ENSG00000102119

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369835 ENSG00000102119 HEK293_OSMI2_6hA HEK293_TMG_6hB EMD protein_coding protein_coding 327.1164 539.8646 135.9263 129.9451 7.298963 -1.989694 37.622390 66.27243 3.939296 21.78940 0.8196403 -4.068959 0.11578750 0.1171333 0.02856667 -0.08856667 5.866430e-05 3.635478e-24 FALSE TRUE
ENST00000369842 ENSG00000102119 HEK293_OSMI2_6hA HEK293_TMG_6hB EMD protein_coding protein_coding 327.1164 539.8646 135.9263 129.9451 7.298963 -1.989694 166.167176 274.62461 62.029870 70.91754 0.6097848 -2.146246 0.50316250 0.5025333 0.45940000 -0.04313333 7.885116e-01 3.635478e-24 FALSE TRUE
ENST00000492448 ENSG00000102119 HEK293_OSMI2_6hA HEK293_TMG_6hB EMD protein_coding processed_transcript 327.1164 539.8646 135.9263 129.9451 7.298963 -1.989694 78.659171 132.34532 38.977470 28.93116 4.5882797 -1.763334 0.22107083 0.2488333 0.28480000 0.03596667 7.621112e-01 3.635478e-24 FALSE TRUE
ENST00000683627 ENSG00000102119 HEK293_OSMI2_6hA HEK293_TMG_6hB EMD protein_coding protein_coding 327.1164 539.8646 135.9263 129.9451 7.298963 -1.989694 6.227814 0.00000 9.954220 0.00000 2.7705114 9.960613 0.02475417 0.0000000 0.07140000 0.07140000 3.635478e-24 3.635478e-24 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000102119 E001 114.37121 1.820477e-03 4.922642e-09 2.480646e-07 X 154379273 154379294 22 + 1.514 1.912 1.350
ENSG00000102119 E002 195.31691 3.569926e-03 3.840787e-09 1.975330e-07 X 154379295 154379340 46 + 1.789 2.136 1.167
ENSG00000102119 E003 274.74319 2.798159e-03 1.996747e-16 3.665876e-14 X 154379341 154379360 20 + 1.852 2.287 1.457
ENSG00000102119 E004 581.18593 2.626251e-03 7.910263e-14 1.004745e-11 X 154379361 154379403 43 + 2.305 2.601 0.989
ENSG00000102119 E005 665.50164 1.695732e-03 1.906870e-10 1.272918e-08 X 154379404 154379416 13 + 2.445 2.654 0.696
ENSG00000102119 E006 693.32540 9.342272e-04 1.495958e-08 6.753008e-07 X 154379417 154379427 11 + 2.514 2.669 0.516
ENSG00000102119 E007 1062.78799 1.357579e-03 1.478736e-03 1.346434e-02 X 154379428 154379484 57 + 2.764 2.846 0.273
ENSG00000102119 E008 1023.80437 1.343589e-03 8.921625e-02 2.623182e-01 X 154379485 154379508 24 + 2.784 2.826 0.141
ENSG00000102119 E009 946.42579 1.669530e-03 4.037415e-01 6.313266e-01 X 154379509 154379524 16 + 2.768 2.790 0.073
ENSG00000102119 E010 955.35502 1.076164e-03 5.848191e-01 7.602039e-01 X 154379525 154379537 13 + 2.783 2.793 0.033
ENSG00000102119 E011 1064.19353 9.158368e-04 8.868389e-01 9.450426e-01 X 154379538 154379562 25 + 2.839 2.839 -0.001
ENSG00000102119 E012 740.27488 1.213930e-03 3.673069e-01 6.018231e-01 X 154379563 154379566 4 + 2.706 2.677 -0.096
ENSG00000102119 E013 21.30926 5.534522e-01 1.000000e+00 1.000000e+00 X 154379625 154379689 65 + 1.138 1.170 0.116
ENSG00000102119 E014 1668.61056 1.180519e-03 1.624324e-02 8.269062e-02 X 154379690 154379794 105 + 3.081 3.025 -0.186
ENSG00000102119 E015 1843.81282 7.078532e-04 2.560796e-04 3.284855e-03 X 154379942 154380019 78 + 3.138 3.067 -0.233
ENSG00000102119 E016 149.43137 4.789651e-02 1.412522e-02 7.484981e-02 X 154380020 154380233 214 + 2.256 1.935 -1.076
ENSG00000102119 E017 1647.59626 4.389136e-04 1.540869e-05 3.053028e-04 X 154380234 154380276 43 + 3.096 3.019 -0.255
ENSG00000102119 E018 2132.44399 7.599377e-05 3.514873e-06 8.517499e-05 X 154380277 154380367 91 + 3.197 3.136 -0.203
ENSG00000102119 E019 77.95175 1.196278e-01 7.817818e-02 2.411746e-01 X 154380368 154380462 95 + 1.991 1.652 -1.142
ENSG00000102119 E020 105.98887 1.399230e-01 7.108158e-02 2.269000e-01 X 154380565 154380752 188 + 2.144 1.777 -1.233
ENSG00000102119 E021 1786.02868 1.161990e-04 1.398439e-01 3.472305e-01 X 154380753 154380802 50 + 3.090 3.063 -0.091
ENSG00000102119 E022 101.54908 4.879904e-02 3.572133e-02 1.434906e-01 X 154380803 154380881 79 + 2.061 1.778 -0.953
ENSG00000102119 E023 3025.28061 3.101618e-04 7.195238e-01 8.479293e-01 X 154380882 154381004 123 + 3.297 3.291 -0.018
ENSG00000102119 E024 3416.34286 5.046153e-04 2.927242e-01 5.334460e-01 X 154381005 154381230 226 + 3.339 3.344 0.019
ENSG00000102119 E025 635.67691 1.690553e-03 2.244705e-01 4.587704e-01 X 154381231 154381331 101 + 2.591 2.617 0.086
ENSG00000102119 E026 702.32241 7.039879e-03 3.793990e-01 6.117263e-01 X 154381332 154381387 56 + 2.703 2.649 -0.180
ENSG00000102119 E027 766.97355 7.307562e-03 2.977175e-01 5.382062e-01 X 154381388 154381574 187 + 2.748 2.686 -0.207