ENSG00000102384

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000403304 ENSG00000102384 HEK293_OSMI2_6hA HEK293_TMG_6hB CENPI protein_coding protein_coding 8.338193 4.2482 13.18537 0.2164492 0.1101797 1.631716 0.8838757 0.2002898 1.7969845 0.20028981 0.1213507 3.1031332 0.07508333 0.04283333 0.13616667 0.093333333 0.354301974 0.007684457   FALSE
ENST00000423383 ENSG00000102384 HEK293_OSMI2_6hA HEK293_TMG_6hB CENPI protein_coding protein_coding 8.338193 4.2482 13.18537 0.2164492 0.1101797 1.631716 1.0564694 0.4036022 1.7987721 0.03782735 0.4366820 2.1286948 0.12570833 0.09600000 0.13696667 0.040966667 0.807275495 0.007684457 FALSE TRUE
ENST00000682095 ENSG00000102384 HEK293_OSMI2_6hA HEK293_TMG_6hB CENPI protein_coding protein_coding 8.338193 4.2482 13.18537 0.2164492 0.1101797 1.631716 1.5637537 0.3254999 2.6496803 0.32549991 1.3307529 2.9868685 0.16783333 0.07936667 0.19950000 0.120133333 0.708726981 0.007684457 FALSE TRUE
ENST00000682304 ENSG00000102384 HEK293_OSMI2_6hA HEK293_TMG_6hB CENPI protein_coding protein_coding 8.338193 4.2482 13.18537 0.2164492 0.1101797 1.631716 0.8029376 0.4129394 1.3878064 0.02508983 0.1877763 1.7246416 0.08945000 0.09793333 0.10540000 0.007466667 0.979370619 0.007684457   FALSE
MSTRG.34594.1 ENSG00000102384 HEK293_OSMI2_6hA HEK293_TMG_6hB CENPI protein_coding   8.338193 4.2482 13.18537 0.2164492 0.1101797 1.631716 0.4631151 0.3040402 0.9198166 0.19352603 0.1759352 1.5659969 0.05566250 0.07593333 0.06956667 -0.006366667 0.938405164 0.007684457 FALSE TRUE
MSTRG.34594.4 ENSG00000102384 HEK293_OSMI2_6hA HEK293_TMG_6hB CENPI protein_coding   8.338193 4.2482 13.18537 0.2164492 0.1101797 1.631716 1.9637118 1.3742307 2.7537667 0.34229930 0.3755844 0.9975514 0.24344167 0.32530000 0.20903333 -0.116266667 0.700630578 0.007684457 FALSE TRUE
MSTRG.34594.5 ENSG00000102384 HEK293_OSMI2_6hA HEK293_TMG_6hB CENPI protein_coding   8.338193 4.2482 13.18537 0.2164492 0.1101797 1.631716 0.7292423 0.7243167 0.5663122 0.13052420 0.1270095 -0.3495518 0.12667500 0.16896667 0.04310000 -0.125866667 0.007684457 0.007684457 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000102384 E001 1.368439 0.0129117155 7.164385e-01   X 101098157 101098187 31 + 0.363 0.324 -0.237
ENSG00000102384 E002 1.368439 0.0129117155 7.164385e-01   X 101098188 101098188 1 + 0.363 0.324 -0.237
ENSG00000102384 E003 3.270830 0.0312336407 3.797003e-01 6.119438e-01 X 101098189 101098199 11 + 0.622 0.506 -0.530
ENSG00000102384 E004 9.919185 0.0336312868 9.551427e-01 9.794941e-01 X 101098200 101098203 4 + 0.975 1.036 0.225
ENSG00000102384 E005 17.711452 0.0023230767 3.052222e-01 5.458252e-01 X 101098204 101098217 14 + 1.233 1.189 -0.156
ENSG00000102384 E006 21.135192 0.0016871705 9.116366e-02 2.658074e-01 X 101098218 101098220 3 + 1.315 1.219 -0.336
ENSG00000102384 E007 24.126672 0.0015949113 2.920861e-02 1.250011e-01 X 101098221 101098234 14 + 1.377 1.247 -0.453
ENSG00000102384 E008 19.550116 0.0020135283 1.278225e-02 6.955432e-02 X 101098235 101098248 14 + 1.303 1.122 -0.641
ENSG00000102384 E009 6.862482 0.0057112801 8.461184e-01 9.227668e-01 X 101098249 101098443 195 + 0.833 0.852 0.076
ENSG00000102384 E010 45.887049 0.0008881336 3.958914e-02 1.537071e-01 X 101098444 101098539 96 + 1.634 1.563 -0.242
ENSG00000102384 E011 2.496369 0.1939055497 7.609677e-01 8.731588e-01 X 101098712 101098843 132 + 0.464 0.579 0.551
ENSG00000102384 E012 17.652652 0.0019937391 5.715595e-01 7.513750e-01 X 101099809 101099930 122 + 1.188 1.287 0.350
ENSG00000102384 E013 14.121318 0.0028511169 6.300148e-01 7.904264e-01 X 101099931 101100065 135 + 1.094 1.190 0.343
ENSG00000102384 E014 3.667885 0.1226453725 2.146414e-02 1.008530e-01 X 101100437 101100700 264 + 0.430 0.922 2.120
ENSG00000102384 E015 91.993919 0.0004580586 1.650601e-01 3.840336e-01 X 101101058 101101296 239 + 1.914 1.909 -0.016
ENSG00000102384 E016 51.517416 0.0007745056 1.737477e-01 3.955348e-01 X 101102274 101102411 138 + 1.671 1.647 -0.079
ENSG00000102384 E017 49.122935 0.0007945904 5.657082e-01 7.471662e-01 X 101109473 101109591 119 + 1.638 1.658 0.067
ENSG00000102384 E018 48.531887 0.0007519874 5.726075e-02 1.966072e-01 X 101109891 101109998 108 + 1.653 1.595 -0.196
ENSG00000102384 E019 41.084725 0.0031990195 1.348311e-01 3.394137e-01 X 101120402 101120450 49 + 1.577 1.529 -0.164
ENSG00000102384 E020 38.063384 0.0017524044 5.692257e-01 7.496805e-01 X 101120738 101120784 47 + 1.529 1.543 0.050
ENSG00000102384 E021 35.668007 0.0021336556 6.731714e-02 2.190628e-01 X 101126709 101126798 90 + 1.526 1.451 -0.258
ENSG00000102384 E022 47.864770 0.0007583347 1.166371e-03 1.117246e-02 X 101127138 101127266 129 + 1.665 1.522 -0.488
ENSG00000102384 E023 68.763944 0.0115560305 1.936885e-02 9.374280e-02 X 101127498 101127665 168 + 1.812 1.693 -0.404
ENSG00000102384 E024 61.715014 0.0013657931 5.009556e-03 3.467169e-02 X 101128716 101128836 121 + 1.763 1.664 -0.338
ENSG00000102384 E025 54.095978 0.0006428059 1.333644e-02 7.179696e-02 X 101129982 101130073 92 + 1.704 1.619 -0.288
ENSG00000102384 E026 61.014707 0.0007237475 9.558475e-02 2.740678e-01 X 101132190 101132307 118 + 1.742 1.708 -0.115
ENSG00000102384 E027 48.422129 0.0029534337 2.092911e-01 4.410224e-01 X 101132392 101132456 65 + 1.640 1.614 -0.090
ENSG00000102384 E028 50.935825 0.0149875107 6.876167e-01 8.275502e-01 X 101140666 101140760 95 + 1.650 1.667 0.059
ENSG00000102384 E029 1.368729 0.0136622244 1.849971e-01   X 101140761 101141293 533 + 0.243 0.509 1.574
ENSG00000102384 E030 49.450769 0.0086654831 6.420420e-01 7.981837e-01 X 101145064 101145199 136 + 1.642 1.665 0.079
ENSG00000102384 E031 45.716024 0.0033937169 2.063123e-01 4.373464e-01 X 101146153 101146277 125 + 1.623 1.594 -0.097
ENSG00000102384 E032 36.393926 0.0009849868 1.164177e-02 6.498930e-02 X 101147763 101147811 49 + 1.545 1.425 -0.412
ENSG00000102384 E033 71.533513 0.0033616165 2.479148e-01 4.857415e-01 X 101147943 101148161 219 + 1.805 1.794 -0.037
ENSG00000102384 E034 33.552602 0.0012409349 7.720678e-01 8.798278e-01 X 101161528 101161569 42 + 1.466 1.536 0.241
ENSG00000102384 E035 449.351319 0.0053237635 1.787781e-12 1.752924e-10 X 101162833 101166126 3294 + 2.513 2.771 0.860