ENSG00000101752

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261537 ENSG00000101752 HEK293_OSMI2_6hA HEK293_TMG_6hB MIB1 protein_coding protein_coding 10.31988 2.301826 20.15309 0.4347661 0.508852 3.124612 4.4613296 0.7738640 6.9323563 0.2646801 0.04533668 3.146750 0.3345333 0.3115333 0.344533333 0.0330000 0.93346535 0.01583555 FALSE TRUE
ENST00000578646 ENSG00000101752 HEK293_OSMI2_6hA HEK293_TMG_6hB MIB1 protein_coding processed_transcript 10.31988 2.301826 20.15309 0.4347661 0.508852 3.124612 0.3151174 0.7466638 0.2447798 0.1439346 0.14173962 -1.570401 0.1133292 0.3844000 0.012500000 -0.3719000 0.01583555 0.01583555 FALSE TRUE
ENST00000695487 ENSG00000101752 HEK293_OSMI2_6hA HEK293_TMG_6hB MIB1 protein_coding retained_intron 10.31988 2.301826 20.15309 0.4347661 0.508852 3.124612 0.4591675 0.3711381 0.1735493 0.3467724 0.08543106 -1.054146 0.1651417 0.1340000 0.008466667 -0.1255333 0.68524328 0.01583555 FALSE FALSE
MSTRG.15558.4 ENSG00000101752 HEK293_OSMI2_6hA HEK293_TMG_6hB MIB1 protein_coding   10.31988 2.301826 20.15309 0.4347661 0.508852 3.124612 4.6735038 0.3141677 12.3207119 0.3141677 0.70651131 5.249372 0.3469583 0.1226667 0.610400000 0.4877333 0.13717487 0.01583555 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000101752 E001 1.7545066 0.0113192189 3.550822e-03 2.665243e-02 18 21704957 21705123 167 + 0.199 0.805 3.214
ENSG00000101752 E002 27.9251425 0.0031788858 9.453870e-03 5.576342e-02 18 21740792 21741548 757 + 1.172 1.522 1.220
ENSG00000101752 E003 41.5218146 0.0029408942 9.535758e-01 9.786969e-01 18 21741549 21741812 264 + 1.375 1.493 0.407
ENSG00000101752 E004 77.4867623 0.0006462113 1.026704e-04 1.528920e-03 18 21765772 21765943 172 + 1.659 1.478 -0.617
ENSG00000101752 E005 75.6137462 0.0007225285 9.545905e-06 2.013306e-04 18 21768623 21768752 130 + 1.650 1.411 -0.820
ENSG00000101752 E006 64.7904473 0.0075135427 6.990764e-03 4.459332e-02 18 21773624 21773728 105 + 1.579 1.445 -0.459
ENSG00000101752 E007 53.9857386 0.0074426739 1.253811e-01 3.244364e-01 18 21778103 21778169 67 + 1.495 1.462 -0.112
ENSG00000101752 E008 104.7384663 0.0017087031 4.239132e-02 1.609619e-01 18 21779481 21779685 205 + 1.774 1.764 -0.035
ENSG00000101752 E009 2.3020776 0.0283289438 6.708460e-01 8.168898e-01 18 21791335 21791373 39 + 0.336 0.498 0.884
ENSG00000101752 E010 103.1063268 0.0004102472 3.369669e-02 1.380639e-01 18 21791374 21791557 184 + 1.767 1.756 -0.037
ENSG00000101752 E011 92.4023016 0.0005398939 2.625074e-03 2.111986e-02 18 21798084 21798228 145 + 1.726 1.644 -0.279
ENSG00000101752 E012 89.3522651 0.0343930611 1.125740e-01 3.034503e-01 18 21799841 21799974 134 + 1.710 1.669 -0.138
ENSG00000101752 E013 0.3150090 0.0310551964 1.211472e-01   18 21803733 21803906 174 + 0.040 0.318 3.480
ENSG00000101752 E014 75.0392039 0.0006197359 4.713257e-02 1.728469e-01 18 21803907 21804014 108 + 1.635 1.611 -0.083
ENSG00000101752 E015 2.3670490 0.0099694517 8.512287e-02 2.548314e-01 18 21808612 21808738 127 + 0.315 0.724 2.014
ENSG00000101752 E016 1.1230109 0.6298388857 1.981799e-01   18 21812392 21812468 77 + 0.139 0.636 3.138
ENSG00000101752 E017 89.3238532 0.0031544307 1.394362e-02 7.411415e-02 18 21815616 21815813 198 + 1.712 1.654 -0.199
ENSG00000101752 E018 0.1779838 0.0355433027 6.611962e-01   18 21819065 21819494 430 + 0.040 0.000 -22.602
ENSG00000101752 E019 86.9439972 0.0034099834 1.846470e-01 4.100227e-01 18 21819495 21819646 152 + 1.692 1.713 0.070
ENSG00000101752 E020 95.5092883 0.0029438590 2.874105e-01 5.281800e-01 18 21838365 21838497 133 + 1.728 1.772 0.149
ENSG00000101752 E021 1.0767030 0.5016238141 2.817443e-01   18 21838498 21839853 1356 + 0.166 0.505 2.238
ENSG00000101752 E022 90.9635249 0.0004906557 3.588260e-01 5.948479e-01 18 21843131 21843217 87 + 1.705 1.764 0.199
ENSG00000101752 E023 113.6916236 0.0008049749 1.825216e-02 8.986154e-02 18 21844092 21844253 162 + 1.810 1.787 -0.077
ENSG00000101752 E024 105.0699005 0.0079892781 2.072987e-02 9.842893e-02 18 21846944 21847125 182 + 1.779 1.713 -0.224
ENSG00000101752 E025 125.2437344 0.0014717483 1.669800e-03 1.481095e-02 18 21849196 21849388 193 + 1.856 1.787 -0.232
ENSG00000101752 E026 2.9924394 0.1088358940 4.385580e-01 6.576814e-01 18 21852225 21853139 915 + 0.390 0.632 1.175
ENSG00000101752 E027 87.1174863 0.0007090993 8.243873e-04 8.476624e-03 18 21853140 21853218 79 + 1.704 1.587 -0.397
ENSG00000101752 E028 115.2642299 0.0004201614 8.681523e-03 5.239055e-02 18 21857130 21857243 114 + 1.815 1.780 -0.119
ENSG00000101752 E029 116.9500401 0.0003360097 3.307366e-04 4.044259e-03 18 21858546 21858646 101 + 1.826 1.730 -0.324
ENSG00000101752 E030 1681.7747549 0.0080439160 3.722345e-08 1.532460e-06 18 21864526 21870953 6428 + 2.944 3.186 0.805