ENSG00000101974

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327569 ENSG00000101974 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP11C protein_coding protein_coding 12.67722 5.851825 20.10135 1.153821 0.3901109 1.778588 0.9550606 0.918055 1.479719 0.6776088 0.7486893 0.6827577 0.0614875 0.16846667 0.07256667 -0.0959000 9.527941e-01 2.570833e-08 FALSE TRUE
ENST00000361648 ENSG00000101974 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP11C protein_coding protein_coding 12.67722 5.851825 20.10135 1.153821 0.3901109 1.778588 2.6734044 0.537428 6.006478 0.5374280 0.5753442 3.4581780 0.2211042 0.06956667 0.29796667 0.2284000 2.181198e-01 2.570833e-08 FALSE TRUE
ENST00000433868 ENSG00000101974 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP11C protein_coding protein_coding 12.67722 5.851825 20.10135 1.153821 0.3901109 1.778588 1.1581805 1.718360 0.000000 0.8912080 0.0000000 -7.4332597 0.2160833 0.25656667 0.00000000 -0.2565667 2.570833e-08 2.570833e-08 FALSE TRUE
ENST00000682941 ENSG00000101974 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP11C protein_coding protein_coding 12.67722 5.851825 20.10135 1.153821 0.3901109 1.778588 2.1102635 1.062383 1.891391 0.1451397 0.4323654 0.8262346 0.1419708 0.19610000 0.09433333 -0.1017667 3.849752e-01 2.570833e-08 FALSE TRUE
MSTRG.34986.7 ENSG00000101974 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP11C protein_coding   12.67722 5.851825 20.10135 1.153821 0.3901109 1.778588 3.7501595 1.017756 7.383354 0.1624522 0.7414497 2.8467309 0.2159667 0.20316667 0.36903333 0.1658667 4.418249e-01 2.570833e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000101974 E001 0.0000000       X 139726346 139726347 2 -      
ENSG00000101974 E002 0.0000000       X 139726348 139726348 1 -      
ENSG00000101974 E003 0.1723744 0.0408656301 1.338402e-01   X 139726349 139726352 4 - 0.000 0.203 11.175
ENSG00000101974 E004 43.3153446 0.0157975685 2.264588e-03 1.882423e-02 X 139726353 139726540 188 - 1.495 1.763 0.913
ENSG00000101974 E005 274.3295742 0.0017329745 3.659988e-09 1.890359e-07 X 139726541 139727215 675 - 2.315 2.499 0.613
ENSG00000101974 E006 363.2050689 0.0034602686 2.897589e-04 3.626749e-03 X 139727216 139728591 1376 - 2.453 2.584 0.437
ENSG00000101974 E007 92.2849076 0.0017239140 9.485659e-02 2.727121e-01 X 139728592 139728785 194 - 1.872 1.962 0.302
ENSG00000101974 E008 105.8988208 0.0003891706 4.622215e-01 6.746717e-01 X 139728786 139728962 177 - 1.946 1.990 0.145
ENSG00000101974 E009 24.7422072 0.0158308164 1.386510e-08 6.295759e-07 X 139731651 139731755 105 - 1.157 1.691 1.848
ENSG00000101974 E010 3.6002958 0.0075088616 9.648129e-01 9.843406e-01 X 139732435 139732525 91 - 0.598 0.600 0.009
ENSG00000101974 E011 1.5713612 0.0113940787 8.105578e-01 9.025820e-01 X 139737731 139737796 66 - 0.379 0.341 -0.226
ENSG00000101974 E012 96.4217033 0.0030346651 7.843155e-02 2.416583e-01 X 139737916 139738069 154 - 1.931 1.857 -0.249
ENSG00000101974 E013 95.4591588 0.0088599178 3.562042e-01 5.926953e-01 X 139740991 139741094 104 - 1.919 1.881 -0.129
ENSG00000101974 E014 84.1059456 0.0004866586 3.626258e-01 5.978507e-01 X 139743559 139743624 66 - 1.844 1.898 0.182
ENSG00000101974 E015 107.8612386 0.0004297172 1.795573e-01 4.033820e-01 X 139745722 139745857 136 - 1.947 2.013 0.221
ENSG00000101974 E016 106.8299811 0.0003791315 4.514642e-01 6.666813e-01 X 139750025 139750152 128 - 1.949 1.992 0.146
ENSG00000101974 E017 68.1963975 0.0006590046 2.854596e-01 5.260556e-01 X 139757808 139757867 60 - 1.775 1.733 -0.142
ENSG00000101974 E018 85.1209921 0.0005133778 7.120955e-01 8.431421e-01 X 139761961 139762097 137 - 1.855 1.885 0.101
ENSG00000101974 E019 36.9710116 0.0013075051 6.090697e-01 7.762665e-01 X 139762098 139762106 9 - 1.496 1.544 0.164
ENSG00000101974 E020 72.6484382 0.0005696306 8.682841e-01 9.350383e-01 X 139763316 139763418 103 - 1.794 1.800 0.019
ENSG00000101974 E021 92.2791137 0.0004192121 8.462155e-01 9.228541e-01 X 139768260 139768434 175 - 1.896 1.902 0.018
ENSG00000101974 E022 109.1333494 0.0022750331 6.477526e-01 8.020480e-01 X 139774690 139774953 264 - 1.970 1.962 -0.027
ENSG00000101974 E023 43.8432449 0.0011581350 2.281610e-01 4.631316e-01 X 139782547 139782556 10 - 1.593 1.529 -0.219
ENSG00000101974 E024 99.7480798 0.0005362717 1.093125e-01 2.979756e-01 X 139782557 139782728 172 - 1.943 1.888 -0.183
ENSG00000101974 E025 82.5201396 0.0006156497 6.388516e-01 7.961952e-01 X 139783164 139783267 104 - 1.854 1.846 -0.026
ENSG00000101974 E026 68.5890718 0.0006222168 8.917605e-01 9.474920e-01 X 139785226 139785299 74 - 1.771 1.778 0.024
ENSG00000101974 E027 72.4406137 0.0006683641 3.818223e-01 6.137701e-01 X 139787173 139787244 72 - 1.803 1.774 -0.099
ENSG00000101974 E028 95.3426359 0.0005885703 5.866106e-02 1.997593e-01 X 139788192 139788343 152 - 1.930 1.860 -0.233
ENSG00000101974 E029 93.9690795 0.0005520396 4.000963e-04 4.731585e-03 X 139789327 139789488 162 - 1.933 1.783 -0.506
ENSG00000101974 E030 98.7261997 0.0231511450 2.579716e-01 4.967120e-01 X 139796273 139796470 198 - 1.944 1.855 -0.300
ENSG00000101974 E031 79.1378779 0.0006872449 6.345393e-03 4.143316e-02 X 139797176 139797326 151 - 1.858 1.738 -0.408
ENSG00000101974 E032 68.1484747 0.0006050107 2.267506e-03 1.884388e-02 X 139798273 139798354 82 - 1.799 1.649 -0.507
ENSG00000101974 E033 64.0437742 0.0007575646 2.532978e-02 1.132114e-01 X 139798679 139798743 65 - 1.767 1.660 -0.364
ENSG00000101974 E034 68.4676312 0.0019268617 1.837008e-02 9.025493e-02 X 139800060 139800110 51 - 1.797 1.681 -0.393
ENSG00000101974 E035 74.2939471 0.0021879613 4.468051e-03 3.176264e-02 X 139802236 139802301 66 - 1.835 1.692 -0.483
ENSG00000101974 E036 56.6923845 0.0008105342 1.330437e-03 1.238699e-02 X 139802302 139802339 38 - 1.723 1.544 -0.607
ENSG00000101974 E037 95.9903050 0.0004367923 4.170641e-04 4.897461e-03 X 139804471 139804599 129 - 1.945 1.800 -0.489
ENSG00000101974 E038 91.6701403 0.0012546211 1.669076e-03 1.480762e-02 X 139814878 139814985 108 - 1.920 1.783 -0.464
ENSG00000101974 E039 70.9827852 0.0007176157 6.011686e-05 9.753117e-04 X 139816863 139816943 81 - 1.822 1.619 -0.690
ENSG00000101974 E040 47.8794059 0.0008430082 1.883390e-03 1.628694e-02 X 139819338 139819427 90 - 1.651 1.463 -0.643
ENSG00000101974 E041 44.1266704 0.0008198781 5.704743e-01 7.505946e-01 X 139826704 139826823 120 - 1.587 1.566 -0.074
ENSG00000101974 E042 0.2735028 0.0254965323 3.801360e-01   X 139832154 139832288 135 - 0.070 0.203 1.773
ENSG00000101974 E043 25.7015406 0.0016820319 6.934652e-01 8.313298e-01 X 139932016 139932087 72 - 1.341 1.385 0.152
ENSG00000101974 E044 20.9733236 0.0016960489 5.741769e-03 3.845274e-02 X 139932088 139932498 411 - 1.209 1.445 0.822
ENSG00000101974 E045 4.6025943 0.0086051003 3.692852e-02 1.467284e-01 X 139932499 139932568 70 - 0.599 0.911 1.268
ENSG00000101974 E046 9.1623451 0.0375309586 2.367013e-01 4.727818e-01 X 139932569 139932645 77 - 0.894 1.067 0.644
ENSG00000101974 E047 20.2051092 0.0144881562 6.214567e-03 4.078907e-02 X 139932646 139933000 355 - 1.176 1.452 0.964
ENSG00000101974 E048 6.1841629 0.0043644209 1.610141e-02 8.216808e-02 X 139933001 139933075 75 - 0.700 1.023 1.249
ENSG00000101974 E049 0.0000000       X 139945200 139945276 77 -