ENSG00000100605

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000553695 ENSG00000100605 HEK293_OSMI2_6hA HEK293_TMG_6hB ITPK1 protein_coding processed_transcript 45.66037 71.12312 32.31618 12.16798 1.294501 -1.137818 3.829879 2.573103 11.022649 2.573103 0.8431755 2.094602 0.11515833 0.05486667 0.34083333 0.2859667 1.218664e-01 4.440727e-05 FALSE FALSE
ENST00000555495 ENSG00000100605 HEK293_OSMI2_6hA HEK293_TMG_6hB ITPK1 protein_coding protein_coding 45.66037 71.12312 32.31618 12.16798 1.294501 -1.137818 19.730622 33.543697 10.891852 7.905595 0.2659339 -1.621898 0.41275000 0.45813333 0.33746667 -0.1206667 2.846501e-01 4.440727e-05 FALSE TRUE
ENST00000555553 ENSG00000100605 HEK293_OSMI2_6hA HEK293_TMG_6hB ITPK1 protein_coding protein_coding 45.66037 71.12312 32.31618 12.16798 1.294501 -1.137818 3.276109 7.320671 2.552700 1.580201 0.3491770 -1.516281 0.07327083 0.10176667 0.07946667 -0.0223000 7.390751e-01 4.440727e-05 FALSE FALSE
ENST00000556603 ENSG00000100605 HEK293_OSMI2_6hA HEK293_TMG_6hB ITPK1 protein_coding protein_coding 45.66037 71.12312 32.31618 12.16798 1.294501 -1.137818 14.696332 23.214719 6.009039 4.362991 0.1895807 -1.948056 0.29503333 0.32470000 0.18636667 -0.1383333 4.440727e-05 4.440727e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000100605 E001 21.913436 0.0482325819 7.633539e-01 8.746892e-01 14 92936914 92938526 1613 - 1.247 1.288 0.144
ENSG00000100605 E002 5.082651 0.0060583091 9.342533e-01 9.692630e-01 14 92938527 92939752 1226 - 0.717 0.712 -0.019
ENSG00000100605 E003 38.290111 0.0009834889 2.310138e-02 1.062636e-01 14 92939753 92939861 109 - 1.378 1.555 0.610
ENSG00000100605 E004 1193.554925 0.0028201987 7.484550e-03 4.695762e-02 14 92939862 92940890 1029 - 2.932 3.012 0.269
ENSG00000100605 E005 1115.295794 0.0001887575 2.175546e-09 1.189114e-07 14 92940891 92941904 1014 - 2.896 2.988 0.304
ENSG00000100605 E006 409.722269 0.0016615713 1.845677e-01 4.099318e-01 14 92946331 92946458 128 - 2.493 2.541 0.160
ENSG00000100605 E007 293.842149 0.0005181823 6.754230e-01 8.198237e-01 14 92946459 92946493 35 - 2.389 2.388 -0.002
ENSG00000100605 E008 394.171926 0.0003914364 2.765809e-01 5.165585e-01 14 92951946 92952013 68 - 2.528 2.514 -0.046
ENSG00000100605 E009 312.893005 0.0012124972 4.064260e-02 1.563992e-01 14 92958201 92958233 33 - 2.454 2.405 -0.165
ENSG00000100605 E010 280.983389 0.0008423950 2.332032e-02 1.069532e-01 14 92958234 92958270 37 - 2.411 2.357 -0.178
ENSG00000100605 E011 376.153456 0.0006986950 1.286485e-04 1.843980e-03 14 92958271 92958366 96 - 2.557 2.476 -0.272
ENSG00000100605 E012 247.224469 0.0004788479 2.381600e-03 1.957271e-02 14 92962355 92962395 41 - 2.370 2.298 -0.241
ENSG00000100605 E013 307.865315 0.0001966776 3.107756e-06 7.664368e-05 14 92962751 92962831 81 - 2.485 2.389 -0.321
ENSG00000100605 E014 187.260562 0.0008281159 5.942410e-06 1.337815e-04 14 92962832 92962849 18 - 2.297 2.167 -0.434
ENSG00000100605 E015 0.423152 0.0491745088 6.201169e-01   14 92962850 92962867 18 - 0.205 0.128 -0.808
ENSG00000100605 E016 322.322220 0.0002623986 6.604874e-05 1.056574e-03 14 92993880 92993997 118 - 2.494 2.413 -0.269
ENSG00000100605 E017 0.000000       14 92998903 92998939 37 -      
ENSG00000100605 E018 295.162530 0.0002995141 9.420066e-01 9.732419e-01 14 93016676 93016801 126 - 2.385 2.395 0.032
ENSG00000100605 E019 0.000000       14 93036847 93036974 128 -      
ENSG00000100605 E020 0.000000       14 93066185 93066358 174 -      
ENSG00000100605 E021 132.899994 0.0003340438 5.777575e-01 7.556375e-01 14 93076595 93076619 25 - 2.021 2.054 0.111
ENSG00000100605 E022 209.592601 0.0002452770 4.745679e-01 6.832483e-01 14 93115069 93115184 116 - 2.218 2.252 0.112
ENSG00000100605 E023 103.305722 0.0004679137 6.962993e-01 8.331645e-01 14 93115185 93115217 33 - 1.915 1.944 0.098
ENSG00000100605 E024 84.395634 0.0017602194 2.297386e-01 4.648525e-01 14 93115218 93115305 88 - 1.791 1.864 0.247
ENSG00000100605 E025 14.041418 0.0023897286 5.139512e-03 3.534778e-02 14 93115772 93115925 154 - 0.807 1.166 1.334
ENSG00000100605 E026 7.758382 0.0038039695 8.704579e-01 9.361793e-01 14 93116076 93116320 245 - 0.846 0.879 0.128