ENSG00000101199

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370283 ENSG00000101199 HEK293_OSMI2_6hA HEK293_TMG_6hB ARFGAP1 protein_coding protein_coding 77.33591 110.3957 60.6925 7.067438 1.311918 -0.8629866 32.996775 56.319137 17.809993 11.235770 0.8480463 -1.66038459 0.40448750 0.50720000 0.29323333 -0.21396667 2.962336e-01 8.87056e-14 FALSE TRUE
ENST00000395285 ENSG00000101199 HEK293_OSMI2_6hA HEK293_TMG_6hB ARFGAP1 protein_coding retained_intron 77.33591 110.3957 60.6925 7.067438 1.311918 -0.8629866 4.067639 4.985273 4.429810 1.739960 0.1676206 -0.17006542 0.05462500 0.04533333 0.07296667 0.02763333 5.867174e-01 8.87056e-14 TRUE FALSE
ENST00000518794 ENSG00000101199 HEK293_OSMI2_6hA HEK293_TMG_6hB ARFGAP1 protein_coding processed_transcript 77.33591 110.3957 60.6925 7.067438 1.311918 -0.8629866 7.359210 10.359427 7.356302 2.576555 0.1964137 -0.49332371 0.09751250 0.09433333 0.12136667 0.02703333 7.618805e-01 8.87056e-14 FALSE FALSE
ENST00000519273 ENSG00000101199 HEK293_OSMI2_6hA HEK293_TMG_6hB ARFGAP1 protein_coding protein_coding 77.33591 110.3957 60.6925 7.067438 1.311918 -0.8629866 4.270705 5.981737 3.874104 0.594938 0.2376565 -0.62539259 0.05663750 0.05406667 0.06376667 0.00970000 7.630729e-01 8.87056e-14 FALSE TRUE
ENST00000519531 ENSG00000101199 HEK293_OSMI2_6hA HEK293_TMG_6hB ARFGAP1 protein_coding retained_intron 77.33591 110.3957 60.6925 7.067438 1.311918 -0.8629866 8.109718 9.988352 9.416338 2.529366 0.4356128 -0.08499293 0.11319167 0.09120000 0.15523333 0.06403333 3.807537e-01 8.87056e-14 FALSE TRUE
ENST00000522959 ENSG00000101199 HEK293_OSMI2_6hA HEK293_TMG_6hB ARFGAP1 protein_coding retained_intron 77.33591 110.3957 60.6925 7.067438 1.311918 -0.8629866 6.243658 6.497929 8.171661 1.544127 0.4136268 0.33019528 0.09231250 0.05923333 0.13450000 0.07526667 6.855717e-02 8.87056e-14 FALSE FALSE
ENST00000549076 ENSG00000101199 HEK293_OSMI2_6hA HEK293_TMG_6hB ARFGAP1 protein_coding protein_coding 77.33591 110.3957 60.6925 7.067438 1.311918 -0.8629866 5.726634 5.633956 0.000000 1.158973 0.0000000 -9.14056288 0.05981667 0.05110000 0.00000000 -0.05110000 8.870560e-14 8.87056e-14 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000101199 E001 0.0000000       20 63272513 63272784 272 +      
ENSG00000101199 E002 0.2027342 0.0376835144 1.000000e+00   20 63272785 63272794 10 + 0.001 0.077 7.294
ENSG00000101199 E003 0.2027342 0.0376835144 1.000000e+00   20 63272795 63272796 2 + 0.000 0.077 9.262
ENSG00000101199 E004 0.2027342 0.0376835144 1.000000e+00   20 63272797 63272801 5 + 0.000 0.077 9.262
ENSG00000101199 E005 0.9338807 0.1061595299 3.190232e-01   20 63272802 63272806 5 + 0.413 0.200 -1.444
ENSG00000101199 E006 3.0939078 0.2727702628 5.471935e-01 7.342739e-01 20 63272807 63272810 4 + 0.489 0.615 0.582
ENSG00000101199 E007 6.9071703 0.0122346304 8.204615e-02 2.488405e-01 20 63272811 63272812 2 + 0.676 0.920 0.966
ENSG00000101199 E008 8.0923059 0.0042341264 9.597251e-02 2.746927e-01 20 63272813 63272815 3 + 0.765 0.970 0.790
ENSG00000101199 E009 15.0059613 0.0031642993 3.357476e-01 5.742156e-01 20 63272816 63272824 9 + 1.107 1.186 0.283
ENSG00000101199 E010 43.2138236 0.0010331204 1.040327e-01 2.888735e-01 20 63272825 63272828 4 + 1.678 1.565 -0.385
ENSG00000101199 E011 59.3519061 0.0006047827 7.062966e-01 8.395247e-01 20 63272829 63272832 4 + 1.758 1.720 -0.129
ENSG00000101199 E012 142.4641471 0.0004210535 2.992674e-01 5.396996e-01 20 63272833 63272863 31 + 2.092 2.108 0.053
ENSG00000101199 E013 142.4641471 0.0004210535 2.992674e-01 5.396996e-01 20 63272864 63272864 1 + 2.092 2.108 0.053
ENSG00000101199 E014 200.2727443 0.0003280980 2.684384e-01 5.081089e-01 20 63272865 63272920 56 + 2.242 2.254 0.040
ENSG00000101199 E015 1.3392968 0.0149184637 2.800020e-01   20 63273204 63273317 114 + 0.497 0.294 -1.147
ENSG00000101199 E016 1.3856047 0.0280435600 6.921148e-01   20 63273318 63273410 93 + 0.417 0.334 -0.475
ENSG00000101199 E017 1.2075010 0.0160649740 1.078199e-01   20 63273411 63273518 108 + 0.498 0.200 -1.876
ENSG00000101199 E018 2.7753977 0.0292377824 1.458466e-01 3.561348e-01 20 63274000 63274033 34 + 0.723 0.467 -1.152
ENSG00000101199 E019 5.2281185 0.0057919087 9.452293e-01 9.748966e-01 20 63274034 63274170 137 + 0.765 0.738 -0.108
ENSG00000101199 E020 3.5697665 0.1281658635 5.938658e-01 7.662735e-01 20 63274171 63274210 40 + 0.722 0.572 -0.646
ENSG00000101199 E021 176.7904806 0.0002695442 5.595409e-02 1.935519e-01 20 63275577 63275622 46 + 2.254 2.178 -0.252
ENSG00000101199 E022 186.6654849 0.0020853968 4.915706e-02 1.775943e-01 20 63275623 63275640 18 + 2.285 2.194 -0.306
ENSG00000101199 E023 372.7784136 0.0069379755 1.647536e-01 3.836885e-01 20 63276091 63276200 110 + 2.579 2.492 -0.291
ENSG00000101199 E024 469.8802685 0.0052763234 2.502739e-01 4.882568e-01 20 63276480 63276651 172 + 2.667 2.598 -0.227
ENSG00000101199 E025 30.5267845 0.0973359485 1.560866e-02 8.039273e-02 20 63276652 63276742 91 + 1.684 1.315 -1.267
ENSG00000101199 E026 341.7771074 0.0026743808 4.947039e-01 6.972305e-01 20 63277205 63277305 101 + 2.481 2.482 0.005
ENSG00000101199 E027 385.0197607 0.0018342767 2.869790e-01 5.277275e-01 20 63278117 63278203 87 + 2.528 2.535 0.026
ENSG00000101199 E028 30.0599562 0.1068549971 1.009979e-01 2.835894e-01 20 63278204 63278553 350 + 1.607 1.357 -0.860
ENSG00000101199 E029 413.9228488 0.0013539035 8.390623e-01 9.188599e-01 20 63278899 63278995 97 + 2.584 2.559 -0.086
ENSG00000101199 E030 2.2003135 0.0219618771 1.723814e-01 3.937102e-01 20 63279220 63279306 87 + 0.626 0.373 -1.242
ENSG00000101199 E031 332.6777284 0.0007571112 5.067549e-01 7.054392e-01 20 63281291 63281347 57 + 2.498 2.461 -0.123
ENSG00000101199 E032 303.1189835 0.0022637546 6.761753e-01 8.203089e-01 20 63282819 63282851 33 + 2.456 2.421 -0.117
ENSG00000101199 E033 222.8349334 0.0667071394 1.479840e-02 7.731926e-02 20 63282852 63283528 677 + 2.494 2.194 -1.000
ENSG00000101199 E034 42.9331001 0.0676485750 2.069115e-02 9.830281e-02 20 63283851 63283880 30 + 1.794 1.485 -1.048
ENSG00000101199 E035 94.2415781 0.0894305304 5.055728e-02 1.809726e-01 20 63284115 63284291 177 + 2.107 1.833 -0.921
ENSG00000101199 E036 42.2391560 0.0776845426 2.283960e-02 1.054441e-01 20 63284292 63284307 16 + 1.791 1.475 -1.078
ENSG00000101199 E037 85.7318271 0.0648731622 2.022731e-02 9.667288e-02 20 63284308 63284434 127 + 2.078 1.786 -0.981
ENSG00000101199 E038 77.3318418 0.0514586902 6.967315e-02 2.241396e-01 20 63284435 63284512 78 + 1.986 1.773 -0.716
ENSG00000101199 E039 164.5851894 0.0568645543 5.653211e-02 1.949054e-01 20 63284513 63284865 353 + 2.316 2.093 -0.746
ENSG00000101199 E040 380.6820235 0.0012418078 2.154353e-01 4.479884e-01 20 63284866 63284922 57 + 2.567 2.514 -0.177
ENSG00000101199 E041 16.1148621 0.1036527130 3.758941e-02 1.485513e-01 20 63285486 63285653 168 + 1.402 1.063 -1.200
ENSG00000101199 E042 415.5726194 0.0016108939 5.703290e-01 7.504863e-01 20 63285654 63285713 60 + 2.571 2.564 -0.020
ENSG00000101199 E043 49.8018630 0.0898028502 6.698459e-02 2.183276e-01 20 63285714 63285789 76 + 1.832 1.562 -0.914
ENSG00000101199 E044 61.6813343 0.0870626873 7.587257e-02 2.365065e-01 20 63285790 63285970 181 + 1.912 1.663 -0.841
ENSG00000101199 E045 29.2227735 0.1145687216 3.159537e-02 1.320476e-01 20 63285971 63285979 9 + 1.658 1.303 -1.221
ENSG00000101199 E046 84.2117635 0.1015752028 1.474531e-02 7.713207e-02 20 63285980 63286218 239 + 2.107 1.750 -1.201
ENSG00000101199 E047 68.2728466 0.0956465947 4.123611e-02 1.579465e-01 20 63286219 63286365 147 + 1.981 1.687 -0.993
ENSG00000101199 E048 250.8455040 0.0009914589 2.409450e-01 4.776513e-01 20 63286366 63286371 6 + 2.339 2.352 0.045
ENSG00000101199 E049 441.1642397 0.0014442441 2.008615e-01 4.308021e-01 20 63286372 63286442 71 + 2.583 2.594 0.037
ENSG00000101199 E050 474.2821918 0.0009570879 3.430495e-02 1.396915e-01 20 63287564 63287655 92 + 2.602 2.629 0.088
ENSG00000101199 E051 386.5387340 0.0005598916 2.151662e-02 1.010290e-01 20 63287656 63287747 92 + 2.511 2.544 0.107
ENSG00000101199 E052 946.6820335 0.0008683952 1.315468e-03 1.227319e-02 20 63287748 63288309 562 + 2.897 2.933 0.120
ENSG00000101199 E053 2187.5120453 0.0007063415 1.256803e-10 8.718714e-09 20 63288310 63289496 1187 + 3.239 3.301 0.205
ENSG00000101199 E054 376.8842739 0.0040279893 1.801113e-04 2.449903e-03 20 63289497 63289677 181 + 2.433 2.552 0.397
ENSG00000101199 E055 163.1316768 0.0027682111 4.596597e-05 7.742589e-04 20 63289678 63289790 113 + 2.049 2.200 0.506