ENSG00000101966

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000371199 ENSG00000101966 HEK293_OSMI2_6hA HEK293_TMG_6hB XIAP protein_coding protein_coding 6.456743 2.500557 10.37646 0.5990504 0.1639716 2.048624 1.4979687 0.99139728 1.8561935 0.45153298 0.72764100 0.8980841 0.19038750 0.35516667 0.17983333 -0.17533333 6.786419e-01 1.705648e-05 FALSE TRUE
ENST00000434753 ENSG00000101966 HEK293_OSMI2_6hA HEK293_TMG_6hB XIAP protein_coding protein_coding 6.456743 2.500557 10.37646 0.5990504 0.1639716 2.048624 1.7858933 0.66575509 3.3701581 0.41757584 0.34612800 2.3225184 0.31599167 0.28970000 0.32436667 0.03466667 9.376591e-01 1.705648e-05 FALSE TRUE
ENST00000481776 ENSG00000101966 HEK293_OSMI2_6hA HEK293_TMG_6hB XIAP protein_coding processed_transcript 6.456743 2.500557 10.37646 0.5990504 0.1639716 2.048624 0.8028552 0.04475969 2.4101640 0.04475969 0.31537033 5.4658466 0.08711250 0.01523333 0.23316667 0.21793333 2.304470e-03 1.705648e-05 FALSE FALSE
ENST00000496602 ENSG00000101966 HEK293_OSMI2_6hA HEK293_TMG_6hB XIAP protein_coding processed_transcript 6.456743 2.500557 10.37646 0.5990504 0.1639716 2.048624 0.8513363 0.47193742 0.5725025 0.25823489 0.12911540 0.2734184 0.19630833 0.15493333 0.05516667 -0.09976667 8.096142e-01 1.705648e-05   FALSE
MSTRG.34828.4 ENSG00000101966 HEK293_OSMI2_6hA HEK293_TMG_6hB XIAP protein_coding   6.456743 2.500557 10.37646 0.5990504 0.1639716 2.048624 0.1904013 0.13730487 0.0000000 0.13730487 0.00000000 -3.8807332 0.03955417 0.10436667 0.00000000 -0.10436667 7.521915e-01 1.705648e-05 FALSE TRUE
MSTRG.34828.7 ENSG00000101966 HEK293_OSMI2_6hA HEK293_TMG_6hB XIAP protein_coding   6.456743 2.500557 10.37646 0.5990504 0.1639716 2.048624 0.3165557 0.00000000 0.9629864 0.00000000 0.08714488 6.6043477 0.03375833 0.00000000 0.09260000 0.09260000 2.512784e-05 1.705648e-05 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000101966 E001 0.0000000       X 123859724 123859763 40 +      
ENSG00000101966 E002 1.2917014 0.015635953 4.596073e-01   X 123859764 123859811 48 + 0.310 0.230 -0.578
ENSG00000101966 E003 2.0660194 0.015779210 4.946542e-01 6.972031e-01 X 123859812 123859826 15 + 0.422 0.379 -0.232
ENSG00000101966 E004 6.9389982 0.004194440 1.439348e-01 3.533009e-01 X 123859827 123859876 50 + 0.813 0.716 -0.392
ENSG00000101966 E005 6.9861139 0.004553092 6.153717e-02 2.062477e-01 X 123859877 123859877 1 + 0.823 0.653 -0.693
ENSG00000101966 E006 9.6296367 0.003158610 3.180090e-03 2.448884e-02 X 123859878 123859905 28 + 0.963 0.653 -1.226
ENSG00000101966 E007 5.6440065 0.068951151 9.852387e-01 9.943967e-01 X 123860053 123860166 114 + 0.701 0.820 0.478
ENSG00000101966 E008 6.6065448 0.055151338 6.273795e-01 7.888135e-01 X 123860167 123860194 28 + 0.783 0.814 0.124
ENSG00000101966 E009 10.3726826 0.009934283 7.851566e-01 8.876465e-01 X 123860195 123860271 77 + 0.919 1.085 0.612
ENSG00000101966 E010 7.2586548 0.004602413 3.708815e-01 6.046226e-01 X 123860272 123860293 22 + 0.761 1.004 0.932
ENSG00000101966 E011 0.3040503 0.024441170 9.316680e-01   X 123860294 123860453 160 + 0.113 0.001 -7.121
ENSG00000101966 E012 2.0346143 0.009895612 5.020610e-01 7.022511e-01 X 123860454 123860545 92 + 0.421 0.380 -0.227
ENSG00000101966 E013 43.0884164 0.001034873 2.057650e-02 9.794813e-02 X 123885631 123886130 500 + 1.534 1.521 -0.044
ENSG00000101966 E014 28.6832500 0.029125519 4.854089e-01 6.908298e-01 X 123886131 123886298 168 + 1.352 1.398 0.158
ENSG00000101966 E015 31.8150972 0.004725660 4.499834e-02 1.675837e-01 X 123886299 123886539 241 + 1.408 1.381 -0.092
ENSG00000101966 E016 37.8360189 0.019284979 1.044958e-02 6.007375e-02 X 123888619 123888718 100 + 1.495 1.390 -0.363
ENSG00000101966 E017 42.6413698 0.012593743 5.595731e-03 3.771117e-02 X 123891238 123891309 72 + 1.543 1.449 -0.325
ENSG00000101966 E018 28.3406330 0.002205559 2.368021e-03 1.948988e-02 X 123891310 123891316 7 + 1.374 1.250 -0.431
ENSG00000101966 E019 44.6965341 0.005846794 1.137704e-06 3.177247e-05 X 123892731 123892773 43 + 1.583 1.327 -0.882
ENSG00000101966 E020 72.4175522 0.004090299 8.756227e-09 4.168794e-07 X 123900493 123900693 201 + 1.787 1.563 -0.761
ENSG00000101966 E021 757.0082345 0.006496319 8.703782e-02 2.583327e-01 X 123906988 123912759 5772 + 2.744 2.851 0.355
ENSG00000101966 E022 48.0440016 0.076179378 1.066374e-02 6.095825e-02 X 123912760 123912991 232 + 1.445 1.928 1.641
ENSG00000101966 E023 18.7829842 0.537774316 1.636886e-01 3.822147e-01 X 123912992 123913016 25 + 1.060 1.527 1.641
ENSG00000101966 E024 46.9055376 0.803320517 1.327727e-01 3.361588e-01 X 123913017 123913244 228 + 1.377 1.989 2.080
ENSG00000101966 E025 18.2068661 0.453713886 5.203806e-02 1.845046e-01 X 123913245 123913277 33 + 0.976 1.607 2.220
ENSG00000101966 E026 59.5045528 0.877698765 1.476213e-01 3.588840e-01 X 123913278 123913976 699 + 1.479 2.088 2.061