ENSG00000100796

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000554308 ENSG00000100796 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP4R3A protein_coding nonsense_mediated_decay 39.44954 26.96786 60.46862 6.86089 2.341297 1.164649 2.275122 1.722968 3.589688 0.4336638 0.29439086 1.0546267 0.05142917 0.06393333 0.05923333 -0.00470000 9.234881e-01 1.718089e-11 TRUE TRUE
ENST00000554684 ENSG00000100796 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP4R3A protein_coding protein_coding 39.44954 26.96786 60.46862 6.86089 2.341297 1.164649 9.533568 6.714330 12.624751 2.2548235 1.68910610 0.9099347 0.25192917 0.23360000 0.20746667 -0.02613333 9.338318e-01 1.718089e-11 FALSE TRUE
ENST00000554943 ENSG00000100796 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP4R3A protein_coding protein_coding 39.44954 26.96786 60.46862 6.86089 2.341297 1.164649 3.029153 4.148686 3.058544 0.9947791 1.72949084 -0.4385737 0.08920000 0.15656667 0.05253333 -0.10403333 6.711597e-01 1.718089e-11 FALSE TRUE
ENST00000555718 ENSG00000100796 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP4R3A protein_coding processed_transcript 39.44954 26.96786 60.46862 6.86089 2.341297 1.164649 2.342280 1.559943 4.278488 0.4459660 0.07223418 1.4497568 0.06099167 0.05700000 0.07103333 0.01403333 7.055012e-01 1.718089e-11 FALSE FALSE
ENST00000557382 ENSG00000100796 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP4R3A protein_coding retained_intron 39.44954 26.96786 60.46862 6.86089 2.341297 1.164649 11.208944 9.920751 11.621500 2.6431910 1.23019125 0.2280625 0.33355833 0.36906667 0.19166667 -0.17740000 1.246409e-03 1.718089e-11   FALSE
MSTRG.10089.11 ENSG00000100796 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP4R3A protein_coding   39.44954 26.96786 60.46862 6.86089 2.341297 1.164649 2.503540 0.000000 5.255867 0.0000000 1.20512232 9.0405274 0.04517083 0.00000000 0.08626667 0.08626667 1.718089e-11 1.718089e-11 FALSE TRUE
MSTRG.10089.4 ENSG00000100796 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP4R3A protein_coding   39.44954 26.96786 60.46862 6.86089 2.341297 1.164649 6.072744 2.452519 16.043913 0.6430918 1.00609722 2.7047182 0.11628333 0.09680000 0.26590000 0.16910000 2.991813e-03 1.718089e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000100796 E001 2.144812 0.022907963 0.0186918881 0.091368157 14 91457508 91457610 103 - 0.279 0.712 2.203
ENSG00000100796 E002 117.233061 1.205931165 0.2659497065 0.505392436 14 91457611 91458138 528 - 1.838 2.294 1.529
ENSG00000100796 E003 192.767722 1.428854415 0.3758060069 0.608846459 14 91458139 91458329 191 - 2.105 2.467 1.209
ENSG00000100796 E004 516.245376 1.784539340 0.4628975780 0.675057715 14 91458330 91458858 529 - 2.567 2.860 0.974
ENSG00000100796 E005 123.637164 1.329824752 0.4595301964 0.672794646 14 91458859 91458869 11 - 1.981 2.208 0.762
ENSG00000100796 E006 346.759553 0.016523038 0.0619057813 0.207104241 14 91461381 91461607 227 - 2.455 2.620 0.547
ENSG00000100796 E007 3.149242 0.008085506 0.1642039841 0.382959970 14 91461608 91461684 77 - 0.642 0.454 -0.876
ENSG00000100796 E008 139.085737 0.004799853 0.9289729893 0.966513948 14 91462049 91462053 5 - 2.104 2.168 0.213
ENSG00000100796 E009 383.312977 0.003785763 0.5819607834 0.758372349 14 91462054 91462221 168 - 2.544 2.594 0.165
ENSG00000100796 E010 180.031700 0.004880085 0.6656904078 0.813458033 14 91462222 91462239 18 - 2.217 2.268 0.171
ENSG00000100796 E011 332.386642 0.002561162 0.1580472743 0.373817023 14 91462735 91462877 143 - 2.493 2.511 0.060
ENSG00000100796 E012 258.451970 0.004506765 0.2256522880 0.460099637 14 91465250 91465419 170 - 2.385 2.395 0.035
ENSG00000100796 E013 13.583599 0.002363121 0.9353907890 0.969864573 14 91466261 91466416 156 - 1.120 1.184 0.229
ENSG00000100796 E014 1.311030 0.326915565 0.7153352212   14 91468964 91469003 40 - 0.373 0.287 -0.540
ENSG00000100796 E015 1.393377 0.012540017 0.3812499823 0.613237630 14 91470210 91470247 38 - 0.412 0.284 -0.777
ENSG00000100796 E016 214.475680 0.004547852 0.1669812146 0.386522876 14 91470837 91470995 159 - 2.307 2.313 0.020
ENSG00000100796 E017 182.437657 0.006496321 0.0224477543 0.104068821 14 91473033 91473135 103 - 2.255 2.208 -0.158
ENSG00000100796 E018 189.616386 0.004508613 0.1025622666 0.286348299 14 91473239 91473348 110 - 2.258 2.252 -0.019
ENSG00000100796 E019 97.938326 0.004123512 0.1443134600 0.353851353 14 91473349 91473370 22 - 1.974 1.966 -0.029
ENSG00000100796 E020 41.712164 0.167510860 0.1047724336 0.290243039 14 91474641 91475810 1170 - 1.683 1.388 -1.010
ENSG00000100796 E021 35.117721 0.011790479 0.7290515180 0.853642284 14 91475811 91475819 9 - 1.524 1.547 0.076
ENSG00000100796 E022 44.823372 0.008533832 0.4538667273 0.668620320 14 91475820 91475849 30 - 1.635 1.638 0.007
ENSG00000100796 E023 193.709331 0.003842244 0.0747313889 0.234265675 14 91475850 91475966 117 - 2.269 2.257 -0.039
ENSG00000100796 E024 160.491079 0.006135175 0.0332732272 0.136790919 14 91476408 91476479 72 - 2.198 2.157 -0.136
ENSG00000100796 E025 117.539236 0.002665019 0.0056717668 0.038096604 14 91476480 91476524 45 - 2.068 2.010 -0.195
ENSG00000100796 E026 167.742625 0.006601881 0.0076103466 0.047525627 14 91476909 91476986 78 - 2.222 2.158 -0.213
ENSG00000100796 E027 484.984081 0.009780809 0.0015009890 0.013627503 14 91481576 91482039 464 - 2.689 2.601 -0.292
ENSG00000100796 E028 244.373352 0.005137771 0.0006808906 0.007276959 14 91482040 91482193 154 - 2.389 2.312 -0.259
ENSG00000100796 E029 167.934181 0.012043202 0.0544622264 0.190166516 14 91485632 91485730 99 - 2.221 2.160 -0.205
ENSG00000100796 E030 117.443511 0.007887873 0.0242043396 0.109705711 14 91490747 91490802 56 - 2.070 2.002 -0.228
ENSG00000100796 E031 115.513215 0.013305650 0.5102381409 0.708174682 14 91509506 91509704 199 - 2.038 2.047 0.028
ENSG00000100796 E032 78.430786 0.008353117 0.1101327306 0.299220406 14 91509705 91510074 370 - 1.817 1.976 0.536
ENSG00000100796 E033 136.938208 0.014019210 0.3976853764 0.626523713 14 91510075 91510507 433 - 2.116 2.118 0.008
ENSG00000100796 E034 4.564138 0.007512043 0.0664007024 0.216961682 14 91510529 91510554 26 - 0.595 0.898 1.236