ENSG00000102241

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000218364 ENSG00000102241 HEK293_OSMI2_6hA HEK293_TMG_6hB HTATSF1 protein_coding protein_coding 85.73475 77.84337 98.75504 13.36875 4.03366 0.3432409 68.469678 64.774485 84.529828 10.670573 4.9129312 0.3839828 0.80449167 0.83443333 0.85470000 0.020266667 8.813497e-01 5.281094e-32 FALSE TRUE
ENST00000448450 ENSG00000102241 HEK293_OSMI2_6hA HEK293_TMG_6hB HTATSF1 protein_coding protein_coding 85.73475 77.84337 98.75504 13.36875 4.03366 0.3432409 4.299610 0.000000 5.232041 0.000000 0.1451786 9.0339847 0.04363333 0.00000000 0.05306667 0.053066667 5.281094e-32 5.281094e-32 FALSE TRUE
MSTRG.34957.2 ENSG00000102241 HEK293_OSMI2_6hA HEK293_TMG_6hB HTATSF1 protein_coding   85.73475 77.84337 98.75504 13.36875 4.03366 0.3432409 10.340869 7.712161 8.741749 2.273763 0.9811110 0.1805668 0.11841250 0.09813333 0.08960000 -0.008533333 9.657646e-01 5.281094e-32 FALSE TRUE
MSTRG.34957.3 ENSG00000102241 HEK293_OSMI2_6hA HEK293_TMG_6hB HTATSF1 protein_coding   85.73475 77.84337 98.75504 13.36875 4.03366 0.3432409 1.811093 3.817025 0.000000 1.082809 0.0000000 -8.5800793 0.02431250 0.05053333 0.00000000 -0.050533333 4.243350e-14 5.281094e-32 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000102241 E001 1.1495465 0.2897732706 3.294213e-01   X 136497079 136497220 142 + 0.204 0.473 1.714
ENSG00000102241 E002 3.4450191 0.0688114009 7.229144e-01 8.499134e-01 X 136497221 136497227 7 + 0.604 0.706 0.435
ENSG00000102241 E003 4.7005634 0.0907934036 9.813421e-01 9.924575e-01 X 136497228 136497232 5 + 0.744 0.782 0.151
ENSG00000102241 E004 6.6575642 0.1681449913 9.164972e-01 9.604219e-01 X 136497233 136497233 1 + 0.872 0.911 0.152
ENSG00000102241 E005 7.0217141 0.1192793604 9.860215e-01 9.948496e-01 X 136497234 136497237 4 + 0.888 0.935 0.178
ENSG00000102241 E006 80.8949627 0.0101744440 1.202097e-01 3.161833e-01 X 136497238 136497439 202 + 1.844 1.987 0.481
ENSG00000102241 E007 0.1614157 0.0337029310 5.266414e-01   X 136497440 136497485 46 + 0.114 0.000 -8.074
ENSG00000102241 E008 48.0280813 0.0030798034 9.991337e-02 2.815847e-01 X 136497592 136497623 32 + 1.722 1.666 -0.188
ENSG00000102241 E009 82.8293884 0.0005031172 5.729712e-01 7.523096e-01 X 136497624 136497629 6 + 1.920 1.937 0.056
ENSG00000102241 E010 127.0649295 0.0006815890 2.481001e-01 4.859475e-01 X 136497630 136497675 46 + 2.112 2.111 -0.001
ENSG00000102241 E011 462.7621857 0.0023710540 3.563666e-04 4.299769e-03 X 136497676 136497870 195 + 2.698 2.632 -0.218
ENSG00000102241 E012 622.1367074 0.0027096328 3.055080e-04 3.785646e-03 X 136499598 136499778 181 + 2.825 2.761 -0.214
ENSG00000102241 E013 395.6024754 0.0010811629 3.968168e-05 6.829697e-04 X 136500158 136500205 48 + 2.628 2.570 -0.195
ENSG00000102241 E014 681.2446723 0.0011630366 2.376718e-08 1.024680e-06 X 136500664 136500818 155 + 2.871 2.792 -0.264
ENSG00000102241 E015 746.3750157 0.0005462655 5.277569e-10 3.237907e-08 X 136502778 136502941 164 + 2.905 2.839 -0.221
ENSG00000102241 E016 552.6009180 0.0032605495 2.113568e-02 9.978108e-02 X 136504364 136504463 100 + 2.762 2.723 -0.128
ENSG00000102241 E017 451.2185914 0.0001369276 2.416985e-01 4.784787e-01 X 136509091 136509180 90 + 2.650 2.669 0.062
ENSG00000102241 E018 597.5470983 0.0003282442 3.047648e-01 5.453519e-01 X 136510082 136510219 138 + 2.769 2.789 0.069
ENSG00000102241 E019 1043.7874743 0.0004536741 6.671958e-01 8.144475e-01 X 136510808 136511126 319 + 3.001 3.043 0.141
ENSG00000102241 E020 478.0938577 0.0001364911 5.377129e-04 6.015944e-03 X 136511127 136511207 81 + 2.637 2.732 0.318
ENSG00000102241 E021 2898.6403125 0.0070764868 1.490400e-04 2.087112e-03 X 136511208 136512346 1139 + 3.386 3.534 0.492