ENSG00000102543

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000251108 ENSG00000102543 HEK293_OSMI2_6hA HEK293_TMG_6hB CDADC1 protein_coding protein_coding 8.236452 5.837353 12.01215 0.9929074 1.262162 1.039839 2.6665283 1.2059235 4.364545 0.31474517 0.18535401 1.8470804 0.3050917 0.19940000 0.3687000 0.1693000 0.04941605 0.04656222 FALSE TRUE
ENST00000466868 ENSG00000102543 HEK293_OSMI2_6hA HEK293_TMG_6hB CDADC1 protein_coding processed_transcript 8.236452 5.837353 12.01215 0.9929074 1.262162 1.039839 2.9554072 2.8355326 3.471358 0.70119054 0.76131598 0.2909516 0.3707542 0.47026667 0.2818333 -0.1884333 0.24025694 0.04656222 FALSE FALSE
ENST00000496061 ENSG00000102543 HEK293_OSMI2_6hA HEK293_TMG_6hB CDADC1 protein_coding nonsense_mediated_decay 8.236452 5.837353 12.01215 0.9929074 1.262162 1.039839 1.6336075 1.4631553 1.847644 0.05129364 0.21631410 0.3345643 0.2120750 0.27310000 0.1542333 -0.1188667 0.47033381 0.04656222 TRUE TRUE
MSTRG.8766.3 ENSG00000102543 HEK293_OSMI2_6hA HEK293_TMG_6hB CDADC1 protein_coding   8.236452 5.837353 12.01215 0.9929074 1.262162 1.039839 0.6945748 0.3146384 1.358779 0.09717853 0.09467778 2.0759839 0.0848875 0.05356667 0.1177667 0.0642000 0.32790331 0.04656222 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000102543 E001 2.7016469 0.0085336737 1.577943e-01 3.734215e-01 13 49247895 49247924 30 + 0.620 0.377 -1.197
ENSG00000102543 E002 6.1917633 0.0045469686 1.768758e-01 3.995688e-01 13 49247925 49247935 11 + 0.891 0.711 -0.710
ENSG00000102543 E003 11.8843750 0.0027892287 4.357916e-01 6.555803e-01 13 49247936 49247940 5 + 1.120 1.046 -0.269
ENSG00000102543 E004 12.9605304 0.0027793302 2.914114e-01 5.320185e-01 13 49247941 49247946 6 + 1.163 1.064 -0.357
ENSG00000102543 E005 28.5741396 0.0017635976 1.081962e-01 2.960288e-01 13 49247947 49247976 30 + 1.416 1.527 0.381
ENSG00000102543 E006 45.0194620 0.0010890005 9.924543e-03 5.782665e-02 13 49247977 49248047 71 + 1.595 1.735 0.475
ENSG00000102543 E007 55.6188354 0.0008187854 1.434339e-03 1.314466e-02 13 49248048 49248119 72 + 1.677 1.831 0.520
ENSG00000102543 E008 7.4432597 0.0198120391 2.789350e-02 1.209866e-01 13 49248120 49248469 350 + 0.984 0.670 -1.232
ENSG00000102543 E009 75.0914592 0.0046431389 4.504203e-04 5.226273e-03 13 49248871 49248965 95 + 1.793 1.966 0.583
ENSG00000102543 E010 80.8601272 0.0010600966 2.075263e-04 2.756569e-03 13 49255839 49255913 75 + 1.833 1.984 0.508
ENSG00000102543 E011 0.5767453 0.0217681645 9.208859e-02   13 49255914 49255915 2 + 0.088 0.376 2.610
ENSG00000102543 E012 78.5730207 0.0010673772 6.638136e-02 2.169222e-01 13 49259346 49259485 140 + 1.850 1.930 0.269
ENSG00000102543 E013 55.8034994 0.0009394079 8.232635e-02 2.493429e-01 13 49259486 49259523 38 + 1.699 1.787 0.298
ENSG00000102543 E014 8.2174170 0.0071909095 9.556104e-01 9.796842e-01 13 49265879 49266003 125 + 0.939 0.946 0.028
ENSG00000102543 E015 147.7012487 0.0003238248 9.758954e-01 9.897370e-01 13 49267490 49268059 570 + 2.150 2.153 0.011
ENSG00000102543 E016 20.1871015 0.0017934210 1.337813e-05 2.698235e-04 13 49274291 49274340 50 + 1.401 1.009 -1.391
ENSG00000102543 E017 30.7856538 0.0012734960 3.189618e-03 2.454774e-02 13 49278350 49278519 170 + 1.537 1.337 -0.690
ENSG00000102543 E018 34.4861049 0.0010700910 7.602155e-05 1.189004e-03 13 49280509 49280698 190 + 1.598 1.337 -0.898
ENSG00000102543 E019 19.8877142 0.0017216834 1.259865e-04 1.810868e-03 13 49286222 49286282 61 + 1.385 1.046 -1.200
ENSG00000102543 E020 65.3104787 0.0009698800 5.974034e-09 2.935142e-07 13 49291684 49292777 1094 + 1.874 1.588 -0.969
ENSG00000102543 E021 39.0522346 0.0010486930 1.000465e-02 5.818757e-02 13 49292778 49293485 708 + 1.629 1.477 -0.519