ENSG00000101290

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000450570 ENSG00000101290 HEK293_OSMI2_6hA HEK293_TMG_6hB CDS2 protein_coding protein_coding 24.21048 20.97336 25.37157 4.820685 0.4891635 0.274536 13.407627 9.091245 14.841329 2.432294 0.1700388 0.7064563 0.5501833 0.4240333 0.5851667 0.1611333 0.007675238 0.007675238 FALSE FALSE
ENST00000460006 ENSG00000101290 HEK293_OSMI2_6hA HEK293_TMG_6hB CDS2 protein_coding protein_coding 24.21048 20.97336 25.37157 4.820685 0.4891635 0.274536 9.214477 9.764522 8.937143 1.933681 0.3985620 -0.1275992 0.3836333 0.4739333 0.3518667 -0.1220667 0.053103348 0.007675238 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000101290 E001 9.7751497 0.0033005557 4.125414e-01 6.379870e-01 20 5126879 5126926 48 + 0.968 1.073 0.386
ENSG00000101290 E002 9.7585816 0.0032768428 4.122276e-01 6.377608e-01 20 5126927 5126978 52 + 0.968 1.073 0.386
ENSG00000101290 E003 15.5999211 0.0025514159 1.905342e-01 4.175970e-01 20 5126979 5127007 29 + 1.140 1.273 0.474
ENSG00000101290 E004 12.1201703 0.0038673742 7.052413e-02 2.257610e-01 20 5127008 5127008 1 + 1.000 1.197 0.715
ENSG00000101290 E005 35.3525016 0.0013440761 9.526528e-01 9.783317e-01 20 5127009 5127047 39 + 1.547 1.563 0.055
ENSG00000101290 E006 88.5375792 0.0005660964 2.363338e-01 4.723254e-01 20 5127048 5127149 102 + 1.957 1.933 -0.080
ENSG00000101290 E007 2.6841853 0.1417012264 8.494507e-01 9.246307e-01 20 5128150 5128750 601 + 0.538 0.571 0.150
ENSG00000101290 E008 158.7701087 0.0003235893 8.490515e-03 5.156406e-02 20 5173523 5173659 137 + 2.222 2.168 -0.179
ENSG00000101290 E009 171.2430316 0.0003773063 2.331881e-05 4.354141e-04 20 5175183 5175279 97 + 2.274 2.177 -0.324
ENSG00000101290 E010 0.1723744 0.0326491905 5.666734e-01   20 5175280 5175652 373 + 0.001 0.114 8.020
ENSG00000101290 E011 0.6957271 0.0193874923 8.544892e-01   20 5176102 5176647 546 + 0.228 0.205 -0.198
ENSG00000101290 E012 196.5885515 0.0002628862 1.916405e-05 3.688233e-04 20 5176648 5176745 98 + 2.331 2.242 -0.297
ENSG00000101290 E013 252.1491940 0.0003353376 1.497771e-01 3.619746e-01 20 5178817 5178956 140 + 2.398 2.388 -0.036
ENSG00000101290 E014 170.6433907 0.0015489798 5.804563e-01 7.574727e-01 20 5182387 5182445 59 + 2.219 2.231 0.039
ENSG00000101290 E015 209.6098896 0.0002783282 1.317642e-01 3.345734e-01 20 5183061 5183143 83 + 2.321 2.305 -0.053
ENSG00000101290 E016 0.6376527 0.0193874923 8.618879e-01   20 5183144 5183178 35 + 0.228 0.205 -0.200
ENSG00000101290 E017 225.6828376 0.0003445478 1.746892e-04 2.388586e-03 20 5184858 5184945 88 + 2.381 2.311 -0.233
ENSG00000101290 E018 168.3226025 0.0004686222 3.250425e-03 2.490736e-02 20 5185758 5185826 69 + 2.249 2.187 -0.206
ENSG00000101290 E019 271.0745805 0.0001983416 1.204644e-02 6.663658e-02 20 5186687 5186839 153 + 2.442 2.409 -0.111
ENSG00000101290 E020 3.6186289 0.0066192757 2.061898e-01 4.372430e-01 20 5186840 5186859 20 + 0.740 0.569 -0.730
ENSG00000101290 E021 3.1353544 0.1695599500 9.239232e-01 9.643534e-01 20 5186860 5187879 1020 + 0.580 0.638 0.254
ENSG00000101290 E022 230.6725561 0.0011482071 7.776945e-01 8.833019e-01 20 5189067 5189186 120 + 2.346 2.362 0.053
ENSG00000101290 E023 242.8454199 0.0017802905 3.674584e-01 6.019669e-01 20 5189735 5189838 104 + 2.378 2.377 -0.006
ENSG00000101290 E024 1837.9410635 0.0009522587 3.142094e-11 2.471513e-09 20 5190102 5197887 7786 + 3.201 3.305 0.345