ENSG00000101104

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372824 ENSG00000101104 HEK293_OSMI2_6hA HEK293_TMG_6hB PABPC1L protein_coding retained_intron 13.20071 17.94023 9.526769 4.837947 0.7586231 -0.9124301 4.7128157 6.2422423 3.1646726 2.06988196 0.2306979 -0.97776589 0.34917083 0.33436667 0.33260000 -0.001766667 1.000000e+00 5.627814e-05 FALSE  
ENST00000465761 ENSG00000101104 HEK293_OSMI2_6hA HEK293_TMG_6hB PABPC1L protein_coding retained_intron 13.20071 17.94023 9.526769 4.837947 0.7586231 -0.9124301 1.3737737 1.7080452 1.3644453 0.62508141 0.2238992 -0.32191850 0.10467500 0.09223333 0.14116667 0.048933333 4.539627e-01 5.627814e-05 FALSE  
ENST00000537323 ENSG00000101104 HEK293_OSMI2_6hA HEK293_TMG_6hB PABPC1L protein_coding nonsense_mediated_decay 13.20071 17.94023 9.526769 4.837947 0.7586231 -0.9124301 0.6733350 0.5748431 0.5955315 0.19726161 0.1115688 0.05015239 0.05457500 0.03050000 0.06540000 0.034900000 4.508466e-01 5.627814e-05 TRUE  
MSTRG.20760.14 ENSG00000101104 HEK293_OSMI2_6hA HEK293_TMG_6hB PABPC1L protein_coding   13.20071 17.94023 9.526769 4.837947 0.7586231 -0.9124301 1.4714482 2.0575292 1.1562418 0.39300229 0.1547639 -0.82604084 0.11256667 0.12246667 0.12513333 0.002666667 1.000000e+00 5.627814e-05 FALSE  
MSTRG.20760.21 ENSG00000101104 HEK293_OSMI2_6hA HEK293_TMG_6hB PABPC1L protein_coding   13.20071 17.94023 9.526769 4.837947 0.7586231 -0.9124301 0.7173505 1.0303691 0.4493138 0.23604849 0.1620489 -1.17954338 0.05440833 0.06453333 0.05070000 -0.013833333 9.075045e-01 5.627814e-05 TRUE  
MSTRG.20760.5 ENSG00000101104 HEK293_OSMI2_6hA HEK293_TMG_6hB PABPC1L protein_coding   13.20071 17.94023 9.526769 4.837947 0.7586231 -0.9124301 0.9010818 1.2468442 0.4275402 0.76363375 0.4275402 -1.52231854 0.06465417 0.05550000 0.04160000 -0.013900000 7.662917e-01 5.627814e-05 TRUE  
MSTRG.20760.7 ENSG00000101104 HEK293_OSMI2_6hA HEK293_TMG_6hB PABPC1L protein_coding   13.20071 17.94023 9.526769 4.837947 0.7586231 -0.9124301 0.7866206 1.5410427 0.7911559 0.31556010 0.4231774 -0.95308348 0.05760000 0.08890000 0.08543333 -0.003466667 9.280086e-01 5.627814e-05 TRUE  
MSTRG.20760.9 ENSG00000101104 HEK293_OSMI2_6hA HEK293_TMG_6hB PABPC1L protein_coding   13.20071 17.94023 9.526769 4.837947 0.7586231 -0.9124301 0.3112275 0.9208438 0.0000000 0.08928715 0.0000000 -6.54046727 0.02142917 0.06150000 0.00000000 -0.061500000 5.627814e-05 5.627814e-05 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000101104 E001 0.0000000       20 44908719 44908753 35 +      
ENSG00000101104 E002 1.0237200 0.0178739446 0.5997351945   20 44910060 44910073 14 + 0.190 0.290 0.794
ENSG00000101104 E003 1.9154743 0.0163847536 0.9465887495 0.975597109 20 44910074 44910083 10 + 0.422 0.433 0.056
ENSG00000101104 E004 6.5723750 0.0205174598 0.0486545427 0.176484694 20 44910084 44910123 40 + 0.572 0.894 1.322
ENSG00000101104 E005 6.3696408 0.0421637261 0.0770202147 0.238835094 20 44910124 44910124 1 + 0.571 0.883 1.284
ENSG00000101104 E006 8.6484572 0.2180190944 0.1019231968 0.285237558 20 44910125 44910138 14 + 0.673 0.996 1.266
ENSG00000101104 E007 11.3099148 0.0906975505 0.2414676174 0.478246205 20 44910139 44910164 26 + 0.902 1.078 0.653
ENSG00000101104 E008 27.0370696 0.1311640621 0.2482528377 0.486040258 20 44910165 44910336 172 + 1.265 1.428 0.567
ENSG00000101104 E009 46.3785678 0.0049271730 0.5905723861 0.764100493 20 44912660 44912853 194 + 1.595 1.630 0.120
ENSG00000101104 E010 39.0052260 0.0010534585 0.3974984707 0.626357091 20 44916756 44916871 116 + 1.583 1.532 -0.177
ENSG00000101104 E011 43.4658758 0.0011072029 0.3797422506 0.611983338 20 44918906 44919045 140 + 1.625 1.573 -0.175
ENSG00000101104 E012 36.1028292 0.0013321671 0.6099939019 0.776870308 20 44919183 44919277 95 + 1.530 1.499 -0.106
ENSG00000101104 E013 22.6731314 0.0029329828 0.7252001216 0.851251488 20 44921594 44921610 17 + 1.329 1.301 -0.095
ENSG00000101104 E014 24.9741932 0.0209687192 0.5859145034 0.760903528 20 44921611 44921624 14 + 1.392 1.335 -0.200
ENSG00000101104 E015 44.0106837 0.0009098582 0.4926182642 0.695739227 20 44921625 44921731 107 + 1.619 1.580 -0.133
ENSG00000101104 E016 41.6156512 0.0043278072 0.3733211174 0.606753115 20 44924161 44924256 96 + 1.523 1.581 0.198
ENSG00000101104 E017 3.8449304 0.0785718280 0.5396607500 0.728752224 20 44930460 44930517 58 + 0.732 0.589 -0.609
ENSG00000101104 E018 33.9653988 0.0016535133 0.2746963819 0.514699219 20 44930518 44930568 51 + 1.419 1.497 0.269
ENSG00000101104 E019 39.8411774 0.0019089305 0.3871728903 0.618267198 20 44930569 44930726 158 + 1.509 1.566 0.196
ENSG00000101104 E020 8.1150417 0.1140044914 0.4465118797 0.663102247 20 44931072 44931130 59 + 1.024 0.845 -0.675
ENSG00000101104 E021 35.4822786 0.0312118336 0.5003888073 0.701019043 20 44931222 44931561 340 + 1.558 1.479 -0.272
ENSG00000101104 E022 59.6476765 0.0008044718 0.8769254583 0.939678399 20 44931562 44931832 271 + 1.725 1.721 -0.014
ENSG00000101104 E023 76.4030837 0.0006102114 0.0012895969 0.012082270 20 44931833 44932026 194 + 1.926 1.789 -0.462
ENSG00000101104 E024 55.2667005 0.0006946096 0.0074475087 0.046785716 20 44932027 44932178 152 + 1.788 1.653 -0.455
ENSG00000101104 E025 38.9956989 0.0009990583 0.1052450873 0.291091799 20 44932179 44932266 88 + 1.613 1.517 -0.330
ENSG00000101104 E026 34.9156162 0.0011661414 0.0057799334 0.038644316 20 44932267 44932341 75 + 1.619 1.446 -0.592
ENSG00000101104 E027 46.4659418 0.0009932615 0.7618810462 0.873761969 20 44932342 44932432 91 + 1.602 1.623 0.073
ENSG00000101104 E028 86.3902731 0.0033856488 0.6886339336 0.828255473 20 44932433 44932681 249 + 1.860 1.891 0.105
ENSG00000101104 E029 26.9956551 0.0029933187 0.8795803364 0.941092094 20 44932682 44932689 8 + 1.391 1.387 -0.016
ENSG00000101104 E030 27.7686701 0.0016904844 0.7825060160 0.886129465 20 44932690 44932713 24 + 1.410 1.393 -0.058
ENSG00000101104 E031 89.1178909 0.0004732906 0.4115245781 0.637198714 20 44932714 44933042 329 + 1.866 1.904 0.128
ENSG00000101104 E032 25.4825523 0.0013765317 0.3436305322 0.581273461 20 44933043 44933056 14 + 1.305 1.383 0.270
ENSG00000101104 E033 33.0265424 0.0013208902 0.1667055915 0.386148042 20 44933057 44933071 15 + 1.391 1.492 0.347
ENSG00000101104 E034 40.7483551 0.0021700329 0.1762008724 0.398707005 20 44933072 44933103 32 + 1.486 1.579 0.317
ENSG00000101104 E035 37.7828804 0.0025236197 0.3233725205 0.562710996 20 44933104 44933134 31 + 1.470 1.544 0.253
ENSG00000101104 E036 41.0186777 0.0013157454 0.1638402172 0.382395168 20 44933135 44933185 51 + 1.494 1.588 0.323
ENSG00000101104 E037 1.2454229 0.3711767463 0.9417910775   20 44934501 44934563 63 + 0.323 0.301 -0.139
ENSG00000101104 E038 26.8738863 0.0015434843 0.3107640039 0.551219215 20 44935391 44935396 6 + 1.328 1.409 0.280
ENSG00000101104 E039 37.5162659 0.0010902408 0.0387848957 0.151593071 20 44935397 44935430 34 + 1.419 1.562 0.491
ENSG00000101104 E040 38.5612327 0.0013844768 0.1049117245 0.290491485 20 44935431 44935461 31 + 1.454 1.567 0.388
ENSG00000101104 E041 37.6564969 0.0140849176 0.1822282459 0.406923700 20 44935462 44935497 36 + 1.434 1.561 0.435
ENSG00000101104 E042 0.8203656 0.0228366240 0.1864990729   20 44935498 44935502 5 + 0.000 0.290 10.084
ENSG00000101104 E043 48.7259432 0.0137982955 0.9772104169 0.990371198 20 44936637 44936730 94 + 1.636 1.643 0.025
ENSG00000101104 E044 13.1447541 0.0200185851 0.0569523470 0.195928580 20 44936731 44936893 163 + 1.229 1.026 -0.729
ENSG00000101104 E045 11.2352541 0.0032564064 0.0861688479 0.256746697 20 44936894 44936976 83 + 1.152 0.971 -0.657
ENSG00000101104 E046 13.1191217 0.0026055559 0.0003608482 0.004345198 20 44936977 44937187 211 + 1.317 0.980 -1.210
ENSG00000101104 E047 8.9369914 0.1058516942 0.7556149730 0.869981744 20 44937826 44937842 17 + 0.991 0.917 -0.277
ENSG00000101104 E048 18.6287256 0.0345678462 0.5007198604 0.701274567 20 44937843 44938044 202 + 1.293 1.207 -0.303
ENSG00000101104 E049 7.6671214 0.0045778062 0.9461350581 0.975416567 20 44938045 44938060 16 + 0.880 0.873 -0.027
ENSG00000101104 E050 32.6886809 0.0015680037 0.7300847580 0.854291951 20 44938061 44938101 41 + 1.486 1.464 -0.078
ENSG00000101104 E051 47.8622918 0.0068892220 0.4894236980 0.693607687 20 44938102 44938191 90 + 1.601 1.641 0.135
ENSG00000101104 E052 33.6410237 0.0013304917 0.0769574914 0.238705974 20 44938674 44938748 75 + 1.381 1.510 0.443
ENSG00000101104 E053 34.4921635 0.0010918474 0.4969948426 0.698922276 20 44939126 44939317 192 + 1.454 1.502 0.165
ENSG00000101104 E054 1.0531700 0.0153787590 0.3293065718   20 44952643 44952704 62 + 0.422 0.245 -1.118
ENSG00000101104 E055 12.6169848 0.0026442881 0.0503928855 0.180610578 20 44958337 44959035 699 + 1.214 1.021 -0.696