ENSG00000101343

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000490258 ENSG00000101343 HEK293_OSMI2_6hA HEK293_TMG_6hB CRNKL1 protein_coding retained_intron 16.04088 7.959415 27.15371 1.233975 1.234136 1.769135 1.462697 1.669036 1.473535 0.4228088 0.7384868 -0.1785945 0.1441458 0.2025333 0.05226667 -0.15026667 0.04046023 0.04046023 FALSE TRUE
ENST00000536226 ENSG00000101343 HEK293_OSMI2_6hA HEK293_TMG_6hB CRNKL1 protein_coding protein_coding 16.04088 7.959415 27.15371 1.233975 1.234136 1.769135 4.052803 1.307360 7.212759 0.3277349 0.2195817 2.4549010 0.2311833 0.1587000 0.26680000 0.10810000 0.17228310 0.04046023 FALSE TRUE
MSTRG.20440.1 ENSG00000101343 HEK293_OSMI2_6hA HEK293_TMG_6hB CRNKL1 protein_coding   16.04088 7.959415 27.15371 1.233975 1.234136 1.769135 10.494826 4.983019 18.444114 0.5040253 0.6093522 1.8859581 0.6230875 0.6387333 0.68000000 0.04126667 0.86108266 0.04046023 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000101343 E001 0.000000       20 20027875 20027929 55 -      
ENSG00000101343 E002 153.126424 0.0036708751 0.0003390861 0.004130002 20 20034368 20036005 1638 - 2.153 1.995 -0.529
ENSG00000101343 E003 38.820484 0.0023958482 0.2624386198 0.501633317 20 20036006 20036141 136 - 1.549 1.470 -0.272
ENSG00000101343 E004 39.488248 0.0025229340 0.2422036653 0.479012933 20 20036142 20036205 64 - 1.519 1.595 0.258
ENSG00000101343 E005 114.171722 0.0003927616 0.0841927127 0.253171475 20 20036206 20036362 157 - 1.979 2.040 0.207
ENSG00000101343 E006 192.192879 0.0018307745 0.0537923436 0.188583579 20 20037323 20037534 212 - 2.201 2.262 0.206
ENSG00000101343 E007 88.101260 0.0006538609 0.0565184243 0.194877941 20 20037535 20037571 37 - 1.861 1.940 0.265
ENSG00000101343 E008 120.184759 0.0004737078 0.3028838579 0.543452005 20 20038349 20038450 102 - 2.007 2.042 0.119
ENSG00000101343 E009 1.565564 0.0114979526 0.2526772623 0.490814173 20 20038451 20038611 161 - 0.317 0.522 1.114
ENSG00000101343 E010 155.770534 0.0003306285 0.8544246195 0.927283958 20 20039609 20039848 240 - 2.124 2.128 0.012
ENSG00000101343 E011 89.728433 0.0004109935 0.9305050109 0.967235622 20 20040686 20040766 81 - 1.889 1.891 0.005
ENSG00000101343 E012 90.065771 0.0004281109 0.2427400588 0.479636054 20 20041566 20041625 60 - 1.881 1.928 0.157
ENSG00000101343 E013 168.014248 0.0008319169 0.2898340835 0.530416748 20 20042325 20042516 192 - 2.150 2.182 0.107
ENSG00000101343 E014 157.314970 0.0037607902 0.5498867870 0.736180861 20 20043492 20043662 171 - 2.124 2.145 0.070
ENSG00000101343 E015 127.075376 0.0004070248 0.1159983959 0.309152473 20 20045308 20045486 179 - 2.024 2.078 0.179
ENSG00000101343 E016 112.747474 0.0009141196 0.7213206010 0.848974471 20 20047765 20047931 167 - 1.994 1.978 -0.055
ENSG00000101343 E017 106.001120 0.0048515689 0.1555553614 0.370233184 20 20048343 20048501 159 - 1.980 1.903 -0.258
ENSG00000101343 E018 81.076003 0.0011470502 0.0200851903 0.096177281 20 20049340 20049431 92 - 1.875 1.758 -0.392
ENSG00000101343 E019 103.513105 0.0004260017 0.0105253222 0.060357999 20 20050470 20050622 153 - 1.976 1.867 -0.367
ENSG00000101343 E020 63.473077 0.0007983715 0.0612343507 0.205562606 20 20052292 20052474 183 - 1.768 1.666 -0.348
ENSG00000101343 E021 0.000000       20 20052475 20052478 4 -      
ENSG00000101343 E022 0.000000       20 20052479 20052628 150 -      
ENSG00000101343 E023 0.000000       20 20052629 20052722 94 -      
ENSG00000101343 E024 0.000000       20 20052723 20052758 36 -      
ENSG00000101343 E025 0.000000       20 20055948 20056046 99 -