ENSG00000101680

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000389658 ENSG00000101680 HEK293_OSMI2_6hA HEK293_TMG_6hB LAMA1 protein_coding protein_coding 2.98493 3.527102 2.34516 0.5531236 0.06679988 -0.5867428 1.745124 2.081433 1.8557260 0.3692374 0.054178187 -0.1647549 0.6240375 0.5865000 0.7915333 0.2050333 0.03448715 0.03448715 FALSE TRUE
ENST00000488064 ENSG00000101680 HEK293_OSMI2_6hA HEK293_TMG_6hB LAMA1 protein_coding retained_intron 2.98493 3.527102 2.34516 0.5531236 0.06679988 -0.5867428 0.998279 1.135902 0.2713572 0.3371693 0.004460244 -2.0260089 0.2910042 0.3072333 0.1158333 -0.1914000 0.07263826 0.03448715 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000101680 E001 1.2439501 0.013708632 0.1118407461   18 6941742 6941888 147 - 0.148 0.445 2.137
ENSG00000101680 E002 6.0908030 0.004576124 0.1340179632 0.338117016 18 6941889 6941947 59 - 0.705 0.912 0.816
ENSG00000101680 E003 42.5829801 0.001882745 0.0031991607 0.024601117 18 6941948 6942239 292 - 1.504 1.687 0.623
ENSG00000101680 E004 47.8966637 0.011575892 0.0182250426 0.089773011 18 6943180 6943402 223 - 1.559 1.736 0.601
ENSG00000101680 E005 36.6057550 0.002456413 0.1613701856 0.378780205 18 6947163 6947296 134 - 1.504 1.600 0.330
ENSG00000101680 E006 38.0525900 0.001126903 0.3156838904 0.555689497 18 6948403 6948556 154 - 1.541 1.609 0.230
ENSG00000101680 E007 34.5790616 0.001049358 0.5234458424 0.717423168 18 6949101 6949259 159 - 1.510 1.557 0.161
ENSG00000101680 E008 29.2638234 0.001621010 0.1049767009 0.290606308 18 6950782 6950971 190 - 1.398 1.514 0.402
ENSG00000101680 E009 1.1488064 0.246861228 0.8485889934   18 6953730 6955352 1623 - 0.349 0.306 -0.266
ENSG00000101680 E010 20.5040371 0.002107166 0.0002736423 0.003463830 18 6955353 6955465 113 - 1.107 1.420 1.102
ENSG00000101680 E011 3.4120501 0.265616689 0.9145648429 0.959381839 18 6955466 6956635 1170 - 0.625 0.642 0.073
ENSG00000101680 E012 20.5590660 0.189556736 0.0491641231 0.177597185 18 6956636 6956765 130 - 1.040 1.434 1.394
ENSG00000101680 E013 29.2990319 0.058353222 0.2923508403 0.533063087 18 6958477 6958662 186 - 1.383 1.519 0.469
ENSG00000101680 E014 29.9957498 0.013632578 0.8396602729 0.919211651 18 6959341 6959492 152 - 1.469 1.497 0.097
ENSG00000101680 E015 1.7842463 0.011374289 0.6327983437 0.792165441 18 6959493 6960695 1203 - 0.482 0.404 -0.406
ENSG00000101680 E016 22.9800904 0.028573969 0.6789214290 0.822052626 18 6961586 6961692 107 - 1.338 1.396 0.203
ENSG00000101680 E017 17.9682652 0.004807642 0.0450394504 0.167713340 18 6961693 6961759 67 - 1.147 1.335 0.663
ENSG00000101680 E018 19.5840135 0.007939419 0.0315528447 0.131922014 18 6961945 6962059 115 - 1.172 1.377 0.721
ENSG00000101680 E019 0.3150090 0.030057853 0.7305209960   18 6963885 6964137 253 - 0.148 0.099 -0.666
ENSG00000101680 E020 22.2315713 0.004013683 0.1686804568 0.388838995 18 6964662 6964803 142 - 1.286 1.406 0.418
ENSG00000101680 E021 20.7548846 0.001682603 0.3264107188 0.565610052 18 6965288 6965399 112 - 1.276 1.361 0.296
ENSG00000101680 E022 14.8181934 0.002222367 0.1961504296 0.424720826 18 6965400 6965432 33 - 1.107 1.233 0.450
ENSG00000101680 E023 1.6064501 0.199140185 0.5473140098 0.734363115 18 6965433 6965956 524 - 0.481 0.359 -0.657
ENSG00000101680 E024 23.8489828 0.001537842 0.7327492434 0.855820110 18 6966147 6966297 151 - 1.361 1.394 0.115
ENSG00000101680 E025 21.3695572 0.019698526 0.9926440912 0.997980034 18 6971857 6971981 125 - 1.328 1.333 0.017
ENSG00000101680 E026 0.0000000       18 6971982 6972208 227 -      
ENSG00000101680 E027 29.3479632 0.002301808 0.8267689488 0.911905687 18 6973057 6973207 151 - 1.469 1.461 -0.027
ENSG00000101680 E028 22.0918056 0.001993227 0.5517702736 0.737507542 18 6974903 6975036 134 - 1.376 1.341 -0.121
ENSG00000101680 E029 16.6923204 0.008952125 0.4942941444 0.696919123 18 6975937 6976080 144 - 1.194 1.269 0.265
ENSG00000101680 E030 19.4522478 0.010248311 0.8425377098 0.920896294 18 6977727 6977881 155 - 1.303 1.290 -0.043
ENSG00000101680 E031 23.6327328 0.002966518 0.3289261111 0.567888525 18 6978196 6978378 183 - 1.418 1.352 -0.229
ENSG00000101680 E032 14.6441509 0.002598826 0.2767894232 0.516784967 18 6980521 6980637 117 - 1.237 1.147 -0.319
ENSG00000101680 E033 14.9522158 0.002293285 0.5203827227 0.715194069 18 6982497 6982590 94 - 1.147 1.213 0.237
ENSG00000101680 E034 20.9514048 0.003911705 0.8777662667 0.940116111 18 6983099 6983234 136 - 1.329 1.322 -0.025
ENSG00000101680 E035 17.8342249 0.002743027 0.8389256860 0.918798380 18 6985237 6985400 164 - 1.247 1.271 0.083
ENSG00000101680 E036 10.7869746 0.003500886 0.9719012838 0.987857264 18 6985527 6985643 117 - 1.048 1.051 0.011
ENSG00000101680 E037 22.3824759 0.010568147 0.1852705610 0.410923799 18 6986137 6986347 211 - 1.413 1.307 -0.369
ENSG00000101680 E038 20.4273760 0.004852158 0.6450708422 0.800238121 18 6992561 6992720 160 - 1.330 1.300 -0.103
ENSG00000101680 E039 16.2620806 0.002287434 0.6619785256 0.811091385 18 6993641 6993752 112 - 1.237 1.207 -0.107
ENSG00000101680 E040 10.7476271 0.002882240 0.3781818432 0.610675840 18 6995357 6995446 90 - 0.998 1.097 0.362
ENSG00000101680 E041 13.0553030 0.002946486 0.6871072008 0.827231368 18 6997742 6997884 143 - 1.159 1.131 -0.102
ENSG00000101680 E042 20.5188465 0.001882412 0.0582038946 0.198732533 18 6999445 6999638 194 - 1.405 1.270 -0.470
ENSG00000101680 E043 13.5065635 0.002670904 0.1330785752 0.336653792 18 6999911 6999997 87 - 1.227 1.097 -0.463
ENSG00000101680 E044 18.3538307 0.011078203 0.0421993550 0.160430290 18 7002264 7002385 122 - 1.377 1.199 -0.623
ENSG00000101680 E045 18.7360918 0.003054248 0.0082223263 0.050350866 18 7007139 7007276 138 - 1.398 1.193 -0.719
ENSG00000101680 E046 17.0327513 0.002233192 0.0213544475 0.100505973 18 7008488 7008608 121 - 1.345 1.163 -0.642
ENSG00000101680 E047 13.7042924 0.019262817 0.0777076539 0.240202525 18 7009239 7009366 128 - 1.249 1.065 -0.659
ENSG00000101680 E048 14.6074533 0.007504321 0.0150039592 0.078095362 18 7010200 7010385 186 - 1.295 1.071 -0.797
ENSG00000101680 E049 12.8959391 0.005559145 0.1614286266 0.378883271 18 7011300 7011479 180 - 1.206 1.078 -0.458
ENSG00000101680 E050 11.7214231 0.002633735 0.5521568114 0.737794087 18 7011995 7012138 144 - 1.121 1.070 -0.184
ENSG00000101680 E051 16.2904719 0.002923635 0.4088170891 0.635099569 18 7013815 7014051 237 - 1.257 1.193 -0.226
ENSG00000101680 E052 12.5846603 0.018059589 0.4376370219 0.656966597 18 7015722 7015858 137 - 1.159 1.083 -0.273
ENSG00000101680 E053 14.5965788 0.012684144 0.4326916351 0.653276326 18 7016491 7016671 181 - 1.216 1.143 -0.260
ENSG00000101680 E054 13.4382290 0.002854739 0.4703677473 0.680336577 18 7017278 7017384 107 - 1.183 1.123 -0.214
ENSG00000101680 E055 17.1907946 0.002266098 0.6777456710 0.821298723 18 7023164 7023375 212 - 1.267 1.240 -0.097
ENSG00000101680 E056 11.3333754 0.010642417 0.4399093594 0.658644277 18 7024380 7024466 87 - 1.121 1.041 -0.290
ENSG00000101680 E057 13.7601327 0.005380512 0.3123619499 0.552668661 18 7025979 7026106 128 - 1.206 1.115 -0.323
ENSG00000101680 E058 11.2037365 0.014476440 0.4249846167 0.647246664 18 7032066 7032176 111 - 1.121 1.041 -0.290
ENSG00000101680 E059 10.8409580 0.002918456 0.1852604495 0.410919549 18 7032984 7033095 112 - 1.134 1.009 -0.454
ENSG00000101680 E060 18.1711415 0.002144568 0.1146889336 0.306914888 18 7034479 7034690 212 - 1.345 1.226 -0.417
ENSG00000101680 E061 10.7575036 0.012196913 0.9807305287 0.992128530 18 7035987 7036088 102 - 1.064 1.068 0.013
ENSG00000101680 E062 11.6883909 0.004417213 0.2161098549 0.448781138 18 7037578 7037751 174 - 1.171 1.059 -0.403
ENSG00000101680 E063 0.8563349 0.018639725 0.3864867185   18 7038572 7038809 238 - 0.148 0.306 1.331
ENSG00000101680 E064 8.2651512 0.005332612 0.5575145215 0.741500679 18 7038810 7038950 141 - 0.920 0.997 0.287
ENSG00000101680 E065 12.2140407 0.002639247 0.7461598128 0.864465609 18 7040076 7040236 161 - 1.121 1.097 -0.084
ENSG00000101680 E066 0.0000000       18 7040237 7040237 1 -      
ENSG00000101680 E067 10.6529547 0.008040049 0.7211913845 0.848909300 18 7042145 7042250 106 - 1.015 1.062 0.171
ENSG00000101680 E068 0.0000000       18 7042251 7043226 976 -      
ENSG00000101680 E069 14.3622263 0.002349621 0.4407594931 0.659299284 18 7043227 7043405 179 - 1.121 1.200 0.282
ENSG00000101680 E070 11.7476802 0.002859367 0.2302532651 0.465426003 18 7044722 7044839 118 - 1.159 1.050 -0.393
ENSG00000101680 E071 9.2599725 0.019066191 0.0356610439 0.143355793 18 7046278 7046367 90 - 1.136 0.895 -0.888
ENSG00000101680 E072 14.5014550 0.002589099 0.0001125822 0.001649616 18 7049078 7049257 180 - 1.354 1.020 -1.189
ENSG00000101680 E073 14.1391738 0.002802602 0.0214261086 0.100729343 18 7050694 7050936 243 - 1.286 1.088 -0.703
ENSG00000101680 E074 9.1902176 0.226754746 0.7675016779 0.877108199 18 7079975 7080087 113 - 0.989 1.011 0.080
ENSG00000101680 E075 9.4393275 0.047647396 0.8957053299 0.949568427 18 7080287 7080457 171 - 1.030 1.005 -0.092
ENSG00000101680 E076 4.8096662 0.005600286 0.8644552655 0.932847880 18 7117660 7117826 167 - 0.738 0.768 0.120