ENSG00000102804

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261489 ENSG00000102804 HEK293_OSMI2_6hA HEK293_TMG_6hB TSC22D1 protein_coding protein_coding 17.66854 13.141 23.65311 1.727066 0.7291987 0.8474671 10.4776650 6.096349 15.3904030 0.7155456 0.3548967 1.3345861 0.58112500 0.46580000 0.65100000 0.18520000 3.220972e-05 3.220972e-05 FALSE TRUE
ENST00000458659 ENSG00000102804 HEK293_OSMI2_6hA HEK293_TMG_6hB TSC22D1 protein_coding protein_coding 17.66854 13.141 23.65311 1.727066 0.7291987 0.8474671 0.9690727 1.438605 0.8048272 0.4854998 0.2325232 -0.8300980 0.05942917 0.10393333 0.03463333 -0.06930000 3.144967e-01 3.220972e-05 FALSE TRUE
ENST00000622051 ENSG00000102804 HEK293_OSMI2_6hA HEK293_TMG_6hB TSC22D1 protein_coding protein_coding 17.66854 13.141 23.65311 1.727066 0.7291987 0.8474671 1.3738079 1.193604 1.4096386 0.1614591 0.1358526 0.2381630 0.08234583 0.09086667 0.05946667 -0.03140000 3.299044e-01 3.220972e-05   FALSE
MSTRG.8681.9 ENSG00000102804 HEK293_OSMI2_6hA HEK293_TMG_6hB TSC22D1 protein_coding   17.66854 13.141 23.65311 1.727066 0.7291987 0.8474671 3.1089950 3.178877 3.8649922 0.2436423 0.2774987 0.2811447 0.17868333 0.24590000 0.16296667 -0.08293333 1.212484e-01 3.220972e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000102804 E001 318.4434963 0.0012138458 1.041959e-03 1.023120e-02 13 44432143 44434014 1872 - 2.531 2.456 -0.249
ENSG00000102804 E002 489.1190749 0.0003924785 5.431017e-07 1.666326e-05 13 44434015 44434566 552 - 2.720 2.643 -0.257
ENSG00000102804 E003 151.7878136 0.0004068564 2.943382e-01 5.349283e-01 13 44434567 44434708 142 - 2.167 2.202 0.115
ENSG00000102804 E004 56.6784791 0.0010111414 1.280046e-01 3.286435e-01 13 44434709 44434715 7 - 1.721 1.797 0.257
ENSG00000102804 E005 196.1876160 0.0003133356 2.856743e-01 5.262822e-01 13 44434716 44434883 168 - 2.301 2.278 -0.078
ENSG00000102804 E006 2.2867970 0.0189561296 4.523377e-01 6.674292e-01 13 44434994 44435284 291 - 0.578 0.456 -0.586
ENSG00000102804 E007 3.6758660 0.0078860198 1.008504e-01 2.833157e-01 13 44435793 44436043 251 - 0.759 0.510 -1.084
ENSG00000102804 E008 143.3407909 0.0003088970 2.574528e-03 2.081356e-02 13 44436044 44436095 52 - 2.192 2.106 -0.288
ENSG00000102804 E009 2.0332093 0.0164661681 3.532663e-04 4.270858e-03 13 44436096 44436426 331 - 0.665 0.000 -13.826
ENSG00000102804 E010 134.4699434 0.0003368165 5.382929e-20 1.600955e-17 13 44436504 44436649 146 - 2.232 1.941 -0.975
ENSG00000102804 E011 109.2106463 0.0006039345 2.303499e-11 1.863683e-09 13 44436650 44436845 196 - 2.125 1.887 -0.798
ENSG00000102804 E012 13.9945732 0.4043152413 4.075104e-01 6.341022e-01 13 44437176 44437345 170 - 1.113 1.244 0.469
ENSG00000102804 E013 0.1614157 0.0338468940 6.379971e-01   13 44474218 44474301 84 - 0.107 0.000 -9.742
ENSG00000102804 E014 5.3067231 0.0160452741 7.382026e-03 4.646414e-02 13 44538326 44538721 396 - 0.608 0.980 1.484
ENSG00000102804 E015 3.4616868 0.0177791691 2.028066e-03 1.724648e-02 13 44538722 44538888 167 - 0.379 0.865 2.181
ENSG00000102804 E016 1.9760218 0.0099517722 6.289958e-01 7.898286e-01 13 44539767 44539923 157 - 0.427 0.511 0.422
ENSG00000102804 E017 1.0018026 0.0278547254 7.344506e-01   13 44539924 44539936 13 - 0.264 0.327 0.425
ENSG00000102804 E018 0.3393995 0.0274424043 2.925931e-01   13 44539937 44540033 97 - 0.193 0.000 -10.888
ENSG00000102804 E019 33.7230499 0.0011495871 2.018001e-06 5.263445e-05 13 44573163 44573206 44 - 1.383 1.675 1.001
ENSG00000102804 E020 204.4372807 0.0003034182 1.354163e-24 6.647573e-22 13 44573207 44574411 1205 - 2.180 2.435 0.852
ENSG00000102804 E021 123.6405509 0.0003857182 4.891544e-09 2.467171e-07 13 44574412 44575167 756 - 2.000 2.189 0.633
ENSG00000102804 E022 82.9343864 0.0004911671 1.540675e-04 2.147423e-03 13 44575168 44575647 480 - 1.853 2.003 0.503
ENSG00000102804 E023 55.2487951 0.0261789785 1.220457e-03 1.158620e-02 13 44575648 44576246 599 - 1.595 1.894 1.011
ENSG00000102804 E024 16.0520628 0.0196172257 2.332629e-04 3.037838e-03 13 44576247 44576434 188 - 1.018 1.413 1.402
ENSG00000102804 E025 9.3460308 0.0555893349 3.085464e-02 1.299085e-01 13 44576435 44576565 131 - 0.850 1.168 1.175
ENSG00000102804 E026 11.6856081 0.1763353650 1.122331e-02 6.328625e-02 13 44577057 44577147 91 - 0.821 1.313 1.797