ENSG00000101210

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000217182 ENSG00000101210 HEK293_OSMI2_6hA HEK293_TMG_6hB EEF1A2 protein_coding protein_coding 62.5964 101.8905 14.58339 24.97167 0.5964051 -2.803773 26.69959 41.78655 3.971744 11.27123 0.5713502 -3.391912 0.3776125 0.4038667 0.2707333 -0.1331333 0.13998115 0.003867134 FALSE TRUE
ENST00000298049 ENSG00000101210 HEK293_OSMI2_6hA HEK293_TMG_6hB EEF1A2 protein_coding non_stop_decay 62.5964 101.8905 14.58339 24.97167 0.5964051 -2.803773 34.81225 57.74722 10.473173 13.28068 0.2967982 -2.461926 0.6027833 0.5726667 0.7196000 0.1469333 0.04236142 0.003867134 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000101210 E001 0.3751086 0.0397964803 1.000000e+00   20 63488013 63488013 1 - 0.001 0.087 7.418
ENSG00000101210 E002 24.1307429 0.0221149754 8.643089e-01 0.932768574 20 63488014 63488152 139 - 1.178 1.211 0.118
ENSG00000101210 E003 119.7132875 0.0004791928 2.506972e-03 0.020373332 20 63488153 63488339 187 - 1.713 1.894 0.609
ENSG00000101210 E004 287.8030090 0.0003558401 7.323110e-02 0.231291719 20 63488340 63488425 86 - 2.190 2.259 0.231
ENSG00000101210 E005 723.7005625 0.0001956083 3.349956e-02 0.137465153 20 63488918 63489152 235 - 2.606 2.656 0.168
ENSG00000101210 E006 3.8153400 0.0219946872 2.798758e-01 0.519963278 20 63490081 63490478 398 - 0.287 0.538 1.384
ENSG00000101210 E007 751.2182255 0.0018212189 1.480018e-04 0.002074308 20 63490479 63490735 257 - 2.562 2.674 0.374
ENSG00000101210 E008 587.7859870 0.0002014487 1.106575e-03 0.010718001 20 63493137 63493287 151 - 2.484 2.570 0.284
ENSG00000101210 E009 495.9207396 0.0002296594 3.242362e-02 0.134467117 20 63494805 63494904 100 - 2.430 2.492 0.206
ENSG00000101210 E010 392.0605521 0.0003966306 5.661534e-01 0.747425774 20 63494905 63494967 63 - 2.394 2.382 -0.039
ENSG00000101210 E011 547.7001190 0.0001644969 3.954306e-02 0.153567321 20 63494968 63495101 134 - 2.568 2.525 -0.142
ENSG00000101210 E012 293.4670279 0.0002294050 5.084813e-03 0.035078124 20 63495856 63495861 6 - 2.334 2.251 -0.279
ENSG00000101210 E013 706.1276091 0.0001981145 8.528174e-05 0.001309645 20 63495862 63496035 174 - 2.706 2.631 -0.252
ENSG00000101210 E014 3.2169960 0.4212885807 8.052551e-01 0.899309723 20 63496036 63496087 52 - 0.592 0.449 -0.684
ENSG00000101210 E015 8.8505891 0.2289495095 2.436869e-01 0.480702130 20 63496088 63497453 1366 - 1.063 0.761 -1.144
ENSG00000101210 E016 2.7612601 0.0209711860 1.053822e-01 0.291319123 20 63497454 63497619 166 - 0.000 0.460 12.457
ENSG00000101210 E017 635.6940645 0.0002855979 8.958351e-03 0.053633086 20 63497620 63497783 164 - 2.643 2.588 -0.183
ENSG00000101210 E018 333.7765361 0.0005664278 2.453459e-02 0.110791539 20 63497784 63497803 20 - 2.374 2.306 -0.226
ENSG00000101210 E019 303.5054688 0.0004381718 9.632011e-02 0.275302445 20 63497804 63497834 31 - 2.319 2.268 -0.170
ENSG00000101210 E020 3.0541641 0.0076691610 9.933531e-01 0.998339202 20 63497835 63497928 94 - 0.459 0.460 0.006
ENSG00000101210 E021 2.2664297 0.1925547790 1.996225e-01 0.429179856 20 63497929 63498748 820 - 0.000 0.407 11.262
ENSG00000101210 E022 243.8286876 0.0017638637 3.478259e-01 0.585268747 20 63499058 63499239 182 - 2.213 2.172 -0.135