ENSG00000100629

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000554502 ENSG00000100629 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP128 protein_coding nonsense_mediated_decay 4.558588 3.920908 6.303063 0.8901835 0.4749217 0.6834774 0.5673517 0.6893567 0.5332638 0.11145877 0.04880303 -0.3643756 0.1540167 0.1843667 0.08653333 -0.09783333 0.165614476 0.002334513 TRUE TRUE
ENST00000555265 ENSG00000100629 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP128 protein_coding protein_coding 4.558588 3.920908 6.303063 0.8901835 0.4749217 0.6834774 2.4663951 2.4865425 4.0024981 0.49458682 0.07142763 0.6845693 0.5389458 0.6506667 0.64046667 -0.01020000 1.000000000 0.002334513 FALSE TRUE
MSTRG.10021.2 ENSG00000100629 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP128 protein_coding   4.558588 3.920908 6.303063 0.8901835 0.4749217 0.6834774 0.9051051 0.2398090 1.1959023 0.06601252 0.06069391 2.2712158 0.1623750 0.0603000 0.19046667 0.13016667 0.002334513 0.002334513 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000100629 E001 25.3627264 0.0067925635 4.355155e-06 0.0001021272 14 80476983 80478177 1195 - 1.207 1.594 1.343
ENSG00000100629 E002 7.2439340 0.0507720885 9.759087e-02 0.2775611296 14 80478178 80478407 230 - 0.765 1.038 1.040
ENSG00000100629 E003 0.3040503 0.0244411696 3.009521e-01   14 80490479 80490722 244 - 0.187 0.000 -11.494
ENSG00000100629 E004 0.7968555 0.0172671820 9.018748e-01   14 80496474 80496478 5 - 0.257 0.249 -0.060
ENSG00000100629 E005 66.8462024 0.5918788587 2.244726e-01 0.4587703574 14 80496479 80497468 990 - 1.672 1.978 1.033
ENSG00000100629 E006 15.7042523 0.4350008772 4.573669e-01 0.6713405264 14 80497469 80497496 28 - 1.169 1.279 0.392
ENSG00000100629 E007 25.9865656 0.5580134857 3.160868e-01 0.5561092281 14 80497497 80497582 86 - 1.317 1.544 0.786
ENSG00000100629 E008 27.8930695 0.0680967370 2.907665e-01 0.5313973634 14 80504912 80505020 109 - 1.387 1.541 0.531
ENSG00000100629 E009 0.5363366 0.0270941216 4.891328e-02   14 80526684 80526868 185 - 0.000 0.335 12.956
ENSG00000100629 E010 30.2348549 0.0168474150 3.610036e-01 0.5964674632 14 80526869 80526982 114 - 1.436 1.557 0.416
ENSG00000100629 E011 0.3206185 0.0274424043 3.008658e-01   14 80527169 80527261 93 - 0.187 0.000 -11.494
ENSG00000100629 E012 29.6944674 0.0027628122 2.935180e-01 0.5341876081 14 80530809 80530886 78 - 1.497 1.460 -0.129
ENSG00000100629 E013 0.1308682 0.0326491905 3.673056e-01   14 80530887 80531000 114 - 0.000 0.142 11.373
ENSG00000100629 E014 23.1772994 0.0022974430 5.396279e-01 0.7287399452 14 80559279 80559302 24 - 1.383 1.370 -0.046
ENSG00000100629 E015 23.5554268 0.0016789408 9.951832e-01 0.9991469536 14 80580374 80580423 50 - 1.373 1.404 0.108
ENSG00000100629 E016 0.0000000       14 80580424 80580425 2 -      
ENSG00000100629 E017 0.2027342 0.0348501445 3.647908e-01   14 80742755 80743074 320 - 0.000 0.142 11.376
ENSG00000100629 E018 44.3645683 0.0012492065 2.500141e-01 0.4879460570 14 80743075 80743267 193 - 1.608 1.700 0.313
ENSG00000100629 E019 24.0002671 0.0016630125 2.775219e-01 0.5175891704 14 80756892 80756951 60 - 1.342 1.448 0.368
ENSG00000100629 E020 41.3832739 0.0011599718 1.031377e-01 0.2874351549 14 80761437 80761613 177 - 1.572 1.690 0.401
ENSG00000100629 E021 42.9172633 0.0010869959 7.685041e-01 0.8777466471 14 80777882 80778046 165 - 1.622 1.668 0.157
ENSG00000100629 E022 93.6115394 0.0006891592 4.380283e-01 0.6572411203 14 80784895 80785545 651 - 1.971 1.972 0.005
ENSG00000100629 E023 62.1842961 0.0009330443 2.464554e-01 0.4841106979 14 80792760 80793110 351 - 1.806 1.785 -0.072
ENSG00000100629 E024 0.1779838 0.0381512379 6.503830e-01   14 80830165 80830283 119 - 0.104 0.000 -10.501
ENSG00000100629 E025 2.9408826 0.0685597312 8.955000e-01 0.9494912471 14 80830284 80831142 859 - 0.565 0.616 0.227
ENSG00000100629 E026 42.8711514 0.0011271513 3.994790e-02 0.1545698701 14 80831143 80831294 152 - 1.675 1.594 -0.275
ENSG00000100629 E027 35.0122711 0.0013705630 4.706775e-01 0.6805796106 14 80836205 80836337 133 - 1.553 1.540 -0.044
ENSG00000100629 E028 24.7677313 0.0032531011 5.750834e-01 0.7537248635 14 80838204 80838278 75 - 1.407 1.397 -0.032
ENSG00000100629 E029 26.0369481 0.0015899156 8.577314e-01 0.9292065866 14 80840682 80840768 87 - 1.411 1.454 0.149
ENSG00000100629 E030 27.4182369 0.0100222711 6.642230e-01 0.8125166480 14 80862757 80862873 117 - 1.421 1.486 0.223
ENSG00000100629 E031 24.7317180 0.0430747028 7.302183e-01 0.8543651127 14 80895718 80895790 73 - 1.413 1.396 -0.059
ENSG00000100629 E032 19.5160543 0.0418720499 3.009994e-01 0.5414595323 14 80899938 80899972 35 - 1.343 1.237 -0.373
ENSG00000100629 E033 17.9627889 0.0284772276 5.288505e-01 0.7211970733 14 80899973 80900029 57 - 1.283 1.239 -0.155
ENSG00000100629 E034 26.2427289 0.0016368311 1.344955e-01 0.3388635811 14 80904813 80904909 97 - 1.458 1.384 -0.256
ENSG00000100629 E035 15.1078088 0.0046117555 8.005811e-02 0.2449544673 14 80904910 80904931 22 - 1.260 1.126 -0.476
ENSG00000100629 E036 0.0000000       14 80905471 80905954 484 -      
ENSG00000100629 E037 21.9008260 0.0020423772 1.782765e-02 0.0884563207 14 80905955 80906081 127 - 1.415 1.265 -0.524
ENSG00000100629 E038 0.0000000       14 80914316 80914321 6 -      
ENSG00000100629 E039 19.9421642 0.0017305871 4.493853e-03 0.0319033295 14 80914322 80914408 87 - 1.392 1.196 -0.688
ENSG00000100629 E040 17.0255138 0.0022852096 3.944242e-02 0.1533231880 14 80916401 80916451 51 - 1.309 1.162 -0.517
ENSG00000100629 E041 19.1200579 0.0041624406 2.141912e-02 0.1007048528 14 80916452 80916540 89 - 1.368 1.205 -0.570
ENSG00000100629 E042 12.3747112 0.0077881668 7.456651e-02 0.2339258571 14 80916541 80916562 22 - 1.191 1.041 -0.538
ENSG00000100629 E043 36.7465778 0.0060538274 3.788649e-02 0.1493187968 14 80939385 80939540 156 - 1.619 1.512 -0.366
ENSG00000100629 E044 25.2665057 0.0015751877 6.925812e-02 0.2233062527 14 80941581 80941745 165 - 1.454 1.355 -0.341
ENSG00000100629 E045 0.0000000       14 80942284 80942380 97 -      
ENSG00000100629 E046 0.0000000       14 80945556 80945767 212 -      
ENSG00000100629 E047 0.0000000       14 80957798 80958177 380 -      
ENSG00000100629 E048 0.0000000       14 80958178 80958285 108 -      
ENSG00000100629 E049 0.0000000       14 80959432 80959517 86 -