47619130 47619429 300 + 0.077 0.000 -8.194
ENSG00000102893 E036 1.5940864 0.0173091707 6.469309e-01 8.014377e-01 16 47633899 47633981 83 + 0.406 0.317 -0.525
ENSG00000102893 E037 49.2343226 0.0176671231 6.530407e-01 8.054187e-01 16 47641035 47641090 56 + 1.666 1.619 -0.160
ENSG00000102893 E038 54.8799703 0.0007815278 8.670414e-01 9.343578e-01 16 47641599 47641692 94 + 1.702 1.693 -0.030
ENSG00000102893 E039 52.0871107 0.0007279929 9.525763e-01 9.782932e-01 16 47648533 47648616 84 + 1.675 1.679 0.014
ENSG00000102893 E040 49.8729877 0.0007890360 7.522076e-01 8.680638e-01 16 47649100 47649204 105 + 1.660 1.643 -0.058
ENSG00000102893 E041 53.1089526 0.0007825795 9.294835e-01 9.667537e-01 16 47650544 47650626 83 + 1.687 1.683 -0.012
ENSG00000102893 E042 0.0000000       16 47650830 47650830 1 +      
ENSG00000102893 E043 53.9728496 0.0006921478 6.301557e-01 7.904874e-01 16 47650831 47650921 91 + 1.685 1.712 0.089
ENSG00000102893 E044 34.9987975 0.0009589105 6.632066e-01 8.118874e-01 16 47660506 47660567 62 + 1.500 1.529 0.099
ENSG00000102893 E045 32.3748275 0.0011272789 6.212288e-01 7.846937e-01 16 47660657 47660702 46 + 1.466 1.500 0.115
ENSG00000102893 E046 57.7657745 0.0008238974 9.225540e-01 9.635829e-01 16 47660703 47660819 117 + 1.717 1.712 -0.017
ENSG00000102893 E047 54.0187609 0.0025899999 1.452598e-01 3.552945e-01 16 47661719 47661800 82 + 1.708 1.622 -0.293
ENSG00000102893 E048 47.8783172 0.0051172523 6.731316e-01 8.183175e-01 16 47663677 47663734 58 + 1.643 1.616 -0.091
ENSG00000102893 E049 7.7626672 0.1512880070 6.392394e-01 7.963824e-01 16 47663735 47664390 656 + 0.865 0.960 0.360
ENSG00000102893 E050 2.1912283 0.0095236918 6.799265e-02 2.205676e-01 16 47664790 47664884 95 + 0.546 0.187 -2.226
ENSG00000102893 E051 3.5326181 0.0191205524 1.710488e-01 3.919213e-01 16 47664885 47664975 91 + 0.670 0.418 -1.185
ENSG00000102893 E052 9.8701818 0.0649259046 4.951339e-01 6.975760e-01 16 47664976 47665941 966 + 0.958 1.056 0.361
ENSG00000102893 E053 49.0711063 0.0074952109 6.593439e-01 8.095785e-01 16 47665942 47666032 91 + 1.652 1.623 -0.099
ENSG00000102893 E054 70.0764585 0.0006161014 2.740562e-01 5.140181e-01 16 47669215 47669417 203 + 1.786 1.837 0.173
ENSG00000102893 E055 0.9116329 0.1574302066 2.271140e-02   16 47675586 47676409 824 + 0.077 0.506 3.510
ENSG00000102893 E056 71.5348641 0.0007798501 6.037717e-01 7.726427e-01 16 47689041 47689175 135 + 1.804 1.830 0.086
ENSG00000102893 E057 91.0083499 0.0005126550 6.464164e-01 8.011217e-01 16 47693378 47693507 130 + 1.909 1.928 0.066
ENSG00000102893 E058 70.2788726 0.0006165375 2.275055e-03 1.889367e-02 16 47696381 47696471 91 + 1.762 1.900 0.466
ENSG00000102893 E059 42.5920780 0.0009796496 3.718236e-03 2.757147e-02 16 47696472 47696488 17 + 1.536 1.703 0.569
ENSG00000102893 E060 89.7612375 0.0005392608 1.101173e-03 1.067721e-02 16 47698448 47698588 141 + 1.866 1.997 0.441
ENSG00000102893 E061 0.9760568 0.0170266783 4.285450e-03   16 47699156 47699228 73 + 0.077 0.566 3.792
ENSG00000102893 E062 232.3309841 0.0002598426 1.429386e-12 1.427897e-10 16 47699229 47701523 2295 + 2.264 2.434 0.570