ENSG00000102081

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370470 ENSG00000102081 HEK293_OSMI2_6hA HEK293_TMG_6hB FMR1 protein_coding protein_coding 20.65475 12.99643 31.0747 2.340797 0.8849998 1.25698 2.511891 1.8938174 3.7052978 0.5470862 0.2876914 0.9645828 0.12447500 0.13926667 0.11890000 -0.02036667 0.877331623 0.0004743202 FALSE TRUE
ENST00000370475 ENSG00000102081 HEK293_OSMI2_6hA HEK293_TMG_6hB FMR1 protein_coding protein_coding 20.65475 12.99643 31.0747 2.340797 0.8849998 1.25698 1.499946 0.7908098 1.1134548 0.0892276 0.4028283 0.4884105 0.06445833 0.06470000 0.03520000 -0.02950000 0.599753477 0.0004743202 FALSE TRUE
ENST00000495717 ENSG00000102081 HEK293_OSMI2_6hA HEK293_TMG_6hB FMR1 protein_coding protein_coding 20.65475 12.99643 31.0747 2.340797 0.8849998 1.25698 1.069625 1.2221916 0.8448636 0.1539863 0.2265551 -0.5274604 0.06648750 0.09646667 0.02680000 -0.06966667 0.006867414 0.0004743202 FALSE TRUE
ENST00000687593 ENSG00000102081 HEK293_OSMI2_6hA HEK293_TMG_6hB FMR1 protein_coding protein_coding 20.65475 12.99643 31.0747 2.340797 0.8849998 1.25698 7.658142 4.5422810 12.5647898 1.1661857 0.4061231 1.4658728 0.35253750 0.33960000 0.40486667 0.06526667 0.709501634 0.0004743202 FALSE TRUE
ENST00000691111 ENSG00000102081 HEK293_OSMI2_6hA HEK293_TMG_6hB FMR1 protein_coding protein_coding 20.65475 12.99643 31.0747 2.340797 0.8849998 1.25698 2.713013 2.4749084 5.0955527 0.8205746 0.1085917 1.0388745 0.12134583 0.18006667 0.16423333 -0.01583333 0.973965209 0.0004743202 FALSE TRUE
ENST00000691793 ENSG00000102081 HEK293_OSMI2_6hA HEK293_TMG_6hB FMR1 protein_coding retained_intron 20.65475 12.99643 31.0747 2.340797 0.8849998 1.25698 1.401708 0.7424634 1.6255613 0.2819665 0.8639932 1.1200925 0.06335833 0.07233333 0.05363333 -0.01870000 0.939550028 0.0004743202 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000102081 E001 0.2735028 0.0254242898 6.065800e-01   X 147911822 147911918 97 + 0.088 0.166 1.052
ENSG00000102081 E002 2.4759117 0.0090024570 6.448413e-02 0.2127502238 X 147911919 147911950 32 + 0.409 0.714 1.415
ENSG00000102081 E003 2.4759117 0.0090024570 6.448413e-02 0.2127502238 X 147911951 147911955 5 + 0.409 0.714 1.415
ENSG00000102081 E004 2.6373274 0.0085388995 1.015914e-01 0.2846549260 X 147911956 147911962 7 + 0.446 0.714 1.223
ENSG00000102081 E005 2.7987431 0.0083951281 1.505413e-01 0.3630774720 X 147911963 147912051 89 + 0.479 0.714 1.053
ENSG00000102081 E006 0.4349185 0.0217681645 1.000000e+00   X 147912052 147912069 18 + 0.161 0.166 0.052
ENSG00000102081 E007 0.0000000       X 147912070 147912075 6 +      
ENSG00000102081 E008 0.1779838 0.0352364369 1.000000e+00   X 147912076 147912078 3 + 0.088 0.000 -17.211
ENSG00000102081 E009 0.1779838 0.0352364369 1.000000e+00   X 147912079 147912079 1 + 0.088 0.000 -17.211
ENSG00000102081 E010 0.1779838 0.0352364369 1.000000e+00   X 147912080 147912081 2 + 0.088 0.000 -17.211
ENSG00000102081 E011 0.1779838 0.0352364369 1.000000e+00   X 147912082 147912084 3 + 0.088 0.000 -17.211
ENSG00000102081 E012 0.3206185 0.0274424043 4.822535e-01   X 147912085 147912093 9 + 0.161 0.000 -18.201
ENSG00000102081 E013 6.5366843 0.0043281941 8.883758e-01 0.9458130697 X 147912094 147912122 29 + 0.848 0.875 0.106
ENSG00000102081 E014 14.1359019 0.0058285473 9.826024e-01 0.9930756669 X 147912123 147912158 36 + 1.147 1.160 0.049
ENSG00000102081 E015 14.1193337 0.0047704640 9.801570e-01 0.9918969540 X 147912159 147912161 3 + 1.146 1.160 0.050
ENSG00000102081 E016 17.3337345 0.0023991755 7.675836e-01 0.8771742023 X 147912162 147912170 9 + 1.240 1.225 -0.051
ENSG00000102081 E017 21.4321239 0.0017606184 8.471494e-01 0.9233983352 X 147912171 147912175 5 + 1.325 1.322 -0.013
ENSG00000102081 E018 22.8306628 0.0015689277 8.685313e-01 0.9351158623 X 147912176 147912179 4 + 1.343 1.367 0.084
ENSG00000102081 E019 40.5674882 0.0009681677 8.174380e-01 0.9066248193 X 147912180 147912230 51 + 1.587 1.612 0.087
ENSG00000102081 E020 0.3393995 0.0274424043 4.812527e-01   X 147912469 147912727 259 + 0.161 0.000 -18.202
ENSG00000102081 E021 3.4326057 0.0070948524 5.571343e-01 0.7412293110 X 147912728 147913077 350 + 0.661 0.578 -0.363
ENSG00000102081 E022 6.4644199 0.0044246444 2.072839e-02 0.0984274091 X 147913078 147914451 1374 + 0.739 1.031 1.122
ENSG00000102081 E023 0.9514940 0.0211634161 4.088769e-01   X 147917726 147917827 102 + 0.223 0.379 1.047
ENSG00000102081 E024 63.5454259 0.0035059853 1.879350e-01 0.4143333662 X 147921933 147921985 53 + 1.806 1.746 -0.204
ENSG00000102081 E025 0.8214337 0.0175720338 9.366739e-02   X 147924919 147925055 137 + 0.326 0.000 -19.498
ENSG00000102081 E026 105.2696581 0.0004360148 7.751425e-02 0.2398852469 X 147925540 147925633 94 + 2.020 1.966 -0.180
ENSG00000102081 E027 1.8343826 0.0172377908 6.940879e-01 0.8317662275 X 147927670 147927735 66 + 0.446 0.380 -0.359
ENSG00000102081 E028 4.4666660 0.0782480934 8.345542e-01 0.9163271836 X 147927736 147928321 586 + 0.724 0.676 -0.197
ENSG00000102081 E029 110.9074151 0.0004401340 1.772052e-01 0.4000628029 X 147928322 147928388 67 + 2.036 2.000 -0.123
ENSG00000102081 E030 60.8524935 0.0007410125 1.664958e-01 0.3858694877 X 147928389 147928393 5 + 1.784 1.728 -0.188
ENSG00000102081 E031 1.4343360 0.0126092562 1.289867e-01 0.3301966206 X 147928394 147928658 265 + 0.446 0.166 -1.949
ENSG00000102081 E032 146.2753194 0.0002968791 9.078917e-01 0.9560775449 X 147928659 147928807 149 + 2.139 2.154 0.053
ENSG00000102081 E033 110.8185824 0.0012169885 1.552986e-01 0.3698934053 X 147929948 147930041 94 + 2.037 1.992 -0.151
ENSG00000102081 E034 146.8243912 0.0002840113 3.371981e-03 0.0255991699 X 147930128 147930244 117 + 2.170 2.089 -0.271
ENSG00000102081 E035 1.9632256 0.1177785783 6.249128e-01 0.7872858550 X 147930873 147930964 92 + 0.480 0.381 -0.522
ENSG00000102081 E036 182.5974264 0.0008582052 1.689139e-02 0.0850469030 X 147932425 147932595 171 + 2.259 2.199 -0.202
ENSG00000102081 E037 138.3911174 0.0003443652 6.709028e-02 0.2186029991 X 147932685 147932763 79 + 2.134 2.087 -0.159
ENSG00000102081 E038 1.9438970 0.0130772083 2.068927e-01 0.4380339244 X 147933401 147933540 140 + 0.511 0.285 -1.271
ENSG00000102081 E039 1.1931617 0.6665218285 8.156163e-01   X 147933541 147933687 147 + 0.340 0.281 -0.385
ENSG00000102081 E040 87.3314736 0.0004974951 2.747495e-01 0.5147402522 X 147936504 147936509 6 + 1.933 1.900 -0.109
ENSG00000102081 E041 172.5383597 0.0002653458 4.442209e-01 0.6615476326 X 147936510 147936613 104 + 2.220 2.210 -0.033
ENSG00000102081 E042 177.8406713 0.0002884937 9.168924e-01 0.9606457647 X 147937466 147937600 135 + 2.226 2.235 0.031
ENSG00000102081 E043 28.4687801 0.0013246639 8.722961e-01 0.9371991095 X 147938099 147938161 63 + 1.438 1.461 0.077
ENSG00000102081 E044 1.7505127 0.0170014665 2.863346e-01 0.5270041879 X 147940157 147940575 419 + 0.479 0.286 -1.111
ENSG00000102081 E045 159.4285734 0.0003139016 1.538319e-01 0.3678116916 X 147940576 147940662 87 + 2.192 2.161 -0.103
ENSG00000102081 E046 243.3037128 0.0004020784 1.394165e-01 0.3466338636 X 147943131 147943326 196 + 2.373 2.348 -0.084
ENSG00000102081 E047 65.6141569 0.1660162569 3.434574e-01 0.5811253103 X 147943327 147944692 1366 + 1.836 1.706 -0.440
ENSG00000102081 E048 17.6937589 0.0326474736 8.717609e-01 0.9369074595 X 147944693 147944868 176 + 1.239 1.261 0.075
ENSG00000102081 E049 67.7611546 0.0007342674 4.968408e-01 0.6987808754 X 147944869 147944883 15 + 1.801 1.843 0.143
ENSG00000102081 E050 74.7566926 0.0017887191 8.354382e-01 0.9167940295 X 147944884 147944904 21 + 1.853 1.875 0.076
ENSG00000102081 E051 116.1187771 0.0004346708 6.391344e-01 0.7963220149 X 147944905 147944943 39 + 2.037 2.065 0.094
ENSG00000102081 E052 106.9332590 0.0004883875 6.289536e-01 0.7897986404 X 147944944 147944952 9 + 2.000 2.029 0.098
ENSG00000102081 E053 157.9894795 0.0014849054 3.056467e-01 0.5462795575 X 147944953 147945024 72 + 2.164 2.210 0.152
ENSG00000102081 E054 103.6663944 0.0084373081 4.960789e-01 0.6982613717 X 147945025 147945051 27 + 1.982 2.029 0.157
ENSG00000102081 E055 154.2393364 0.0003928839 1.646724e-01 0.3835947843 X 147945534 147945616 83 + 2.149 2.202 0.179
ENSG00000102081 E056 1.9992651 0.0109082967 1.552050e-01 0.3697468545 X 147945617 147945715 99 + 0.539 0.285 -1.405
ENSG00000102081 E057 7.8020748 0.0726978367 3.562255e-03 0.0267205311 X 147948413 147948415 3 + 0.697 1.180 1.829
ENSG00000102081 E058 15.1564114 0.0048102241 2.047533e-05 0.0003897749 X 147948416 147948682 267 + 1.017 1.409 1.391
ENSG00000102081 E059 28.7293870 0.0021010466 1.436377e-02 0.0757363625 X 147948683 147948687 5 + 1.378 1.555 0.609
ENSG00000102081 E060 45.9719112 0.0013411464 3.200887e-01 0.5598305283 X 147948688 147948733 46 + 1.623 1.689 0.224
ENSG00000102081 E061 1142.5752191 0.0065280762 1.916610e-01 0.4189797785 X 147948734 147951125 2392 + 3.014 3.066 0.172