ENSG00000102572

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376547 ENSG00000102572 HEK293_OSMI2_6hA HEK293_TMG_6hB STK24 protein_coding protein_coding 49.64021 60.13666 41.31923 11.72689 3.377993 -0.5413221 43.185376 55.1144665 32.748390 11.5364391 2.1696358 -0.7508283 0.85780417 0.909466667 0.79483333 -0.1146333 0.02601610 0.0260161 FALSE TRUE
ENST00000397517 ENSG00000102572 HEK293_OSMI2_6hA HEK293_TMG_6hB STK24 protein_coding protein_coding 49.64021 60.13666 41.31923 11.72689 3.377993 -0.5413221 3.324643 3.8037143 1.979131 0.4502996 0.2190616 -0.9390581 0.06885417 0.065833333 0.04783333 -0.0180000 0.54099949 0.0260161 FALSE TRUE
ENST00000491878 ENSG00000102572 HEK293_OSMI2_6hA HEK293_TMG_6hB STK24 protein_coding processed_transcript 49.64021 60.13666 41.31923 11.72689 3.377993 -0.5413221 2.165158 0.2502996 5.531011 0.2502996 1.1781938 4.4119044 0.05120833 0.006833333 0.13086667 0.1240333 0.04721092 0.0260161 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000102572 E001 7.5213344 0.3020747333 0.4968101092 0.698752151 13 98445185 98450198 5014 - 0.793 0.961 0.645
ENSG00000102572 E002 0.2735028 0.0274424043 0.5917497904   13 98450199 98450200 2 - 0.157 0.093 -0.881
ENSG00000102572 E003 69.6523572 0.4840709055 0.1506230259 0.363177729 13 98450201 98452158 1958 - 1.570 1.921 1.189
ENSG00000102572 E004 1213.0993136 1.8070978221 0.4752011135 0.683683928 13 98452159 98453209 1051 - 2.875 3.137 0.872
ENSG00000102572 E005 10.1980840 0.0593098110 0.0447086711 0.166879528 13 98455421 98455981 561 - 1.187 0.922 -0.969
ENSG00000102572 E006 11.1910370 0.0234497235 0.0005495791 0.006127712 13 98455982 98456560 579 - 1.268 0.899 -1.340
ENSG00000102572 E007 15.4418856 0.1631378476 0.0956645370 0.274190118 13 98456561 98457167 607 - 1.356 1.075 -0.995
ENSG00000102572 E008 336.6231693 0.0029229501 0.2101989780 0.442079842 13 98457168 98457304 137 - 2.446 2.541 0.317
ENSG00000102572 E009 282.6742446 0.0012770813 0.0497923880 0.179146474 13 98460372 98460440 69 - 2.431 2.434 0.011
ENSG00000102572 E010 491.2676594 0.0008476216 0.0025527412 0.020674051 13 98461774 98461897 124 - 2.677 2.670 -0.023
ENSG00000102572 E011 577.3706553 0.0027168988 0.4693498411 0.679594081 13 98463691 98463836 146 - 2.716 2.754 0.127
ENSG00000102572 E012 618.1026715 0.0098802038 0.5260628193 0.719280910 13 98466376 98466561 186 - 2.750 2.781 0.103
ENSG00000102572 E013 320.4506162 0.0098642555 0.2758849334 0.515970656 13 98474821 98474860 40 - 2.484 2.486 0.007
ENSG00000102572 E014 420.2245080 0.0090101921 0.1207812758 0.317091035 13 98474861 98474978 118 - 2.613 2.598 -0.049
ENSG00000102572 E015 392.6429671 0.0085005257 0.0413019207 0.158119346 13 98475250 98475358 109 - 2.597 2.561 -0.121
ENSG00000102572 E016 248.4682801 0.0017147236 0.0027079671 0.021613719 13 98482265 98482321 57 - 2.400 2.366 -0.115
ENSG00000102572 E017 0.6895701 0.2165234394 0.5017159136   13 98505028 98505053 26 - 0.276 0.169 -0.898
ENSG00000102572 E018 0.2027342 0.0354589138 1.0000000000   13 98508779 98508967 189 - 0.000 0.093 9.813
ENSG00000102572 E019 390.0034344 0.0057661985 0.0003291498 0.004028628 13 98519243 98519473 231 - 2.626 2.540 -0.284
ENSG00000102572 E020 0.0000000       13 98521775 98521998 224 -      
ENSG00000102572 E021 0.3336024 0.0244411696 0.4907776931   13 98575995 98576204 210 - 0.000 0.169 10.809
ENSG00000102572 E022 112.8881317 0.0062515576 0.4676577684 0.678467974 13 98576745 98577151 407 - 2.025 2.043 0.061
ENSG00000102572 E023 0.1614157 0.0329297531 0.2364924424   13 98577909 98577940 32 - 0.158 0.000 -11.603