ENSG00000101347

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262878 ENSG00000101347 HEK293_OSMI2_6hA HEK293_TMG_6hB SAMHD1 protein_coding protein_coding 16.98377 13.03037 23.83535 2.806109 1.053566 0.8707232 1.942908 0.3255638 3.563569 0.2202824 0.7656776 3.4127064 0.09298333 0.03803333 0.1471667 0.1091333 3.621561e-01 1.632889e-14 FALSE TRUE
ENST00000646673 ENSG00000101347 HEK293_OSMI2_6hA HEK293_TMG_6hB SAMHD1 protein_coding protein_coding 16.98377 13.03037 23.83535 2.806109 1.053566 0.8707232 11.732550 12.0210912 13.927426 3.0587385 0.3172303 0.2121966 0.74732083 0.90006667 0.5873000 -0.3127667 3.583630e-02 1.632889e-14 FALSE TRUE
MSTRG.20675.13 ENSG00000101347 HEK293_OSMI2_6hA HEK293_TMG_6hB SAMHD1 protein_coding   16.98377 13.03037 23.83535 2.806109 1.053566 0.8707232 1.612414 0.0000000 4.347101 0.0000000 0.8079239 8.7672246 0.06695000 0.00000000 0.1820000 0.1820000 1.632889e-14 1.632889e-14 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000101347 E001 7.6188407 0.0421095852 4.248570e-01 6.471736e-01 20 36890229 36890250 22 - 0.873 1.019 0.547
ENSG00000101347 E002 10.0010710 0.0379540812 2.192458e-01 4.525022e-01 20 36890251 36890261 11 - 0.947 1.149 0.736
ENSG00000101347 E003 11.2260182 0.0133939552 3.016043e-01 5.421298e-01 20 36890262 36890268 7 - 1.033 1.165 0.478
ENSG00000101347 E004 21.9103528 0.0111574775 9.647198e-03 5.659905e-02 20 36890269 36890393 125 - 1.243 1.483 0.834
ENSG00000101347 E005 14.1447456 0.0027686516 9.244509e-04 9.295579e-03 20 36890394 36890438 45 - 1.022 1.331 1.103
ENSG00000101347 E006 7.5911556 0.0061518324 5.712971e-03 3.830519e-02 20 36890439 36890444 6 - 0.760 1.097 1.274
ENSG00000101347 E007 24.0320600 0.0369449352 3.682502e-02 1.464541e-01 20 36890445 36890518 74 - 1.268 1.516 0.859
ENSG00000101347 E008 18.5242614 0.0764867774 1.255514e-01 3.247262e-01 20 36890519 36890523 5 - 1.174 1.395 0.773
ENSG00000101347 E009 42.3586081 0.0134552727 2.980247e-02 1.267448e-01 20 36890524 36890573 50 - 1.544 1.726 0.620
ENSG00000101347 E010 42.1724966 0.0009678664 1.850078e-05 3.575805e-04 20 36890574 36890578 5 - 1.506 1.752 0.837
ENSG00000101347 E011 175.8738786 0.0032362898 2.577362e-06 6.507513e-05 20 36890579 36890903 325 - 2.148 2.343 0.652
ENSG00000101347 E012 374.4573552 0.0017715437 6.825438e-06 1.507108e-04 20 36890904 36891552 649 - 2.509 2.639 0.435
ENSG00000101347 E013 136.3428559 0.0003755965 7.544936e-05 1.181687e-03 20 36891553 36891690 138 - 2.072 2.205 0.446
ENSG00000101347 E014 94.9178089 0.0009519802 5.635631e-03 3.791838e-02 20 36891691 36891794 104 - 1.923 2.040 0.394
ENSG00000101347 E015 41.7822552 0.0085012002 4.743191e-02 1.735848e-01 20 36891795 36891801 7 - 1.557 1.707 0.509
ENSG00000101347 E016 41.9979734 0.0087206121 2.772638e-02 1.204880e-01 20 36891802 36891807 6 - 1.550 1.716 0.565
ENSG00000101347 E017 389.8323227 0.0027497207 7.124419e-02 2.272478e-01 20 36891808 36892578 771 - 2.558 2.622 0.212
ENSG00000101347 E018 55.5916323 0.0006737032 2.571619e-02 1.144325e-01 20 36892579 36892618 40 - 1.694 1.811 0.396
ENSG00000101347 E019 65.5628154 0.0045357149 3.195901e-03 2.458162e-02 20 36892619 36892715 97 - 1.735 1.906 0.579
ENSG00000101347 E020 35.2055957 0.0071637089 1.616791e-02 8.239853e-02 20 36892716 36892739 24 - 1.465 1.655 0.647
ENSG00000101347 E021 28.4046202 0.0304363010 9.302381e-02 2.693433e-01 20 36892740 36892746 7 - 1.357 1.580 0.767
ENSG00000101347 E022 29.4891798 0.0417087093 8.128190e-02 2.474062e-01 20 36892747 36892762 16 - 1.351 1.611 0.893
ENSG00000101347 E023 31.2034335 0.0288181705 9.620659e-02 2.750984e-01 20 36892763 36892770 8 - 1.405 1.615 0.717
ENSG00000101347 E024 54.1519023 0.0865197848 1.775896e-01 4.005578e-01 20 36892771 36892807 37 - 1.631 1.850 0.742
ENSG00000101347 E025 107.8753066 0.2557694968 3.208486e-01 5.604496e-01 20 36892808 36892931 124 - 1.962 2.111 0.500
ENSG00000101347 E026 136.9397596 1.3860202411 5.823193e-01 7.585951e-01 20 36892932 36893066 135 - 2.090 2.189 0.333
ENSG00000101347 E027 12.0001007 0.4051188212 2.274081e-01 4.622690e-01 20 36893067 36893929 863 - 0.976 1.242 0.960
ENSG00000101347 E028 2.4390873 0.0096791290 8.122461e-01 9.035817e-01 20 36897571 36897668 98 - 0.510 0.557 0.220
ENSG00000101347 E029 1.8692545 0.0108613334 5.042318e-02 1.806651e-01 20 36897669 36897821 153 - 0.580 0.241 -1.912
ENSG00000101347 E030 138.2968714 0.0518326083 6.751500e-01 8.196231e-01 20 36897822 36897959 138 - 2.125 2.160 0.119
ENSG00000101347 E031 127.8869197 0.0004193477 3.912076e-01 6.213639e-01 20 36898440 36898544 105 - 2.113 2.097 -0.056
ENSG00000101347 E032 0.6869813 0.5171195532 7.094884e-01   20 36903953 36904021 69 - 0.266 0.141 -1.132
ENSG00000101347 E033 1.7468583 0.1642742431 8.994283e-01 9.515735e-01 20 36904022 36904156 135 - 0.429 0.405 -0.127
ENSG00000101347 E034 142.0521349 0.0007502824 1.097598e-03 1.065448e-02 20 36904157 36904249 93 - 2.188 2.094 -0.314
ENSG00000101347 E035 1.0018026 0.0183472414 7.540941e-01   20 36904250 36905363 1114 - 0.265 0.326 0.415
ENSG00000101347 E036 158.8540135 0.0003235289 6.559364e-05 1.050383e-03 20 36905364 36905503 140 - 2.243 2.138 -0.349
ENSG00000101347 E037 139.9488002 0.0024141529 1.561973e-02 8.043023e-02 20 36911218 36911333 116 - 2.179 2.099 -0.268
ENSG00000101347 E038 0.8621321 0.4840171791 9.147610e-01   20 36911334 36912247 914 - 0.270 0.245 -0.184
ENSG00000101347 E039 0.5173834 0.0963396877 1.485419e-01   20 36912248 36912347 100 - 0.266 0.000 -13.250
ENSG00000101347 E040 0.3393995 0.0254731896 2.894731e-01   20 36912348 36912460 113 - 0.193 0.000 -12.935
ENSG00000101347 E041 124.1727406 0.0011898904 1.345849e-03 1.250370e-02 20 36912461 36912552 92 - 2.136 2.032 -0.348
ENSG00000101347 E042 0.1614157 0.0342295531 6.352326e-01   20 36916531 36916721 191 - 0.107 0.000 -11.913
ENSG00000101347 E043 63.1959863 0.0013017507 3.562979e-04 4.299245e-03 20 36916722 36916722 1 - 1.869 1.709 -0.541
ENSG00000101347 E044 121.3325089 0.0003996298 1.122371e-03 1.083780e-02 20 36916723 36916830 108 - 2.124 2.027 -0.326
ENSG00000101347 E045 108.6374806 0.0003796775 1.820364e-02 8.970452e-02 20 36916949 36917049 101 - 2.066 1.995 -0.238
ENSG00000101347 E046 1.4700451 0.0119578863 5.405552e-01 7.293889e-01 20 36917050 36917096 47 - 0.428 0.326 -0.588
ENSG00000101347 E047 0.1308682 0.0326491905 3.779334e-01   20 36917152 36917215 64 - 0.000 0.137 12.032
ENSG00000101347 E048 131.4313143 0.0011023338 2.200385e-03 1.841079e-02 20 36919364 36919519 156 - 2.161 2.066 -0.318
ENSG00000101347 E049 0.1614157 0.0342295531 6.352326e-01   20 36926952 36927181 230 - 0.107 0.000 -11.913
ENSG00000101347 E050 117.6636020 0.0057031475 3.195363e-03 2.457971e-02 20 36927182 36927252 71 - 2.128 1.986 -0.476
ENSG00000101347 E051 0.1779838 0.0435922404 6.348477e-01   20 36929016 36929053 38 - 0.107 0.000 -11.878
ENSG00000101347 E052 90.0995303 0.0051615194 2.462816e-03 2.008851e-02 20 36930760 36930798 39 - 2.018 1.864 -0.515
ENSG00000101347 E053 111.3265460 0.0094608547 2.278952e-03 1.891309e-02 20 36930799 36930875 77 - 2.116 1.937 -0.599
ENSG00000101347 E054 0.3453689 0.0273574305 8.462587e-01   20 36930978 36931049 72 - 0.107 0.138 0.417
ENSG00000101347 E055 0.7007164 0.8900646078 8.407246e-01   20 36934658 36935028 371 - 0.200 0.247 0.391
ENSG00000101347 E056 107.0906620 0.0071651271 1.307582e-04 1.870430e-03 20 36935029 36935080 52 - 2.109 1.905 -0.687
ENSG00000101347 E057 137.3269532 0.0035112892 2.501376e-06 6.347745e-05 20 36935081 36935189 109 - 2.211 2.024 -0.628
ENSG00000101347 E058 0.1779838 0.0435922404 6.348477e-01   20 36935190 36935203 14 - 0.107 0.000 -11.878
ENSG00000101347 E059 0.0000000       20 36935341 36935403 63 -      
ENSG00000101347 E060 0.1779838 0.0435922404 6.348477e-01   20 36940165 36941038 874 - 0.107 0.000 -11.878
ENSG00000101347 E061 114.0417066 0.0053414304 1.020250e-04 1.521042e-03 20 36941039 36941111 73 - 2.128 1.953 -0.587
ENSG00000101347 E062 0.0000000       20 36946409 36946737 329 -      
ENSG00000101347 E063 91.6801351 0.0039702216 3.457707e-03 2.608958e-02 20 36946738 36946804 67 - 2.019 1.889 -0.436
ENSG00000101347 E064 0.0000000       20 36946911 36947059 149 -      
ENSG00000101347 E065 130.9577172 0.0216719410 3.021982e-02 1.279965e-01 20 36951436 36951893 458 - 2.183 2.016 -0.559