ENSG00000100731

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000304743 ENSG00000100731 HEK293_OSMI2_6hA HEK293_TMG_6hB PCNX1 protein_coding protein_coding 8.801453 4.898938 14.80238 1.136996 0.3963441 1.593321 0.7704927 0.23282336 1.049780 0.01741035 0.13600531 2.1257862 0.07822917 0.05216667 0.07103333 0.01886667 7.835675e-01 2.118199e-13 FALSE TRUE
ENST00000439984 ENSG00000100731 HEK293_OSMI2_6hA HEK293_TMG_6hB PCNX1 protein_coding protein_coding 8.801453 4.898938 14.80238 1.136996 0.3963441 1.593321 0.6378197 0.09363701 1.179247 0.02391201 0.41503544 3.5204368 0.05662083 0.02336667 0.08060000 0.05723333 4.956810e-01 2.118199e-13 FALSE TRUE
ENST00000553272 ENSG00000100731 HEK293_OSMI2_6hA HEK293_TMG_6hB PCNX1 protein_coding processed_transcript 8.801453 4.898938 14.80238 1.136996 0.3963441 1.593321 0.5753595 0.00000000 2.316847 0.00000000 0.03065761 7.8622324 0.03952083 0.00000000 0.15673333 0.15673333 2.118199e-13 2.118199e-13 FALSE TRUE
MSTRG.9831.11 ENSG00000100731 HEK293_OSMI2_6hA HEK293_TMG_6hB PCNX1 protein_coding   8.801453 4.898938 14.80238 1.136996 0.3963441 1.593321 1.8965120 1.71444048 2.801361 0.51813833 0.12129513 0.7051405 0.24920833 0.33763333 0.18916667 -0.14846667 7.518733e-02 2.118199e-13 FALSE TRUE
MSTRG.9831.4 ENSG00000100731 HEK293_OSMI2_6hA HEK293_TMG_6hB PCNX1 protein_coding   8.801453 4.898938 14.80238 1.136996 0.3963441 1.593321 4.2348154 2.64761225 7.041131 0.58960934 0.53244966 1.4077241 0.47437500 0.54366667 0.47446667 -0.06920000 6.736495e-01 2.118199e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000100731 E001 0.0000000       14 70907405 70907458 54 +      
ENSG00000100731 E002 0.6072928 0.0201209204 4.505261e-01   14 70907459 70907531 73 + 0.158 0.290 1.111
ENSG00000100731 E003 11.9149697 0.0035126217 3.967123e-01 6.257302e-01 14 70907532 70907669 138 + 1.109 1.020 -0.324
ENSG00000100731 E004 11.4447021 0.0031422055 3.787679e-01 6.112248e-01 14 70907670 70907738 69 + 1.094 1.000 -0.342
ENSG00000100731 E005 24.0651268 0.0766287673 5.764325e-01 7.547397e-01 14 70907739 70908003 265 + 1.401 1.307 -0.325
ENSG00000100731 E006 0.1723744 0.0374439617 2.238358e-01   14 70942873 70942940 68 + 0.000 0.169 11.574
ENSG00000100731 E007 0.0000000       14 70946882 70946914 33 +      
ENSG00000100731 E008 37.3475918 0.8727577310 7.722524e-01 8.799762e-01 14 70946915 70947123 209 + 1.583 1.489 -0.321
ENSG00000100731 E009 36.9179227 0.1053808067 7.251237e-01 8.512030e-01 14 70962226 70962331 106 + 1.583 1.476 -0.365
ENSG00000100731 E010 0.0000000       14 70965365 70965369 5 +      
ENSG00000100731 E011 0.0000000       14 70965370 70965432 63 +      
ENSG00000100731 E012 27.6792781 0.0061725544 1.085993e-02 6.177409e-02 14 70968198 70968243 46 + 1.491 1.279 -0.734
ENSG00000100731 E013 42.6389166 0.0015730607 1.391508e-04 1.970071e-03 14 70969021 70969110 90 + 1.675 1.433 -0.827
ENSG00000100731 E014 0.4654660 0.0261779323 2.868738e-01   14 70969111 70969271 161 + 0.220 0.000 -12.609
ENSG00000100731 E015 0.1308682 0.0311928836 2.246573e-01   14 70969859 70969999 141 + 0.000 0.168 11.649
ENSG00000100731 E016 291.2575281 0.0002485146 1.049060e-26 6.408436e-24 14 70976942 70978377 1436 + 2.501 2.242 -0.862
ENSG00000100731 E017 79.4658473 0.0009661972 3.418856e-03 2.587345e-02 14 70978378 70978648 271 + 1.910 1.778 -0.447
ENSG00000100731 E018 9.5617419 0.0036945940 4.735103e-01 6.824593e-01 14 70988567 70988569 3 + 0.960 1.040 0.296
ENSG00000100731 E019 19.0236636 0.0021939723 9.074416e-01 9.558347e-01 14 70988570 70988699 130 + 1.279 1.268 -0.036
ENSG00000100731 E020 13.8301341 0.0031911992 6.809811e-01 8.232760e-01 14 70995741 70995843 103 + 1.131 1.169 0.138
ENSG00000100731 E021 13.9757894 0.0028910134 9.158893e-01 9.601237e-01 14 70995844 70995925 82 + 1.151 1.140 -0.039
ENSG00000100731 E022 42.3395507 0.0009967138 5.409230e-02 1.892835e-01 14 71009634 71009724 91 + 1.637 1.522 -0.393
ENSG00000100731 E023 0.0000000       14 71009725 71009868 144 +      
ENSG00000100731 E024 46.2767205 0.0055004445 1.196866e-01 3.153447e-01 14 71011492 71011549 58 + 1.674 1.569 -0.356
ENSG00000100731 E025 0.3040503 0.0274424043 5.091139e-01   14 71011550 71012838 1289 + 0.158 0.000 -12.023
ENSG00000100731 E026 32.4737531 0.0064450625 3.957623e-01 6.250312e-01 14 71012985 71012999 15 + 1.514 1.448 -0.226
ENSG00000100731 E027 40.7012035 0.0092125913 4.646544e-01 6.763323e-01 14 71013000 71013030 31 + 1.604 1.548 -0.193
ENSG00000100731 E028 75.7065617 0.0062008802 2.759503e-01 5.160124e-01 14 71013031 71013202 172 + 1.869 1.807 -0.209
ENSG00000100731 E029 70.0290053 0.0019632385 2.404349e-02 1.092140e-01 14 71019009 71019162 154 + 1.850 1.738 -0.380
ENSG00000100731 E030 44.6103482 0.0009678673 1.544527e-02 7.976653e-02 14 71023200 71023232 33 + 1.665 1.522 -0.487
ENSG00000100731 E031 46.9079794 0.0007508965 1.152934e-04 1.682375e-03 14 71026117 71026194 78 + 1.710 1.483 -0.773
ENSG00000100731 E032 39.3453602 0.0010649815 1.011539e-02 5.862884e-02 14 71026195 71026288 94 + 1.623 1.462 -0.551
ENSG00000100731 E033 29.5156055 0.0204332122 2.103254e-01 4.421869e-01 14 71026772 71026821 50 + 1.494 1.370 -0.428
ENSG00000100731 E034 29.4001197 0.0170069060 4.821067e-01 6.884870e-01 14 71026822 71026882 61 + 1.477 1.416 -0.211
ENSG00000100731 E035 0.0000000       14 71026883 71027202 320 +      
ENSG00000100731 E036 41.5721504 0.0009729761 8.927082e-01 9.479593e-01 14 71028700 71028791 92 + 1.603 1.596 -0.024
ENSG00000100731 E037 53.8896179 0.0007051973 6.313233e-01 7.912398e-01 14 71033429 71033538 110 + 1.714 1.690 -0.082
ENSG00000100731 E038 55.6353468 0.0007979397 1.584470e-01 3.744639e-01 14 71033931 71034036 106 + 1.740 1.668 -0.246
ENSG00000100731 E039 44.9941861 0.0010271975 6.411451e-01 7.976250e-01 14 71036065 71036157 93 + 1.637 1.611 -0.088
ENSG00000100731 E040 53.1295600 0.0007371389 5.054078e-01 7.045688e-01 14 71045133 71045283 151 + 1.715 1.681 -0.116
ENSG00000100731 E041 57.7042792 0.0006142147 9.995148e-01 1.000000e+00 14 71046964 71047105 142 + 1.737 1.737 0.002
ENSG00000100731 E042 71.7274333 0.0038382113 1.530362e-01 3.666577e-01 14 71047807 71047959 153 + 1.799 1.879 0.269
ENSG00000100731 E043 42.7399843 0.0117898179 5.399226e-01 7.289605e-01 14 71047960 71047984 25 + 1.586 1.644 0.195
ENSG00000100731 E044 34.0506882 0.0293545951 5.501824e-01 7.364038e-01 14 71050652 71050657 6 + 1.479 1.570 0.311
ENSG00000100731 E045 54.7783985 0.0077532775 3.006167e-01 5.410986e-01 14 71050658 71050760 103 + 1.689 1.761 0.245
ENSG00000100731 E046 61.7636884 0.0112802153 3.569611e-01 5.932548e-01 14 71051883 71052012 130 + 1.745 1.809 0.217
ENSG00000100731 E047 0.8214337 0.0176673907 1.048058e-01   14 71053297 71053412 116 + 0.322 0.000 -13.417
ENSG00000100731 E048 61.2596774 0.0007391073 1.279428e-01 3.285644e-01 14 71055504 71055562 59 + 1.740 1.813 0.247
ENSG00000100731 E049 103.6974851 0.0008146042 2.434509e-01 4.804796e-01 14 71057509 71057724 216 + 1.976 2.021 0.149
ENSG00000100731 E050 0.0000000       14 71060668 71060742 75 +      
ENSG00000100731 E051 109.0567377 0.0004319577 1.041364e-02 5.991381e-02 14 71073545 71073798 254 + 1.977 2.069 0.308
ENSG00000100731 E052 99.9197653 0.0006149656 7.550243e-02 2.358642e-01 14 71076189 71076419 231 + 1.945 2.014 0.230
ENSG00000100731 E053 1.0941287 0.0156684297 5.422196e-01   14 71078651 71078739 89 + 0.274 0.384 0.693
ENSG00000100731 E054 63.0386481 0.0010502181 1.599989e-01 3.767956e-01 14 71088330 71088430 101 + 1.749 1.817 0.230
ENSG00000100731 E055 82.0319239 0.0006556959 3.740714e-02 1.480204e-01 14 71089192 71089342 151 + 1.851 1.939 0.296
ENSG00000100731 E056 0.8709345 0.0848125484 7.193758e-01   14 71092554 71093845 1292 + 0.219 0.292 0.547
ENSG00000100731 E057 93.4787315 0.0062010428 9.368491e-01 9.706398e-01 14 71101990 71102220 231 + 1.935 1.949 0.048
ENSG00000100731 E058 124.2085382 0.0049316062 4.118211e-01 6.373991e-01 14 71103395 71103669 275 + 2.045 2.094 0.165
ENSG00000100731 E059 102.6462820 0.0133024211 4.570133e-02 1.692613e-01 14 71105235 71105440 206 + 1.927 2.079 0.509
ENSG00000100731 E060 169.5113042 0.0002595662 1.236098e-11 1.048017e-09 14 71108604 71109019 416 + 2.127 2.317 0.634
ENSG00000100731 E061 53.5244387 0.0047378548 7.121683e-03 4.519190e-02 14 71109020 71109046 27 + 1.652 1.807 0.525
ENSG00000100731 E062 87.6051630 0.0005388223 1.869740e-06 4.912965e-05 14 71109452 71109592 141 + 1.845 2.032 0.631
ENSG00000100731 E063 52.5321292 0.0042297560 1.940512e-05 3.726603e-04 14 71109795 71109831 37 + 1.601 1.849 0.841
ENSG00000100731 E064 87.0776173 0.0068407065 2.467727e-04 3.183760e-03 14 71109832 71109982 151 + 1.837 2.045 0.698
ENSG00000100731 E065 431.8701120 0.0073603465 6.413202e-01 7.977068e-01 14 71109983 71115382 5400 + 2.608 2.601 -0.024