ENSG00000101639

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000325971 ENSG00000101639 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP192 protein_coding protein_coding 4.533004 2.394922 6.610256 0.1536225 0.6580911 1.460897 0.4337809 0.0000000 0.8841008 0.00000000 0.2335548 6.4823656 0.06840833 0.00000000 0.13593333 0.13593333 0.0002174738 0.0002174738 FALSE TRUE
ENST00000506447 ENSG00000101639 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP192 protein_coding protein_coding 4.533004 2.394922 6.610256 0.1536225 0.6580911 1.460897 0.3335026 0.1043162 0.7085481 0.10431624 0.7085481 2.6520544 0.06423750 0.04100000 0.13343333 0.09243333 0.9549577252 0.0002174738 FALSE TRUE
ENST00000508539 ENSG00000101639 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP192 protein_coding processed_transcript 4.533004 2.394922 6.610256 0.1536225 0.6580911 1.460897 0.6622123 0.4705546 1.2115992 0.23132951 0.5124994 1.3459987 0.15201667 0.19153333 0.17006667 -0.02146667 0.9922768011 0.0002174738 TRUE FALSE
ENST00000513183 ENSG00000101639 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP192 protein_coding processed_transcript 4.533004 2.394922 6.610256 0.1536225 0.6580911 1.460897 0.3400792 0.1883418 0.3103066 0.04054968 0.1079566 0.6914645 0.09179583 0.07720000 0.04436667 -0.03283333 0.6936951053 0.0002174738   FALSE
MSTRG.15531.1 ENSG00000101639 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP192 protein_coding   4.533004 2.394922 6.610256 0.1536225 0.6580911 1.460897 0.4332782 0.3834499 0.8377381 0.12330530 0.4396351 1.1074388 0.09047917 0.15476667 0.13103333 -0.02373333 0.9256498155 0.0002174738 FALSE TRUE
MSTRG.15531.10 ENSG00000101639 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP192 protein_coding   4.533004 2.394922 6.610256 0.1536225 0.6580911 1.460897 0.0399243 0.1927554 0.0000000 0.13116840 0.0000000 -4.3416686 0.01612500 0.08846667 0.00000000 -0.08846667 0.2354844105 0.0002174738 FALSE TRUE
MSTRG.15531.13 ENSG00000101639 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP192 protein_coding   4.533004 2.394922 6.610256 0.1536225 0.6580911 1.460897 0.3349647 0.4522449 0.0000000 0.23897986 0.0000000 -5.5305854 0.13540000 0.20080000 0.00000000 -0.20080000 0.2132355404 0.0002174738 FALSE TRUE
MSTRG.15531.6 ENSG00000101639 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP192 protein_coding   4.533004 2.394922 6.610256 0.1536225 0.6580911 1.460897 1.1425643 0.0000000 1.5950250 0.00000000 0.8430027 7.3264519 0.19903333 0.00000000 0.22090000 0.22090000 0.3943020522 0.0002174738 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000101639 E001 0.1779838 0.034002121 1.0000000000   18 12991321 12991361 41 + 0.075 0.000 -8.500
ENSG00000101639 E002 0.1779838 0.034002121 1.0000000000   18 12991362 12991364 3 + 0.075 0.000 -10.051
ENSG00000101639 E003 0.3393995 0.027442404 0.6981066555   18 12991365 12991367 3 + 0.140 0.000 -11.027
ENSG00000101639 E004 1.8565603 0.011003989 0.5609038780 0.743948166 18 12991368 12991376 9 + 0.432 0.322 -0.634
ENSG00000101639 E005 6.4982826 0.004251306 0.2264886930 0.461197982 18 12991377 12991437 61 + 0.861 0.686 -0.700
ENSG00000101639 E006 14.3451937 0.002327071 0.0057356671 0.038420974 18 12999421 12999588 168 + 1.193 0.881 -1.145
ENSG00000101639 E007 0.0000000       18 13000312 13000486 175 +      
ENSG00000101639 E008 17.0764764 0.011800897 0.0012587540 0.011853465 18 13001457 13001582 126 + 1.271 0.882 -1.416
ENSG00000101639 E009 11.2342523 0.017815388 0.0231023620 0.106265234 18 13008456 13008499 44 + 1.094 0.775 -1.202
ENSG00000101639 E010 19.0226901 0.001887159 0.0071348392 0.045255865 18 13008500 13008631 132 + 1.300 1.037 -0.938
ENSG00000101639 E011 13.3853104 0.038237285 0.0137617061 0.073393029 18 13012973 13013025 53 + 1.177 0.811 -1.360
ENSG00000101639 E012 17.7170832 0.019676236 0.0037543907 0.027766828 18 13015328 13015448 121 + 1.291 0.937 -1.279
ENSG00000101639 E013 17.9523925 0.059665460 0.0990348638 0.280078374 18 13017188 13017336 149 + 1.281 1.046 -0.838
ENSG00000101639 E014 17.6443602 0.002071796 0.0039087409 0.028640447 18 13018480 13018615 136 + 1.283 0.990 -1.050
ENSG00000101639 E015 12.0052911 0.002863689 0.3532415492 0.590173008 18 13019082 13019123 42 + 1.092 0.990 -0.372
ENSG00000101639 E016 11.1623135 0.012655448 0.0766363881 0.238031702 18 13019124 13019170 47 + 1.079 0.848 -0.863
ENSG00000101639 E017 10.8051131 0.026359656 0.2290381681 0.464016496 18 13019171 13019206 36 + 1.057 0.882 -0.650
ENSG00000101639 E018 15.8301440 0.002939138 0.1962133285 0.424820403 18 13029663 13029786 124 + 1.208 1.079 -0.464
ENSG00000101639 E019 8.7382199 0.003939778 0.3728514304 0.606362029 18 13029787 13029812 26 + 0.961 0.848 -0.431
ENSG00000101639 E020 23.5715818 0.001841200 0.0707445027 0.226223354 18 13029813 13030002 190 + 1.368 1.215 -0.539
ENSG00000101639 E021 19.1289596 0.003227972 0.1867729362 0.412752002 18 13030465 13030608 144 + 1.275 1.152 -0.436
ENSG00000101639 E022 9.6322050 0.010448817 0.0677035234 0.219927237 18 13037237 13037301 65 + 1.021 0.774 -0.943
ENSG00000101639 E023 9.6052257 0.003660489 0.0575985360 0.197391859 18 13038370 13038514 145 + 1.020 0.774 -0.939
ENSG00000101639 E024 6.3143790 0.009638633 0.7066903609 0.839733195 18 13038515 13038579 65 + 0.826 0.774 -0.206
ENSG00000101639 E025 12.7098881 0.010263586 0.1840228111 0.409177043 18 13040830 13040956 127 + 1.120 0.964 -0.567
ENSG00000101639 E026 14.7241463 0.008586682 0.5465505232 0.733852744 18 13042204 13042334 131 + 1.160 1.098 -0.225
ENSG00000101639 E027 65.7535510 0.001516535 0.0025988354 0.020954422 18 13048859 13049681 823 + 1.803 1.642 -0.546
ENSG00000101639 E028 13.8879907 0.003784677 0.9364273742 0.970433668 18 13049765 13049891 127 + 1.124 1.117 -0.026
ENSG00000101639 E029 19.7088294 0.029515948 0.8062397249 0.899906333 18 13052919 13053090 172 + 1.260 1.298 0.135
ENSG00000101639 E030 34.4716406 0.022084776 0.4998927297 0.700657605 18 13055780 13056046 267 + 1.515 1.462 -0.182
ENSG00000101639 E031 34.1927525 0.001160093 0.0213431399 0.100461655 18 13056047 13056527 481 + 1.533 1.371 -0.559
ENSG00000101639 E032 12.5605834 0.002986541 0.9915810907 0.997560946 18 13056528 13056604 77 + 1.079 1.079 -0.001
ENSG00000101639 E033 10.6219815 0.046146182 0.6078018979 0.775414787 18 13056605 13056630 26 + 0.991 1.058 0.246
ENSG00000101639 E034 13.3149827 0.065772248 0.1997712473 0.429385553 18 13056631 13056698 68 + 1.046 1.228 0.650
ENSG00000101639 E035 20.8534808 0.019302679 0.1038131893 0.288556103 18 13057585 13057733 149 + 1.234 1.393 0.555
ENSG00000101639 E036 0.0000000       18 13057734 13058293 560 +      
ENSG00000101639 E037 0.0000000       18 13058294 13058435 142 +      
ENSG00000101639 E038 0.4349185 0.021768165 0.7588657572   18 13058436 13059081 646 + 0.139 0.190 0.535
ENSG00000101639 E039 19.2822977 0.002032497 0.7154822986 0.845219333 18 13059082 13059181 100 + 1.261 1.229 -0.113
ENSG00000101639 E040 21.3084011 0.002152753 0.9386781439 0.971663305 18 13059182 13059312 131 + 1.300 1.294 -0.020
ENSG00000101639 E041 0.0000000       18 13059313 13059314 2 +      
ENSG00000101639 E042 17.8715916 0.002421667 0.2772859561 0.517308223 18 13067831 13067956 126 + 1.198 1.294 0.338
ENSG00000101639 E043 21.3332509 0.001834704 0.2153417892 0.447914231 18 13068094 13068237 144 + 1.270 1.371 0.353
ENSG00000101639 E044 17.3234275 0.029348737 0.8801677043 0.941335114 18 13068359 13068414 56 + 1.213 1.196 -0.057
ENSG00000101639 E045 13.4569536 0.018830310 0.9186546740 0.961514996 18 13068415 13068422 8 + 1.107 1.097 -0.035
ENSG00000101639 E046 29.3399762 0.001496849 0.8255170306 0.911245908 18 13068852 13068991 140 + 1.434 1.419 -0.051
ENSG00000101639 E047 23.4930860 0.001644726 0.5118519128 0.709399249 18 13069089 13069181 93 + 1.347 1.294 -0.184
ENSG00000101639 E048 21.2790126 0.001872557 0.7619388880 0.873781099 18 13069738 13069856 119 + 1.291 1.317 0.091
ENSG00000101639 E049 29.8446993 0.001355296 0.8344774525 0.916282669 18 13071039 13071212 174 + 1.431 1.446 0.053
ENSG00000101639 E050 25.9063660 0.001510660 0.8664359863 0.934019478 18 13072755 13072845 91 + 1.368 1.382 0.046
ENSG00000101639 E051 23.6894123 0.001901274 0.6726702491 0.817996733 18 13073009 13073115 107 + 1.328 1.361 0.117
ENSG00000101639 E052 21.0583413 0.002934500 0.4888043799 0.693185058 18 13073116 13073185 70 + 1.270 1.329 0.205
ENSG00000101639 E053 27.3278380 0.001332038 0.9539549392 0.978899501 18 13087017 13087148 132 + 1.396 1.401 0.018
ENSG00000101639 E054 27.2922857 0.001369500 0.3617077257 0.597061567 18 13087149 13087277 129 + 1.379 1.446 0.232
ENSG00000101639 E055 23.0238911 0.001465521 0.2440726928 0.481127764 18 13087531 13087646 116 + 1.300 1.391 0.319
ENSG00000101639 E056 0.2735028 0.026105996 0.4367549626   18 13088754 13088904 151 + 0.075 0.190 1.535
ENSG00000101639 E057 23.3939132 0.001872138 0.2603342906 0.499296978 18 13089456 13089565 110 + 1.312 1.401 0.308
ENSG00000101639 E058 26.7896421 0.005642889 0.4996068264 0.700479329 18 13092377 13092527 151 + 1.379 1.435 0.196
ENSG00000101639 E059 28.2070068 0.001276356 0.1589371671 0.375153745 18 13095503 13095681 179 + 1.386 1.486 0.347
ENSG00000101639 E060 0.1779838 0.034002121 1.0000000000   18 13095682 13095685 4 + 0.075 0.000 -10.051
ENSG00000101639 E061 23.6948856 0.001441741 0.3002274451 0.540644986 18 13096184 13096307 124 + 1.320 1.401 0.280
ENSG00000101639 E062 26.9776585 0.001538224 0.0270585653 0.118487101 18 13099476 13099581 106 + 1.343 1.502 0.549
ENSG00000101639 E063 40.7213260 0.003136334 0.0057322180 0.038400886 18 13100305 13100512 208 + 1.513 1.684 0.583
ENSG00000101639 E064 26.6364880 0.001695322 0.0272233978 0.118951245 18 13103509 13103588 80 + 1.343 1.502 0.550
ENSG00000101639 E065 0.6778738 0.442861915 0.2952875259   18 13103875 13103967 93 + 0.137 0.406 2.065
ENSG00000101639 E066 27.8711258 0.001326333 0.3951268192 0.624474159 18 13104984 13105079 96 + 1.392 1.454 0.214
ENSG00000101639 E067 32.6352008 0.016844708 0.1162619685 0.309568295 18 13113586 13113705 120 + 1.432 1.568 0.467
ENSG00000101639 E068 22.7133619 0.007251357 0.2579864638 0.496735093 18 13114130 13114251 122 + 1.295 1.392 0.337
ENSG00000101639 E069 7.1024914 0.080967461 0.6626183375 0.811531351 18 13116374 13116376 3 + 0.852 0.909 0.216
ENSG00000101639 E070 14.4425954 0.024035759 0.1634073256 0.381804604 18 13116377 13116403 27 + 1.089 1.246 0.559
ENSG00000101639 E071 31.0684612 0.015739096 0.0632884286 0.210111446 18 13116404 13116503 100 + 1.403 1.562 0.546
ENSG00000101639 E072 25.8397811 0.001837661 0.0355653811 0.143096563 18 13117585 13117643 59 + 1.324 1.479 0.538
ENSG00000101639 E073 3.3390393 0.007421591 0.2214805459 0.455254653 18 13124487 13124631 145 + 0.539 0.732 0.836
ENSG00000101639 E074 32.1124988 0.001151179 0.0002529864 0.003251317 18 13124632 13125052 421 + 1.389 1.625 0.811