ENSG00000100934

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307712 ENSG00000100934 HEK293_OSMI2_6hA HEK293_TMG_6hB SEC23A protein_coding protein_coding 29.71404 4.970202 54.85793 1.43867 3.709611 3.461687 20.254553 4.798615 34.596087 1.451152 1.0233683 2.847333 0.80166667 0.9518 0.63456667 -0.31723333 2.136568e-04 2.221197e-23 FALSE TRUE
ENST00000545328 ENSG00000100934 HEK293_OSMI2_6hA HEK293_TMG_6hB SEC23A protein_coding protein_coding 29.71404 4.970202 54.85793 1.43867 3.709611 3.461687 7.617936 0.000000 15.928481 0.000000 0.9746526 10.638298 0.14177500 0.0000 0.29066667 0.29066667 2.221197e-23 2.221197e-23 FALSE TRUE
ENST00000555017 ENSG00000100934 HEK293_OSMI2_6hA HEK293_TMG_6hB SEC23A protein_coding protein_coding 29.71404 4.970202 54.85793 1.43867 3.709611 3.461687 1.516533 0.000000 3.821984 0.000000 1.9365422 8.581948 0.02694583 0.0000 0.06533333 0.06533333 5.788124e-01 2.221197e-23 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000100934 E001 284.2396401 1.7109156346 0.317012915 0.55701528 14 39031919 39032940 1022 - 2.166 2.626 1.533
ENSG00000100934 E002 118.6747142 1.4462823502 0.383680254 0.61529927 14 39032941 39033203 263 - 1.820 2.150 1.111
ENSG00000100934 E003 114.1633412 1.4821242246 0.528100892 0.72067498 14 39033204 39033328 125 - 1.819 2.062 0.815
ENSG00000100934 E004 124.3813026 0.0864758741 0.550949688 0.73700361 14 39039031 39039096 66 - 1.872 2.021 0.502
ENSG00000100934 E005 2.9063566 0.0083621074 0.979351584 0.99145409 14 39039097 39040731 1635 - 0.440 0.463 0.119
ENSG00000100934 E006 220.6983511 0.0044929773 0.847779944 0.92374170 14 39040732 39040887 156 - 2.132 2.196 0.214
ENSG00000100934 E007 0.6709767 0.1809828201 0.420397813   14 39040888 39041433 546 - 0.124 0.291 1.530
ENSG00000100934 E008 215.1104570 0.0019283848 0.326214847 0.56539179 14 39042786 39042872 87 - 2.116 2.214 0.329
ENSG00000100934 E009 249.7471720 0.0068453641 0.927713003 0.96592975 14 39045163 39045324 162 - 2.183 2.246 0.209
ENSG00000100934 E010 137.8619886 0.0003491204 0.241748887 0.47849650 14 39048652 39048729 78 - 1.926 2.031 0.352
ENSG00000100934 E011 198.5527856 0.0002402630 0.672547921 0.81791826 14 39055143 39055296 154 - 2.091 2.127 0.122
ENSG00000100934 E012 186.7583251 0.0004745605 0.105991388 0.29234938 14 39061765 39061871 107 - 2.068 2.053 -0.049
ENSG00000100934 E013 167.2794323 0.0022205251 0.159167085 0.37552942 14 39063324 39063413 90 - 2.020 2.006 -0.045
ENSG00000100934 E014 1.4317472 0.1018878850 0.388258773 0.61911051 14 39064549 39064912 364 - 0.298 0.000 -11.520
ENSG00000100934 E015 182.0301309 0.0169857349 0.131004949 0.33338100 14 39064913 39064993 81 - 2.059 1.989 -0.235
ENSG00000100934 E016 245.5706718 0.0144605170 0.031435441 0.13160913 14 39067173 39067296 124 - 2.191 2.091 -0.336
ENSG00000100934 E017 248.0706453 0.0119554804 0.107042687 0.29404029 14 39074415 39074530 116 - 2.192 2.131 -0.206
ENSG00000100934 E018 276.9754213 0.0131251740 0.076162327 0.23707548 14 39075935 39076093 159 - 2.242 2.160 -0.274
ENSG00000100934 E019 255.7983176 0.0060590671 0.090446481 0.26458556 14 39085762 39085906 145 - 2.204 2.169 -0.117
ENSG00000100934 E020 196.2982088 0.0081003876 0.169548126 0.38992684 14 39086929 39087008 80 - 2.088 2.060 -0.094
ENSG00000100934 E021 0.1723744 0.2669673721 0.047778017   14 39087524 39088723 1200 - 0.000 0.292 14.549
ENSG00000100934 E022 0.8048655 0.0188186047 0.870444326   14 39091370 39091476 107 - 0.190 0.000 -10.671
ENSG00000100934 E023 204.8860921 0.0130489300 0.084749852 0.25423908 14 39091477 39091572 96 - 2.110 2.052 -0.193
ENSG00000100934 E024 188.1225246 0.0131575717 0.054248452 0.18965404 14 39091573 39091657 85 - 2.074 2.006 -0.228
ENSG00000100934 E025 146.3010679 0.0069165293 0.500937661 0.70146969 14 39091658 39091713 56 - 1.958 1.976 0.063
ENSG00000100934 E026 161.0826132 0.0012030854 0.575432475 0.75396123 14 39092541 39092627 87 - 1.999 2.027 0.095
ENSG00000100934 E027 0.0000000       14 39092761 39093184 424 -      
ENSG00000100934 E028 0.0000000       14 39093185 39093186 2 -      
ENSG00000100934 E029 153.5402345 0.0054341518 0.043605438 0.16415738 14 39093187 39093244 58 - 1.986 1.921 -0.218
ENSG00000100934 E030 0.2922838 0.0249811605 0.136362143   14 39094898 39094977 80 - 0.045 0.290 3.114
ENSG00000100934 E031 0.0000000       14 39094978 39095014 37 -      
ENSG00000100934 E032 0.0000000       14 39095015 39095017 3 -      
ENSG00000100934 E033 204.2666758 0.0025585866 0.001279482 0.01200672 14 39095898 39095998 101 - 2.113 2.011 -0.344
ENSG00000100934 E034 179.6784635 0.0002691208 0.040912332 0.15706336 14 39095999 39096139 141 - 2.054 2.019 -0.115
ENSG00000100934 E035 80.6223090 0.0367794023 0.655246618 0.80682686 14 39103032 39103123 92 - 1.699 1.765 0.225
ENSG00000100934 E036 42.0308638 0.5089957597 0.320197399 0.55990075 14 39103124 39103197 74 - 1.402 1.610 0.713
ENSG00000100934 E037 24.6190124 0.7493913723 0.607171422 0.77500853 14 39103198 39103228 31 - 1.206 1.226 0.069
ENSG00000100934 E038 3.0172600 0.1834717009 0.239448914 0.47596897 14 39103229 39103243 15 - 0.418 0.687 1.256
ENSG00000100934 E039 0.1614157 0.0364937404 0.720801592   14 39103593 39103663 71 - 0.045 0.000 -8.349
ENSG00000100934 E040 0.1426347 0.0340457460 0.720389710   14 39103664 39103829 166 - 0.045 0.000 -8.347
ENSG00000100934 E041 0.0000000       14 39109473 39109646 174 -