ENSG00000101773

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327155 ENSG00000101773 HEK293_OSMI2_6hA HEK293_TMG_6hB RBBP8 protein_coding protein_coding 23.20563 9.813991 37.90148 2.184807 2.825767 1.948254 11.3725242 2.980425 18.955803 0.6083673 1.4078925 2.66497785 0.4250000 0.3070667 0.50050000 0.193433333 1.207431e-04 8.179943e-19 FALSE TRUE
ENST00000399722 ENSG00000101773 HEK293_OSMI2_6hA HEK293_TMG_6hB RBBP8 protein_coding protein_coding 23.20563 9.813991 37.90148 2.184807 2.825767 1.948254 0.8147054 1.630753 0.000000 0.5124815 0.0000000 -7.35821431 0.0634750 0.1579667 0.00000000 -0.157966667 8.179943e-19 8.179943e-19 FALSE TRUE
ENST00000583057 ENSG00000101773 HEK293_OSMI2_6hA HEK293_TMG_6hB RBBP8 protein_coding protein_coding 23.20563 9.813991 37.90148 2.184807 2.825767 1.948254 2.1729411 2.207260 2.176288 0.5880418 1.2742454 -0.02029419 0.1565833 0.2199333 0.05293333 -0.167000000 4.988532e-01 8.179943e-19 FALSE TRUE
MSTRG.15575.10 ENSG00000101773 HEK293_OSMI2_6hA HEK293_TMG_6hB RBBP8 protein_coding   23.20563 9.813991 37.90148 2.184807 2.825767 1.948254 5.7708260 2.740836 10.248858 0.8187942 0.7865603 1.89892821 0.2301042 0.2765000 0.27043333 -0.006066667 1.000000e+00 8.179943e-19 FALSE TRUE
MSTRG.15575.11 ENSG00000101773 HEK293_OSMI2_6hA HEK293_TMG_6hB RBBP8 protein_coding   23.20563 9.813991 37.90148 2.184807 2.825767 1.948254 1.8926216 0.000000 5.027036 0.0000000 0.5845436 8.97643125 0.0505875 0.0000000 0.13650000 0.136500000 4.949555e-11 8.179943e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000101773 E001 0.0000000       18 22798261 22798487 227 +      
ENSG00000101773 E002 0.0000000       18 22911600 22911685 86 +      
ENSG00000101773 E003 0.0000000       18 22914121 22914122 2 +      
ENSG00000101773 E004 0.0000000       18 22914123 22914138 16 +      
ENSG00000101773 E005 0.0000000       18 22914139 22914306 168 +      
ENSG00000101773 E006 0.0000000       18 22915420 22915485 66 +      
ENSG00000101773 E007 0.1779838 0.0403701578 1.000000e+00   18 22916941 22917026 86 + 0.070 0.000 -7.615
ENSG00000101773 E008 0.0000000       18 22929383 22929437 55 +      
ENSG00000101773 E009 1.4944356 0.0132745227 9.687249e-01 9.861870e-01 18 22933328 22933348 21 + 0.348 0.340 -0.048
ENSG00000101773 E010 57.9321535 0.0007166905 1.862769e-04 2.521380e-03 18 22933349 22933564 216 + 1.745 1.519 -0.769
ENSG00000101773 E011 0.0000000       18 22933826 22933840 15 +      
ENSG00000101773 E012 0.2735028 0.0274424043 3.677878e-01   18 22933841 22933858 18 + 0.070 0.202 1.760
ENSG00000101773 E013 1.2062158 0.0222191398 1.044956e-01   18 22933859 22933870 12 + 0.231 0.527 1.755
ENSG00000101773 E014 1.9617528 0.0190902723 2.269503e-01 4.617172e-01 18 22933871 22933875 5 + 0.380 0.597 1.077
ENSG00000101773 E015 8.2664812 0.0114855305 8.575112e-01 9.290989e-01 18 22933876 22933880 5 + 0.912 0.938 0.099
ENSG00000101773 E016 50.6038460 0.0007756292 2.308352e-01 4.661306e-01 18 22933881 22934078 198 + 1.629 1.696 0.228
ENSG00000101773 E017 37.0172074 0.0010777578 7.045383e-01 8.384713e-01 18 22934079 22934159 81 + 1.510 1.534 0.083
ENSG00000101773 E018 1.4983797 0.0143958826 9.787952e-01 9.911981e-01 18 22934160 22934264 105 + 0.348 0.340 -0.044
ENSG00000101773 E019 0.0000000       18 22934750 22934774 25 +      
ENSG00000101773 E020 197.6047282 0.0009453938 1.332065e-03 1.239944e-02 18 22936754 22936960 207 + 2.253 2.144 -0.363
ENSG00000101773 E021 0.6129023 0.0189712222 9.615086e-01   18 22937060 22937118 59 + 0.183 0.202 0.174
ENSG00000101773 E022 0.1779838 0.0403701578 1.000000e+00   18 22946339 22946443 105 + 0.070 0.000 -9.825
ENSG00000101773 E023 100.9569265 0.0005244542 2.104921e-02 9.951670e-02 18 22946444 22946486 43 + 1.963 1.862 -0.339
ENSG00000101773 E024 133.8463496 0.0068382862 4.609084e-02 1.702472e-01 18 22949618 22949713 96 + 2.083 1.979 -0.348
ENSG00000101773 E025 0.5705386 0.8496899323 8.742595e-01   18 22949714 22950035 322 + 0.221 0.000 -10.319
ENSG00000101773 E026 89.8553704 0.0005198269 3.210726e-01 5.606217e-01 18 22968806 22968841 36 + 1.900 1.855 -0.153
ENSG00000101773 E027 105.1478915 0.0004160844 1.352975e-01 3.402113e-01 18 22968842 22968918 77 + 1.969 1.906 -0.213
ENSG00000101773 E028 72.0642472 0.0005168033 3.945528e-02 1.533521e-01 18 22975153 22975180 28 + 1.817 1.711 -0.358
ENSG00000101773 E029 72.6101989 0.0008397726 3.562540e-01 5.927491e-01 18 22975181 22975219 39 + 1.810 1.763 -0.160
ENSG00000101773 E030 0.7577498 0.0751852155 9.753543e-01   18 22977790 22977887 98 + 0.230 0.202 -0.245
ENSG00000101773 E031 167.7802983 0.0005100907 1.946905e-02 9.407308e-02 18 22982218 22982393 176 + 2.174 2.093 -0.273
ENSG00000101773 E032 146.1974876 0.0007568531 4.396144e-02 1.649870e-01 18 22984886 22984990 105 + 2.114 2.037 -0.257
ENSG00000101773 E033 108.9241907 0.0005662167 3.986071e-01 6.271484e-01 18 22989221 22989271 51 + 1.980 1.943 -0.123
ENSG00000101773 E034 105.2138288 0.0014634121 5.202898e-01 7.151287e-01 18 22989272 22989318 47 + 1.963 1.931 -0.108
ENSG00000101773 E035 152.1349979 0.0022921884 1.436360e-01 3.528320e-01 18 22990937 22991049 113 + 2.129 2.066 -0.211
ENSG00000101773 E036 426.2157921 0.0002452898 1.795582e-01 4.033820e-01 18 22992748 22993483 736 + 2.566 2.538 -0.095
ENSG00000101773 E037 175.2017099 0.0002827604 1.959273e-01 4.244691e-01 18 22993484 22993639 156 + 2.166 2.204 0.129
ENSG00000101773 E038 182.3450719 0.0009496763 3.135200e-01 5.537358e-01 18 22993721 22993847 127 + 2.200 2.163 -0.123
ENSG00000101773 E039 169.0911712 0.0044384348 5.334253e-01 7.245253e-01 18 22996374 22996462 89 + 2.165 2.134 -0.103
ENSG00000101773 E040 217.0121240 0.0020185398 6.848729e-02 2.217064e-01 18 22997620 22997734 115 + 2.252 2.309 0.191
ENSG00000101773 E041 1.1058952 0.0145191552 7.225433e-01   18 23001571 23001585 15 + 0.273 0.340 0.438
ENSG00000101773 E042 240.4671380 0.0002292310 2.458710e-03 2.006176e-02 18 23001586 23001729 144 + 2.293 2.370 0.256
ENSG00000101773 E043 157.5921614 0.0002761306 3.561133e-05 6.242386e-04 18 23006363 23006432 70 + 2.096 2.225 0.429
ENSG00000101773 E044 1.3493278 0.1545115423 3.418190e-02   18 23016796 23016827 32 + 0.184 0.602 2.506
ENSG00000101773 E045 185.1067704 0.0002466141 6.087933e-08 2.378355e-06 18 23016828 23016924 97 + 2.158 2.312 0.514
ENSG00000101773 E046 177.8572813 0.0010722996 3.516450e-04 4.255802e-03 18 23022129 23022270 142 + 2.153 2.267 0.382
ENSG00000101773 E047 139.8476359 0.0003499995 2.546216e-02 1.136386e-01 18 23026143 23026488 346 + 2.060 2.135 0.251