ENSG00000100811

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262238 ENSG00000100811 HEK293_OSMI2_6hA HEK293_TMG_6hB YY1 protein_coding protein_coding 29.53683 17.28243 38.8319 2.858854 0.7514649 1.167474 26.768766 16.31816941 33.300864 2.95781291 0.8775077 1.028630 0.91247917 0.9379667 0.8573333 -0.08063333 0.136234876 0.005838028 FALSE TRUE
ENST00000553625 ENSG00000100811 HEK293_OSMI2_6hA HEK293_TMG_6hB YY1 protein_coding protein_coding 29.53683 17.28243 38.8319 2.858854 0.7514649 1.167474 1.386711 0.09162071 4.072742 0.09162071 0.2460154 5.328272 0.03755417 0.0043000 0.1048667 0.10056667 0.006092611 0.005838028 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000100811 E001 1.639586 0.3770888992 5.925446e-01 7.652937e-01 14 100238298 100238299 2 + 0.327 0.526 1.066
ENSG00000100811 E002 9.016187 0.1657685436 8.299775e-01 9.137519e-01 14 100238300 100238790 491 + 0.954 1.012 0.213
ENSG00000100811 E003 33.744420 0.0050822971 7.063719e-04 7.497387e-03 14 100239144 100239203 60 + 1.392 1.694 1.035
ENSG00000100811 E004 348.003339 0.0049937890 5.129440e-01 7.102099e-01 14 100239204 100239753 550 + 2.482 2.577 0.316
ENSG00000100811 E005 72.264027 0.0031502469 1.447889e-01 3.546382e-01 14 100239754 100239758 5 + 1.787 1.929 0.477
ENSG00000100811 E006 168.199284 0.0031983016 6.357744e-01 7.941125e-01 14 100239759 100239886 128 + 2.170 2.258 0.293
ENSG00000100811 E007 129.014251 0.0003355050 6.834294e-02 2.213868e-01 14 100239887 100239923 37 + 2.084 2.095 0.035
ENSG00000100811 E008 376.934445 0.0007192797 3.594341e-09 1.859882e-07 14 100262304 100262466 163 + 2.569 2.508 -0.205
ENSG00000100811 E009 364.020696 0.0002163009 2.864192e-13 3.260092e-11 14 100274698 100274758 61 + 2.559 2.482 -0.257
ENSG00000100811 E010 11.919819 0.0686708683 8.225093e-01 9.094467e-01 14 100275729 100275942 214 + 1.080 1.105 0.090
ENSG00000100811 E011 12.169546 0.0554715572 7.124104e-01 8.432852e-01 14 100275943 100276074 132 + 1.092 1.102 0.037
ENSG00000100811 E012 12.976597 0.1668723791 9.926924e-01 9.979991e-01 14 100276075 100276198 124 + 1.078 1.194 0.414
ENSG00000100811 E013 13.322450 0.2325280803 3.957953e-01 6.250326e-01 14 100276199 100276489 291 + 0.972 1.338 1.314
ENSG00000100811 E014 574.347202 0.0014309484 4.841139e-17 9.667310e-15 14 100276490 100276648 159 + 2.770 2.649 -0.402
ENSG00000100811 E015 18.673244 0.0454965279 4.842096e-01 6.899757e-01 14 100276649 100277356 708 + 1.278 1.248 -0.104
ENSG00000100811 E016 6.478843 0.0048846628 3.997627e-01 6.280601e-01 14 100277357 100277417 61 + 0.787 0.952 0.635
ENSG00000100811 E017 3219.932562 0.0035205579 4.163179e-06 9.829050e-05 14 100277418 100282788 5371 + 3.434 3.562 0.424