ENSG00000101596

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000320876 ENSG00000101596 HEK293_OSMI2_6hA HEK293_TMG_6hB SMCHD1 protein_coding protein_coding 9.67578 2.348117 18.35058 0.2766499 0.4338504 2.960904 5.4986065 0.7840152 11.16101731 0.18395191 0.51317507 3.8144502 0.41100417 0.32316667 0.610166667 0.287000000 2.890929e-02 2.524236e-05 FALSE TRUE
ENST00000581631 ENSG00000101596 HEK293_OSMI2_6hA HEK293_TMG_6hB SMCHD1 protein_coding retained_intron 9.67578 2.348117 18.35058 0.2766499 0.4338504 2.960904 0.8401824 0.0000000 1.59714183 0.00000000 0.08846946 7.3283534 0.05082917 0.00000000 0.087100000 0.087100000 2.524236e-05 2.524236e-05 FALSE FALSE
ENST00000583800 ENSG00000101596 HEK293_OSMI2_6hA HEK293_TMG_6hB SMCHD1 protein_coding processed_transcript 9.67578 2.348117 18.35058 0.2766499 0.4338504 2.960904 0.6643354 0.1926360 1.32759452 0.03571916 0.21554698 2.7226783 0.07081667 0.08406667 0.072000000 -0.012066667 9.036011e-01 2.524236e-05   FALSE
ENST00000642953 ENSG00000101596 HEK293_OSMI2_6hA HEK293_TMG_6hB SMCHD1 protein_coding nonsense_mediated_decay 9.67578 2.348117 18.35058 0.2766499 0.4338504 2.960904 0.1674101 0.0000000 0.08572073 0.00000000 0.05822395 3.2588314 0.05930833 0.00000000 0.004633333 0.004633333 8.929969e-01 2.524236e-05 TRUE TRUE
ENST00000645355 ENSG00000101596 HEK293_OSMI2_6hA HEK293_TMG_6hB SMCHD1 protein_coding nonsense_mediated_decay 9.67578 2.348117 18.35058 0.2766499 0.4338504 2.960904 0.1395033 0.1638824 0.00000000 0.16388241 0.00000000 -4.1200401 0.06725417 0.06306667 0.000000000 -0.063066667 6.233077e-01 2.524236e-05 FALSE TRUE
ENST00000686763 ENSG00000101596 HEK293_OSMI2_6hA HEK293_TMG_6hB SMCHD1 protein_coding nonsense_mediated_decay 9.67578 2.348117 18.35058 0.2766499 0.4338504 2.960904 0.8218131 0.7572712 1.22513433 0.08961685 0.37574404 0.6868594 0.16150417 0.32300000 0.066000000 -0.257000000 4.773104e-03 2.524236e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000101596 E001 3.6005561 0.0078026018 6.894704e-01 0.8286770495 18 2655726 2655918 193 + 0.519 0.449 -0.349
ENSG00000101596 E002 3.5124818 0.0066561723 3.857787e-01 0.6170969073 18 2655919 2655987 69 + 0.487 0.664 0.804
ENSG00000101596 E003 7.0907428 0.0041336169 2.454262e-01 0.4828726163 18 2655988 2656124 137 + 0.721 0.915 0.765
ENSG00000101596 E004 19.5096260 0.0019894479 2.096686e-01 0.4414883469 18 2656125 2656261 137 + 1.142 1.002 -0.509
ENSG00000101596 E005 22.9362846 0.0018979854 4.737330e-03 0.0332029572 18 2666157 2666232 76 + 1.224 0.865 -1.315
ENSG00000101596 E006 52.7258778 0.0013050578 4.154391e-05 0.0007109857 18 2666870 2667031 162 + 1.572 1.214 -1.240
ENSG00000101596 E007 49.1623063 0.0007233792 2.062158e-04 0.0027425944 18 2673281 2673363 83 + 1.538 1.214 -1.123
ENSG00000101596 E008 55.6875459 0.0027746821 2.404721e-04 0.0031157165 18 2674015 2674145 131 + 1.592 1.281 -1.075
ENSG00000101596 E009 44.5876444 0.0365983314 1.205543e-01 0.3167119640 18 2688394 2688508 115 + 1.491 1.297 -0.674
ENSG00000101596 E010 17.3499874 0.7625448383 8.375831e-01 0.9180833906 18 2688628 2688640 13 + 1.094 0.992 -0.371
ENSG00000101596 E011 26.0602076 0.2526441346 8.642787e-01 0.9327576418 18 2688641 2688692 52 + 1.253 1.212 -0.145
ENSG00000101596 E012 28.7642693 0.0745047142 6.799848e-01 0.8226795674 18 2688693 2688747 55 + 1.298 1.216 -0.288
ENSG00000101596 E013 0.3040503 0.0274424043 1.000000e+00   18 2690666 2690761 96 + 0.090 0.000 -11.186
ENSG00000101596 E014 54.1101721 0.0177438257 1.244921e-02 0.0682427809 18 2694527 2694693 167 + 1.575 1.321 -0.878
ENSG00000101596 E015 47.2521727 0.0018528360 2.194881e-04 0.0028874527 18 2697032 2697122 91 + 1.525 1.189 -1.169
ENSG00000101596 E016 0.0000000       18 2697123 2697216 94 +      
ENSG00000101596 E017 64.3911695 0.0005627328 3.388258e-04 0.0041280155 18 2697831 2698041 211 + 1.649 1.389 -0.891
ENSG00000101596 E018 42.4811999 0.0008804430 6.821464e-03 0.0437990628 18 2700539 2700659 121 + 1.472 1.238 -0.815
ENSG00000101596 E019 31.8672175 0.0032290232 3.702445e-03 0.0274879895 18 2700735 2700776 42 + 1.355 1.039 -1.122
ENSG00000101596 E020 45.2453754 0.0143327330 1.474788e-02 0.0771366958 18 2700777 2700858 82 + 1.496 1.239 -0.891
ENSG00000101596 E021 41.1311178 0.0194257948 8.396670e-02 0.2527245513 18 2700859 2700918 60 + 1.450 1.262 -0.655
ENSG00000101596 E022 0.3206185 0.0274424043 1.000000e+00   18 2700919 2701255 337 + 0.090 0.000 -11.187
ENSG00000101596 E023 0.0000000       18 2702217 2702292 76 +      
ENSG00000101596 E024 27.0313465 0.0221218533 1.076634e-01 0.2951414503 18 2703692 2703693 2 + 1.277 1.074 -0.722
ENSG00000101596 E025 61.4732926 0.0018099980 9.548086e-03 0.0561792003 18 2703694 2703886 193 + 1.620 1.435 -0.633
ENSG00000101596 E026 50.6059700 0.0006867332 6.445610e-02 0.2126865847 18 2705694 2705807 114 + 1.536 1.405 -0.450
ENSG00000101596 E027 0.7616940 0.0842663348 5.662948e-01   18 2705808 2706363 556 + 0.163 0.280 0.989
ENSG00000101596 E028 43.0825171 0.0015136482 2.287365e-02 0.1055386897 18 2706364 2706442 79 + 1.471 1.281 -0.659
ENSG00000101596 E029 28.8541783 0.0011917630 3.149330e-01 0.5550813606 18 2706443 2706470 28 + 1.298 1.214 -0.296
ENSG00000101596 E030 2.0895524 0.0097543592 1.498072e-01 0.3620011221 18 2706471 2707228 758 + 0.397 0.000 -13.888
ENSG00000101596 E031 0.5339515 0.8671225590 1.000000e+00   18 2707444 2707562 119 + 0.135 0.000 -11.850
ENSG00000101596 E032 36.1276415 0.0009825891 9.445256e-01 0.9746211485 18 2707563 2707645 83 + 1.380 1.405 0.086
ENSG00000101596 E033 35.6138264 0.0011065930 9.541730e-01 0.9789962193 18 2707807 2707920 114 + 1.376 1.389 0.046
ENSG00000101596 E034 29.8264431 0.0014541803 9.822506e-01 0.9928618992 18 2718158 2718211 54 + 1.303 1.320 0.058
ENSG00000101596 E035 27.1977075 0.0014382372 7.950024e-01 0.8933301565 18 2718212 2718235 24 + 1.267 1.259 -0.026
ENSG00000101596 E036 45.4554044 0.0008347086 6.289703e-01 0.7898079744 18 2718315 2718434 120 + 1.482 1.463 -0.066
ENSG00000101596 E037 36.5628760 0.0020674762 5.625945e-01 0.7450926398 18 2722519 2722603 85 + 1.389 1.356 -0.116
ENSG00000101596 E038 35.7851117 0.0011611147 2.713030e-01 0.5112743195 18 2722604 2722663 60 + 1.385 1.301 -0.292
ENSG00000101596 E039 25.8421340 0.0013195656 6.007858e-01 0.7707382604 18 2724899 2724901 3 + 1.250 1.214 -0.128
ENSG00000101596 E040 45.2741265 0.0013008528 3.987516e-01 0.6272523364 18 2724902 2724995 94 + 1.485 1.435 -0.173
ENSG00000101596 E041 36.5299479 0.0010256819 1.442873e-01 0.3538025047 18 2726452 2726524 73 + 1.399 1.281 -0.412
ENSG00000101596 E042 8.8996715 0.1287401013 4.097767e-01 0.6358400362 18 2726525 2727163 639 + 0.842 0.669 -0.699
ENSG00000101596 E043 0.4986023 0.0411512738 1.000000e+00   18 2728371 2728413 43 + 0.129 0.000 -11.774
ENSG00000101596 E044 0.9994175 0.0169363038 5.437210e-01   18 2728414 2728456 43 + 0.228 0.000 -12.774
ENSG00000101596 E045 30.9800548 0.0023065990 1.946640e-01 0.4228988848 18 2728457 2728483 27 + 1.328 1.214 -0.400
ENSG00000101596 E046 51.7080923 0.0013613846 1.553107e-01 0.3698971732 18 2728484 2728596 113 + 1.542 1.449 -0.320
ENSG00000101596 E047 0.0000000       18 2728597 2728830 234 +      
ENSG00000101596 E048 61.9967705 0.0021527767 4.048551e-01 0.6321743134 18 2729275 2729409 135 + 1.598 1.673 0.256
ENSG00000101596 E049 66.6354993 0.0326283831 9.028548e-01 0.9532772095 18 2732265 2732454 190 + 1.640 1.643 0.010
ENSG00000101596 E050 30.4200662 0.0013999998 7.360462e-01 0.8579909000 18 2732455 2732492 38 + 1.315 1.301 -0.051
ENSG00000101596 E051 2.1376251 0.0158572218 1.515562e-02 0.0786684746 18 2736465 2738396 1932 + 0.284 0.743 2.298
ENSG00000101596 E052 61.4617119 0.0006662057 3.935547e-01 0.6231850795 18 2738397 2738545 149 + 1.611 1.570 -0.139
ENSG00000101596 E053 50.9924758 0.0011767940 1.673740e-01 0.3870679645 18 2739432 2739520 89 + 1.539 1.449 -0.309
ENSG00000101596 E054 66.0752022 0.0020526482 7.304523e-01 0.8544988500 18 2740703 2740821 119 + 1.634 1.629 -0.015
ENSG00000101596 E055 83.8968709 0.0004992732 2.350743e-01 0.4709919552 18 2743761 2743928 168 + 1.743 1.690 -0.180
ENSG00000101596 E056 65.9976848 0.0029350321 9.222981e-01 0.9634350029 18 2747522 2747647 126 + 1.633 1.657 0.080
ENSG00000101596 E057 54.4000275 0.0008065978 8.829766e-01 0.9428142702 18 2750043 2750122 80 + 1.552 1.560 0.027
ENSG00000101596 E058 45.9847196 0.0009325155 1.935738e-01 0.4215496542 18 2750350 2750429 80 + 1.467 1.581 0.391
ENSG00000101596 E059 48.7130425 0.0007652333 3.557698e-01 0.5923433753 18 2750430 2750507 78 + 1.495 1.581 0.294
ENSG00000101596 E060 49.8572694 0.0009254101 6.555248e-01 0.8070613697 18 2751278 2751393 116 + 1.508 1.560 0.177
ENSG00000101596 E061 44.3969955 0.0013270113 9.181104e-01 0.9612652423 18 2752488 2752552 65 + 1.462 1.489 0.093
ENSG00000101596 E062 0.3559677 0.5255339866 1.000000e+00   18 2752553 2754748 2196 + 0.092 0.000 -11.231
ENSG00000101596 E063 0.0000000       18 2756621 2756901 281 +      
ENSG00000101596 E064 0.0000000       18 2759606 2759685 80 +      
ENSG00000101596 E065 0.0000000       18 2759686 2759758 73 +      
ENSG00000101596 E066 0.0000000       18 2759759 2759764 6 +      
ENSG00000101596 E067 0.3206185 0.0274424043 1.000000e+00   18 2759765 2760400 636 + 0.090 0.000 -11.187
ENSG00000101596 E068 0.0000000       18 2760401 2760651 251 +      
ENSG00000101596 E069 49.3232513 0.0015874986 8.511192e-01 0.9256524527 18 2760652 2760739 88 + 1.509 1.514 0.015
ENSG00000101596 E070 68.4258030 0.0005941373 1.422094e-01 0.3507331414 18 2762105 2762236 132 + 1.661 1.581 -0.275
ENSG00000101596 E071 2.0863645 0.3134834855 3.067470e-01 0.5473706929 18 2762237 2763636 1400 + 0.406 0.000 -13.938
ENSG00000101596 E072 71.0148243 0.0012063049 7.176731e-01 0.8467236003 18 2763637 2763789 153 + 1.664 1.705 0.139
ENSG00000101596 E073 0.0000000       18 2763876 2763969 94 +      
ENSG00000101596 E074 0.0000000       18 2764034 2764068 35 +      
ENSG00000101596 E075 0.0000000       18 2764069 2764106 38 +      
ENSG00000101596 E076 71.9271401 0.0005839152 3.658976e-02 0.1458257801 18 2769694 2769820 127 + 1.655 1.796 0.477
ENSG00000101596 E077 68.1149074 0.0006192646 7.655016e-03 0.0477415566 18 2769989 2770108 120 + 1.625 1.802 0.598
ENSG00000101596 E078 58.4865173 0.0007121271 2.758336e-03 0.0219209570 18 2771533 2771618 86 + 1.557 1.763 0.698
ENSG00000101596 E079 0.1614157 0.0338663413 7.363160e-01   18 2771619 2771785 167 + 0.047 0.000 -10.188
ENSG00000101596 E080 54.6996416 0.0013461716 4.726713e-02 0.1731894311 18 2772250 2772295 46 + 1.538 1.689 0.517
ENSG00000101596 E081 63.4297794 0.0019941523 2.889820e-01 0.5295462794 18 2772296 2772372 77 + 1.609 1.697 0.300
ENSG00000101596 E082 86.2311271 0.0006288164 3.898818e-01 0.6203602765 18 2775734 2775924 191 + 1.742 1.808 0.225
ENSG00000101596 E083 76.4309902 0.0019722072 4.496909e-01 0.6654687350 18 2777806 2777915 110 + 1.691 1.756 0.220
ENSG00000101596 E084 0.4514866 0.0217681645 2.896589e-01   18 2777916 2778168 253 + 0.090 0.279 1.972
ENSG00000101596 E085 68.0379854 0.0036848006 9.052680e-02 0.2647459589 18 2778169 2778239 71 + 1.628 1.758 0.441
ENSG00000101596 E086 0.7860845 0.0170297269 7.071708e-01   18 2778240 2778940 701 + 0.197 0.000 -12.509
ENSG00000101596 E087 2.9102076 0.2197460582 3.150311e-02 0.1317754889 18 2778941 2780231 1291 + 0.336 0.881 2.500
ENSG00000101596 E088 3.0114559 0.0085428655 2.088041e-05 0.0003962414 18 2782786 2784449 1664 + 0.309 1.001 3.124
ENSG00000101596 E089 118.2638061 0.0004916186 5.663760e-02 0.1951778953 18 2784450 2784621 172 + 1.870 1.978 0.365
ENSG00000101596 E090 0.0000000       18 2784845 2784987 143 +      
ENSG00000101596 E091 107.3187481 0.0003842688 1.704987e-01 0.3910933373 18 2795949 2796098 150 + 1.834 1.921 0.292
ENSG00000101596 E092 40.5538052 0.0010914644 6.820004e-01 0.8239604910 18 2796099 2796107 9 + 1.424 1.476 0.179
ENSG00000101596 E093 85.6778485 0.0009286620 1.251208e-02 0.0684747271 18 2796407 2796521 115 + 1.726 1.881 0.524
ENSG00000101596 E094 0.6434498 0.0195076839 1.000000e+00   18 2796768 2796860 93 + 0.164 0.000 -12.188
ENSG00000101596 E095 7.1326454 0.0344710989 7.637910e-01 0.8749474722 18 2800523 2800740 218 + 0.745 0.807 0.247
ENSG00000101596 E096 13.3454093 0.0425629413 2.700902e-01 0.5100643352 18 2800741 2801263 523 + 0.954 1.133 0.656
ENSG00000101596 E097 347.4145586 0.0135796902 7.692727e-05 0.0012007370 18 2802528 2805017 2490 + 2.312 2.557 0.819