ENSG00000102054

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330735 ENSG00000102054 HEK293_OSMI2_6hA HEK293_TMG_6hB RBBP7 protein_coding retained_intron 255.7989 109.2059 375.6339 7.112288 9.654289 1.782183 23.50343 20.905945 17.01332 3.755416 2.161053 -0.2970905 0.12925833 0.19286667 0.04533333 -0.14753333 0.0001159523 0.0001159523 FALSE TRUE
ENST00000380087 ENSG00000102054 HEK293_OSMI2_6hA HEK293_TMG_6hB RBBP7 protein_coding protein_coding 255.7989 109.2059 375.6339 7.112288 9.654289 1.782183 21.45981 9.149692 32.17708 1.739745 1.827132 1.8131108 0.07977083 0.08303333 0.08563333 0.00260000 0.9759257037 0.0001159523 FALSE TRUE
ENST00000404022 ENSG00000102054 HEK293_OSMI2_6hA HEK293_TMG_6hB RBBP7 protein_coding protein_coding 255.7989 109.2059 375.6339 7.112288 9.654289 1.782183 66.93729 21.604212 105.06668 3.307317 5.301468 2.2813904 0.24290833 0.19673333 0.27933333 0.08260000 0.2432559366 0.0001159523 FALSE TRUE
MSTRG.33950.3 ENSG00000102054 HEK293_OSMI2_6hA HEK293_TMG_6hB RBBP7 protein_coding   255.7989 109.2059 375.6339 7.112288 9.654289 1.782183 111.05064 42.559223 168.46266 7.490153 4.414879 1.9846318 0.41938333 0.38393333 0.44846667 0.06453333 0.7353539302 0.0001159523 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000102054 E001 1.642060 1.784949e-02 7.447972e-01 8.635526e-01 X 16839283 16839390 108 - 0.387 0.335 -0.304
ENSG00000102054 E002 18.837991 1.583803e-01 1.281907e-01 3.289181e-01 X 16844341 16844649 309 - 1.149 1.430 0.987
ENSG00000102054 E003 9.536971 6.300303e-02 9.517472e-06 2.008058e-04 X 16844650 16844653 4 - 0.678 1.357 2.531
ENSG00000102054 E004 206.145514 2.706780e-02 2.845067e-03 2.247246e-02 X 16844654 16844689 36 - 2.162 2.443 0.939
ENSG00000102054 E005 2377.719160 3.280767e-03 1.278590e-04 1.833902e-03 X 16844690 16845027 338 - 3.277 3.394 0.391
ENSG00000102054 E006 1578.284150 5.453803e-05 5.854946e-01 7.606170e-01 X 16845028 16845103 76 - 3.128 3.141 0.044
ENSG00000102054 E007 1126.097013 8.139738e-05 3.189754e-01 5.587003e-01 X 16845828 16845870 43 - 2.983 2.989 0.021
ENSG00000102054 E008 1189.312029 1.755759e-04 7.485913e-01 8.658650e-01 X 16845871 16845938 68 - 3.003 3.026 0.076
ENSG00000102054 E009 82.453269 1.385172e-01 6.805766e-01 8.231258e-01 X 16845939 16848990 3052 - 1.799 1.992 0.648
ENSG00000102054 E010 11.440271 4.324733e-02 9.759946e-01 9.897962e-01 X 16848991 16849243 253 - 1.022 1.042 0.073
ENSG00000102054 E011 1073.266873 1.220584e-04 1.051965e-01 2.910001e-01 X 16849244 16849301 58 - 2.954 2.994 0.133
ENSG00000102054 E012 1005.926965 1.993436e-03 2.715133e-01 5.113772e-01 X 16852046 16852122 77 - 2.924 2.969 0.151
ENSG00000102054 E013 33.353974 1.550925e-01 9.682552e-01 9.859793e-01 X 16852123 16852280 158 - 1.441 1.548 0.366
ENSG00000102054 E014 72.969568 6.894782e-02 4.441596e-01 6.615203e-01 X 16852416 16852550 135 - 1.759 1.910 0.507
ENSG00000102054 E015 500.787167 1.343479e-03 9.771622e-01 9.903535e-01 X 16852551 16852551 1 - 2.628 2.648 0.065
ENSG00000102054 E016 994.803364 1.075385e-03 3.870752e-01 6.182080e-01 X 16852552 16852628 77 - 2.922 2.957 0.117
ENSG00000102054 E017 64.219053 2.225551e-01 9.210242e-01 9.627517e-01 X 16852629 16852748 120 - 1.689 1.892 0.684
ENSG00000102054 E018 1329.123160 1.988581e-04 5.768517e-03 3.858774e-02 X 16852749 16852875 127 - 3.044 3.097 0.176
ENSG00000102054 E019 350.846000 1.572006e-01 9.913880e-01 9.974613e-01 X 16852876 16853681 806 - 2.443 2.574 0.437
ENSG00000102054 E020 1710.488744 7.526643e-05 2.518746e-01 4.899313e-01 X 16853682 16853842 161 - 3.159 3.189 0.102
ENSG00000102054 E021 1793.041141 9.716024e-05 2.152289e-03 1.809088e-02 X 16857594 16857709 116 - 3.190 3.177 -0.043
ENSG00000102054 E022 1851.018885 6.700134e-05 7.309431e-08 2.805219e-06 X 16858676 16858822 147 - 3.209 3.174 -0.116
ENSG00000102054 E023 962.247998 4.980001e-04 7.299638e-03 4.606468e-02 X 16858823 16858849 27 - 2.922 2.894 -0.093
ENSG00000102054 E024 840.123239 5.583447e-04 1.339359e-03 1.245572e-02 X 16862955 16862956 2 - 2.866 2.825 -0.137
ENSG00000102054 E025 1709.381178 5.800692e-05 2.429186e-10 1.587882e-08 X 16862957 16863100 144 - 3.177 3.130 -0.155
ENSG00000102054 E026 946.865750 1.118749e-04 3.238418e-06 7.925607e-05 X 16869076 16869115 40 - 2.920 2.873 -0.157
ENSG00000102054 E027 1139.995722 7.638223e-05 3.981190e-05 6.847251e-04 X 16869116 16869220 105 - 2.998 2.965 -0.110
ENSG00000102054 E028 2.384165 1.001492e-02 4.433080e-01 6.609370e-01 X 16869221 16869254 34 - 0.446 0.592 0.699
ENSG00000102054 E029 52.332018 7.219501e-04 9.411589e-01 9.728141e-01 X 16869494 16870037 544 - 1.659 1.682 0.079
ENSG00000102054 E030 519.880561 4.456881e-04 3.358183e-04 4.097188e-03 X 16870038 16870046 9 - 2.662 2.605 -0.190
ENSG00000102054 E031 1092.903242 2.412153e-04 4.533772e-02 1.684325e-01 X 16870047 16870362 316 - 2.975 2.965 -0.032