ENSG00000100697

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343455 ENSG00000100697 HEK293_OSMI2_6hA HEK293_TMG_6hB DICER1 protein_coding protein_coding 9.721496 4.540434 17.14782 1.074799 0.5254691 1.91479 2.6089107 2.42426009 3.8857216 0.50953113 0.5043919 0.6784072 0.36430417 0.54586667 0.225433333 -0.32043333 3.915901e-05 3.915901e-05 FALSE TRUE
ENST00000393063 ENSG00000100697 HEK293_OSMI2_6hA HEK293_TMG_6hB DICER1 protein_coding protein_coding 9.721496 4.540434 17.14782 1.074799 0.5254691 1.91479 0.6949961 0.00000000 0.8584677 0.00000000 0.6032124 6.4404004 0.04621667 0.00000000 0.052300000 0.05230000 5.730849e-01 3.915901e-05 FALSE TRUE
ENST00000526495 ENSG00000100697 HEK293_OSMI2_6hA HEK293_TMG_6hB DICER1 protein_coding protein_coding 9.721496 4.540434 17.14782 1.074799 0.5254691 1.91479 2.7387666 0.83373218 6.3581867 0.41688761 0.4964674 2.9160256 0.22487917 0.14860000 0.372366667 0.22376667 5.667022e-01 3.915901e-05 FALSE TRUE
ENST00000527414 ENSG00000100697 HEK293_OSMI2_6hA HEK293_TMG_6hB DICER1 protein_coding protein_coding 9.721496 4.540434 17.14782 1.074799 0.5254691 1.91479 0.4242800 0.01664749 1.9027183 0.01664749 0.6922628 6.1654810 0.02659167 0.00290000 0.108666667 0.10576667 3.095661e-03 3.915901e-05 FALSE TRUE
ENST00000527416 ENSG00000100697 HEK293_OSMI2_6hA HEK293_TMG_6hB DICER1 protein_coding processed_transcript 9.721496 4.540434 17.14782 1.074799 0.5254691 1.91479 0.2251297 0.28954705 0.0000000 0.15928205 0.0000000 -4.9047107 0.05770833 0.07630000 0.000000000 -0.07630000 1.745424e-01 3.915901e-05 FALSE TRUE
ENST00000529720 ENSG00000100697 HEK293_OSMI2_6hA HEK293_TMG_6hB DICER1 protein_coding protein_coding 9.721496 4.540434 17.14782 1.074799 0.5254691 1.91479 0.4767220 0.29242172 0.1491840 0.29242172 0.1491840 -0.9258665 0.05995417 0.05333333 0.008666667 -0.04466667 9.097425e-01 3.915901e-05 FALSE TRUE
ENST00000674628 ENSG00000100697 HEK293_OSMI2_6hA HEK293_TMG_6hB DICER1 protein_coding protein_coding 9.721496 4.540434 17.14782 1.074799 0.5254691 1.91479 0.9310424 0.29729608 1.6640825 0.10486518 0.1053927 2.4456694 0.07121667 0.06490000 0.097600000 0.03270000 6.488743e-01 3.915901e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000100697 E001 4.2214122 0.0929934661 4.616525e-03 3.256049e-02 14 95086228 95086242 15 - 0.433 1.061 2.619
ENSG00000100697 E002 4.2214122 0.0929934661 4.616525e-03 3.256049e-02 14 95086243 95086243 1 - 0.433 1.061 2.619
ENSG00000100697 E003 34.6003386 0.5481708989 1.001518e-01 2.820795e-01 14 95086244 95086455 212 - 1.263 1.847 2.002
ENSG00000100697 E004 32.3521615 0.5968548076 1.687137e-01 3.888849e-01 14 95086456 95086503 48 - 1.239 1.813 1.970
ENSG00000100697 E005 39.6251135 0.5875541830 8.408500e-02 2.529308e-01 14 95086504 95086573 70 - 1.275 1.946 2.289
ENSG00000100697 E006 119.7592981 1.2095168185 2.209341e-01 4.545693e-01 14 95086574 95087082 509 - 1.764 2.401 2.135
ENSG00000100697 E007 35.8148331 0.6197021153 2.016967e-01 4.317536e-01 14 95087083 95087083 1 - 1.310 1.824 1.756
ENSG00000100697 E008 53.7533464 0.7306265190 1.923970e-01 4.199724e-01 14 95087084 95087148 65 - 1.476 2.001 1.779
ENSG00000100697 E009 48.0210390 0.6701085710 1.421483e-01 3.506385e-01 14 95087149 95087229 81 - 1.407 1.978 1.940
ENSG00000100697 E010 134.6765296 1.2738326940 2.637624e-01 5.030256e-01 14 95087230 95087839 610 - 1.848 2.418 1.908
ENSG00000100697 E011 56.3249954 0.7724141093 2.652647e-01 5.046101e-01 14 95087840 95087898 59 - 1.531 1.973 1.496
ENSG00000100697 E012 186.3489204 1.4409497039 3.996267e-01 6.279715e-01 14 95087899 95088664 766 - 2.050 2.477 1.426
ENSG00000100697 E013 55.8295825 0.7892046046 3.161014e-01 5.561214e-01 14 95088665 95088848 184 - 1.553 1.929 1.273
ENSG00000100697 E014 49.7991913 0.7631113969 3.019899e-01 5.425474e-01 14 95088849 95089008 160 - 1.507 1.876 1.253
ENSG00000100697 E015 48.2206959 0.7284834583 2.631986e-01 5.023920e-01 14 95089009 95089246 238 - 1.475 1.893 1.422
ENSG00000100697 E016 22.7985367 0.4655989848 1.773984e-01 4.003023e-01 14 95089247 95089269 23 - 1.142 1.610 1.628
ENSG00000100697 E017 190.2156680 1.4675124482 4.433625e-01 6.609671e-01 14 95089270 95090320 1051 - 2.077 2.457 1.270
ENSG00000100697 E018 47.8934658 0.7551280818 3.640768e-01 5.990970e-01 14 95090321 95090431 111 - 1.506 1.831 1.104
ENSG00000100697 E019 47.9585066 0.7618357170 3.949754e-01 6.243278e-01 14 95090432 95090491 60 - 1.512 1.822 1.053
ENSG00000100697 E020 37.1131975 0.6938848382 4.267432e-01 6.485702e-01 14 95090492 95090502 11 - 1.416 1.689 0.936
ENSG00000100697 E021 34.7414126 0.6737400157 4.271571e-01 6.488296e-01 14 95090503 95090512 10 - 1.385 1.669 0.976
ENSG00000100697 E022 40.7323993 0.7213541865 4.107642e-01 6.365813e-01 14 95090513 95090536 24 - 1.451 1.737 0.977
ENSG00000100697 E023 71.9090549 0.8906905729 3.720468e-01 6.056393e-01 14 95090537 95090663 127 - 1.672 2.017 1.161
ENSG00000100697 E024 0.3641499 0.0298837498 4.550017e-01   14 95090664 95090664 1 - 0.064 0.221 2.072
ENSG00000100697 E025 1.3274104 0.0136968632 5.172189e-01   14 95090665 95091033 369 - 0.252 0.475 1.331
ENSG00000100697 E026 55.5275350 0.0299672975 2.193176e-01 4.525868e-01 14 95091034 95091109 76 - 1.586 1.873 0.972
ENSG00000100697 E027 102.1435991 0.0059313415 5.059189e-01 7.048857e-01 14 95091203 95091360 158 - 1.863 2.083 0.739
ENSG00000100697 E028 51.3102691 0.0341680508 6.346528e-01 7.933371e-01 14 95091361 95091365 5 - 1.592 1.720 0.434
ENSG00000100697 E029 1.4618628 0.1314321464 7.715336e-01 8.795220e-01 14 95091366 95091422 57 - 0.325 0.364 0.241
ENSG00000100697 E030 0.3807181 0.0567218117 4.647227e-01   14 95092569 95092593 25 - 0.064 0.221 2.072
ENSG00000100697 E031 0.8026527 0.0172671820 1.722205e-01   14 95092594 95092694 101 - 0.252 0.000 -11.642
ENSG00000100697 E032 128.1774579 0.0404957245 8.318730e-01 9.149154e-01 14 95093888 95094156 269 - 1.968 2.153 0.619
ENSG00000100697 E033 0.0000000       14 95095346 95095366 21 -      
ENSG00000100697 E034 2.3997940 0.0091143812 1.106317e-01 3.000168e-01 14 95095367 95095824 458 - 0.354 0.750 1.875
ENSG00000100697 E035 264.0043109 0.0180549223 6.810207e-01 8.233111e-01 14 95095825 95096713 889 - 2.286 2.451 0.549
ENSG00000100697 E036 76.8465304 0.0259431019 4.714191e-01 6.811692e-01 14 95099780 95099906 127 - 1.766 1.888 0.414
ENSG00000100697 E037 50.2034234 0.0366497187 5.904388e-01 7.640125e-01 14 95099907 95099935 29 - 1.581 1.713 0.448
ENSG00000100697 E038 129.9978590 0.0232219746 2.417844e-01 4.785296e-01 14 95103346 95103707 362 - 1.998 2.094 0.321
ENSG00000100697 E039 113.8691058 0.0325619997 1.645649e-01 3.834708e-01 14 95103708 95104049 342 - 1.952 2.001 0.164
ENSG00000100697 E040 43.8042399 0.0264836671 4.051931e-01 6.324318e-01 14 95104050 95104126 77 - 1.530 1.643 0.386
ENSG00000100697 E041 64.4922405 0.0202264999 4.337169e-01 6.540309e-01 14 95105071 95105246 176 - 1.691 1.826 0.456
ENSG00000100697 E042 0.0000000       14 95105247 95105403 157 -      
ENSG00000100697 E043 65.7071525 0.0250983417 3.129960e-01 5.533103e-01 14 95105678 95105783 106 - 1.704 1.811 0.362
ENSG00000100697 E044 49.6260739 0.0352010504 3.351827e-02 1.375165e-01 14 95106041 95106079 39 - 1.616 1.568 -0.165
ENSG00000100697 E045 78.7405073 0.0325665461 7.508103e-02 2.350060e-01 14 95106080 95106223 144 - 1.803 1.812 0.030
ENSG00000100697 E046 0.0000000       14 95106224 95106236 13 -      
ENSG00000100697 E047 80.5351121 0.0297659026 1.905552e-01 4.176053e-01 14 95107608 95107761 154 - 1.802 1.859 0.192
ENSG00000100697 E048 0.3228314 0.3371592463 8.277099e-01   14 95107762 95107773 12 - 0.119 0.000 -10.325
ENSG00000100697 E049 111.3103455 0.0216127294 3.781198e-02 1.491047e-01 14 95107880 95108093 214 - 1.950 1.958 0.027
ENSG00000100697 E050 100.0215321 0.0169671272 1.398439e-04 1.978729e-03 14 95108324 95108503 180 - 1.925 1.827 -0.332
ENSG00000100697 E051 0.3228314 0.3371592463 8.277099e-01   14 95111307 95111316 10 - 0.119 0.000 -10.325
ENSG00000100697 E052 107.0334116 0.0134256554 2.001255e-05 3.823367e-04 14 95111317 95111456 140 - 1.958 1.852 -0.355
ENSG00000100697 E053 75.0060293 0.0006230557 2.369742e-10 1.552012e-08 14 95112172 95112247 76 - 1.814 1.668 -0.495
ENSG00000100697 E054 93.2457169 0.0026439808 1.003088e-14 1.468512e-12 14 95113092 95113224 133 - 1.917 1.679 -0.802
ENSG00000100697 E055 78.5195148 0.0089557717 2.829505e-07 9.366764e-06 14 95115667 95115821 155 - 1.832 1.661 -0.578
ENSG00000100697 E056 68.8551397 0.0092535655 3.846196e-05 6.665027e-04 14 95116453 95116580 128 - 1.768 1.660 -0.367
ENSG00000100697 E057 68.4542168 0.0090682449 4.631407e-05 7.791179e-04 14 95116581 95116695 115 - 1.766 1.664 -0.343
ENSG00000100697 E058 73.4981989 0.0190263977 3.589117e-05 6.285600e-04 14 95117622 95117754 133 - 1.804 1.636 -0.569
ENSG00000100697 E059 136.2985100 0.0187748489 5.956783e-07 1.809011e-05 14 95124196 95124668 473 - 2.073 1.869 -0.684
ENSG00000100697 E060 66.9043278 0.0184478836 1.012600e-05 2.119073e-04 14 95126580 95126748 169 - 1.767 1.568 -0.676
ENSG00000100697 E061 0.4764247 0.0221091235 7.897122e-01   14 95129061 95129471 411 - 0.119 0.220 1.070
ENSG00000100697 E062 64.5372208 0.0405215135 1.884616e-03 1.629484e-02 14 95129472 95129632 161 - 1.744 1.603 -0.482
ENSG00000100697 E063 65.1294919 0.0246670618 4.359058e-04 5.089504e-03 14 95130058 95130192 135 - 1.747 1.611 -0.462
ENSG00000100697 E064 0.6356275 0.0476113228 1.000000e+00   14 95131245 95131508 264 - 0.168 0.221 0.488
ENSG00000100697 E065 63.7437768 0.0231570137 5.776274e-03 3.862441e-02 14 95131509 95131639 131 - 1.725 1.664 -0.205
ENSG00000100697 E066 4.4738345 0.6110506433 3.775272e-01 6.102726e-01 14 95131640 95132052 413 - 0.674 0.572 -0.446
ENSG00000100697 E067 4.1871287 0.1199682059 8.169126e-01 9.063979e-01 14 95132053 95132514 462 - 0.583 0.763 0.761
ENSG00000100697 E068 73.7007577 0.0214748337 1.755814e-03 1.540571e-02 14 95132515 95132677 163 - 1.791 1.702 -0.303
ENSG00000100697 E069 64.0860268 0.0181777856 1.706757e-04 2.341817e-03 14 95133315 95133503 189 - 1.739 1.595 -0.490
ENSG00000100697 E070 5.5478337 0.0171001465 4.158503e-02 1.588455e-01 14 95134361 95134503 143 - 0.758 0.562 -0.838
ENSG00000100697 E071 0.4054685 0.4421622033 9.199069e-02   14 95136623 95136810 188 - 0.000 0.379 14.499
ENSG00000100697 E072 17.2252045 0.0369871941 1.318412e-02 7.118904e-02 14 95140659 95140754 96 - 1.196 1.034 -0.583
ENSG00000100697 E073 6.8991555 0.0503220398 5.329458e-01 7.241270e-01 14 95140755 95140759 5 - 0.803 0.876 0.286
ENSG00000100697 E074 0.2735028 0.0274424043 4.577019e-01   14 95141154 95141187 34 - 0.063 0.220 2.067
ENSG00000100697 E075 9.9942824 0.0297665227 7.232243e-02 2.294354e-01 14 95141683 95141748 66 - 0.971 0.879 -0.346
ENSG00000100697 E076 0.8323924 0.0285035316 7.578581e-01   14 95146565 95146617 53 - 0.212 0.220 0.068
ENSG00000100697 E077 0.4929928 0.0323120191 7.923571e-01   14 95156187 95156403 217 - 0.119 0.220 1.070
ENSG00000100697 E078 13.7436484 0.0027905458 4.525954e-01 6.675796e-01 14 95157230 95157390 161 - 1.057 1.153 0.346
ENSG00000100697 E079 3.1568198 0.1607550656 9.916360e-01 9.975701e-01 14 95157391 95157529 139 - 0.511 0.636 0.568
ENSG00000100697 E080 0.0000000       14 95157931 95158010 80 -