ENSG00000102125

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000483674 ENSG00000102125 HEK293_OSMI2_6hA HEK293_TMG_6hB TAFAZZIN protein_coding retained_intron 45.2807 65.34854 24.72443 5.707557 0.5912146 -1.401855 2.093824 2.5950703 2.7281795 0.7633483 0.2687705 0.07189471 0.05480833 0.03860000 0.10996667 0.07136667 0.019611281 4.447241e-08 TRUE TRUE
ENST00000612460 ENSG00000102125 HEK293_OSMI2_6hA HEK293_TMG_6hB TAFAZZIN protein_coding protein_coding 45.2807 65.34854 24.72443 5.707557 0.5912146 -1.401855 2.205385 4.4128188 0.3402136 0.9846114 0.3402136 -3.65865907 0.03653333 0.06666667 0.01443333 -0.05223333 0.241200950 4.447241e-08 FALSE TRUE
ENST00000613002 ENSG00000102125 HEK293_OSMI2_6hA HEK293_TMG_6hB TAFAZZIN protein_coding protein_coding 45.2807 65.34854 24.72443 5.707557 0.5912146 -1.401855 10.956333 15.9045169 3.3389666 3.7036249 0.6535972 -2.24855547 0.24185833 0.23893333 0.13476667 -0.10416667 0.442257926 4.447241e-08 FALSE TRUE
ENST00000614595 ENSG00000102125 HEK293_OSMI2_6hA HEK293_TMG_6hB TAFAZZIN protein_coding retained_intron 45.2807 65.34854 24.72443 5.707557 0.5912146 -1.401855 2.600095 3.4671970 2.2624117 0.7834576 0.1159388 -0.61370055 0.06682500 0.05433333 0.09180000 0.03746667 0.452600902 4.447241e-08 FALSE TRUE
ENST00000652354 ENSG00000102125 HEK293_OSMI2_6hA HEK293_TMG_6hB TAFAZZIN protein_coding protein_coding 45.2807 65.34854 24.72443 5.707557 0.5912146 -1.401855 1.647222 0.7710272 1.6651278 0.3146139 0.2234428 1.10082645 0.03710833 0.01123333 0.06780000 0.05656667 0.001150427 4.447241e-08 FALSE TRUE
ENST00000652390 ENSG00000102125 HEK293_OSMI2_6hA HEK293_TMG_6hB TAFAZZIN protein_coding protein_coding 45.2807 65.34854 24.72443 5.707557 0.5912146 -1.401855 5.468676 7.3305550 1.8309412 2.0525286 0.9350652 -1.99544564 0.11271667 0.11306667 0.07520000 -0.03786667 0.871212979 4.447241e-08 FALSE TRUE
ENST00000652476 ENSG00000102125 HEK293_OSMI2_6hA HEK293_TMG_6hB TAFAZZIN protein_coding retained_intron 45.2807 65.34854 24.72443 5.707557 0.5912146 -1.401855 2.859711 4.1281927 1.9954302 1.1572887 0.3163350 -1.04508907 0.06950833 0.06470000 0.08033333 0.01563333 0.850371220 4.447241e-08 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000102125 E001 1.874086 0.0153490776 6.310356e-01 7.910677e-01 X 154411524 154411538 15 + 0.463 0.365 -0.529
ENSG00000102125 E002 2.360921 0.0758316202 2.734954e-01 5.133495e-01 X 154411539 154411540 2 + 0.623 0.395 -1.107
ENSG00000102125 E003 3.403235 0.0466715093 7.202463e-01 8.483509e-01 X 154411541 154411549 9 + 0.622 0.542 -0.360
ENSG00000102125 E004 5.116452 0.0565210901 8.776458e-01 9.400676e-01 X 154411550 154411552 3 + 0.683 0.700 0.070
ENSG00000102125 E005 17.187401 0.0021350859 9.980553e-03 5.807728e-02 X 154411553 154411560 8 + 0.934 1.216 1.024
ENSG00000102125 E006 19.406048 0.0020406225 9.515102e-03 5.603312e-02 X 154411561 154411561 1 + 0.994 1.261 0.961
ENSG00000102125 E007 31.772657 0.0013333293 3.213724e-05 5.725600e-04 X 154411562 154411573 12 + 1.115 1.478 1.274
ENSG00000102125 E008 37.323857 0.0010241159 5.258730e-04 5.912303e-03 X 154411574 154411584 11 + 1.272 1.536 0.912
ENSG00000102125 E009 64.172862 0.0006718433 8.190865e-06 1.763882e-04 X 154411585 154411618 34 + 1.505 1.767 0.890
ENSG00000102125 E010 73.294020 0.0008620110 6.520792e-05 1.045192e-03 X 154411619 154411649 31 + 1.605 1.819 0.728
ENSG00000102125 E011 71.449914 0.0007736849 1.965794e-05 3.768762e-04 X 154411650 154411682 33 + 1.576 1.811 0.795
ENSG00000102125 E012 94.443081 0.0080791945 5.026738e-06 1.156558e-04 X 154411683 154411758 76 + 1.637 1.936 1.009
ENSG00000102125 E013 56.013973 0.0121233367 5.670529e-09 2.809264e-07 X 154411759 154411790 32 + 1.192 1.733 1.866
ENSG00000102125 E014 35.023299 0.0066615238 2.042523e-08 8.937578e-07 X 154411791 154411791 1 + 0.965 1.537 2.024
ENSG00000102125 E015 51.521917 0.0045461152 2.224655e-12 2.156378e-10 X 154411792 154411829 38 + 1.093 1.704 2.122
ENSG00000102125 E016 42.394764 0.0009243479 1.711863e-12 1.688233e-10 X 154411830 154411843 14 + 0.994 1.621 2.202
ENSG00000102125 E017 57.105233 0.1638262629 6.195384e-03 4.068990e-02 X 154411844 154411878 35 + 1.217 1.738 1.794
ENSG00000102125 E018 58.780376 0.2283378986 3.205259e-02 1.333676e-01 X 154411879 154411897 19 + 1.302 1.744 1.518
ENSG00000102125 E019 71.422309 0.3488936086 9.434196e-02 2.718035e-01 X 154411898 154411921 24 + 1.443 1.821 1.288
ENSG00000102125 E020 77.212148 0.4189671759 1.417891e-01 3.501531e-01 X 154411922 154411952 31 + 1.516 1.850 1.132
ENSG00000102125 E021 12.035613 0.0198881884 4.687848e-01 6.792294e-01 X 154411953 154411978 26 + 0.963 1.044 0.299
ENSG00000102125 E022 14.077766 0.0952642123 7.138332e-01 8.442638e-01 X 154411979 154412006 28 + 1.065 1.099 0.125
ENSG00000102125 E023 14.293348 0.2718077589 7.320839e-01 8.554705e-01 X 154412007 154412085 79 + 1.230 1.057 -0.620
ENSG00000102125 E024 146.338784 0.1244312784 3.239170e-01 5.632371e-01 X 154412086 154412160 75 + 1.990 2.094 0.348
ENSG00000102125 E025 121.502281 0.0501484096 4.550350e-01 6.695207e-01 X 154412161 154412180 20 + 1.955 2.005 0.168
ENSG00000102125 E026 102.985391 0.0313518054 5.245789e-01 7.181887e-01 X 154412181 154412185 5 + 1.895 1.932 0.126
ENSG00000102125 E027 117.621514 0.0147793924 4.762186e-01 6.844105e-01 X 154412186 154412202 17 + 1.956 1.989 0.113
ENSG00000102125 E028 122.743695 0.0287683782 4.152531e-01 6.399682e-01 X 154412203 154412214 12 + 1.959 2.010 0.172
ENSG00000102125 E029 97.825392 0.0423454337 2.992696e-04 3.722196e-03 X 154412215 154412714 500 + 2.167 1.797 -1.242
ENSG00000102125 E030 20.716920 0.0534255414 2.573717e-03 2.080820e-02 X 154412715 154412717 3 + 1.530 1.132 -1.390
ENSG00000102125 E031 20.698947 0.0549180385 1.559867e-03 1.404029e-02 X 154412718 154412720 3 + 1.545 1.122 -1.479
ENSG00000102125 E032 55.851481 0.0742569817 2.119312e-02 9.996886e-02 X 154412721 154412865 145 + 1.883 1.581 -1.020
ENSG00000102125 E033 38.198483 0.0893794129 6.198706e-02 2.072373e-01 X 154412866 154412919 54 + 1.689 1.437 -0.859
ENSG00000102125 E034 42.667826 0.0899698618 1.528752e-01 3.664374e-01 X 154412920 154412987 68 + 1.691 1.501 -0.647
ENSG00000102125 E035 63.697401 0.0458079683 3.757061e-02 1.485012e-01 X 154412988 154413206 219 + 1.885 1.663 -0.751
ENSG00000102125 E036 169.897419 0.0002570971 2.616631e-01 5.007280e-01 X 154413207 154413252 46 + 2.121 2.148 0.091
ENSG00000102125 E037 52.335022 0.0298063305 6.928605e-02 2.233490e-01 X 154413253 154413339 87 + 1.769 1.593 -0.600
ENSG00000102125 E038 22.290994 0.0476753151 6.935043e-01 8.313466e-01 X 154413340 154413352 13 + 1.313 1.272 -0.144
ENSG00000102125 E039 19.749254 0.0678602806 8.063850e-01 8.999593e-01 X 154413353 154413358 6 + 1.241 1.227 -0.049
ENSG00000102125 E040 37.342948 0.0367015499 1.608690e-01 3.780590e-01 X 154413359 154413481 123 + 1.610 1.456 -0.528
ENSG00000102125 E041 174.445523 0.0016635047 7.153262e-01 8.451349e-01 X 154413482 154413551 70 + 2.172 2.146 -0.087
ENSG00000102125 E042 117.366459 0.0020631434 1.181381e-01 3.127885e-01 X 154413552 154413567 16 + 2.044 1.965 -0.265
ENSG00000102125 E043 12.606845 0.1065678897 1.324041e-02 7.140900e-02 X 154413568 154414100 533 + 1.345 0.919 -1.534
ENSG00000102125 E044 36.318313 0.0159066290 4.074988e-01 6.340905e-01 X 154414101 154414106 6 + 1.548 1.463 -0.293
ENSG00000102125 E045 65.095429 0.0007404970 1.298027e-02 7.036128e-02 X 154414107 154414190 84 + 1.833 1.696 -0.464
ENSG00000102125 E046 8.038702 0.0623872291 1.157494e-02 6.472014e-02 X 154414191 154414673 483 + 1.154 0.762 -1.474
ENSG00000102125 E047 7.559834 0.1344328760 8.555840e-01 9.279718e-01 X 154418475 154418545 71 + 0.861 0.847 -0.052
ENSG00000102125 E048 6.757816 0.1724182999 5.512591e-01 7.371957e-01 X 154418546 154418602 57 + 0.863 0.792 -0.277
ENSG00000102125 E049 34.658059 0.0578943723 8.343375e-02 2.516468e-01 X 154418603 154419542 940 + 1.619 1.409 -0.719
ENSG00000102125 E050 113.907901 0.0005208035 8.220118e-04 8.459882e-03 X 154419543 154419545 3 + 2.077 1.937 -0.471
ENSG00000102125 E051 205.184458 0.0033787382 1.157555e-02 6.472014e-02 X 154419546 154419623 78 + 2.308 2.195 -0.379
ENSG00000102125 E052 67.360620 0.0329198329 1.013361e-02 5.871040e-02 X 154419624 154419704 81 + 1.928 1.679 -0.839
ENSG00000102125 E053 110.029952 0.0004399523 3.655818e-02 1.457307e-01 X 154419705 154419746 42 + 2.026 1.931 -0.317
ENSG00000102125 E054 116.454683 0.0377347053 2.693693e-01 5.091670e-01 X 154419747 154419990 244 + 2.057 1.953 -0.351
ENSG00000102125 E055 59.527756 0.0558022200 2.431038e-01 4.801374e-01 X 154419991 154420031 41 + 1.808 1.652 -0.526
ENSG00000102125 E056 229.913084 0.0046949543 6.556975e-01 8.071372e-01 X 154420032 154420094 63 + 2.298 2.262 -0.120
ENSG00000102125 E057 25.057605 0.0041160437 2.113731e-01 4.434033e-01 X 154420095 154420211 117 + 1.420 1.308 -0.390
ENSG00000102125 E058 226.929445 0.0071296074 5.633862e-01 7.456507e-01 X 154420212 154420264 53 + 2.300 2.254 -0.153
ENSG00000102125 E059 6.473690 0.0091860770 1.232790e-01 3.209456e-01 X 154420325 154420459 135 + 0.965 0.748 -0.840
ENSG00000102125 E060 278.331698 0.0044698427 8.136948e-01 9.044822e-01 X 154420658 154420735 78 + 2.373 2.348 -0.081
ENSG00000102125 E061 18.370818 0.0074393402 1.404925e-01 3.482626e-01 X 154420736 154420902 167 + 1.314 1.161 -0.540
ENSG00000102125 E062 518.710985 0.0102606349 9.025256e-01 9.531276e-01 X 154420903 154421136 234 + 2.641 2.616 -0.082
ENSG00000102125 E063 327.416137 0.0061452449 9.798395e-01 9.917293e-01 X 154421137 154421256 120 + 2.434 2.420 -0.046
ENSG00000102125 E064 523.182268 0.0040391417 8.486619e-01 9.241466e-01 X 154421257 154421726 470 + 2.642 2.622 -0.067