ENSG00000102312

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355961 ENSG00000102312 HEK293_OSMI2_6hA HEK293_TMG_6hB PORCN protein_coding protein_coding 11.784 16.60311 7.916495 1.743692 0.5248112 -1.067567 1.42697443 1.3758581 0.89901044 0.2004983 0.29301053 -0.6084108 0.117741667 0.08586667 0.11036667 0.024500000 9.191903e-01 7.33004e-15 FALSE TRUE
ENST00000361988 ENSG00000102312 HEK293_OSMI2_6hA HEK293_TMG_6hB PORCN protein_coding protein_coding 11.784 16.60311 7.916495 1.743692 0.5248112 -1.067567 2.94920049 3.9190617 2.86038680 2.0253444 0.24890084 -0.4529397 0.251187500 0.21366667 0.36046667 0.146800000 8.269954e-01 7.33004e-15 FALSE TRUE
ENST00000470275 ENSG00000102312 HEK293_OSMI2_6hA HEK293_TMG_6hB PORCN protein_coding nonsense_mediated_decay 11.784 16.60311 7.916495 1.743692 0.5248112 -1.067567 0.08796073 0.0000000 0.47052682 0.0000000 0.47052682 5.5865450 0.009670833 0.00000000 0.05253333 0.052533333 7.818376e-01 7.33004e-15 FALSE FALSE
ENST00000472520 ENSG00000102312 HEK293_OSMI2_6hA HEK293_TMG_6hB PORCN protein_coding nonsense_mediated_decay 11.784 16.60311 7.916495 1.743692 0.5248112 -1.067567 0.45808017 1.0047383 0.05725821 0.2806999 0.05725821 -3.9152535 0.031950000 0.05916667 0.00760000 -0.051566667 1.424993e-01 7.33004e-15 FALSE TRUE
ENST00000485288 ENSG00000102312 HEK293_OSMI2_6hA HEK293_TMG_6hB PORCN protein_coding nonsense_mediated_decay 11.784 16.60311 7.916495 1.743692 0.5248112 -1.067567 0.62209012 0.6869082 0.28315196 0.2113271 0.21321972 -1.2493199 0.054233333 0.04043333 0.03660000 -0.003833333 8.638930e-01 7.33004e-15 FALSE TRUE
ENST00000486272 ENSG00000102312 HEK293_OSMI2_6hA HEK293_TMG_6hB PORCN protein_coding processed_transcript 11.784 16.60311 7.916495 1.743692 0.5248112 -1.067567 0.60435753 0.4592137 0.54042312 0.1337613 0.05831012 0.2302959 0.053645833 0.02650000 0.06820000 0.041700000 1.178621e-01 7.33004e-15 FALSE FALSE
ENST00000491243 ENSG00000102312 HEK293_OSMI2_6hA HEK293_TMG_6hB PORCN protein_coding retained_intron 11.784 16.60311 7.916495 1.743692 0.5248112 -1.067567 0.66915304 0.8182442 0.55345861 0.4517669 0.03419721 -0.5557466 0.065091667 0.05643333 0.07090000 0.014466667 7.820507e-01 7.33004e-15 FALSE TRUE
MSTRG.34201.9 ENSG00000102312 HEK293_OSMI2_6hA HEK293_TMG_6hB PORCN protein_coding   11.784 16.60311 7.916495 1.743692 0.5248112 -1.067567 1.92971768 3.4316438 0.00000000 0.1545253 0.00000000 -8.4269540 0.144533333 0.21206667 0.00000000 -0.212066667 7.330040e-15 7.33004e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000102312 E001 1.7555363 0.0114225455 0.559139228 0.74267491 X 48508439 48508639 201 + 0.324 0.429 0.601
ENSG00000102312 E002 2.0420230 0.0313953504 0.111252215 0.30105783 X 48508726 48508958 233 + 0.192 0.510 2.013
ENSG00000102312 E003 0.2027342 0.0385216691 1.000000000   X 48508959 48508961 3 + 0.000 0.075 9.370
ENSG00000102312 E004 0.2027342 0.0385216691 1.000000000   X 48508962 48508965 4 + 0.000 0.075 9.370
ENSG00000102312 E005 1.4477818 0.1476705163 0.085733557 0.25591074 X 48508966 48508981 16 + 0.000 0.405 11.887
ENSG00000102312 E006 2.4995965 0.0139117618 0.250060073 0.48799660 X 48508982 48508991 10 + 0.325 0.536 1.132
ENSG00000102312 E007 2.4995965 0.0139117618 0.250060073 0.48799660 X 48508992 48508993 2 + 0.325 0.536 1.132
ENSG00000102312 E008 3.9041544 0.0082989145 0.032814938 0.13554669 X 48508994 48509001 8 + 0.325 0.709 1.890
ENSG00000102312 E009 10.2892777 0.0033279785 0.525776089 0.71908466 X 48509002 48509010 9 + 0.943 1.008 0.239
ENSG00000102312 E010 14.1396772 0.0023961896 0.279593434 0.51971593 X 48509011 48509018 8 + 1.041 1.144 0.370
ENSG00000102312 E011 17.0506542 0.0020299023 0.190850241 0.41796606 X 48509019 48509029 11 + 1.103 1.219 0.415
ENSG00000102312 E012 17.0506542 0.0020299023 0.190850241 0.41796606 X 48509030 48509030 1 + 1.103 1.219 0.415
ENSG00000102312 E013 20.5199758 0.0017223597 0.187600091 0.41388453 X 48509031 48509039 9 + 1.189 1.295 0.375
ENSG00000102312 E014 32.8345677 0.0011548313 0.744982224 0.86365515 X 48509040 48509103 64 + 1.459 1.470 0.036
ENSG00000102312 E015 0.3032425 0.0274424043 0.689052955   X 48509234 48509423 190 + 0.000 0.138 10.396
ENSG00000102312 E016 5.8942076 0.0048868178 0.003610312 0.02698922 X 48509424 48509461 38 + 1.041 0.659 -1.491
ENSG00000102312 E017 12.1526441 0.0032286578 0.032332768 0.13419150 X 48509462 48509567 106 + 1.219 0.991 -0.822
ENSG00000102312 E018 9.1159036 0.0038554883 0.951536440 0.97771975 X 48509568 48509577 10 + 0.943 0.939 -0.016
ENSG00000102312 E019 12.7156608 0.0055530265 0.786495928 0.88842023 X 48509578 48509675 98 + 1.063 1.081 0.066
ENSG00000102312 E020 7.3560951 0.0046568433 0.045495394 0.16879305 X 48509676 48509707 32 + 0.637 0.920 1.133
ENSG00000102312 E021 8.6865898 0.0852838164 0.854384732 0.92726330 X 48509708 48509783 76 + 0.945 0.913 -0.122
ENSG00000102312 E022 44.7475897 0.0009923289 0.367653115 0.60212983 X 48509784 48509856 73 + 1.647 1.583 -0.218
ENSG00000102312 E023 39.8273884 0.0051313678 0.692879434 0.83096856 X 48509857 48509892 36 + 1.582 1.547 -0.121
ENSG00000102312 E024 53.8943054 0.0037122285 0.575033720 0.75368881 X 48509893 48509956 64 + 1.663 1.688 0.084
ENSG00000102312 E025 31.4296641 0.0014790568 0.681902123 0.82388401 X 48511295 48511365 71 + 1.483 1.444 -0.137
ENSG00000102312 E026 81.6737991 0.0063619102 0.384974319 0.61649883 X 48511366 48511487 122 + 1.904 1.844 -0.201
ENSG00000102312 E027 61.4163984 0.0115084517 0.413301495 0.63858450 X 48511892 48511935 44 + 1.788 1.721 -0.227
ENSG00000102312 E028 12.0916314 0.1751023419 0.459836907 0.67300001 X 48511936 48512325 390 + 1.123 1.033 -0.326
ENSG00000102312 E029 98.4317829 0.0022596973 0.230720086 0.46597028 X 48512326 48512507 182 + 1.986 1.923 -0.215
ENSG00000102312 E030 76.8936302 0.0059399236 0.888846596 0.94608299 X 48512589 48512719 131 + 1.830 1.827 -0.009
ENSG00000102312 E031 7.0213839 0.0231748799 0.028700138 0.12345974 X 48512835 48512852 18 + 1.062 0.755 -1.168
ENSG00000102312 E032 27.0136895 0.2147381301 0.085934813 0.25630780 X 48512853 48514126 1274 + 1.598 1.285 -1.079
ENSG00000102312 E033 3.7382215 0.3401384880 0.229183394 0.46417502 X 48514127 48514141 15 + 0.820 0.537 -1.197
ENSG00000102312 E034 6.2225640 0.4448689531 0.230047884 0.46520466 X 48514142 48514239 98 + 1.004 0.710 -1.139
ENSG00000102312 E035 83.0678176 0.0030740615 0.454382475 0.66903591 X 48514240 48514365 126 + 1.841 1.865 0.084
ENSG00000102312 E036 3.3432502 0.1525057221 0.954682638 0.97925342 X 48514366 48514524 159 + 0.579 0.586 0.032
ENSG00000102312 E037 78.0838178 0.0166606359 0.777190734 0.88304271 X 48514525 48514625 101 + 1.826 1.836 0.037
ENSG00000102312 E038 1.3736456 0.7748243862 0.657580836   X 48515442 48515636 195 + 0.330 0.337 0.044
ENSG00000102312 E039 0.1779838 0.0335081435 0.162100542   X 48515637 48515716 80 + 0.192 0.000 -12.322
ENSG00000102312 E040 74.3935290 0.0092594911 0.544273334 0.73213406 X 48515717 48515793 77 + 1.790 1.819 0.099
ENSG00000102312 E041 75.7013922 0.0006920350 0.601901685 0.77143827 X 48515890 48515953 64 + 1.812 1.825 0.042
ENSG00000102312 E042 0.3032425 0.0274424043 0.689052955   X 48515954 48516060 107 + 0.000 0.138 10.396
ENSG00000102312 E043 89.8614936 0.0006619666 0.190383195 0.41743849 X 48516061 48516146 86 + 1.865 1.909 0.150
ENSG00000102312 E044 16.7025795 0.1368925801 0.171489306 0.39250682 X 48516147 48517182 1036 + 1.343 1.121 -0.783
ENSG00000102312 E045 95.4107819 0.0019508035 0.043490202 0.16382310 X 48517183 48517293 111 + 1.861 1.940 0.266
ENSG00000102312 E046 132.0795719 0.0006304029 0.574841745 0.75355504 X 48520375 48520814 440 + 2.056 2.064 0.026