ENSG00000100603

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261531 ENSG00000100603 HEK293_OSMI2_6hA HEK293_TMG_6hB SNW1 protein_coding protein_coding 48.63698 28.04358 67.903 5.63214 4.386909 1.275503 43.439837 24.826260 64.51429 4.842714 4.195473 1.377394 0.86546667 0.88810000 0.9500333 0.06193333 0.0002689725 0.0002689725 FALSE TRUE
ENST00000554775 ENSG00000100603 HEK293_OSMI2_6hA HEK293_TMG_6hB SNW1 protein_coding protein_coding 48.63698 28.04358 67.903 5.63214 4.386909 1.275503 3.072682 2.162538 0.00000 1.138007 0.000000 -7.763238 0.09147083 0.06393333 0.0000000 -0.06393333 0.1641784625 0.0002689725 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000100603 E001 4.1087098 0.034839218 4.807367e-03 0.0335705215 14 77717599 77717627 29 - 0.487 0.955 1.952
ENSG00000100603 E002 202.3771649 0.008709970 2.404203e-01 0.4770510406 14 77717628 77717790 163 - 2.248 2.348 0.337
ENSG00000100603 E003 392.8067532 0.011167291 9.110191e-01 0.9576666313 14 77717791 77717952 162 - 2.559 2.596 0.124
ENSG00000100603 E004 639.0494809 0.005707098 8.799604e-01 0.9412244423 14 77717953 77718286 334 - 2.773 2.805 0.108
ENSG00000100603 E005 14.2272505 0.015454159 9.056278e-01 0.9549430191 14 77718287 77718366 80 - 1.164 1.174 0.039
ENSG00000100603 E006 439.8875818 0.006894647 1.210986e-01 0.3176111980 14 77718367 77718530 164 - 2.592 2.677 0.284
ENSG00000100603 E007 320.7869086 1.626666017 5.197765e-01 0.7148811124 14 77720711 77720828 118 - 2.422 2.585 0.540
ENSG00000100603 E008 304.6524373 0.023951698 1.763862e-01 0.3989562631 14 77723181 77723277 97 - 2.426 2.527 0.338
ENSG00000100603 E009 0.6709767 0.153719015 7.017153e-01   14 77730856 77730987 132 - 0.229 0.163 -0.613
ENSG00000100603 E010 367.9414020 0.001559605 5.166151e-01 0.7127617294 14 77730988 77731129 142 - 2.531 2.575 0.145
ENSG00000100603 E011 239.4470975 0.008688735 3.084051e-01 0.5490138254 14 77732485 77732538 54 - 2.367 2.344 -0.074
ENSG00000100603 E012 256.9289645 0.007148686 3.064745e-01 0.5471140574 14 77732539 77732601 63 - 2.395 2.378 -0.058
ENSG00000100603 E013 241.8641784 0.009887356 5.421462e-01 0.7305896368 14 77734947 77735012 66 - 2.362 2.366 0.011
ENSG00000100603 E014 208.0650958 0.012260603 8.709685e-01 0.9364860301 14 77735937 77736006 70 - 2.290 2.316 0.087
ENSG00000100603 E015 188.4272674 0.011778391 2.558723e-01 0.4945878968 14 77736971 77737075 105 - 2.266 2.237 -0.095
ENSG00000100603 E016 1.8753413 0.109025439 2.838747e-01 0.5243343580 14 77738738 77738777 40 - 0.491 0.282 -1.199
ENSG00000100603 E017 201.8810978 0.009549782 1.359273e-01 0.3412111450 14 77738778 77738884 107 - 2.301 2.256 -0.150
ENSG00000100603 E018 218.7514317 0.006013937 5.447374e-02 0.1901768008 14 77738966 77739061 96 - 2.337 2.285 -0.175
ENSG00000100603 E019 346.7734916 0.000275011 3.133007e-07 0.0000102535 14 77751319 77751480 162 - 2.547 2.465 -0.274
ENSG00000100603 E020 272.6779224 0.008298273 1.484690e-01 0.3600737338 14 77754967 77755098 132 - 2.435 2.378 -0.188
ENSG00000100603 E021 117.4441837 0.148771477 5.045260e-01 0.7039578730 14 77755099 77755120 22 - 2.033 2.086 0.179
ENSG00000100603 E022 100.5235661 0.525957361 4.257807e-01 0.6478681013 14 77761114 77761207 94 - 1.947 2.049 0.344