ENSG00000102034

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308167 ENSG00000102034 HEK293_OSMI2_6hA HEK293_TMG_6hB ELF4 protein_coding protein_coding 6.885605 12.10165 2.044017 2.45227 0.1284323 -2.559875 1.6239977 2.647690 0.2521446 0.63894841 0.09164597 -3.3417383 0.20572083 0.2148333 0.1299667 -0.08486667 0.58340461 0.02213154 FALSE TRUE
ENST00000335997 ENSG00000102034 HEK293_OSMI2_6hA HEK293_TMG_6hB ELF4 protein_coding protein_coding 6.885605 12.10165 2.044017 2.45227 0.1284323 -2.559875 4.8332027 8.882339 1.5031667 1.71594298 0.29673613 -2.5549921 0.70247083 0.7386000 0.7232333 -0.01536667 1.00000000 0.02213154 FALSE TRUE
MSTRG.34864.5 ENSG00000102034 HEK293_OSMI2_6hA HEK293_TMG_6hB ELF4 protein_coding   6.885605 12.10165 2.044017 2.45227 0.1284323 -2.559875 0.2334185 0.225123 0.2887053 0.06645984 0.09082284 0.3453069 0.06375417 0.0205000 0.1468000 0.12630000 0.02213154 0.02213154 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000102034 E001 30.239350 0.0100001977 0.0389056568 0.15192521 X 130063955 130064873 919 - 1.004 1.363 1.282
ENSG00000102034 E002 477.540380 1.1475567600 0.3788405588 0.61127484 X 130064874 130067125 2252 - 2.265 2.535 0.902
ENSG00000102034 E003 37.805373 0.0029167960 0.0752565620 0.23533421 X 130067126 130067145 20 - 1.177 1.450 0.957
ENSG00000102034 E004 94.523947 0.1301405107 0.1118947823 0.30225208 X 130067146 130067525 380 - 1.527 1.841 1.065
ENSG00000102034 E005 97.460397 0.0004714335 0.0142700365 0.07541286 X 130069300 130069677 378 - 1.847 1.822 -0.083
ENSG00000102034 E006 70.347558 0.0009039098 0.0307739749 0.12967418 X 130071040 130071232 193 - 1.710 1.678 -0.109
ENSG00000102034 E007 54.526211 0.0007842684 0.4182648565 0.64232613 X 130071336 130071419 84 - 1.542 1.582 0.137
ENSG00000102034 E008 74.997356 0.0474067410 0.1578591246 0.37352414 X 130072226 130072417 192 - 1.754 1.704 -0.170
ENSG00000102034 E009 41.800295 0.0043003409 0.0204202976 0.09737772 X 130074049 130074104 56 - 1.542 1.454 -0.302
ENSG00000102034 E010 34.867373 0.0037166406 0.0167549242 0.08457292 X 130074105 130074141 37 - 1.487 1.384 -0.355
ENSG00000102034 E011 59.203607 0.0019283969 0.0006834632 0.00729986 X 130074581 130074752 172 - 1.717 1.600 -0.398
ENSG00000102034 E012 24.623144 0.0513077708 0.0097556054 0.05707338 X 130081256 130081312 57 - 1.454 1.205 -0.868
ENSG00000102034 E013 29.298544 0.0460190647 0.0562485838 0.19420682 X 130081313 130081436 124 - 1.442 1.292 -0.520
ENSG00000102034 E014 19.145104 0.0226292163 0.8647151740 0.93297580 X 130081437 130081539 103 - 1.038 1.154 0.419
ENSG00000102034 E015 10.362823 0.0470927248 0.5589465390 0.74250028 X 130110325 130110473 149 - 0.711 0.917 0.808
ENSG00000102034 E016 4.948733 0.0267408322 0.1543743984 0.36852805 X 130110474 130110529 56 - 0.261 0.659 2.113
ENSG00000102034 E017 8.932915 0.0040797622 0.6188110118 0.78303759 X 130110620 130110842 223 - 0.710 0.878 0.666